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Article: Nonbacterial Thrombotic Endocarditis with Multiple Systemic Emboli in a Patient with Primary Lung Cancer.

Benedetti, Martina / Morroni, Sara / Fiaschini, Paola / Coiro, Stefano / Savino, Ketty

2022 Volume 32, Issue 2, Page(s) 129–131

Abstract: Nonbacterial thrombotic endocarditis (NBTE) is a rare condition that refers to a spectrum of noninfectious lesions of cardiac valves that is most commonly seen in advanced malignancy. We describe a case report of a 63-year-old male with NBTE and multiple ...

Abstract	Nonbacterial thrombotic endocarditis (NBTE) is a rare condition that refers to a spectrum of noninfectious lesions of cardiac valves that is most commonly seen in advanced malignancy. We describe a case report of a 63-year-old male with NBTE and multiple embolizations (encephalic, coronary, splenic, and renal). The patient was admitted to the emergency department for stroke. During hospitalization, the patient complained of left leg pain and a venous echo color Doppler of the lower limbs was performed, showing bilateral distal deep-vein thrombosis. A thoracoabdominal computed tomography scan, which was performed to rule out pulmonary embolism, revealed a primary lung cancer and subcarinal lymphadenopathy. As collateral findings, multiple ischemic lesions in the spleen and in both kidneys were identified. In addition, areas of subendocardial hypodensity compatible with ischemia were also highlighted. An electrocardiogram showed acute myocardial infarction and focused echocardiographic evaluation displayed hypokinesis of the lateral and posterior in the mid- and distal segments and aortic and mitral valve vegetations, confirmed by a transesophageal echocardiography. Empiric antimicrobial therapy was started; all blood culture sets were negative and the patient was apyretic throughout the hospitalization. These findings supported the hypothesis of NBTE with multiple embolizations during a hypercoagulable state associated with advanced lung cancer.
Language	English
Publishing date	2022-08-17
Publishing country	India
Document type	Case Reports
ZDB-ID	2734045-4
ISSN	2347-193X ; 2211-4122
ISSN (online)	2347-193X
ISSN	2211-4122
DOI	10.4103/jcecho.jcecho_68_21
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Article: Acute Myocarditis Associated with Legionella Infection: Usefulness of Layer-specific Two-dimensional Longitudinal Speckle-tracking Analysis.

Spighi, Lorenzo / Coiro, Stefano / Morroni, Sara / Benedetti, Martina / Savino, Ketty / Ambrosio, Giuseppe / Cavallini, Claudio

Journal of cardiovascular echography

2021 Volume 31, Issue 2, Page(s) 98–101

Abstract: Pneumonia is the most commonly described manifestation ... ...

Abstract	Pneumonia is the most commonly described manifestation of
Language	English
Publishing date	2021-07-28
Publishing country	India
Document type	Case Reports
ZDB-ID	2734045-4
ISSN	2347-193X ; 2211-4122
ISSN (online)	2347-193X
ISSN	2211-4122
DOI	10.4103/jcecho.jcecho_130_20
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Article ; Online: The Flavonoid Cyanidin Shows Immunomodulatory and Broad-Spectrum Antiviral Properties, Including SARS-CoV-2.

Vicente, Josefina / Benedetti, Martina / Martelliti, Paula / Vázquez, Luciana / Gentilini, María Virginia / Peñaranda Figueredo, Freddy Armando / Nabaes Jodar, Mercedes Soledad / Viegas, Mariana / Barquero, Andrea Alejandra / Bueno, Carlos Alberto

Viruses

2023 Volume 15, Issue 4

Abstract: New antiviral treatments are needed to deal with the unpredictable emergence of viruses. Furthermore, vaccines and antivirals are only available for just a few viral infections, and antiviral drug resistance is an increasing concern. Cyanidin (a natural ... ...

Abstract	New antiviral treatments are needed to deal with the unpredictable emergence of viruses. Furthermore, vaccines and antivirals are only available for just a few viral infections, and antiviral drug resistance is an increasing concern. Cyanidin (a natural product also called A18), a key flavonoid that is present in red berries and other fruits, attenuates the development of several diseases, through its anti-inflammatory effects. Regarding its mechanism of action, A18 was identified as an IL-17A inhibitor, resulting in the attenuation of IL-17A signaling and associated diseases in mice. Importantly, A18 also inhibits the NF-κB signaling pathway in different cell types and conditions in vitro and in vivo. In this study, we report that A18 restricts RSV, HSV-1, canine coronavirus, and SARS-CoV-2 multiplication, indicating a broad-spectrum antiviral activity. We also found that A18 can control cytokine and NF-κB induction in RSV-infected cells independently of its antiviral activity. Furthermore, in mice infected with RSV, A18 not only significantly reduces viral titers in the lungs, but also diminishes lung injury. Thus, these results provide evidence that A18 could be used as a broad-spectrum antiviral and may contribute to the development of novel therapeutic targets to control these viral infections and pathogenesis.
MeSH term(s)	Mice ; Animals ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; SARS-CoV-2/metabolism ; NF-kappa B/metabolism ; Interleukin-17 ; Flavonoids/pharmacology ; COVID-19
Chemical Substances	Antiviral Agents ; cyanidin (7732ZHU564) ; NF-kappa B ; Interleukin-17 ; Flavonoids
Language	English
Publishing date	2023-04-18
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15040989
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Article ; Online: Point-of-Care and Label-Free Detection of Porcine Reproductive and Respiratory Syndrome and Swine Influenza Viruses Using a Microfluidic Device with Photonic Integrated Circuits.

Manessis, Georgios / Frant, Maciej / Wozniakowski, Grzegorz / Nannucci, Lapo / Benedetti, Martina / Denes, Lilla / Gyula, Balka / Gelasakis, Athanasios I / Squires, Clare / Recuero, Sara / Sanchez, Carlos / Griol, Amadeu / Giusti, Alessandro / Bossis, Ioannis

Viruses

2022 Volume 14, Issue 5

Abstract: Swine viral diseases challenge the sector's sustainability by affecting productivity and the health and welfare of the animals. The lack of antiviral drugs and/or effective vaccines renders early and reliable diagnosis the basis of viral disease ... ...

Abstract	Swine viral diseases challenge the sector's sustainability by affecting productivity and the health and welfare of the animals. The lack of antiviral drugs and/or effective vaccines renders early and reliable diagnosis the basis of viral disease management, underlining the importance of point-of-care (POC) diagnostics. A novel POC diagnostic device utilizing photonic integrated circuits (PICs), microfluidics, and information and communication technologies for the detection of porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza A (SIV) was validated using spiked and clinical oral fluid samples. Metrics including sensitivity, specificity, accuracy, precision, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were calculated to assess the performance of the device. For PRRSV, the device achieved a sensitivity of 83.5%, specificity of 77.8%, and DOR values of 17.66, whereas the values for SIV were 81.8%, 82.2%, and 20.81, respectively. The POC device and PICs can be used for the detection of PRRSV and SIV in the field, paving the way for the introduction of novel technologies in the field of animal POC diagnostics to further optimize livestock biosecurity.
MeSH term(s)	Animals ; Influenza A virus ; Lab-On-A-Chip Devices ; Orthomyxoviridae Infections/diagnosis ; Orthomyxoviridae Infections/veterinary ; Point-of-Care Systems ; Porcine Reproductive and Respiratory Syndrome ; Porcine respiratory and reproductive syndrome virus ; Swine ; Swine Diseases
Language	English
Publishing date	2022-05-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14050988
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Article ; Online: Amiata Donkey Milk Chain: Animal Health Evaluation and Milk Quality

Ragona, Giuseppe / Corrias, Franco / Benedetti, Martina / Paladini, Maria / Salari, Federica / Altomonte, lolanda / Martini, Mina

Italian journal of food safety. 2016 Aug. 03, v. 5, no. 3

2016

Abstract: This study presents an investigation of Amiata donkey health and quality of milk for human consumption. Thirty-one lactating dairy jennies were examined. The following samples were collected: faecal samples from the rectum of animals for parasitological ... ...

Abstract	This study presents an investigation of Amiata donkey health and quality of milk for human consumption. Thirty-one lactating dairy jennies were examined. The following samples were collected: faecal samples from the rectum of animals for parasitological examination; cervical swabs for the detection of bacteria causing reproductive disorders; and blood samples for serological diagnosis of main zoonotic (Brucella spp., Leptospira spp.) and donkey abortion agents (Brucella spp., Leptospira spp., Salmonella abortus equi, Equine viral arterithis virus, Equine herpesvirus type 1). In addition, individual milk samples were collected and analysed for mastitis-causing pathogens and milk quality. Regarding animal health, we detected a high prevalence of strongyle parasites in donkeys. It is very important to tackle parasitic diseases correctly. Selective control programmes are preferable in order to reduce anthelmintic drug use. For dairy donkeys, withdrawal periods from anthelmintic drugs need to be carefully managed, in accordance with EU and national regulations. The isolation of Staphylococcus aureus in milk highlights the importance of preventing contamination during milking, by adopting appropriate hygiene and safety practices at a farm level. Lysozyme activity was high compared to cow’s milk, contributing to the inhibitory activity against certain bacteria. Donkey milk was characterised by high lactose content, low caseins, low fat, higher levels of unsaturated fatty acids compared to ruminant milks. Unsaturated fatty acids and omega 3 fatty acids in particular have become known for their beneficial health effect, which is favourable for human diet. These characteristics make it suitable for infants and children affected by food intolerance/allergies to bovine milk proteins and multiple food allergies as well as for adults with dyslipidemias. It is also recommended to prevent cardiovascular diseases.
Keywords	Staphylococcus aureus ; parasites ; parasitoses ; European Union ; milk ; ruminants ; Leptospira ; adults ; Brucella ; food analysis ; blood sampling ; drugs ; farms ; feces ; milk quality ; lactating females ; viruses ; omega-3 fatty acids ; food intolerance ; lactose ; humans ; ass milk ; animal pathogenic bacteria ; children ; anthelmintics ; casein ; human nutrition ; milking ; food allergies ; hygiene ; infants ; lysozyme ; Equid alphaherpesvirus 1 ; cardiovascular diseases ; Salmonella ; serodiagnosis ; food contamination ; lactation ; asses ; bovine mastitis ; horses ; Donkey health ; Milk hygiene ; Pathogen ; Equid herpesvirus 1 ; Milk quality
Language	English
Dates of publication	2016-0803
Publishing place	PAGEPress Publications, Pavia, Italy
Document type	Article ; Online
Note	Funding: the study was supported by the contribution of the regional government of Tuscany: Direzione Generate dei Diritti di Cittadinanza e Coesione Sociale - Settore Ricerca, Innovazione e Risorse umane - Bando pubblico per progetti di ricerca nel settore Nutraceutica. ; 2019-12-06 ; Resource is Open Access ; This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0). (http://creativecommons.org/licenses/by-nc/3.0/)
ZDB-ID	2717104-8
ISSN	2239-7132
ISSN	2239-7132
DOI	10.4081/ijfs.2016.5951
Database	NAL-Catalogue (AGRICOLA)

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Article: Amiata Donkey Milk Chain: Animal Health Evaluation and Milk Quality.

Ragona, Giuseppe / Corrias, Franco / Benedetti, Martina / Paladini, Maria / Salari, Federica / Altomonte, Lolanda / Martini, Mina

Italian journal of food safety

2016 Volume 5, Issue 3, Page(s) 5951

Abstract	This study presents an investigation of Amiata donkey health and quality of milk for human consumption. Thirty-one lactating dairy jennies were examined. The following samples were collected: faecal samples from the rectum of animals for parasitological examination; cervical swabs for the detection of bacteria causing reproductive disorders; and blood samples for serological diagnosis of main zoonotic (
Language	English
Publishing date	2016-08-03
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2717109-7
ISSN	2239-7132
ISSN	2239-7132
DOI	10.4081/ijfs.2016.5951
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Article ; Online: Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs.

Salinas, Franco Maximiliano / Nebreda, Antonela Díaz / Vázquez, Luciana / Gentilini, María Virginia / Marini, Victoria / Benedetti, Martina / Nabaes Jodar, Mercedes Soledad / Viegas, Mariana / Shayo, Carina / Bueno, Carlos Alberto

Antiviral research

2020 Volume 179, Page(s) 104817

Abstract: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease and bronchiolitis in children, as well as an important cause of morbidity and mortality in elderly and immunocompromised individuals. However, there is no safe and ... ...

Abstract	Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease and bronchiolitis in children, as well as an important cause of morbidity and mortality in elderly and immunocompromised individuals. However, there is no safe and efficacious RSV vaccine or antiviral treatment. Toll Like Receptors (TLR) are important molecular mediators linking innate and adaptive immunity, and their stimulation by cognate agonists has been explored as antiviral agents. Imiquimod is known as a TLR7 agonist, but additionally acts as an antagonist for adenosine receptors. In this study, we demonstrate that imiquimod, but not resiquimod, has direct anti-RSV activity via PKA pathway in HEp-2 and A549 cells, independently of an innate response. Imiquimod restricts RSV infection after viral entry into the host cell, interfering with viral RNA and protein synthesis. Probably as a consequence of these anti-RSV properties, imiquimod displays cytokine modulating activity in RSV infected epithelial cells. Moreover, in a murine model of RSV infection, imiquimod treatment improves the course of acute disease, evidenced by decreased weight loss, reduced RSV lung titers, and attenuated airway inflammation. Consequently, imiquimod represents a promising therapeutic alternative against RSV infection and may inform the development of novel therapeutic targets to control RSV pathogenesis.
MeSH term(s)	A549 Cells ; Animals ; Antiviral Agents/therapeutic use ; Cell Line, Tumor ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Cytokines/antagonists & inhibitors ; Cytokines/immunology ; Disease Models, Animal ; Epithelial Cells/drug effects ; Epithelial Cells/immunology ; Epithelial Cells/virology ; Female ; Humans ; Imiquimod/therapeutic use ; Inflammation/drug therapy ; Inflammation/virology ; Lung/drug effects ; Lung/virology ; Mice ; Mice, Inbred BALB C ; Respiratory Syncytial Virus Infections/drug therapy ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus, Human/drug effects ; Respiratory Syncytial Virus, Human/physiology ; Signal Transduction ; Viral Load ; Virus Replication/drug effects
Chemical Substances	Antiviral Agents ; Cytokines ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Imiquimod (P1QW714R7M)
Keywords	covid19
Language	English
Publishing date	2020-05-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/j.antiviral.2020.104817
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Article ; Online: Predictors of poor clinical outcomes in patients with acute myocardial infarction and non-obstructed coronary arteries (MINOCA).

Ciliberti, Giuseppe / Coiro, Stefano / Tritto, Isabella / Benedetti, Martina / Guerra, Federico / Del Pinto, Maurizio / Finocchiaro, Gherardo / Cavallini, Claudio / Capucci, Alessandro / Kaski, Juan Carlos / Ambrosio, Giuseppe

International journal of cardiology

2018 Volume 267, Page(s) 41–45

Abstract: Objective: To assess the characteristics and prognosis of patients with myocardial infarction and non-obstructed coronary arteries (MINOCA).: Methods: MINOCA was defined as acute myocardial infarction (AMI) with angiographic coronary stenosis <50% ... ...

Abstract	Objective: To assess the characteristics and prognosis of patients with myocardial infarction and non-obstructed coronary arteries (MINOCA). Methods: MINOCA was defined as acute myocardial infarction (AMI) with angiographic coronary stenosis <50%.Cardiomyopathies and myocarditis were - a priori - excluded from the study. Stenoses <30% were considered normal coronary arteries (NCA); stenoses ≥30% but <50% were considered mild coronary artery disease (MCAD). Patients were subdivided in 3 groups: I) NCA (0 vessels; stenosis <30%); II) 1-2 vessels showing MCAD and III) MCAD in 3 vessels or the left main stem (LMS). Results: From January 2006 to December 2014, 7935 consecutive AMI patients were entered into our institutional database;150 (2%) were diagnosed as having MINOCA. At a median follow-up of 7.1 years the composite end-point (cardiovascular death, AMI or acute coronary syndrome, heart failure, stroke) occurred in 23 patients (17.4%). Survival analysis showed no differences between NCA versus MCAD (p = 0.781). When assessed by distribution of CAD, group III had a lower event-free survival compared to group I and group II, respectively 54 ± 14%, 83 ± 4% and 90 ± 5% (p = 0.001). In a multivariate model, only 3 vessel disease or LMS involvement (HR = 23.5, 95% CI 2.59-173.49, P = 0.001) and high C-reactive protein at hospital admission (HR = 1.47, 95% CI 1.06-2.07, P = 0.005) were significant predictors of the study composite endpoint. Conclusions: In patients with MINOCA, the presence of NCA or 1-2 vessel MCAD was associated with better long-term clinical outcomes compared with patients with MCAD affecting 3 vessels or the LMS. Increased CRP concentrations on hospital admission were also a marker of worse clinical outcome during follow-up.
MeSH term(s)	Aged ; Biomarkers/analysis ; C-Reactive Protein/analysis ; Cause of Death ; Coronary Angiography/methods ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/physiopathology ; Coronary Occlusion/diagnosis ; Coronary Occlusion/diagnostic imaging ; Coronary Vessels/diagnostic imaging ; Female ; Follow-Up Studies ; Heart Failure/epidemiology ; Heart Failure/etiology ; Humans ; Italy/epidemiology ; Long Term Adverse Effects/epidemiology ; Long Term Adverse Effects/etiology ; Male ; Middle Aged ; Myocardial Infarction/diagnosis ; Myocardial Infarction/etiology ; Myocardial Infarction/mortality ; Outcome Assessment (Health Care) ; Predictive Value of Tests ; Prognosis ; Risk Factors ; Severity of Illness Index ; Stroke/epidemiology ; Stroke/etiology ; Survival Analysis
Chemical Substances	Biomarkers ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2018-06-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2018.03.092
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Article ; Online: The lived experience of parents whose children discharged to home after cardiac surgery for congenital heart disease.

Simeone, Silvio / Platone, Nicol / Perrone, Marco / Marras, Valentina / Pucciarelli, Gianluca / Benedetti, Martina / Dell'Angelo, Grazia / Rea, Teresa / Guillari, Assunta / Da Valle, Paola / Gargiulo, Gianpaolo / Botti, Stefano / Artioli, Giovanna / Comentale, Giuseppe / Ferrigno, Salvatore / Palma, Gaetano / Baratta, Stefania

Acta bio-medica : Atenei Parmensis

2018 Volume 89, Issue 4-S, Page(s) 71–77

Abstract: Background: Congenital Heart Diseases (CHDs) afflicting children are estimated in 8 per 1000 live births. Recent advances in surgery and medical treatments allowed an improvement in survival rates leading to changes in diseases management as chronic ... ...

Abstract	Background: Congenital Heart Diseases (CHDs) afflicting children are estimated in 8 per 1000 live births. Recent advances in surgery and medical treatments allowed an improvement in survival rates leading to changes in diseases management as chronic conditions. Parents involvement during clinical pathways is considered an essential component of care, but frequently they experience stress and anxiety conditions during the care path. These feelings are typical of the pre and peri-operative period, however they don't disappear easily and sometimes they can increase after hospital discharge, affecting the family environment and its behaviors. Aim of the work: The purpose of this qualitative study is to examine the lived experience of parents during the time just after their children return home from hospital after undergoing surgery for CHD. Methods: Parents were enrolled and interviewed as a prepositive sampling until concept saturation using Cohen's phenomenology approach. A quantitative approach was also applied using SF-12 questionnaire. The study was conducted in two Italian hospitals: the Pediatric Heart Surgery Center of the Fondazione Toscana G. Monasterio Institute in Massa and the Pediatric Cardiac Surgery Center of the Federico II University Hospital in Naples. Results: The main themes emerged after the analysis were "happiness and uncertainty"; "chronic psychophysical fatigue"; "the rediscovery of a strong link with health care professionals". Conclusions: Fully understand the life experience of these families will allow the implementation of targeted health interventions through the implementation of shared strategies and tools to reduce families and children discomfort after hospital discharge.
MeSH term(s)	Adolescent ; Adult ; Body Weight ; Cardiac Surgical Procedures/psychology ; Child ; Chronic Disease ; Fatigue/epidemiology ; Fatigue/etiology ; Female ; Happiness ; Heart Defects, Congenital ; Humans ; Italy ; Male ; Middle Aged ; Parents/psychology ; Patient Discharge ; Professional-Family Relations ; Qualitative Research ; Socioeconomic Factors ; Stress, Psychological ; Young Adult
Language	English
Publishing date	2018-04-04
Publishing country	Italy
Document type	Journal Article ; Multicenter Study
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v89i4-S.7223
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