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  1. Article: Micromagnetic Stimulation (μMS) Controls Dopamine Release: An

    Saha, Renata / Goyal, Abhinav / Yuen, Jason / Oh, Yoonbae / Bloom, Robert P / Benally, Onri J / Wu, Kai / Netoff, Theoden I / Low, Walter C / Bennet, Kevin E / Lee, Kendall H / Shin, Hojin / Wang, Jian-Ping

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Objective: Research into the role of neurotransmitters in regulating normal and pathologic brain functions has made significant progress. Yet, clinical trials that aim to improve therapeutic interventions do not take advantage of the : Approach: ... ...

    Abstract Objective: Research into the role of neurotransmitters in regulating normal and pathologic brain functions has made significant progress. Yet, clinical trials that aim to improve therapeutic interventions do not take advantage of the
    Approach: Although still in its infancy, micromagnetic stimulation (µMS) using micro-meter sized coils or microcoils (μcoils) has shown incredible promise in spatially selective, galvanic contact free and highly focal neuromodulation. These μcoils are powered by a time-varying current which generates a magnetic field. As per Faraday's Laws of Electromagnetic Induction, this magnetic field induces an electric field in a conducting medium (here, the brain tissues). We used a solenoidal-shaped μcoil to stimulate the medial forebrain bundle (MFB) of the rodent brain
    Results: Our experiments report that μcoils can successfully activate the MFB in rodent brains, triggering dopamine release
    Significance: This work helps us better understand the brain and its conditions arising from a new therapeutic intervention, like µMS, at the level of neurotransmitter release. Despite its early stage, this study potentially paves the path for µMS to enter the clinical world as a precisely controlled and optimized neuromodulation therapy.
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.25.542334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Micromagnetic stimulation (

    Saha, Renata / Sanger, Zachary / Bloom, Robert P / Benally, Onri J / Wu, Kai / Tonini, Denis / Low, Walter C / Keirstead, Susan A / Netoff, Theoden I / Wang, Jian-Ping

    Journal of neural engineering

    2023  Volume 20, Issue 3

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Rats ; Animals ; Sciatic Nerve/physiology ; Muscle, Skeletal/physiology ; Electrodes ; Electric Stimulation/methods
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2170901-4
    ISSN 1741-2552 ; 1741-2560
    ISSN (online) 1741-2552
    ISSN 1741-2560
    DOI 10.1088/1741-2552/acd582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Strength-frequency curve for micromagnetic neurostimulation through excitatory postsynaptic potentials (EPSPs) on rat hippocampal neurons and numerical modeling of magnetic microcoil (

    Saha, Renata / Faramarzi, Sadegh / Bloom, Robert P / Benally, Onri J / Wu, Kai / di Girolamo, Arturo / Tonini, Denis / Keirstead, Susan A / Low, Walter C / Netoff, Theoden I / Wang, Jian-Ping

    Journal of neural engineering

    2022  Volume 19, Issue 1

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Animals ; Electric Stimulation ; Excitatory Postsynaptic Potentials ; Hippocampus/physiology ; Magnetic Phenomena ; Neurons ; Rats ; Synapses/physiology ; Synaptic Transmission
    Language English
    Publishing date 2022-02-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2170901-4
    ISSN 1741-2552 ; 1741-2560
    ISSN (online) 1741-2552
    ISSN 1741-2560
    DOI 10.1088/1741-2552/ac4baf
    Database MEDical Literature Analysis and Retrieval System OnLINE

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