Article: Micromagnetic Stimulation (μMS) Controls Dopamine Release: An
bioRxiv : the preprint server for biology
2023
Abstract: Objective: Research into the role of neurotransmitters in regulating normal and pathologic brain functions has made significant progress. Yet, clinical trials that aim to improve therapeutic interventions do not take advantage of the : Approach: ... ...
Abstract | Objective: Research into the role of neurotransmitters in regulating normal and pathologic brain functions has made significant progress. Yet, clinical trials that aim to improve therapeutic interventions do not take advantage of the Approach: Although still in its infancy, micromagnetic stimulation (µMS) using micro-meter sized coils or microcoils (μcoils) has shown incredible promise in spatially selective, galvanic contact free and highly focal neuromodulation. These μcoils are powered by a time-varying current which generates a magnetic field. As per Faraday's Laws of Electromagnetic Induction, this magnetic field induces an electric field in a conducting medium (here, the brain tissues). We used a solenoidal-shaped μcoil to stimulate the medial forebrain bundle (MFB) of the rodent brain Results: Our experiments report that μcoils can successfully activate the MFB in rodent brains, triggering dopamine release Significance: This work helps us better understand the brain and its conditions arising from a new therapeutic intervention, like µMS, at the level of neurotransmitter release. Despite its early stage, this study potentially paves the path for µMS to enter the clinical world as a precisely controlled and optimized neuromodulation therapy. |
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Language | English |
Publishing date | 2023-05-25 |
Publishing country | United States |
Document type | Preprint |
DOI | 10.1101/2023.05.25.542334 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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