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  1. Article ; Online: Optic neuritis: current challenges in diagnosis and management.

    Benard-Seguin, Etienne / Costello, Fiona

    Current opinion in neurology

    2022  Volume 36, Issue 1, Page(s) 10–18

    Abstract: Purpose of review: The primary aim of this review is to describe the clinical course, salient imaging features, and relevant serological profiles of common optic neuritis (ON) subtypes. Key diagnostic challenges and treatment options will also be ... ...

    Abstract Purpose of review: The primary aim of this review is to describe the clinical course, salient imaging features, and relevant serological profiles of common optic neuritis (ON) subtypes. Key diagnostic challenges and treatment options will also be discussed.
    Recent findings: ON is a broad term that describes an inflammatory optic nerve injury arising from a variety of potential causes. ON can occur sporadically, however there is particular concern for co-associated central nervous system (CNS) inflammatory syndromes including multiple sclerosis (MS), neuromyelitis optic spectrum disorders (NMOSD), and myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD). The ON subtypes that often herald MS, NMOSD, and MOGAD differ with respect to serological antibody profile and neuroimaging characteristics, yet there is significant overlap in their clinical presentations. A discerning history and thorough examination are critical to rendering the correct diagnosis.
    Summary: Optic neuritis subtypes vary with respect to their long-term prognosis and accordingly, require different acute treatment strategies. Moreover, delays in identifying MOGAD, and certainly NMOSD, can be highly detrimental because affected individuals are vulnerable to permanent vision loss and neurologic disability from relapses.
    MeSH term(s) Humans ; Neuromyelitis Optica/complications ; Neuromyelitis Optica/diagnosis ; Neuromyelitis Optica/therapy ; Aquaporin 4 ; Myelin-Oligodendrocyte Glycoprotein ; Autoantibodies ; Optic Neuritis/diagnosis ; Optic Neuritis/therapy ; Multiple Sclerosis/diagnosis ; Inflammation
    Chemical Substances Aquaporin 4 ; Myelin-Oligodendrocyte Glycoprotein ; Autoantibodies
    Language English
    Publishing date 2022-12-05
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000001128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2524: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Predictors of Long-Term Visual Acuity in a Modern Cohort of Patients With Acute Idiopathic and Multiple Sclerosis-Associated Optic Neuritis.

    Jarocki, Adrienne / Benard-Seguin, Etienne / Gonzalez, Lizbeth A / Costello, Fiona / Andrews, Chris A / Kerber, Kevin / De Lott, Lindsey B

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2023  Volume 43, Issue 4, Page(s) 475–480

    Abstract: Background: For patients with idiopathic or multiple sclerosis (MS)-associated optic neuritis (ON), the largest multicenter clinical trial (Optic Neuritis Treatment Trial [ONTT]) showed excellent visual outcomes and baseline high-contrast visual acuity ( ...

    Abstract Background: For patients with idiopathic or multiple sclerosis (MS)-associated optic neuritis (ON), the largest multicenter clinical trial (Optic Neuritis Treatment Trial [ONTT]) showed excellent visual outcomes and baseline high-contrast visual acuity (HCVA) was the only predictor of HCVA at 1 year. We aimed to evaluate predictors of long-term HCVA in a modern, real-world population of patients with ON and compare with previously published ONTT models.
    Methods: We performed a retrospective, longitudinal, observational study at the University of Michigan and the University of Calgary evaluating 135 episodes of idiopathic or MS-associated ON in 118 patients diagnosed by a neuro-ophthalmologist within 30 days of onset (January 2011-June 2021). Primary outcome measured was HCVA (Snellen equivalents) at 6-18 months. Multiple linear regression models of 107 episodes from 93 patients assessed the association between HCVA at 6-18 months and age, sex, race, pain, optic disc swelling, symptoms (days), viral illness prodrome, MS status, high-dose glucocorticoid treatment, and baseline HCVA.
    Results: Of the 135 acute episodes (109 Michigan and 26 Calgary), median age at presentation was 39 years (interquartile range [IQR], 31-49 years), 91 (67.4%) were women, 112 (83.0%) were non-Hispanic Caucasians, 101 (75.9%) had pain, 33 (24.4%) had disc edema, 8 (5.9%) had a viral prodrome, 66 (48.9%) had MS, and 62 (46.6%) were treated with glucocorticoids. The median (IQR) time between symptom onset and diagnosis was 6 days (range, 4-11 days). The median (IQR) HCVA at baseline and at 6-18 months were 20/50 (20/22, 20/200) and 20/20 (20/20, 20/27), respectively; 62 (45.9%) had better than 20/40 at baseline and 117 (86.7%) had better than 20/40 at 6-18 months. In linear regression models (n = 107 episodes in 93 patients with baseline HCVA better than CF), only baseline HCVA (β = 0.076; P = 0.027) was associated with long-term HCVA. Regression coefficients were similar and within the 95% confidence interval of coefficients from published ONTT models.
    Conclusions: In a modern cohort of patients with idiopathic or MS-associated ON with baseline HCVA better than CF, long-term outcomes were good, and the only predictor was baseline HCVA. These findings were similar to prior analyses of ONTT data, and as a result, these are validated for use in conveying prognostic information about long-term HCVA outcomes.
    MeSH term(s) Humans ; Female ; Adult ; Middle Aged ; Male ; Multiple Sclerosis/complications ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/drug therapy ; Retrospective Studies ; Optic Neuritis/diagnosis ; Optic Neuritis/drug therapy ; Optic Neuritis/etiology ; Glucocorticoids/therapeutic use ; Visual Acuity ; Pain/complications ; Pain/drug therapy
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000001870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1670: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Silent Post Cataract Bilateral Sequential Nonarteritic Anterior Ischaemic Optic Neuropathy.

    Bénard-Séguin, Étienne / Weisbrod, Lawrence / Sundaram, Arun Ne

    Neuro-ophthalmology (Aeolus Press)

    2019  Volume 43, Issue 5, Page(s) 318–322

    Abstract: Nonarteritic anterior ischaemic optic neuropathy (NAION) has been reported as a rare occurrence following cataract surgery. Bilateral sequential NAION following cataract surgery is extremely rare. We report an 83-year-old male who developed bilateral ... ...

    Abstract Nonarteritic anterior ischaemic optic neuropathy (NAION) has been reported as a rare occurrence following cataract surgery. Bilateral sequential NAION following cataract surgery is extremely rare. We report an 83-year-old male who developed bilateral sequential NAION within 5 and 3 weeks of undergoing uneventful cataract surgeries in each eye. A brief review of the literature on this topic is provided. This case serves to add to the ongoing debate about the association between cataract surgery and NAION.
    Language English
    Publishing date 2019-03-28
    Publishing country England
    Document type Case Reports
    ZDB-ID 604820-1
    ISSN 1744-506X ; 0165-8107
    ISSN (online) 1744-506X
    ISSN 0165-8107
    DOI 10.1080/01658107.2018.1517805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1784: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Use of a fundus photograph matching program in imparting proficiency in ophthalmoscopy.

    Bénard-Séguin, Étienne / Kwok, Jason / Liao, Walter / Baxter, Stephanie

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2018  Volume 53, Issue 5, Page(s) 480–485

    Abstract: Objective: To determine whether practice using an online fundus photograph program results in a long-term increase in proficiency with direct ophthalmoscopy skills in medical students.: Design: This study was a prospective medical education trial. ... ...

    Abstract Objective: To determine whether practice using an online fundus photograph program results in a long-term increase in proficiency with direct ophthalmoscopy skills in medical students.
    Design: This study was a prospective medical education trial. Students were enrolled to participate in a voluntary Objective Structured Clinical Examination (OSCE) using 5 patients with ocular findings. Students who matched a minimum of 6 discs 16 months before the study were assigned to the intervention group and were compared with students who did not participate in the exercise.
    Participants: Forty-six second-year medical students at Queen's University: 15 in the intervention group and 31 in the control group.
    Methods: Students were evaluated using the Queen's University Ophthalmoscopy OSCE Checklist (QUOOC). Students were asked to calculate the cup-to-disc ratio, comment on disc margins, and whether there was any macular pathology. Students participated in a summative OSCE as part of the curriculum in which all students attempted to match fundus photographs.
    Results: Students in the intervention group performed significantly better on the QUOOC, with a mean score of 78.3% (± 4.2), compared with the control, who had a mean score of 69.4% (± 4.2) (p = 0.005). The intervention group was significantly more accurate at matching optic nerve photographs, with 100% (15/15) of the students correctly identifying the correct optic nerve on first attempt compared with 53.3% (16/30) in the control group (p = 0.0014).
    Conclusions: The use of an online peer fundus photograph program leads to a long-term increase in examination technique, proficiency in ophthalmoscopy, and accuracy at matching optic nerve photographs.
    MeSH term(s) Clinical Competence ; Curriculum ; Education, Medical, Undergraduate/methods ; Educational Measurement ; Eye Diseases/diagnosis ; Fundus Oculi ; Humans ; Ophthalmology/education ; Ophthalmoscopy/standards ; Optic Nerve/diagnostic imaging ; Prospective Studies ; Students, Medical
    Language English
    Publishing date 2018-02-09
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2017.11.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 588: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Optimization of femtosecond laser-constructed clear corneal wound sealability for cataract surgery.

    Benard-Seguin, Étienne / Bostan, Cristina / Fadous, Raphaëlle / Sylvestre-Bouchard, Antoine / de Alwis Weerasekera, Hasitha Jaliya / Giguère, Charles-Édouard / Harasymowycz, Paul / Brunette, Isabelle

    Journal of cataract and refractive surgery

    2020  Volume 46, Issue 12, Page(s) 1611–1617

    Abstract: Purpose: To compare the sealability of femtosecond laser (FSL)-assisted corneal incisions (CIs) with that of triplanar manual (M)-CIs and to determine FSL wound parameters minimizing leakage.: Setting: Private practice.: Design: Phase IV, single- ... ...

    Abstract Purpose: To compare the sealability of femtosecond laser (FSL)-assisted corneal incisions (CIs) with that of triplanar manual (M)-CIs and to determine FSL wound parameters minimizing leakage.
    Setting: Private practice.
    Design: Phase IV, single-surgeon, retrospective cohort study.
    Methods: One eye per patient was included. Two groups defined by the main wound (FSL-CI or M-CI) were compared for leakage, inferred by placement of a suture at the end of surgery. Leakage in FSL-CIs was analyzed as a function of customizable wound parameters: anterior plane depth (APD), posterior plane depth (PPD), anterior side-cut angle (ASCA), and posterior side-cut angle (PSCA). The risk of leakage of FSL-CIs with optimal and nonoptimal parameters was further compared with that of M-CIs.
    Results: A total of 1100 eyes (757 [68.8%] FSL-CI; 343 [31.2%] M-CI) were included. Wound leakage occurred in 133 FSL-CI (17.6%) and 30 M-CI eyes (8.7%) (P < .001). FSL wound parameters associated with the lowest risk of leakage were 60% APD, 70% PPD, 120 degrees ASCA, and 70 degrees PSCA. FSL-CIs constructed with at least 3 optimal parameters (60% APD, 70% PPD, and 120 degrees ASCA) had a similar risk of leakage to M-CIs (odds ratio [OR], 1.1; 95% CI, 0.5-2.3). FSL-CIs with suboptimal parameters had twice the risk of leakage of M-CIs (OR, 2.0; 95% CI, 1.1-3.8).
    Conclusions: Overall, FSL-CIs leaked more than M-CIs. However, FSL-CIs with optimized wound profiles had an equivalent risk of leakage to M-CIs. Wound parameter customization is an asset of FSL technology that allows optimization of FSL-CI sealability.
    Language English
    Publishing date 2020-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632744-8
    ISSN 1873-4502 ; 0886-3350
    ISSN (online) 1873-4502
    ISSN 0886-3350
    DOI 10.1097/j.jcrs.0000000000000336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1806: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Systematic Review of the Yield of Temporal Artery Biopsy for Suspected Giant Cell Arteritis.

    Ing, Edsel B / Wang, Dan Ni / Kirubarajan, Abirami / Benard-Seguin, Etienne / Ma, Jingyi / Farmer, James P / Belliveau, Michel J / Sholohov, Galina / Torun, Nurhan

    Neuro-ophthalmology (Aeolus Press)

    2018  Volume 43, Issue 1, Page(s) 18–25

    Abstract: Purpose: To determine the positive yield (utility rate) of temporal artery biopsy (TAB) in patients with suspected giant cell arteritis (GCA).: Study design: Systematic review (CRD42017078508) and meta-regression.: Materials and methods: All ... ...

    Abstract Purpose: To determine the positive yield (utility rate) of temporal artery biopsy (TAB) in patients with suspected giant cell arteritis (GCA).
    Study design: Systematic review (CRD42017078508) and meta-regression.
    Materials and methods: All articles concerning TAB for suspected GCA with English language abstracts from 1998 to 2017 were retrieved. Articles were excluded if they exclusively reported positive TAB, or only cases of known GCA. Where available, the pre-specified predictors of age, sex, vision symptoms, jaw claudication, duration of steroid treatment prior to TAB, specimen length, bilateral TAB, and use of ultrasound/MRI (imaging) were recorded for meta-regression.
    Results: One hundred and thirteen articles met eligibility criteria. The
    Conclusions: Systematic review revealed high heterogeneity in the yield of TAB. The median utility rate of 25% and its interquartile range provides a benchmark for decisions regarding the under/overutilization of TAB and aids in the evaluation of non-invasive alternatives for the investigation of GCA.
    Language English
    Publishing date 2018-06-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 604820-1
    ISSN 1744-506X ; 0165-8107
    ISSN (online) 1744-506X
    ISSN 0165-8107
    DOI 10.1080/01658107.2018.1474372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1784: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The incidence of giant cell arteritis in Ontario, Canada.

    Ing, Edsel B / Lahaie Luna, Gabriela / Pagnoux, Christian / Baer, Philip A / Wang, Dani / Benard-Seguin, Etienne / Godra, Ishan / Godra, Anita / Munoz, David G / McReelis, Kylen / Ten Hove, Martin

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2018  Volume 54, Issue 1, Page(s) 119–124

    Abstract: Objective: The incidence of giant cell arteritis (GCA) is insufficiently documented for Canada, but important to ascertain for public health planning. We estimate the incidence of biopsy-proven GCA (BPGCA) in Kingston, Ontario, and for the province of ... ...

    Abstract Objective: The incidence of giant cell arteritis (GCA) is insufficiently documented for Canada, but important to ascertain for public health planning. We estimate the incidence of biopsy-proven GCA (BPGCA) in Kingston, Ontario, and for the province of Ontario.
    Method: The number of cases of BPGCA was tabulated from retrospective chart review of all temporal artery biopsies (TABx) in Kingston, Ontario from 2011-15. The relevant population denominator was determined from the Canada census federal electoral district and the patient's postal code. The province-wide estimate for the incidence of BPGCA was calculated from provincial billing data of TABx from 2015-17, the Canada census for Ontario, and the expected positive yield of TABx.
    Results: There were 35 subjects with BPGCA in the Kingston area over the 4-year period, from a population of 179 503 individuals 50 years of age or older (≥50 years). Ontario billing data identified 2404 patients who underwent TABx for suspected GCA over a 2-year period, from a population of 5 143 610 persons ≥50 years. Meta-analysis of 5 provincial TABx series suggested a 21% positive yield from TABx procedures (95% CI 0.18-0.24). The minimum cumulative incidence of BPGCA was 4.9 per 100 000 persons ≥50 years in Kingston, and 4.9 (95% CI 4.2-5.6) per 100 000 persons ≥50 years for Ontario as a whole.
    Conclusion: The estimated incidence of BPGCA in Ontario using 2 different estimation techniques was comparable, but low compared with other countries. The actual incidence of GCA in Ontario may be higher.
    MeSH term(s) Aged ; Biopsy ; Female ; Giant Cell Arteritis/diagnosis ; Giant Cell Arteritis/epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Ontario/epidemiology ; Public Health ; Retrospective Studies ; Temporal Arteries/pathology ; Visual Acuity
    Language English
    Publishing date 2018-11-12
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2018.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 588: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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