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  1. Article ; Online: Recurrent Bilateral Salpingitis in a Sexually Inactive Adolescent: Don't Forget about the Appendix.

    Rubino, Chiara / Barbati, Federica / Regoli, Marta / Bencini, Erica / Mattei, Alberto / Fierro, Francesca / Brizzi, Ilaria / Indolfi, Giuseppe

    Journal of pediatric and adolescent gynecology

    2020  Volume 34, Issue 2, Page(s) 217–219

    Abstract: Background: Salpingitis is an acute inflammation of the fallopian tubes and is extremely uncommon in patients who are sexually inactive or premenarchal.: Case: We describe a 15-year-old sexually inactive patient with recurrent bilateral salpingitis. ... ...

    Abstract Background: Salpingitis is an acute inflammation of the fallopian tubes and is extremely uncommon in patients who are sexually inactive or premenarchal.
    Case: We describe a 15-year-old sexually inactive patient with recurrent bilateral salpingitis. After the second episode, she underwent an exploratory laparoscopy and was diagnosed with chronic appendicitis.
    Summary and conclusion: Appendicular involvement should be kept in mind in recurrent salpingitis episodes, especially if previous imaging studies do not show signs of appendicitis. Imaging studies should be repeated in experienced centers in case of recurrent episodes. Laparoscopy is the gold standard for the diagnosis of salpingitis and can confirm appendicular or other abdominal involvement. Early diagnosis can help to prevent recurrent episodes of salpingitis and thus reduce the risk of sequelae.
    MeSH term(s) Adolescent ; Appendicitis/complications ; Appendicitis/diagnosis ; Appendicitis/pathology ; Appendix/pathology ; Chronic Disease ; Diagnosis, Differential ; Fallopian Tubes/pathology ; Female ; Humans ; Laparoscopy ; Medical Illustration ; Recurrence ; Salpingitis/diagnosis ; Salpingitis/etiology ; Salpingitis/pathology ; Sexual Abstinence
    Language English
    Publishing date 2020-12-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1325079-6
    ISSN 1873-4332 ; 1083-3188
    ISSN (online) 1873-4332
    ISSN 1083-3188
    DOI 10.1016/j.jpag.2020.12.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Increased incidence of precocious and accelerated puberty in females during and after the Italian lockdown for the coronavirus 2019 (COVID-19) pandemic.

    Stagi, Stefano / De Masi, Salvatore / Bencini, Erica / Losi, Stefania / Paci, Silvia / Parpagnoli, Maria / Ricci, Franco / Ciofi, Daniele / Azzari, Chiara

    Italian journal of pediatrics

    2020  Volume 46, Issue 1, Page(s) 165

    Abstract: Background: The timing of puberty in girls is occurring at an increasingly early age. While a positive family history is recognised as a predisposing factor for early or precocious puberty, the role of environmental factors is not fully understood.: ... ...

    Abstract Background: The timing of puberty in girls is occurring at an increasingly early age. While a positive family history is recognised as a predisposing factor for early or precocious puberty, the role of environmental factors is not fully understood.
    Aims of the study: To make a retrospective evaluation of the incidence of newly diagnosed central precocious puberty (CPP) and the rate of pubertal progression in previously diagnosed patients during and after the Italian lockdown for COVID-19, comparing data with corresponding data from the previous 5 years. To determine whether body mass index (BMI) and the use of electronic devices increased during lockdown in these patients.
    Patients and methods: The study included 49 females with CPP. We divided the patients into two groups: group 1, patients presenting a newly diagnosed CPP and group 2, patients with previously diagnosed slow progression CPP whose pubertal progression accelerated during or after lockdown. We collected auxological, clinical, endocrinological and radiological data which were compared with data from two corresponding control groups (patients followed by our Unit, March to July 2015-2019). Patients' families completed a questionnaire to assess differences in the use of electronic devices before and during lockdown.
    Results: Thirty-seven patients presented newly diagnosed CPP (group 1) and 12, with previously diagnosed but untreated slow progression CPP presented an acceleration in the rate of pubertal progression (group 2). The number of new CPP diagnoses was significantly higher than the mean for the same period of the previous 5 years (p < 0.0005). There were no significant differences between patients in group 1 and control group 1 regarding time between appearance of B2 and CPP diagnosis, although group 1 patients had a significantly earlier chronological age at B2, a more advanced Tanner stage at diagnosis (p < 0.005), higher basal LH and E2 levels, higher LH peak after LHRH test (p < 0.05) and increased uterine length (p < 0.005) and ovarian volume (p < 0.0005). The number of patients with previously diagnosed CPP whose pubertal development accelerated was also statistically higher compared to controls (p < 0.0005). In this group, patients' basal LH (p < 0.05) and E2 levels (p < 0.0005) became more markedly elevated as did the LH peak after LHRH test (p < 0.05). These patients also showed a significantly accelerated progression rate as measured by the Tanner scale (p < 0.0005), uterine length (p < 0.005), and ovarian volume (p < 0.0005). In both group 1 and group 2, BMI increased significantly (p < 0.05) and patients' families reported an increased use of electronic devices (p < 0.0005).
    Conclusion: Our data show an increased incidence of newly diagnosed CPP and a faster rate of pubertal progression in patients with a previous diagnosis, during and after lockdown compared to previous years. We hypothesize that triggering environmental factors, such as the BMI and the use of electronic devices, were enhanced during lockdown, stressing their possible role in triggering/influencing puberty and its progression. However, more studies are needed to determine which factors were involved and how they interacted.
    MeSH term(s) Betacoronavirus ; Body Mass Index ; COVID-19 ; Child ; Coronavirus Infections/epidemiology ; Female ; Humans ; Incidence ; Italy/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; Puberty ; Puberty, Precocious/diagnosis ; Puberty, Precocious/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; Social Isolation
    Keywords covid19
    Language English
    Publishing date 2020-11-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2088556-8
    ISSN 1824-7288 ; 1720-8424
    ISSN (online) 1824-7288
    ISSN 1720-8424
    DOI 10.1186/s13052-020-00931-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Increased incidence of precocious and accelerated puberty in females during and after the Italian lockdown for the coronavirus 2019 (COVID-19) pandemic

    Stagi, Stefano / De Masi, Salvatore / Bencini, Erica / Losi, Stefania / Paci, Silvia / Parpagnoli, Maria / Ricci, Franco / Ciofi, Daniele / Azzari, Chiara

    Ital J Pediatr

    Abstract: BACKGROUND: The timing of puberty in girls is occurring at an increasingly early age. While a positive family history is recognised as a predisposing factor for early or precocious puberty, the role of environmental factors is not fully understood. AIMS ... ...

    Abstract BACKGROUND: The timing of puberty in girls is occurring at an increasingly early age. While a positive family history is recognised as a predisposing factor for early or precocious puberty, the role of environmental factors is not fully understood. AIMS OF THE STUDY: To make a retrospective evaluation of the incidence of newly diagnosed central precocious puberty (CPP) and the rate of pubertal progression in previously diagnosed patients during and after the Italian lockdown for COVID-19, comparing data with corresponding data from the previous 5 years. To determine whether body mass index (BMI) and the use of electronic devices increased during lockdown in these patients. PATIENTS AND METHODS: The study included 49 females with CPP. We divided the patients into two groups: group 1, patients presenting a newly diagnosed CPP and group 2, patients with previously diagnosed slow progression CPP whose pubertal progression accelerated during or after lockdown. We collected auxological, clinical, endocrinological and radiological data which were compared with data from two corresponding control groups (patients followed by our Unit, March to July 2015-2019). Patients' families completed a questionnaire to assess differences in the use of electronic devices before and during lockdown. RESULTS: Thirty-seven patients presented newly diagnosed CPP (group 1) and 12, with previously diagnosed but untreated slow progression CPP presented an acceleration in the rate of pubertal progression (group 2). The number of new CPP diagnoses was significantly higher than the mean for the same period of the previous 5 years (p < 0.0005). There were no significant differences between patients in group 1 and control group 1 regarding time between appearance of B2 and CPP diagnosis, although group 1 patients had a significantly earlier chronological age at B2, a more advanced Tanner stage at diagnosis (p < 0.005), higher basal LH and E2 levels, higher LH peak after LHRH test (p < 0.05) and increased uterine length (p < 0.005) and ovarian volume (p < 0.0005). The number of patients with previously diagnosed CPP whose pubertal development accelerated was also statistically higher compared to controls (p < 0.0005). In this group, patients' basal LH (p < 0.05) and E2 levels (p < 0.0005) became more markedly elevated as did the LH peak after LHRH test (p < 0.05). These patients also showed a significantly accelerated progression rate as measured by the Tanner scale (p < 0.0005), uterine length (p < 0.005), and ovarian volume (p < 0.0005). In both group 1 and group 2, BMI increased significantly (p < 0.05) and patients' families reported an increased use of electronic devices (p < 0.0005). CONCLUSION: Our data show an increased incidence of newly diagnosed CPP and a faster rate of pubertal progression in patients with a previous diagnosis, during and after lockdown compared to previous years. We hypothesize that triggering environmental factors, such as the BMI and the use of electronic devices, were enhanced during lockdown, stressing their possible role in triggering/influencing puberty and its progression. However, more studies are needed to determine which factors were involved and how they interacted.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #909268
    Database COVID19

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  4. Article ; Online: Triple X syndrome and puberty: focus on the hypothalamus-hypophysis-gonad axis.

    Stagi, Stefano / di Tommaso, Mariarosaria / Scalini, Perla / Lapi, Elisabetta / Losi, Stefania / Bencini, Erica / Masoni, Fabrizio / Dosa, Laura / Becciani, Sabrina / de Martino, Maurizio

    Fertility and sterility

    2016  Volume 105, Issue 6, Page(s) 1547–1553

    Abstract: Objective: To evaluate the hypothalamus-hypophysis-gonad axis in a cohort of children and adolescents with nonmosaic triple X syndrome.: Design: Cross-sectional study with retrospective analysis.: Setting: University pediatric hospital.: Patient( ...

    Abstract Objective: To evaluate the hypothalamus-hypophysis-gonad axis in a cohort of children and adolescents with nonmosaic triple X syndrome.
    Design: Cross-sectional study with retrospective analysis.
    Setting: University pediatric hospital.
    Patient(s): Fifteen prepubertal subjects (median age 9.0 years, range 6.9-11.9 years) with nonmosaic triple X syndrome and age- and pubertal-matched control group (30 girls, median age 9.1 y, range 6.9-11.6 years).
    Intervention(s): None.
    Main outcome measure(s): We evaluated FSH, LH, and E2 levels and performed an autoimmunity screening as well as a pelvic ultrasonography and an LH-releasing hormone stimulation test.
    Result(s): All triple X patients (with and without pubertal signs) showed a pubertal LH peak level that was significantly different from controls. Triple X patients showed increased basal and peak FSH and LH values compared with control subjects. However, the mean E2 level was significantly lower than control subjects. However, triple X patients showed reduced DHEAS levels and reduced inhibin levels compared with control subjects. Finally, triple X patients had a significantly reduced ovarian volume compared with control subjects, in both prepubertal and pubertal patients.
    Conclusion(s): Triple X patients showed premature activation of the GnRH pulse generator, even without puberty signs. Both basal and peak LH and FSH levels were higher than in control subjects, and E2 and inhibin levels and ovarian volume were reduced, which led to a reduced gonadal function. Other studies and a longitudinal evaluation is necessary to better understand the endocrinologic features of these subjects.
    MeSH term(s) Child ; Chromosomes, Human, X ; Cross-Sectional Studies ; Female ; Follicle Stimulating Hormone/blood ; Gonadal Hormones/blood ; Gonadotropin-Releasing Hormone/blood ; Humans ; Hypothalamo-Hypophyseal System/metabolism ; Luteinizing Hormone/blood ; Male ; Puberty/blood ; Puberty, Precocious/blood ; Puberty, Precocious/diagnosis ; Retrospective Studies ; Sex Chromosome Aberrations ; Sex Chromosome Disorders of Sex Development/blood ; Sex Chromosome Disorders of Sex Development/diagnosis ; Trisomy/diagnosis
    Chemical Substances Gonadal Hormones ; Gonadotropin-Releasing Hormone (33515-09-2) ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2016.02.019
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  5. Article: HLA-G expression in early embryos is a fundamental prerequisite for the obtainment of pregnancy.

    Fuzzi, Beatrice / Rizzo, Roberta / Criscuoli, Luciana / Noci, Ivo / Melchiorri, Loredana / Scarselli, Benedetta / Bencini, Erica / Menicucci, Adriana / Baricordi, Olavio R

    European journal of immunology

    2002  Volume 32, Issue 2, Page(s) 311–315

    Abstract: Different mechanisms mediated by the expression of the HLA-class Ib HLA-G products are suggested to account for the induction of immune tolerance against the paternal antigens of the fetus during pregnancy. Soluble HLA-G antigens, mainly produced by ... ...

    Abstract Different mechanisms mediated by the expression of the HLA-class Ib HLA-G products are suggested to account for the induction of immune tolerance against the paternal antigens of the fetus during pregnancy. Soluble HLA-G antigens, mainly produced by cytotrophoblast cells at the materno-fetal interface and circulating in the body fluids, show a capacity analogous to that of membrane-boundstructures to inhibit NK cells. In the present report we have investigated, using specific ELISA, the presence of sHLA-G molecules in culture supernatants of early embryos obtained by in vitro fertilization (IVF) before transfer. The data obtained from the analysis of 285 supernatants corresponding to 101 IVF procedures (43 IVF, 58 intracytoplasmic sperm injection) identify two groups of patients on the basis of sHLA-G antigen presence. No differences in clinical parameters were observed between the groups, but positive embryo implantations occurred only in women showing sHLA-G molecules in culture supernatants (Fisher's exact p value 2.56 x 10(-3)). The results obtained indicate that expression of HLA-G products in embryo cells is a mandatory, but not sufficient, prerequisite for the development of pregnancy.
    MeSH term(s) Adult ; Blastocyst/immunology ; Culture Media ; Embryo Implantation/immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; Fertilization in Vitro ; HLA Antigens/analysis ; HLA Antigens/metabolism ; HLA-G Antigens ; Histocompatibility Antigens Class I/analysis ; Histocompatibility Antigens Class I/metabolism ; Humans ; Infertility/immunology ; Infertility/therapy ; Male ; Pregnancy ; Prospective Studies ; Solubility ; Sperm Injections, Intracytoplasmic
    Chemical Substances Culture Media ; HLA Antigens ; HLA-G Antigens ; Histocompatibility Antigens Class I
    Language English
    Publishing date 2002-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/1521-4141(200202)32:2<311::AID-IMMU311>3.0.CO;2-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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