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  1. Article: A Comprehensive Analysis of 3 Moroccan Genomes Revealed Contributions From Both African and European Ancestries.

    Boumajdi, Nasma / Bendani, Houda / Kartti, Souad / Alouane, Tarek / Belyamani, Lahcen / Ibrahimi, Azeddine

    Evolutionary bioinformatics online

    2024  Volume 20, Page(s) 11769343241229278

    Abstract: Genetic variations in the human genome represent the differences in DNA sequence within individuals. This highlights the important role of whole human genome sequencing which has become the keystone for precision medicine and disease prediction. Morocco ... ...

    Abstract Genetic variations in the human genome represent the differences in DNA sequence within individuals. This highlights the important role of whole human genome sequencing which has become the keystone for precision medicine and disease prediction. Morocco is an important hub for studying human population migration and mixing history. This study presents the analysis of 3 Moroccan genomes; the variant analysis revealed 6 379 606 single nucleotide variants (SNVs) and 1 050 577 small InDels. Of those identified SNVs, 219 152 were novel, with 1233 occurring in coding regions, and 5580 non-synonymous single nucleotide variants (nsSNP) variants were predicted to affect protein functions. The InDels produced 1055 coding variants and 454 non-3n length variants, and their size ranged from -49 and 49 bp. We further analysed the gene pathways of 8 novel coding variants found in the 3 genomes and revealed 5 genes involved in various diseases and biological pathways. We found that the Moroccan genomes share 92.78% of African ancestry, and 92.86% of Non-Finnish European ancestry, according to the gnomAD database. Then, population structure inference, by admixture analysis and network-based approach, revealed that the studied genomes form a mixed population structure, highlighting the increased genetic diversity in Morocco.
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2227610-5
    ISSN 1176-9343
    ISSN 1176-9343
    DOI 10.1177/11769343241229278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19: The end of a story through the eyes of an emergency Practitioner.

    Jidane, Saïd / Belyamani, Lahcen

    The American journal of emergency medicine

    2020  Volume 42, Page(s) 239

    MeSH term(s) Attitude of Health Personnel ; COVID-19/epidemiology ; COVID-19/psychology ; Communicable Disease Control/organization & administration ; Emergency Service, Hospital/organization & administration ; Humans
    Keywords covid19
    Language English
    Publishing date 2020-06-06
    Publishing country United States
    Document type Letter
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2020.05.116
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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Topical Nitric Acid Burns: Initial Assessment and Management.

    Laanaya, Asmaa / Ami Ali, Mehdi / Miqdadi, Amal / Noussair, Mostapha / Nafaa, Mourad / Belyamani, Lahcen

    Case reports in dermatological medicine

    2023  Volume 2023, Page(s) 9995933

    Abstract: Nitric acid (NA) is corrosive. On contact with the skin, liquid splashes with nitric acid and may produce severe burns. These burns usually take on a characteristic yellowish hue. We report the case of a 54-year-old man presenting a nitric acid burn with ...

    Abstract Nitric acid (NA) is corrosive. On contact with the skin, liquid splashes with nitric acid and may produce severe burns. These burns usually take on a characteristic yellowish hue. We report the case of a 54-year-old man presenting a nitric acid burn with a pathognomonic skin lesion and perfect healing. NA is a chemical that is important in industry, and it is a very strong acid that is used for engraving, metal refining, electroplating, and fertilizer manufacturing. Skin contact with NA leads to severe burns. The pathophysiology depends on the type of concentration, the strength, quality, and duration of contact, and the penetration power of the acids concerned. The early and abundant irrigation with water or sterile isotonic saline solution, the use of panthenol-containing creams and covering with silver sulphadiazine dressing, carefully monitoring wounds, keeping wounds clean and moist, and preventing and managing secondary infection allow the healing.
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2684644-5
    ISSN 2090-6471 ; 2090-6463
    ISSN (online) 2090-6471
    ISSN 2090-6463
    DOI 10.1155/2023/9995933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Virtual docking screening and quantitative structure-activity relationship studies to explore AKT and PI3K inhibitors acting on mTOR in cancers by theoretical biology and medical modeling.

    Kandoussi, Ilham / Abbou, Hanane / Haddoumi, Ghyzlane El / Mansouri, Mariam / Belyamani, Lahcen / Ibrahimi, Azeddine

    Contemporary oncology (Poznan, Poland)

    2023  Volume 27, Issue 3, Page(s) 155–162

    Abstract: Introduction: The mechanistic target of rapamycin (mTOR) coordinates the growth and metabolism of eukaryotic cells with a central role in the regulation of many fundamental cellular processes. It is strongly connected to phosphatidylinositol 3-kinase ( ... ...

    Abstract Introduction: The mechanistic target of rapamycin (mTOR) coordinates the growth and metabolism of eukaryotic cells with a central role in the regulation of many fundamental cellular processes. It is strongly connected to phosphatidylinositol 3-kinase (PI3K) and AKT signaling. Activation of the PI3K/AKT/mTOR pathway leads to a profound disruption in the control of cell growth and survival, which ultimately leads to competitive growth advantage, metastatic competence, angiogenesis and therapeutic resistance.
    Material and methods: To explore the common competitive adenosine triphosphate (ATP) inhibitors PI3K/AKT and PI3K/mTOR, we built a 2D mTOR-SAR model that predicted the bioactivity of AKT and PI3K inhibitors towards mTOR. The interaction of the best inhibitors was evaluated by docking analysis and compared to that of the standard AZ8055 and XL388 inhibitors.
    Results: A mechanistic target of rapamycin-quantitative structure-activity relationship (mTOR-QSAR) model with a correlation coefficient (R
    Conclusions: After docking and several comparisons, the inhibitors with better predictions showed better affinity and interaction with mTOR compared to AZ8055 and XL388, so we have found that 2 AKT inhibitors and 9 mTOR inhibitors met the Lipinski and Veber criteria and could be future drugs.
    Language English
    Publishing date 2023-12-13
    Publishing country Poland
    Document type Journal Article
    ISSN 1428-2526
    ISSN 1428-2526
    DOI 10.5114/wo.2023.133709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: In Silico

    Magri, Meryam / Bouricha, El Mehdi / Hakmi, Mohammed / Jaoudi, Rachid El / Belyamani, Lahcen / Ibrahimi, Azeddine

    Bioinformatics and biology insights

    2023  Volume 17, Page(s) 11779322231212755

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2423808-9
    ISSN 1177-9322
    ISSN 1177-9322
    DOI 10.1177/11779322231212755
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  6. Article: Compliance With World Health Organization (WHO)-World Federation of Societies of Anesthesiologists (WFAS) Standards for General Anesthesia at Ibn Sina University Hospital Center, Morocco.

    Harfaoui, Wafaa / Ziani, Hicham / Slaihi, Zakaria / Arfaoui, Manal / Armel, Bouchra / Elhamzaoui, Hamza / Belyamani, Lahcen / Alilou, Mustapha / Obtel, Majdouline

    Cureus

    2024  Volume 16, Issue 1, Page(s) e51980

    Abstract: Introduction: Patient safety in anaesthesia has significantly improved over the past decades, largely due to pharmacological and technological advancements, as well as the widespread adoption of guidelines and standards recommended by international ... ...

    Abstract Introduction: Patient safety in anaesthesia has significantly improved over the past decades, largely due to pharmacological and technological advancements, as well as the widespread adoption of guidelines and standards recommended by international organisations. This study aimed to evaluate the practice of anaesthesia and its compliance with the international standards for safe anaesthesia practice recommended by the World Federation of Societies of Anaesthesiologists (WFSA) and the World Health Organization (WHO). This study also describes the operating room within Ibn Sina University Hospital Centre (CHUIS) of Rabat, Morocco, the referral centre, with the aim of identifying its potential and shortcomings.
    Methods: This was a prospective analytical descriptive study from March 1, 2021, to July 31, 2021. All facilities within an operating room and information regarding patients undergoing general anaesthesia, whether it be emergency or scheduled procedures, administered by an anaesthetist, were included. A survey form based on the WHO-WFSA International Standards for a Safe Practice of Anesthesia was used to collect data about the anaesthesia sites. Sources of information included direct observation of anaesthesia procedures, patient records, registers, and qualified anaesthesia personnel. Manual data analysis and encoding were performed using Microsoft Word and Excel (Microsoft Corporation, Redmond, Washington, United States).  Results: All the facilities within the operating rooms of CHUIS were surveyed. In total, 250 patients were recorded, with 43.6% at Ibn Sina Hospital, 18.4% in the Children's Hospital, 14% at the National Institute of Oncology, 12% at the Specialties, 6% at Maternity Hospital Souissi, and 6% at Orangers Maternity Hospital. The median age of patients was 50 years old with 37% of them aged 36-55 years. Overall, 67.6% of these patients were admitted for scheduled interventions. Anaesthetic risk assessment showed that 67.2% of the patients were in American Society of Anesthesiologists (ASA) class I. Pre-anaesthesia consultations were conducted in 65.6% of cases, and pre-anaesthesia visits were conducted in 89.6% of cases. Anaesthesia checklists were used in 89.6% of cases. General anaesthesia, including tracheal intubation 85.2% and facemask 7.2%, was the most common type of anaesthesia. Regarding anaesthetic agents, propofol was the most used intravenous narcotic, with fentanyl still being used in most cases 92% and rocuronium in 82% of cases. Electrocardiogram, non-invasive blood pressure, and pulse oxygen saturation (SPO2) monitoring were consistently used, while capnography was not available in 6% of cases. Crystalloid fluid resuscitation was used in 91.2% of cases, and colloid resuscitation was used in 1.2% of cases. The post-anesthesia care unit (PACU) was present in 58.8% of cases. Postoperative analgesia was administered in 80% of cases. Adverse events occurred in 58.4% of cases. Preoperative transfusion strategies were employed in 18% of cases. Patient transfers to the intensive care unit were done for 18%.
    Conclusion: Despite the shortcomings of the healthcare system in Morocco, our study indicates that the anaesthesia practice at CHUIS remains highly acceptable by adhering to the highest international standards.
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.51980
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  8. Article ; Online: COVID-19

    Jidane, Saïd / Belyamani, Lahcen

    The American Journal of Emergency Medicine ; ISSN 0735-6757

    The end of a story through the eyes of an emergency Practitioner

    2020  

    Keywords Emergency Medicine ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.ajem.2020.05.116
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Uncertainty Quantification for Epidemic Risk Management: Case of SARS-CoV-2 in Morocco.

    Hammadi, Lamia / Raillani, Hajar / Ndiaye, Babacar Mbaye / Aggoug, Badria / El Ballouti, Abdessamad / Jidane, Said / Belyamani, Lahcen / Souza de Cursi, Eduardo

    International journal of environmental research and public health

    2023  Volume 20, Issue 5

    Abstract: In this paper, we propose a new method for epidemic risk modelling and prediction, based on uncertainty quantification (UQ) approaches. In UQ, we consider the state variables as members of a convenient separable Hilbert space, and we look for their ... ...

    Abstract In this paper, we propose a new method for epidemic risk modelling and prediction, based on uncertainty quantification (UQ) approaches. In UQ, we consider the state variables as members of a convenient separable Hilbert space, and we look for their representation in finite dimensional subspaces generated by truncations of a suitable Hilbert basis. The coefficients of the finite expansion can be determined by approaches established in the literature, adapted to the determination of the probability distribution of epidemic risk variables. Here, we consider two approaches: collocation (COL) and moment matching (MM). Both are applied to the case of SARS-CoV-2 in Morocco, as an epidemic risk example. For all the epidemic risk indicators computed in this study (number of detections, number of deaths, number of new cases, predictions and human impact probabilities), the proposed models were able to estimate the values of the state variables with precision, i.e., with very low root mean square errors (RMSE) between predicted values and observed ones. Finally, the proposed approaches are used to generate a decision-making tool for future epidemic risk management, or, more generally, a quantitative disaster management approach in the humanitarian supply chain.
    MeSH term(s) Humans ; SARS-CoV-2 ; Uncertainty ; COVID-19 ; Morocco ; Probability
    Language English
    Publishing date 2023-02-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20054102
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  10. Article: Facing Antitubercular Resistance: Identification of Potential Direct Inhibitors Targeting InhA Enzyme and Generation of 3D-pharmacophore Model by in silico Approach.

    El Haddoumi, Ghyzlane / Mansouri, Mariam / Bendani, Houda / Bouricha, El Mehdi / Kandoussi, Ilham / Belyamani, Lahcen / Ibrahimi, Azeddine

    Advances and applications in bioinformatics and chemistry : AABC

    2023  Volume 16, Page(s) 49–59

    Abstract: Purpose: The enoyl-acyl carrier protein reductase (InhA) is one of the important key enzymes employed in mycolic acids biosynthesis pathway and an important component of mycobacterial cell walls. This enzyme has also been identified as major target of ... ...

    Abstract Purpose: The enoyl-acyl carrier protein reductase (InhA) is one of the important key enzymes employed in mycolic acids biosynthesis pathway and an important component of mycobacterial cell walls. This enzyme has also been identified as major target of isoniazid drug, except that isoniazid needs to be activated first by the catalase peroxidase (KatG) protein to form the isonicotinoyl-NAD (INH-NAD) adduct that inhibits the action of InhA enzyme. However, this activation becomes more difficult and unreachable with the problem of mutation-related resistance caused mainly by acquired mutations in KatG and InhA protein. Our main interest in this study is to identify direct InhA inhibitors using computer-aided drug design.
    Methods: Computer-aided drug design was used to solve this problem by applying three different approaches including mutation impact modelling, virtual screening and 3D-pharmacophore search.
    Results: A total of 15 mutations were collected from the literature, then a 3D model was generated for each of them and their impact was predicted. Of the 15 mutations, 10 were found to be deleterious and have a direct effect on flexibility, stability and SASA of the protein. In virtual screening, from 1,000 similar INH-NAD analogues obtained by the similarity search method, 823 compounds passed toxicity filter and drug likeness rules, which were then docked to the wild-type of InhA protein. Subsequently, 34 compounds with binding energy score better than that of INH-NAD were selected and docked against the 10 generated mutated models of InhA. Only three leads showed a lower binding affinity better than the reference. The 3D-pharmacophore model approach was used to identify the common features between those three compounds by generating a pharmacophoric map.
    Conclusion: The result of this study may pave the way to develop more potent mutant-specific inhibitors to overcome this resistance.
    Language English
    Publishing date 2023-04-28
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494731-3
    ISSN 1178-6949
    ISSN 1178-6949
    DOI 10.2147/AABC.S394535
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