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  1. Article: Old Drug, New Pain. Roles and Challenges of Methadone Therapy in Pediatric Palliative Care: A Systematic Review.

    Benedetti, Francesca / Zoletto, Silvia / Salerno, Annalisa / Avagnina, Irene / Benini, Franca

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 874529

    Abstract: Background: Pediatric palliative care (PPC) is defined as the prevention and relief from suffering of families and children with life-limiting (LLDs) or life-threatening diseases (LTDs). These patients often experience pain, with morphine being the most ...

    Abstract Background: Pediatric palliative care (PPC) is defined as the prevention and relief from suffering of families and children with life-limiting (LLDs) or life-threatening diseases (LTDs). These patients often experience pain, with morphine being the most widely used drug to treat it. Few studies investigated the role of methadone in PPC patients, although it is considered among the most effective and underutilized drugs in PPC.
    Objectives: Our aim was to evaluate the efficacy, safety, and dosage of methadone in PPC.
    Methods: Between August and October 2021 PubMed, Scopus and the Cochrane Library were searched for studies on the use of methadone in children with LLDs and LTDs. Articles were included if they met the following criteria: published in the last 10 years, English language, patients aged 0-23 years; children enrolled in a PPC center or receiving declared support from a PPC service; reporting of specific data on methadone in interventional trials, observational studies, or case series on >10 patients. The reporting of the article was guided by the PRISMA guidelines, and a critical appraisal of the included studies was performed using the JBI-tool.
    Results: After duplicates removal and full-text assessment, four studies were included and another one was added after checking the references of the retrieved papers. All were retrospective, and the literature is concordant in documenting the lack of evidence. A total of 116 children received methadone in PPC. From our review emerges the poor quality of data collection: in only one study pain was assessed with standardized scales. All studies documented the effectiveness of methadone in treating complex pain, either nociceptive or neuropathic. No serious adverse events were reported, with no cases of cardiac arrhythmias.
    Conclusion: Our results suggest that methadone could represent a suitable strategy for treating pain in PPC. However, the evidence base is insufficient, and further research is warranted.
    Language English
    Publishing date 2022-05-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.874529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Occurrence of Terrifying Nightmares after Few Days of Mirtazapine Use in Elderly Patients.

    Dell'Osso, Liliana / Lorenzi, Primo / Nardi, Benedetta / Carpita, Barbara / Benedetti, Francesca / Cremone, Ivan Mirko

    Case reports in psychiatry

    2023  Volume 2023, Page(s) 8843206

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2629914-8
    ISSN 2090-6838 ; 2090-682X
    ISSN (online) 2090-6838
    ISSN 2090-682X
    DOI 10.1155/2023/8843206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A STEM Training Approach Focused on Microscopy at Morgan State University.

    Denaro, Frank J / Nyaga, Simon / Zella, Davide / Bryant, J / Benedetti, Francesca

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue 29 Suppl 1, Page(s) 2111–2112

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.1095
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  4. Article: Mycoplasmas-Host Interaction: Mechanisms of Inflammation and Association with Cellular Transformation.

    Benedetti, Francesca / Curreli, Sabrina / Zella, Davide

    Microorganisms

    2020  Volume 8, Issue 9

    Abstract: Mycoplasmas are the smallest and simplest self-replicating prokaryotes. Located everywhere in nature, they are widespread as parasites of humans, mammals, reptiles, fish, arthropods, and plants. They usually exhibiting organ and tissue specificity. ... ...

    Abstract Mycoplasmas are the smallest and simplest self-replicating prokaryotes. Located everywhere in nature, they are widespread as parasites of humans, mammals, reptiles, fish, arthropods, and plants. They usually exhibiting organ and tissue specificity. Mycoplasmas belong to the class named Mollicutes (mollis = soft and cutis = skin, in Latin), and their small size and absence of a cell wall contribute to distinguish them from other bacteria.
    Language English
    Publishing date 2020-09-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8091351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Mycoplasmas–Host Interaction: Mechanisms of Inflammation and Association with Cellular Transformation

    Benedetti, Francesca / Curreli, Sabrina / Zella, Davide

    Microorganisms. 2020 Sept. 04, v. 8, no. 9

    2020  

    Abstract: Mycoplasmas are the smallest and simplest self-replicating prokaryotes. Located everywhere in nature, they are widespread as parasites of humans, mammals, reptiles, fish, arthropods, and plants. They usually exhibiting organ and tissue specificity. ... ...

    Abstract Mycoplasmas are the smallest and simplest self-replicating prokaryotes. Located everywhere in nature, they are widespread as parasites of humans, mammals, reptiles, fish, arthropods, and plants. They usually exhibiting organ and tissue specificity. Mycoplasmas belong to the class named Mollicutes (mollis = soft and cutis = skin, in Latin), and their small size and absence of a cell wall contribute to distinguish them from other bacteria. Mycoplasma species are found both outside the cells as membrane surface parasites and inside the cells, where they become intracellular residents as “silent parasites”. In humans, some Mycoplasma species are found as commensal inhabitants, while others have a significant impact on the cellular metabolism and physiology. Mollicutes lack typical bacterial PAMPs (e.g., lipoteichoic acid, flagellin, and some lipopolysaccharides) and consequently the exact molecular mechanisms of Mycoplasmas’ recognition by the cells of the immune system is the subjects of several researches for its pathogenic implications. It is well known that several strains of Mycoplasma suppress the transcriptional activity of p53, resulting in reduced apoptosis of damaged cells. In addition, some Mycoplasmas were reported to have oncogenic potential since they demonstrated not just accumulation of abnormalities but also phenotypic changes of the cells. Aim of this review is to provide an update of the current literature that implicates Mycoplasmas in triggering inflammation and altering critical cellular pathways, thus providing a better insight into potential mechanisms of cellular transformation.
    Keywords Mycoplasma ; apoptosis ; cell walls ; fish ; flagellin ; immune system ; inflammation ; lipopolysaccharides ; lipoteichoic acids ; metabolism ; phenotype ; prokaryotic cells ; transcription (genetics)
    Language English
    Dates of publication 2020-0904
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8091351
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Exogenous bacterial DnaK increases protein kinases activity in human cancer cell lines.

    Benedetti, Francesca / Curreli, Sabrina / Gallo, Robert C / Zella, Davide

    Journal of translational medicine

    2021  Volume 19, Issue 1, Page(s) 60

    Abstract: Background: Studies of molecular mechanisms underlying tumor cell signaling highlighted a critical role for kinases in carcinogenesis and cancer progression. To this regard, protein kinases regulates a number of critical cellular pathways by adding ... ...

    Abstract Background: Studies of molecular mechanisms underlying tumor cell signaling highlighted a critical role for kinases in carcinogenesis and cancer progression. To this regard, protein kinases regulates a number of critical cellular pathways by adding phosphate groups to specific substrates. For this reason, their involvement in the complex interactions between the human microbiota and cancer cells to determine therapy and tumor progression outcome is becoming increasingly relevant. Mycoplasmas are components of the normal human microbiota, and several species have also been associated to human diseases, including certain cancers. It is also important to note that Mycoplasmas and their proteins are a component of the common tumor microenvironment. In addition, several epidemiological, in vivo and in vitro studies indicate a close involvement of Mycoplasmas in cellular transformation and cancer progression.
    Methods: In this study, we investigate the effect of exogenous Mycoplasma DnaK on kinases activity by treating in vitro four different eukaryotic cancer cell lines, namely lung and prostate cancer, colon adenocarcinoma, and neuroblastoma. Phosphorylation of kinases and specific substrates was measured at 20 and 60 min.
    Results: Kinome analysis of our data indicates that Mycoplasma DnaK promotes the dysregulation of the activity of specific kinases and their substrates, with a known involvement in carcinogenesis and cancer progression.
    Conclusions: Given the similarity in structure and amino acid composition of this protein with other bacterial DnaKs we provide a novel mechanism whereby components of the human microbiota and present in the tumor microenvironment are able to deregulate phosphorylation events occurring during carcinogenesis and cancer progression.
    MeSH term(s) Carcinogenesis ; Cell Line ; Cell Transformation, Neoplastic ; Humans ; Male ; Phosphorylation ; Protein Kinases/metabolism ; Tumor Microenvironment
    Chemical Substances Protein Kinases (EC 2.7.-)
    Language English
    Publishing date 2021-02-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1479-5876
    ISSN (online) 1479-5876
    DOI 10.1186/s12967-021-02734-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Tampering of Viruses and Bacteria with Host DNA Repair: Implications for Cellular Transformation.

    Benedetti, Francesca / Curreli, Sabrina / Gallo, Robert C / Zella, Davide

    Cancers

    2021  Volume 13, Issue 2

    Abstract: A reduced ability to properly repair DNA is linked to a variety of human diseases, which in almost all cases is associated with an increased probability of the development of cellular transformation and cancer. DNA damage, that ultimately can lead to ... ...

    Abstract A reduced ability to properly repair DNA is linked to a variety of human diseases, which in almost all cases is associated with an increased probability of the development of cellular transformation and cancer. DNA damage, that ultimately can lead to mutations and genomic instability, is due to many factors, such as oxidative stress, metabolic disorders, viral and microbial pathogens, excess cellular proliferation and chemical factors. In this review, we examine the evidence connecting DNA damage and the mechanisms that viruses and bacteria have evolved to hamper the pathways dedicated to maintaining the integrity of genetic information, thus affecting the ability of their hosts to repair the damage(s). Uncovering new links between these important aspects of cancer biology might lead to the development of new targeted therapies in DNA-repair deficient cancers and improving the efficacy of existing therapies. Here we provide a comprehensive summary detailing the major mechanisms that viruses and bacteria associated with cancer employ to interfere with mechanisms of DNA repair. Comparing these mechanisms could ultimately help provide a common framework to better understand how certain microorganisms are involved in cellular transformation.
    Language English
    Publishing date 2021-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13020241
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  8. Article ; Online: Validation of the Short Version of the Panic Agoraphobic Spectrum (PAS-SV) Questionnaire.

    Dell'Osso, Liliana / Amatori, Giulia / Nardi, Benedetta / Bonelli, Chiara / Gravina, Davide / Benedetti, Francesca / Massimetti, Enrico / Cremone, Ivan Mirko / Carpita, Barbara

    Clinical neuropsychiatry

    2023  Volume 20, Issue 2, Page(s) 151–156

    Abstract: Objective: a spectrum model of psychopathology has allowed, in recent years, to recognize the subclinical or sub-threshold symptomatology that may be associated with full-blown mental disorders. The conceptualization of a panic - agoraphobic spectrum ... ...

    Abstract Objective: a spectrum model of psychopathology has allowed, in recent years, to recognize the subclinical or sub-threshold symptomatology that may be associated with full-blown mental disorders. The conceptualization of a panic - agoraphobic spectrum was developed in consideration of the substantial clinical heterogeneity revealed by studies on panic disorder with or without agoraphobia. The current study aims to determine the psychometric properties of the Panic Agoraphobic Spectrum - Short Version (PAS-SV), a new questionnaire designed to identify the spectrum of panic - agoraphobic symptoms.
    Method: 42 subjects with panic disorder or agoraphobia (PAD) according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), 41 subjects with autism spectrum disorder (ASD), and 60 healthy controls (HC) were recruited from the Psychiatric Clinic of the University of Pisa and assessed with the SCID-5, the Panic Disorder Severity Scale (PDSS) and the PAS-SV.
    Results: PAS-SV demonstrated a high level of internal consistency and the test-retest reliability for total and domain scores was excellent. PAS-SV domain scores were positively and significantly correlated with each other (p < 0.001), with Pearson's coefficients ranging from 0.771 to 0.943. All the PAS-SV domain scores were highly correlated with the PAS-SV total score. The correlation coefficients between PAS-SV and alternative measures of panic - agoraphobic symptoms appeared all significant and positive. Significant differences among diagnostic groups on both PAS-SV domains and total scores were found. PAS-SV total score increased significantly and progressively from HC, to the ASD up to the PA group.
    Conclusions: The PAS-SV showed excellent internal consistency and test-retest reliability and strong convergent validity with alternative dimensional measures of PA. The questionnaire performed differently among the three diagnostic groups, with an increasing score gradient from HC to patients with ASD to the PA group.
    Language English
    Publishing date 2023-04-28
    Publishing country Italy
    Document type Journal Article
    ISSN 2385-0787
    ISSN (online) 2385-0787
    DOI 10.36131/cnfioritieditore20230207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Joining Forces against Antibiotic Resistance: The One Health Solution.

    Cella, Eleonora / Giovanetti, Marta / Benedetti, Francesca / Scarpa, Fabio / Johnston, Catherine / Borsetti, Alessandra / Ceccarelli, Giancarlo / Azarian, Taj / Zella, Davide / Ciccozzi, Massimo

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: Antibiotic resistance is a significant global health concern that affects both human and animal populations. ... ...

    Abstract Antibiotic resistance is a significant global health concern that affects both human and animal populations. The
    Language English
    Publishing date 2023-08-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12091074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Neuroprotective properties of antiepileptics: what are the implications for psychiatric disorders?

    Dell'Osso, Liliana / Nardi, Benedetta / Massoni, Leonardo / Gravina, Davide / Benedetti, Francesca / Cremone, Ivan Mirko / Carpita, Barbara

    Current medicinal chemistry

    2023  

    Abstract: Since the discovery of the first antiepileptic compound, increasing attention has been paid to antiepileptic drugs (AEDs), and recently, with the understanding of the molecular mechanism underlying cells death, a new interest has revolved around a ... ...

    Abstract Since the discovery of the first antiepileptic compound, increasing attention has been paid to antiepileptic drugs (AEDs), and recently, with the understanding of the molecular mechanism underlying cells death, a new interest has revolved around a potential neuroprotective effect of AEDs. While many neurobiological studies in this field have focused on the protection of neurons, growing data are reporting how exposure to AEDs can also affect glial cells and the plastic response underlying recovery; however, demonstrating the neuroprotective abilities of AEDs remains a changeling task. The present work aims to summarize and review the literature available on the neuroprotective properties of the most commonly used AEDs. Results highlighted how further studies should investigate the link between AEDs and neuroprotective properties; while many studies are available on valproate, results for other AEDs are very limited and the majority of the research has been carried out on animal models. Moreover, a better understanding of the biological basis underlying neuro-regenerative defects may pave the way for the investigation of further therapeutic targets and eventually lead to an improvement in the actual treatment strategies.
    Language English
    Publishing date 2023-05-23
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867330666230523155728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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