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Article ; Online: The authors reply.

Ben Hmida, Mohamed / Mechichi, Tahar / Piccoli, Giorgina Barbara / Ksibi, Mohamed

2024 Volume 104, Issue 4, Page(s) 857–858

Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2023.07.015
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Zs.A 797: Show issues

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Article ; Online: Water implications in dialysis therapy, threats and opportunities to reduce water consumption: a call for the planet.

Ben Hmida, Mohamed / Mechichi, Tahar / Piccoli, Giorgina Barbara / Ksibi, Mohamed

Kidney international

2023 Volume 104, Issue 1, Page(s) 46–52

Abstract: Water is a dwindling natural resource, and potable water is wrongly considered an unlimited resource. Dialysis, particularly hemodialysis, is a water-hungry treatment that impacts the environment. The global annual water use of hemodialysis is ... ...

Abstract	Water is a dwindling natural resource, and potable water is wrongly considered an unlimited resource. Dialysis, particularly hemodialysis, is a water-hungry treatment that impacts the environment. The global annual water use of hemodialysis is approximately 265 million m
MeSH term(s)	Humans ; Renal Dialysis/adverse effects ; Drinking Water ; Drinking ; Planets ; Water Purification
Chemical Substances	Drinking Water
Language	English
Publishing date	2023-04-26
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2023.04.008
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Zs.A 797: Show issues

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Article ; Online: Chronic Kidney Disease, Hypokalemia, and Appendicular Mucocele in a 66-Year-Old Man.

Mrabet, Sanda / Chaabouni, Yosr / Ben Hmida, Mohamed

American journal of men's health

2022 Volume 16, Issue 5, Page(s) 15579883221125569

Abstract: Appendicular mucocele (AM) is a rare and potentially malignant entity linked to obstructive dilatation of the appendix with an intraluminal accumulation of mucoid material. Most AM is asymptomatic or simulates acute appendicitis. We report an exceptional ...

Abstract	Appendicular mucocele (AM) is a rare and potentially malignant entity linked to obstructive dilatation of the appendix with an intraluminal accumulation of mucoid material. Most AM is asymptomatic or simulates acute appendicitis. We report an exceptional case of AM discovered in the face of hypokalemia and aggravation of chronic kidney disease (CKD) without diarrhea in an old man. Investigations led to the diagnosis of AM in its malignant form complicated by gelatinous ascites. We retained mucinous hypersecretion as the cause of hypokalemia and acute renal failure. Aggressive surgery and intraperitoneal chemotherapy corrected hydroelectrolyte imbalance.
MeSH term(s)	Aged ; Appendix/pathology ; Appendix/surgery ; Humans ; Hypokalemia/complications ; Hypokalemia/pathology ; Male ; Mucocele/diagnosis ; Mucocele/diagnostic imaging ; Renal Insufficiency, Chronic
Language	English
Publishing date	2022-09-23
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2275106-3
ISSN	1557-9891 ; 1557-9883
ISSN (online)	1557-9891
ISSN	1557-9883
DOI	10.1177/15579883221125569
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Article ; Online: Tacrolimus trough level and oxidative stress in Tunisian kidney transplanted patients.

Ammar, Mariam / Yaich, Soumaya / Hakim, Ahmed / Ghozzi, Hanen / Sahnoun, Zouheir / Ben Hmida, Mohamed / Zghal, Khaled / Ben Mahmoud, Lobna

Renal failure

2024 Volume 46, Issue 1, Page(s) 2313863

Abstract: Background: The effect of tacrolimus (TAC) on oxidative stress after kidney transplantation (KT) is unclear. This study aimed to evaluate the influence of TAC trough levels of oxidative stress status in Tunisian KT patients during the post- ... ...

Abstract	Background: The effect of tacrolimus (TAC) on oxidative stress after kidney transplantation (KT) is unclear. This study aimed to evaluate the influence of TAC trough levels of oxidative stress status in Tunisian KT patients during the post-transplantation period (PTP). Methods: A prospective study including 90 KT patients was performed. TAC whole-blood concentrations were measured by the microparticle enzyme immunoassay method and adjusted according to the target range. Plasma levels of oxidants (malondialdehyde (MDA) and advanced oxidation protein products (AOPP)) and antioxidants (ascorbic acid, glutathione (GSH), glutathione peroxidase (GPx), and superoxide dismutase (SOD)) were measured using spectrophotometry. The subjects were subdivided according to PTP into three groups: patients with early, intermediate, and late PT. According to the TAC level, they were subdivided into LL-TAC, NL-TAC, and HL-TAC groups. Results: A decrease in MDA levels, SOD activity, and an increase in GSH levels and GPx activity were observed in patients with late PT compared to those with early and intermediate PT ( Conclusion: Our results have shown that in KT patients, despite the recovery of kidney function, the TAC reduced but did not normalize oxidative stress levels in long-term therapy, and the TAC effect significantly depends on the concentration used.
MeSH term(s)	Humans ; Tacrolimus/therapeutic use ; Kidney Transplantation/adverse effects ; Prospective Studies ; Oxidative Stress ; Antioxidants/pharmacology ; Glutathione/metabolism ; Superoxide Dismutase/metabolism ; Kidney/metabolism ; Glutathione Peroxidase/metabolism ; Glutathione Peroxidase/pharmacology
Chemical Substances	Tacrolimus (WM0HAQ4WNM) ; Antioxidants ; Glutathione (GAN16C9B8O) ; Superoxide Dismutase (EC 1.15.1.1) ; Glutathione Peroxidase (EC 1.11.1.9)
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2024.2313863
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Zs.A 1331: Show issues

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Article ; Online: Bone marrow aspirate: a diagnostic tool for primary hyperoxaluria type 1.

Chaker, Hanen / Dammak, Najla / Zalila, Dorra / Feki, Habib / Boudawara, Tahya / Ben Hmida, Mohamed

La Tunisie medicale

2023 Volume 100, Issue 11, Page(s) 775–781

Abstract: Introduction: Type1 primary hyperoxaluria is an infrequent autosomal recessive metabolic disease characterized by the accumulation of calcium oxalate in the kidney, which leads to end stage renal disease. In fact, the diagnosis of this disease is ... ...

Abstract	Introduction: Type1 primary hyperoxaluria is an infrequent autosomal recessive metabolic disease characterized by the accumulation of calcium oxalate in the kidney, which leads to end stage renal disease. In fact, the diagnosis of this disease is mandatory in order to avoid graft loss. Aim: To assess the incidence of primary hyperoxaluria and to develop the diagnostic value of bone marrow infiltration by calcium oxalate in uremic stone former patients. Methods: This study was conducted on a cohort of stone former patients identified in the south of Tunisia over a period of 18 years. Baseline characteristics were recorded. Clinical and laboratory data were collected on chart review. Secondary forms of hyperoxaluria were excluded. Bone marrow aspirate was performed in uremic patients from this cohort because early hyperoxaluria was suspected. Diagnostic accuracy of this test relating to sensitivity, specificity, positive predictive value and negative predictive value were also calculated. Results: A cohort of 31 patients comprising 17 male patients and 14 female patients were identified. During this time of diagnosis, the patient's ages ranged from 9 to 57 years old and 22 of them (70%) unfortunately died. Bone marrow aspirate was safely done in 16 uremic patients. It was positive in 12 patients and negative in 4 patients. Sensitivity, specificity, positive predictive value and negative predictive value were respectively 85%, 100%, 100% and 50%. Conclusion: The bone marrow examination represents both an easy and a worldwide feasible solution for the diagnosis of oxalosis, which affords an early diagnosis.
Language	English
Publishing date	2023-08-08
Publishing country	Tunisia
Document type	Journal Article
ZDB-ID	128627-4
ISSN	2724-7031 ; 0041-4131
ISSN (online)	2724-7031
ISSN	0041-4131
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Zs.B 223: Show issues

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Article ; Online: Roadmaps to green nephrology: a mediterranean point of view.

Ben Hmida, Mohamed / Torreggiani, Massimo / Berman-Parks, Nathan / Salomone, Mario / Piccoli, Giorgina Barbara

Current opinion in nephrology and hypertension

2023 Volume 33, Issue 1, Page(s) 115–121

Abstract: Purpose of review: Green nephrology is a movement whose aim is to find ways to reduce the environmental impact of kidney care. The question is of particular concern in this field since haemodialysis is one of the major contributors to waste generation, ... ...

Abstract	Purpose of review: Green nephrology is a movement whose aim is to find ways to reduce the environmental impact of kidney care. The question is of particular concern in this field since haemodialysis is one of the major contributors to waste generation, energy use and water consumption in healthcare. Although several ways for improving sustainability have been advocated, they are all context sensitive. This review aims to analyse the interventions that have been proposed to improve the ecologic sustainability and reduce the carbon footprint of nephrology care adapting to specific settings, and taking advantage of local expertise. Recent findings: Green hospitals are becoming a reality in several high-income settings, thanks to new building guidelines, with greater awareness of climate change and users' demands. Water saving is feasible, and is increasingly done, in different ways (improving hardware, reducing and adapting dialysate flows). Recycling noncontaminated plastic waste is feasible, but is still rarely performed. However, ecological transition has been slow even in high-income countries, while in low and middle-income countries lack of resources limit the ability to cope with the planet's urgent needs. Conversely, where man-power cost is low, some time-consuming tasks, such as separation of various components for recycling may be affordable. Theoretically, implementation of all clinical tasks aiming to avoid or retard dialysis, should be a priority. Summary: There is no single roadmap for achieving green nephrology. Each setting should start from those feasible interventions most in line with its specific needs and priorities.
MeSH term(s)	Humans ; Nephrology ; Renal Dialysis ; Environment
Language	English
Publishing date	2023-11-02
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1151092-4
ISSN	1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
ISSN (online)	1473-6543 ; 1535-3842
ISSN	1062-4813 ; 1062-4821
DOI	10.1097/MNH.0000000000000943
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Zs.A 3686: Show issues

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Article ; Online: Acinetobacter lwoffi peritonitis in peritoneal dialysis: two cases report.

Dammak, Najla / Chaker, Hanen / Agrebi, Ikram / Toumi, Salma / Mseddi, Fatma / Kammoun, Khawla / Yaich, Soumaya / Ben Hmida, Mohamed

La Tunisie medicale

2022 Volume 100, Issue 6, Page(s) 481–484

Abstract: Peritonitis is an important cause of morbidity and technique failure in peritoneal dialysis. Herein, we report peritonitis related to Acinetobacter lwoffi in two patients on peritoneal dialysis. The first case is a 63-year-old patient treated by ... ...

Abstract	Peritonitis is an important cause of morbidity and technique failure in peritoneal dialysis. Herein, we report peritonitis related to Acinetobacter lwoffi in two patients on peritoneal dialysis. The first case is a 63-year-old patient treated by automated peritoneal dialysis admitted with abdominal pain. The peritoneal effluent White Blood Cells count consisted of 280 cells/mm3. Then culture identified a multisensitive Acinetobacter lwoffi. Treatment with ceftazidime and ciprofloxacin had been started. The control dialysate culture was sterile after three weeks. The second patient is a 59-year-old female admitted because of diffuse abdominal pain and cloudy dialysate. The peritoneal effluent White Blood Cells count consisted of countless leukocytes, with predominantly polynuclear and culture identified Acinetobacter lwoffi. He received intraperitoneal ceftazidim and amikacin for three weeks. The control dialysate was sterile. Acinetobacter lwoffi is a rare cause of peritonitis and it can be treated successfully with early recognition and appropriate antibiotic therapy based on culture instead of catheter removal.
MeSH term(s)	Abdominal Pain ; Acinetobacter ; Amikacin ; Anti-Bacterial Agents/therapeutic use ; Ceftazidime ; Ciprofloxacin ; Dialysis Solutions ; Female ; Humans ; Male ; Middle Aged ; Peritoneal Dialysis/adverse effects ; Peritonitis/diagnosis ; Peritonitis/drug therapy ; Peritonitis/etiology
Chemical Substances	Anti-Bacterial Agents ; Dialysis Solutions ; Ciprofloxacin (5E8K9I0O4U) ; Amikacin (84319SGC3C) ; Ceftazidime (9M416Z9QNR)
Language	English
Publishing date	2022-10-07
Publishing country	Tunisia
Document type	Case Reports ; Journal Article
ZDB-ID	128627-4
ISSN	2724-7031 ; 0041-4131
ISSN (online)	2724-7031
ISSN	0041-4131
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Zs.B 223: Show issues

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Article ; Online: Melatonin intake before intradialytic exercise reverses oxidative stress and improves antioxidant status in hemodialysis patients.

Marzougui, Houssem / Turki, Mouna / Ben Dhia, Imen / Maaloul, Rami / Chaker, Hanen / Makhlouf, Rihab / Agrebi, Ikram / Kammoun, Khawla / Jamoussi, Kamel / Ayadi, Fatma / Ben Hmida, Mohamed / Hammouda, Omar

The International journal of artificial organs

2023 Volume 46, Issue 5, Page(s) 264–273

Abstract: Purpose: The present study aimed to investigate for the first time the effects of melatonin (MEL) intake on oxidative stress and cellular damage during intradialytic exercise (IEX).: Methods: Thirteen hemodialysis (HD) patients volunteered to ... ...

Abstract	Purpose: The present study aimed to investigate for the first time the effects of melatonin (MEL) intake on oxidative stress and cellular damage during intradialytic exercise (IEX). Methods: Thirteen hemodialysis (HD) patients volunteered to participate in the current randomized crossover trial. Participants performed four HD sessions in four different conditions: (Exercise (EX)-MEL), (EX-Placebo (PLA)), (Control (C)-MEL), and (C-PLA). 3 mg of MEL or PLA were taken 60 min before starting exercise, or at the equivalent time in the C conditions. Blood samples were taken before HD (T0), immediately after the end of IEX (T1), 60 min after IEX (T2), or at the corresponding times in the C conditions to measure free radicals damage, antioxidant biomarkers, as well as biomarkers of muscle and liver damage. Results: Malondialdehyde and Advanced Oxidation Protein Products decreased in (C-MEL) ( Conclusion: This pilot study is the first to show that MEL ingestion, alone or combined with IEX, could improve oxidant-antioxidant balance during HD.
MeSH term(s)	Humans ; Antioxidants/therapeutic use ; Antioxidants/pharmacology ; Melatonin/therapeutic use ; Melatonin/pharmacology ; Pilot Projects ; Lipid Peroxidation ; Oxidative Stress ; Renal Dialysis/adverse effects ; Biomarkers ; Polyesters
Chemical Substances	Antioxidants ; Melatonin (JL5DK93RCL) ; C-Mel ; Biomarkers ; Polyesters
Language	English
Publishing date	2023-04-13
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	80456-3
ISSN	1724-6040 ; 0391-3988
ISSN (online)	1724-6040
ISSN	0391-3988
DOI	10.1177/03913988231165324
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Zs.A 1439: Show issues

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Article ; Online: Effects of intradialytic exercise in combination with melatonin supplementation on functional capacity, postural balance, and quality of life in hemodialysis patients.

Marzougui, Houssem / Maaloul, Rami / Ben Dhia, Imen / Toumi, Salma / Kammoun, Khawla / Ben Hmida, Mohamed / Ayadi, Fatma / Turki, Mouna / Elleuch, Mohamed Habib / Ghroubi, Sameh / Hammouda, Omar

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

2023 Volume 27, Issue 4, Page(s) 669–681

Abstract: Introduction: We evaluated the effect of intradialytic concurrent (resistance-endurance) training combined with melatonin (MEL) supplementation on functional capacity, muscle strength, postural balance, and quality of life (QoL) in hemodialysis (HD) ... ...

Abstract	Introduction: We evaluated the effect of intradialytic concurrent (resistance-endurance) training combined with melatonin (MEL) supplementation on functional capacity, muscle strength, postural balance, and quality of life (QoL) in hemodialysis (HD) patients. Methods: Thirty-three HD patients were randomized into three groups: Exercise (EX)-MEL (n = 11); EX-Placebo (PLA) (n = 11) and Control (C)-PLA (n = 11). Participants included in the EX-MEL and EX-PLA groups were submitted to concurrent training for 12 weeks. Results: EX-MEL and EX-PLA improved functional capacity, muscle strength, QoL, and postural balance parameters in eyes open and eyes closed conditions. Parameters of postural balance in the dual task condition were improved only in EX-MEL. EX-MEL induced better results in some domains of QoL compared with EX-PLA. Conclusion: Intradialytic concurrent training induced beneficial effects on physical function, muscle strength, postural balance, and QoL in HD patients. MEL supplementation combined with intradialytic exercise lead to better improvements in postural balance and QoL.
MeSH term(s)	Humans ; Quality of Life ; Melatonin/pharmacology ; Renal Dialysis/methods ; Muscle Strength/physiology ; Postural Balance/physiology ; Dietary Supplements ; Polyesters
Chemical Substances	Melatonin (JL5DK93RCL) ; Polyesters
Language	English
Publishing date	2023-02-09
Publishing country	Australia
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2119809-3
ISSN	1744-9987 ; 1091-6660 ; 1744-9979
ISSN (online)	1744-9987
ISSN	1091-6660 ; 1744-9979
DOI	10.1111/1744-9987.13964
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Zs.A 5208: Show issues

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Article ; Online: The presence of two light chain bands on immunofixation is associated with poor outcomes in newly diagnosed multiple myeloma patients.

Jerbi, Ameni / Turki, Omar / Hachicha, Hend / Kallel Sarbeji, Faten / Feki, Sawsan / Mejdoub, Sabrina / Kammoun, Khaoula / Ben Hmida, Mohamed / Elloumi, Moez / Masmoudi, Hatem

Annals of hematology

2023 Volume 102, Issue 6, Page(s) 1459–1466

Abstract: We aimed to describe the clinical and biological characteristics and the prognosis of patients presenting with an additional light chain (LC) band along with a complete monoclonal protein on immunofixation (IF).An 8-year descriptive study was conducted ... ...

Abstract	We aimed to describe the clinical and biological characteristics and the prognosis of patients presenting with an additional light chain (LC) band along with a complete monoclonal protein on immunofixation (IF).An 8-year descriptive study was conducted to assess all cases with confirmed monoclonal gammopathies (MG). We studied those with an entire M-protein with 2 bands of LC of the same isotype based on the results of IF. Data were collected from patients' files.Among 548 cases of MG, we found 32 cases (5.8%) with an additional LC band. We included 28 patients (5%) with a confirmed diagnosis of multiple myeloma (MM). The m/f ratio was 2.5 with a median age of 63 years [32-80 years]. All MM patients had anemia, 16 (57%) had renal failure, 14 (50%) had lytic lesions, 9 (32%) received hemodialysis, and 7 (25%) had hypercalcemia. The free-kappa-lambda ratio was abnormal in all cases: median = 0.07 [0.002-58.57]. The mean overall survival (OS) was 22 months ± 38.76.Fifteen MM patients (48%) received chemotherapy, and 7 (22%) autologous stem cell transplants (SCT). Patients who received SCT had an OS higher than those who received other treatments (p = 0.038). OS was low in patients with high β2microglobulin levels (rho = -0.791; p = 0.001), and abnormally low free-kappa-lambda ratio (rho = -0.852;p = 0.04).The presence of an additional LC band with a complete monoclonal protein seems to identify newly diagnosed MM patients with poor outcomes and frequent renal impairment.
MeSH term(s)	Humans ; Middle Aged ; Multiple Myeloma/therapy ; Multiple Myeloma/drug therapy ; Immunoglobulin Light Chains ; Paraproteinemias/diagnosis ; Prognosis ; Stem Cell Transplantation ; Immunoglobulin lambda-Chains ; Immunoglobulin kappa-Chains
Chemical Substances	Immunoglobulin Light Chains ; Immunoglobulin lambda-Chains ; Immunoglobulin kappa-Chains
Language	English
Publishing date	2023-04-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-023-05221-6
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