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  1. Article: Designing local air pollution policies focusing on mobility and heating to avoid a targeted number of pollution-related deaths: Forward and backward approaches combining air pollution modeling, health impact assessment and cost-benefit analysis

    Bouscasse, Hélène / Gabet, Stephan / Kerneis, Glen / Provent, Ariane / Rieux, Camille / Ben Salem, Nabil / Dupont, Harry / Troude, Florence / Mathy, Sandrine / Slama, Rémy

    Environment international. 2022 Jan. 15, v. 159

    2022  

    Abstract: Policies aiming at decreasing air pollutants (e.g., fine particulate matter, PM₂.₅) are often designed without targeting an explicit health benefit nor carrying out cost-benefit analyses.We developed a transdisciplinary backward and forward approach at ... ...

    Abstract Policies aiming at decreasing air pollutants (e.g., fine particulate matter, PM₂.₅) are often designed without targeting an explicit health benefit nor carrying out cost-benefit analyses.We developed a transdisciplinary backward and forward approach at the conurbation level: from health objectives set by local decision-makers, we estimated which reductions in PM₂.₅ exposures and emissions would allow to reach them, and identified urban policies leading to these reductions (backward approach). We finally conducted health impact and cost-benefit analyses of these policies (forward approach). The policies were related to the most emitting sectors in the considered area (Grenoble, France), wood heating and transport sectors. The forward approach also considered the health impact and co-benefits of these policies related to changes in physical activity and CO₂ emissions.Decision-makers set three health targets, corresponding to decreases by 33% to 67% in PM₂.₅-attributable mortality in 2030, compared to 2016. A decrease by 42% in PM₂.₅ exposure (from 13.9 µg/m³) was required to reach the decrease by 67% in PM₂.₅-attributable mortality. For each Euro invested, the total benefit was about 30€ for policies focusing on wood heating, and 1 to 68€ for traffic policies. Acting on a single sector was not enough to attain a 67% decrease in PM₂.₅-attributable mortality. This target could be achieved by replacing all inefficient wood heating equipment by low-emission pellet stoves and reducing by 36% the traffic of private motorized vehicles. This would require to increase the share of active modes (walking, biking…), inducing increases in physical activity and additional health benefits beyond the initial target. Annual net benefits were between €484 and €629 per capita for policies with report on active modes, compared to between €162 and €270 without.Urban policies strongly reducing air pollution-attributable mortality can be identified by our approach. Such policies can be cost-efficient.
    Keywords air ; air pollution ; carbon dioxide ; cost benefit analysis ; cost effectiveness ; decision making ; environment ; equipment ; health effects assessments ; heat ; mortality ; particulates ; traffic ; wood ; France
    Language English
    Dates of publication 2022-0115
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2021.107030
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Designing local air pollution policies focusing on mobility and heating to avoid a targeted number of pollution-related deaths: Forward and backward approaches combining air pollution modeling, health impact assessment and cost-benefit analysis.

    Bouscasse, Hélène / Gabet, Stephan / Kerneis, Glen / Provent, Ariane / Rieux, Camille / Ben Salem, Nabil / Dupont, Harry / Troude, Florence / Mathy, Sandrine / Slama, Rémy

    Environment international

    2021  Volume 159, Page(s) 107030

    Abstract: Context: Policies aiming at decreasing air pollutants (e.g., fine particulate matter, PM: Methods: We developed a transdisciplinary backward and forward approach at the conurbation level: from health objectives set by local decision-makers, we ... ...

    Abstract Context: Policies aiming at decreasing air pollutants (e.g., fine particulate matter, PM
    Methods: We developed a transdisciplinary backward and forward approach at the conurbation level: from health objectives set by local decision-makers, we estimated which reductions in PM
    Findings: Decision-makers set three health targets, corresponding to decreases by 33% to 67% in PM
    Conclusions: Urban policies strongly reducing air pollution-attributable mortality can be identified by our approach. Such policies can be cost-efficient.
    MeSH term(s) Air Pollutants/analysis ; Air Pollutants/toxicity ; Air Pollution/analysis ; Air Pollution/statistics & numerical data ; Cost-Benefit Analysis ; Health Impact Assessment ; Heating/adverse effects ; Particulate Matter/analysis ; Particulate Matter/toxicity ; Policy
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2021-12-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2021.107030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Quantitative analysis of human herpesvirus-6 and human cytomegalovirus in blood and saliva from patients with acute leukemia.

    Nefzi, Faten / Ben Salem, Nabil Abid / Khelif, Abderrahim / Feki, Salma / Aouni, Mahjoub / Gautheret-Dejean, Agnès

    Journal of medical virology

    2015  Volume 87, Issue 3, Page(s) 451–460

    Abstract: Human herpesvirus-6 (HHV-6) and human cytomegalovirus (HCMV) DNAs were quantified by real-time PCR assays in blood and saliva obtained from 50 patients with acute leukemia at the time of diagnosis (50 of each matrix), aplasia (65 of each matrix), ... ...

    Abstract Human herpesvirus-6 (HHV-6) and human cytomegalovirus (HCMV) DNAs were quantified by real-time PCR assays in blood and saliva obtained from 50 patients with acute leukemia at the time of diagnosis (50 of each matrix), aplasia (65 of each matrix), remission (55 of each matrix), and relapse (20 of each matrix) to evaluate which biological matrix was more suitable to identify a viral reactivation, search for a possible link between HHV-6 and HCMV reactivations, and evaluate the relations between viral loads and count of different leukocyte types in blood. The median HHV-6 loads were 136; 219; 226, and 75 copies/million cells in blood at diagnosis, aplasia, remission and relapse, respectively. The HCMV loads were 193 and 317 copies/million cells in blood at diagnosis and remission. In the saliva samples, the HHV-6 loads were 22,165; 15,238; 30,214, and 17,454 copies/million cells at diagnosis, aplasia, remission, and relapse, respectively. The HCMV loads were 8,991; 1,461; 2,980, and 4,283 copies/million cells at diagnosis, aplasia, remission, and relapse, respectively. The HHV-6 load in the blood was correlated to the counts of polymorphonuclear leukocytes (R(2)  = 0.5; P < 0.0001) and lymphocytes (R(2)  = 0.4; P = 0.001) and was not correlated to the monocyte counts (R(2)  = 0.07; P = 0.7). Saliva appears to be a more sensitive biological matrix than whole blood in the detection of HHV-6 or HCMV reactivations. The HHV-6 and HCMV reactivations were linked only in saliva.
    MeSH term(s) Adolescent ; Adult ; Blood/virology ; Child ; Child, Preschool ; Cytomegalovirus/isolation & purification ; Cytomegalovirus Infections/virology ; Female ; Herpesvirus 6, Human/isolation & purification ; Humans ; Leukemia/complications ; Male ; Middle Aged ; Real-Time Polymerase Chain Reaction ; Roseolovirus Infections/virology ; Saliva/virology ; Viral Load ; Young Adult
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.24059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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