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  1. Article: Volatile Organic Compounds Emitted by Flowers: Ecological Roles, Production by Plants, Extraction, and Identification.

    Lo, Mame-Marietou / Benfodda, Zohra / Molinié, Roland / Meffre, Patrick

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 3

    Abstract: Volatile organic compounds (VOCs) with a large chemical diversity are emitted by plant flowers. These compounds play an important role in the ecology of plants. This review presents the different ecological roles of VOCs present in the odor plumes of ... ...

    Abstract Volatile organic compounds (VOCs) with a large chemical diversity are emitted by plant flowers. These compounds play an important role in the ecology of plants. This review presents the different ecological roles of VOCs present in the odor plumes of plant flowers, such as pollination, defense, adaptation to their environment, and communication with other organisms. The production and accumulation sites of VOCs in plants with their spatial and temporal variations, including environmental issues, are also summarized. To evaluate the qualitative and quantitative chemical composition of VOCs, several methods of extraction and analysis were used. Headspace (HS) sampling coupled with solid phase microextraction (SPME) is now well-developed for the extraction process. Parameters are known, and several fibers are now available to optimize this extraction. Most of the time, SPME is coupled with gas chromatography-mass spectrometry (GC-MS) to determine the structural identification of the VOCs, paying attention to the use of several complementary methods for identification like the use of databases, retention indices, and, when available, comparison with authentic standards analyses. The development of the knowledge on VOCs emitted by flowers is of great importance for plant ecology in the context of environmental and climate changes.
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13030417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Green methodologies for the synthesis of 2-aminothiophene

    Duvauchelle, Valentin / Meffre, Patrick / Benfodda, Zohra

    Environ Chem Lett. 2023 Feb., v. 21, no. 1 p.597-621

    2023  

    Abstract: Pollution and the rising energy demand have prompted the design of new synthetic reactions that meet the principles of green chemistry. In particular, alternative synthesis of 2-aminothiophene have recently focused interest because 2-aminothiophene is a ... ...

    Abstract Pollution and the rising energy demand have prompted the design of new synthetic reactions that meet the principles of green chemistry. In particular, alternative synthesis of 2-aminothiophene have recently focused interest because 2-aminothiophene is a unique 5-membered S-heterocycle and a pharmacophore providing antiprotozoal, antiproliferative, antiviral, antibacterial or antifungal properties. Here, we review new synthetic routes to 2-aminothiophenes, including multicomponent reactions, homogeneously- or heterogeneously-catalyzed reactions, with focus on green pathways.
    Keywords energy ; green chemistry ; pharmacology ; pollution
    Language English
    Dates of publication 2023-02
    Size p. 597-621.
    Publishing place Springer International Publishing
    Document type Article ; Online
    Note Review
    ZDB-ID 2107984-5
    ISSN 1610-3661 ; 1610-3653
    ISSN (online) 1610-3661
    ISSN 1610-3653
    DOI 10.1007/s10311-022-01482-1
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: An overview on the antibacterial properties of juglone, naphthazarin, plumbagin and lawsone derivatives and their metal complexes.

    Majdi, Chaimae / Duvauchelle, Valentin / Meffre, Patrick / Benfodda, Zohra

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 162, Page(s) 114690

    Abstract: Bacterial resistance development represents a serious threat to human health across the globe and has become a very serious clinical problem for many classes of antibiotics. Hence, there is a constant and urgent need for the discovery and development of ... ...

    Abstract Bacterial resistance development represents a serious threat to human health across the globe and has become a very serious clinical problem for many classes of antibiotics. Hence, there is a constant and urgent need for the discovery and development of new effective antibacterial agents to stem the emergence of resistant bacteria. 1,4-naphthoquinones are an important class of natural products and have been known for decades as a privileged scaffold in medicinal chemistry regarding their many biological properties. The significant biological properties of specific 1,4-naphthoquinones hydroxyderivatives have drawn the attention of researchers in order to find new derivatives with an optimized activity, mainly as antibacterial agents. Based on juglone, naphthazarin, plumbagin and lawsone moieties, structural optimization was realized with the purpose of improving the antibacterial activity. Thereupon, relevant antibacterial activities have been observed on different panels of bacterial strains including resistant ones. In this review, we highlight the interest of developing new 1,4-naphthoquinones hydroxyderivatives and some metal complexes as promising antibacterial agents alternatives. Here, we thoroughly report for the first time both the antibacterial activity and the chemical synthesis of four different 1,4-naphthoquinones (juglone, naphthazarin, plumbagin and lawsone) from 2002 to 2022 with an emphasis on the structure-activity relationship, when applicable.
    MeSH term(s) Humans ; Coordination Complexes/pharmacology ; Naphthoquinones/pharmacology ; Bacteria ; Anti-Bacterial Agents/pharmacology
    Chemical Substances lawsone (TLH4A6LV1W) ; plumbagin (YAS4TBQ4OQ) ; juglone (W6Q80SK9L6) ; Coordination Complexes ; Naphthoquinones ; naphthazarin (475-38-7) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-17
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Enzyme inhibitors for drug discovery.

    Meffre, Patrick / Benfodda, Zohra / Albrecht, Sébastien

    Amino acids

    2023  Volume 55, Issue 12, Page(s) 1707–1708

    MeSH term(s) Drug Discovery ; Enzyme Inhibitors/pharmacology ; Drug Design
    Chemical Substances Enzyme Inhibitors
    Language English
    Publishing date 2023-11-28
    Publishing country Austria
    Document type Editorial
    ZDB-ID 1121341-3
    ISSN 1438-2199 ; 0939-4451
    ISSN (online) 1438-2199
    ISSN 0939-4451
    DOI 10.1007/s00726-023-03357-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Catalyst-Free Site Selective Hydroxyalkylation of 5-Phenylthiophen-2-amine with α-Trifluoromethyl Ketones through Electrophilic Aromatic Substitution.

    Duvauchelle, Valentin / Bénimélis, David / Meffre, Patrick / Benfodda, Zohra

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 3

    Abstract: An original and effective approach for achieving trifluoromethyl hydroxyalkylation of 5-phenylthiophen-2-amine using α-trifluoromethyl ketones is described. In the last few years, reaction of Friedel-Crafts had been widely used to realize ... ...

    Abstract An original and effective approach for achieving trifluoromethyl hydroxyalkylation of 5-phenylthiophen-2-amine using α-trifluoromethyl ketones is described. In the last few years, reaction of Friedel-Crafts had been widely used to realize hydroxyalkylation on heterocycles such as indoles or thiophenes by means of Lewis acid as catalyst. Additionally, amine functions are rarely free when carbonyl reagents are used because of their tendency to form imines. This is the first time that a site-selective electrophilic aromatic substitution on C
    Language English
    Publishing date 2022-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27030925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Recent contribution of medicinally active 2-aminothiophenes: A privileged scaffold for drug discovery.

    Duvauchelle, Valentin / Meffre, Patrick / Benfodda, Zohra

    European journal of medicinal chemistry

    2022  Volume 238, Page(s) 114502

    Abstract: In medicinal chemistry, 2-aminothiophene is a central five-membered heterocyclic core that is mostly synthesized using Gewald methodology. Its incorporation into a molecule can confer broad biological activities, making 2-aminothiophene an attractive ... ...

    Abstract In medicinal chemistry, 2-aminothiophene is a central five-membered heterocyclic core that is mostly synthesized using Gewald methodology. Its incorporation into a molecule can confer broad biological activities, making 2-aminothiophene an attractive scaffold for drug discovery. Another interesting feature of 2-aminothiophene moiety is its ability to act as synthon for the synthesis of biological active thiophene-containing heterocycles, conjugates or hybrids. Compounds from the 2-aminothiophene family are promising selective inhibitors and modulators in medicinal chemistry, and even exhibit effective pharmacological properties in the various clinical phases of appropriate diseases. Likewise, the biological actions of 2-aminothiophenes or their 2-N-substituted analogs are still being investigated because of their diverse mechanisms of action (e.g., pharmacophore and pharmacokinetic properties). In this review, we focus on the structure-activity relationship, the synthesis and the biological activities of 2-aminothiophene derivatives, including antiprotozoal, antiproliferative, antiviral, antibacterial, antifungal, channel and cannabinoid receptor inhibitors. Most perspective drug-candidate hits were selected for discussion and described, along with additional synthetic pathways. Since there has been several contributions in this field recently, we emphasized on the literature dedicated to 2-aminothiophenes and 2-N-substituted derivatives which have been published from 2017 to 2022.
    MeSH term(s) Antifungal Agents/pharmacology ; Chemistry, Pharmaceutical ; Drug Discovery ; Structure-Activity Relationship ; Thiophenes/chemistry ; Thiophenes/pharmacology
    Chemical Substances Antifungal Agents ; Thiophenes
    Language English
    Publishing date 2022-06-02
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2022.114502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Green methodologies for the synthesis of 2-aminothiophene.

    Duvauchelle, Valentin / Meffre, Patrick / Benfodda, Zohra

    Environmental chemistry letters

    2022  Volume 21, Issue 1, Page(s) 597–621

    Abstract: Pollution and the rising energy demand have prompted the design of new synthetic reactions that meet the principles of green chemistry. In particular, alternative synthesis of 2-aminothiophene have recently focused interest because 2-aminothiophene is a ... ...

    Abstract Pollution and the rising energy demand have prompted the design of new synthetic reactions that meet the principles of green chemistry. In particular, alternative synthesis of 2-aminothiophene have recently focused interest because 2-aminothiophene is a unique 5-membered S-heterocycle and a pharmacophore providing antiprotozoal, antiproliferative, antiviral, antibacterial or antifungal properties. Here, we review new synthetic routes to 2-aminothiophenes, including multicomponent reactions, homogeneously- or heterogeneously-catalyzed reactions, with focus on green pathways.
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2107984-5
    ISSN 1610-3661 ; 1610-3653
    ISSN (online) 1610-3661
    ISSN 1610-3653
    DOI 10.1007/s10311-022-01482-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Determination of the maximum bioaccumulation capacity of various metals in leaves of two Tillandsia species.

    Gonzalez, Alexandre / Benfodda, Zohra / Bénimélis, David / Bourgeois, Damien / Herfurth, Damien / Fontaine, Jean-Xavier / Molinié, Roland / Meffre, Patrick

    Environmental science and pollution research international

    2024  Volume 31, Issue 20, Page(s) 29644–29655

    Abstract: Tillandsia species are plants from the Bromeliaceae family which display biomonitoring capacities in both active and passive modes. The bioaccumulation potential of Tillandsia aeranthos (Loisiel.) Desf. and Tillandsia bergeri Mez acclimated to Southern/ ... ...

    Abstract Tillandsia species are plants from the Bromeliaceae family which display biomonitoring capacities in both active and passive modes. The bioaccumulation potential of Tillandsia aeranthos (Loisiel.) Desf. and Tillandsia bergeri Mez acclimated to Southern/Mediterranean Europe has never been studied. More generally, few studies have detailed the maximum accumulation potential of Tillandsia leaves through controlled experiments. The aim of this study is to evaluate the maximum accumulation values of seven metals (Co, Cu, Mn, Ni, Pb, Pt, and Zn) in T. aeranthos and T. bergeri leaves. Plants were immersed in different mono elemental metallic solutions of Co (II), Cu (II), Mn (II), Ni (II), Pb (II), Pt (IV), and Zn (II) ions at different concentrations. In addition, cocktail solutions of these seven metals at different concentrations were prepared to study the main differences and the potential selectivity between metals. After exposure, the content of these metals in the leaves were measured by inductively coupled plasma-optical emission spectrometry. Data sets were evaluated by a fitted regression hyperbola model and principal component analysis, maximum metal loading capacity, and thermodynamic affinity constant were determined. The results showed important differences between the two species, with T. bergeri demonstrating higher capacity and affinity for metals than T. aeranthos. Furthermore, between the seven metals, Pb and Ni showed higher enrichment factors (EF). T. bergeri might be a better bioaccumulator than T. aeranthos with marked selectivity for Pb and Ni, metals of concern in air quality biomonitoring.
    MeSH term(s) Tillandsia/metabolism ; Plant Leaves/metabolism ; Air Pollutants/metabolism ; Environmental Monitoring/methods ; Metals/metabolism ; Spectrophotometry, Atomic ; Principal Component Analysis ; Regression Analysis ; Bioaccumulation ; Mediterranean Region
    Chemical Substances Air Pollutants ; Metals
    Language English
    Publishing date 2024-04-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-33183-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Synergistic effect of tryptamine-urea derivatives to overcome the chromosomally-mediated colistin resistance in Klebsiella pneumoniae.

    Majdi, Chaimae / Dessolin, Jean / Bénimélis, David / Dunyach-Rémy, Catherine / Pantel, Alix / Meffre, Patrick / Benfodda, Zohra

    Bioorganic & medicinal chemistry

    2024  Volume 100, Page(s) 117604

    Abstract: Colistin is considered as the last-resort antibiotics to treat multi-drug resistant Gram-negative bacterial infections in humans. However, the clinical use of colistin was limited because of the apparition of chromosomal mutations and mobile colistin ... ...

    Abstract Colistin is considered as the last-resort antibiotics to treat multi-drug resistant Gram-negative bacterial infections in humans. However, the clinical use of colistin was limited because of the apparition of chromosomal mutations and mobile colistin resistance genes in bacterial isolates. One promising strategy is to combine existing antibiotics with promising non-antibiotics to overcome the widespread emergence of antibiotic-resistant pathogens. Moreover, colistin resistance would be regulated by two component systems PhoP/PhoQ which leads to permanent synthesis of cationic groups compensating for Mg
    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacterial Proteins/metabolism ; Colistin/pharmacology ; Drug Resistance, Bacterial ; Klebsiella Infections/drug therapy ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae ; Microbial Sensitivity Tests ; Tryptamines/chemistry ; Tryptamines/pharmacology ; Urea/chemistry ; Urea/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Colistin (Z67X93HJG1) ; Tryptamines ; Urea (8W8T17847W)
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2024.117604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Extraction and Identification of Volatile Organic Compounds in Scentless Flowers of 14

    Gonzalez, Alexandre / Benfodda, Zohra / Bénimélis, David / Fontaine, Jean-Xavier / Molinié, Roland / Meffre, Patrick

    Metabolites

    2022  Volume 12, Issue 7

    Abstract: VOCs emitted by flowers play an important role in plant ecology. In the past few years, ... ...

    Abstract VOCs emitted by flowers play an important role in plant ecology. In the past few years, the
    Language English
    Publishing date 2022-07-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12070628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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