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  1. Article ; Online: [Hypothalamic-pituitary dysfunction in a patient with neurosarcoidosis].

    Bengtsen, Mads Bisgaard / Rasmussen, Tue Kruse / Nørgaard, Louise Jung

    Ugeskrift for laeger

    2021  Volume 183, Issue 25

    Abstract: This is a case report of a 64-year-old man with pulmonary sarcoidosis also affecting the joints. He was admitted to an emergency department following 21 days of fatigue, visual disturbances and headache. Initial blood tests revealed hypothalamic- ... ...

    Abstract This is a case report of a 64-year-old man with pulmonary sarcoidosis also affecting the joints. He was admitted to an emergency department following 21 days of fatigue, visual disturbances and headache. Initial blood tests revealed hypothalamic-pituitary dysfunction including acute adrenal insufficiency, and an MRI scan of the cerebrum showed a neurosarcoidosis tumour involving the hypothalamus-pituitary gland. Neurosarcoidosis is a condition with widespread clinical variation and early, and correct diagnosis is important.
    MeSH term(s) Central Nervous System Diseases/complications ; Central Nervous System Diseases/diagnosis ; Central Nervous System Diseases/drug therapy ; Humans ; Hypothalamus ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Pituitary Gland ; Sarcoidosis/diagnosis ; Sarcoidosis/diagnostic imaging
    Language Danish
    Publishing date 2021-06-25
    Publishing country Denmark
    Document type Case Reports ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  2. Article ; Online: Hospitalization for hypoglycaemia in people with diabetes in Denmark, 1997-2017: Time trends in incidence and HbA

    Bengtsen, Mads Bisgaard / Knudsen, Jakob Schöllhammer / Bengtsen, Maria Bisgaard / Møller, Niels / Thomsen, Reimar Wernich

    Endocrinology, diabetes & metabolism

    2021  Volume 4, Issue 3, Page(s) e00227

    Abstract: Objective: To assess incidence trends of first hospitalization for hypoglycaemia in Denmark and to examine HbA: Research design and methods: We performed a population-based study linking diagnosis, prescription and laboratory data. Standardized ... ...

    Abstract Objective: To assess incidence trends of first hospitalization for hypoglycaemia in Denmark and to examine HbA
    Research design and methods: We performed a population-based study linking diagnosis, prescription and laboratory data. Standardized incidence of first hospitalization for hypoglycaemia in Denmark was assessed for each calendar year 1997-2017. HbA1c and glucose-lowering drug use was compared with age- and sex-matched diabetes comparisons without hospitalization for hypoglycaemia.
    Results: The annual age- and sex-standardized incidence rate of first hospitalization for hypoglycaemia per 100,000 person-years increased during 1997-2003 (from 17.7 to 30.3 per 100,000 person-years), remained stable until 2010 (30.4) and gradually declined until 2017 (22.0). During this period, we identified 3,479 people with type 1 diabetes and 15,329 people with type 2 diabetes experiencing first hospitalization for hypoglycaemia. Both diabetes groups experienced a mean HbA1c decrease of ~12%-15% in the months preceding first hospitalization, followed by a gradually increasing HbA1c afterwards. People with type 1 diabetes and hospitalization used similar insulin therapies as those without hospitalization. People with type 2 diabetes and hospitalization more often received insulin (55%) than comparisons (45%), and 45% discontinued insulin or stopped all glucose-lowering therapy after first hospitalization.
    Conclusions: Incidence of hospitalizations for hypoglycaemia has declined by one fourth the last decade in the Danish population. A HbA1c decrease precedes first hospitalization for hypoglycaemia in individuals with diabetes, and profound changes in glucose-lowering drug therapy for type 2 diabetes occur after hospitalization.
    MeSH term(s) Denmark/epidemiology ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Glucose/therapeutic use ; Glycated Hemoglobin A ; Hospitalization ; Humans ; Hypoglycemia/chemically induced ; Hypoglycemia/epidemiology ; Hypoglycemic Agents/adverse effects ; Incidence
    Chemical Substances Glycated Hemoglobin A ; Hypoglycemic Agents ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-01-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2398-9238
    ISSN (online) 2398-9238
    DOI 10.1002/edm2.227
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  3. Article ; Online: Effects of transdermal estrogen therapy on satellite cell number and molecular markers for muscle hypertrophy in response to resistance training in early postmenopausal women.

    Dam, Tine Vrist / Dalgaard, Line Barner / Johansen, Frank Ted / Bengtsen, Mads Bisgaard / Mose, Maike / Lauritsen, Katrine Meyer / Gravholt, Claus H / Hansen, Mette

    European journal of applied physiology

    2022  Volume 123, Issue 3, Page(s) 667–681

    Abstract: Purpose: To investigate the effects of resistance training with or without transdermal estrogen therapy (ET) on satellite cell (SC) number and molecular markers for muscle hypertrophy in early postmenopausal women.: Methods: Using a double-blinded ... ...

    Abstract Purpose: To investigate the effects of resistance training with or without transdermal estrogen therapy (ET) on satellite cell (SC) number and molecular markers for muscle hypertrophy in early postmenopausal women.
    Methods: Using a double-blinded randomized controlled design, we allocated healthy, untrained postmenopausal women to perform 12 weeks of resistance training with placebo (PLC, n = 16) or ET (n = 15). Muscle biopsies obtained before and after the intervention, and two hours after the last training session were analyzed for fiber type, SC number and molecular markers for muscle hypertrophy and degradation (real-time PCR, western blotting).
    Results: The analysis of SCs per Type I fiber showed a time x treatment interaction caused by a 47% decrease in PLC, and a 26% increase after ET after the training period. Also, SCs per Type II fiber area was lower after the intervention driven by a 57% decrease in PLC. Most molecular markers changed similarly in the two groups.
    Conclusion: A decline in SC per muscle fiber was observed after the 12-week training period in postmenopausal women, which was counteracted when combined with use of transdermal ET.
    Clinical trial registration number: nct03020953.
    MeSH term(s) Female ; Humans ; Estrogens ; Hypertrophy/pathology ; Muscle Fibers, Skeletal/physiology ; Muscle, Skeletal/physiology ; Postmenopause ; Resistance Training ; Satellite Cells, Skeletal Muscle/metabolism ; Double-Blind Method
    Chemical Substances Estrogens
    Language English
    Publishing date 2022-12-31
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 124793-1
    ISSN 1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
    ISSN (online) 1439-6327 ; 1432-1025
    ISSN 0301-5548 ; 1439-6319
    DOI 10.1007/s00421-022-05093-0
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  4. Article ; Online: Estrogen modulates metabolic risk profile after resistance training in early postmenopausal women: a randomized controlled trial.

    Dam, Tine Vrist / Dalgaard, Line Barner / Thomsen, Christian Bejlegaard / Hjortebjerg, Rikke / Ringgaard, Steffen / Johansen, Frank Ted / Bengtsen, Mads Bisgaard / Mose, Maike / Lauritsen, Katrine Meyer / Søndergaard, Esben / Gravholt, Claus H / Hansen, Mette

    Menopause (New York, N.Y.)

    2022  Volume 28, Issue 11, Page(s) 1214–1224

    Abstract: Objective: Women experience an unhealthy change in metabolic risk profile at menopause. The purpose of the present study was to determine effects of resistance training with or without transdermal estrogen therapy (ET) on adipose tissue mass and ... ...

    Abstract Objective: Women experience an unhealthy change in metabolic risk profile at menopause. The purpose of the present study was to determine effects of resistance training with or without transdermal estrogen therapy (ET) on adipose tissue mass and metabolic risk profile in early postmenopausal women.
    Methods: A double-blinded randomized controlled trial, where healthy, untrained postmenopausal women were allocated to supervised resistance training with placebo (PLC, n = 16) or transdermal ET (n = 15) for 12 weeks. Endpoints with prespecified hypotheses were the change in total fat mass (FM) (main endpoint) and the change in visceral FM (secondary endpoint) from before to after the intervention. Additionally, prespecified endpoints of body composition, metabolic health-related blood markers, fat%, fat cell size, and lipogenic markers in subcutaneous adipose tissue (SAT) from abdominal and femoral region were explored.
    Results: Compared with the ET group, the PLC group experienced a greater reduction (time × treatment interaction P < 0.05) in total FM (PLC vs ET: -5.6% vs -1.1%) and visceral FM (-18.6% vs -6.8%), and femoral SAT (-5.6% vs 1.0%), but not abdominal SAT mass (-8.5% vs -2.8%, P = 0.15).The ET group improved their metabolic blood profile by reduced low-density lipoprotein, glucose and hemoglobin A1c compared with PLC (time × treatment interaction P < 0.05). The intervention induced changes in lipolytic markers of abdominal SAT, whereas no changes were detected in femoral SAT.
    Conclusion: Use of transdermal ET reduced adipose tissue loss, but improved metabolic blood markers when combined with 12 weeks of progressive resistance training in early postmenopausal women.
    MeSH term(s) Body Composition ; Estrogens ; Female ; Humans ; Intra-Abdominal Fat ; Postmenopause ; Resistance Training
    Chemical Substances Estrogens
    Language English
    Publishing date 2022-01-26
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1205262-0
    ISSN 1530-0374 ; 1072-3714
    ISSN (online) 1530-0374
    ISSN 1072-3714
    DOI 10.1097/GME.0000000000001841
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  5. Article ; Online: A model mimicking catabolic inflammatory disease; a controlled randomized study in humans.

    Mose, Maike / Rittig, Nikolaj / Mikkelsen, Ulla Ramer / Jessen, Niels / Bengtsen, Mads Bisgaard / Christensen, Brit / Jørgensen, Jens Otto Lunde / Møller, Niels

    PloS one

    2020  Volume 15, Issue 11, Page(s) e0241274

    Abstract: Objective: Inflammatory disease is catabolic and associated with insulin resistance, increased energy expenditure, lipolysis and muscle protein loss. The main contributors to these metabolic adaptations are inflammation, malnutrition and immobilisation. ...

    Abstract Objective: Inflammatory disease is catabolic and associated with insulin resistance, increased energy expenditure, lipolysis and muscle protein loss. The main contributors to these metabolic adaptations are inflammation, malnutrition and immobilisation. Controlled experimental models incorporating these central elements of hospitalisation are lacking. The aim of this study was to validate such a human experimental model.
    Methods: In a randomized crossover design, six healthy young men underwent; (i) overnight fast (CTR), or (ii) exposure to systemic lipopolysaccharide (1 ng/kg) combined with 36-hour fast and bed rest (CAT). The difference in insulin sensitivity between CAT and CTR was the main outcome, determined by a hyperinsulinemic euglycemic glucose clamp. Palmitate, glucose, urea, phenylalanine and tyrosine tracers were infused to estimate metabolic shifts during interventions. Indirect calorimetry was used to estimate energy expenditure and substrate oxidation.
    Results: Insulin sensitivity was 41% lower in CAT than in CTR (M-value, mg/kg/min): 4.3 ± 0.2 vs 7.3 ± 1.3, p<0.05. The median (min max) palmitate flux (μmol/min) was higher during CAT than in CTR (257.0 (161.7 365.4) vs 131.6 (92.3 189.4), p = 0.004), and protein kinetics did not differ between interventions. C-reactive peptide (mg/L) was elevated in CAT compared with CTR (30.57 ± 4.08 vs 1.03 ± 0.19, p<0.001). Energy expenditure increased by 6% during CAT compared with CTR (1869 ± 94 vs 1756 ± 58, p = 0.04), CAT having higher lipid oxidation rates (p = 0.01) and lower glucose oxidation rates (p = 0.03). Lipopolysaccharide caused varying abdominal discomfort 2 hours post-injection, which had disappeared the following day.
    Conclusion: We found that combined systemic inflammation, fasting and bed rest induced marked insulin resistance and increased energy expenditure and lipolysis, rendering this controlled experimental model suitable for anti-catabolic intervention studies, mimicking clinical conditions.
    MeSH term(s) Adult ; Biomarkers/metabolism ; Glucose Clamp Technique ; Humans ; Inflammation/pathology ; Insulin Resistance ; Kinetics ; Lipids/analysis ; Models, Biological ; Muscle, Skeletal/metabolism ; Proteins/analysis ; Signal Transduction ; Young Adult
    Chemical Substances Biomarkers ; Lipids ; Proteins
    Language English
    Publishing date 2020-11-05
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0241274
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  6. Article ; Online: A Human Randomized Controlled Trial Comparing Metabolic Responses to Single and Repeated Hypoglycemia in Type 1 Diabetes.

    Bengtsen, Mads Bisgaard / Støy, Julie / Rittig, Nikolaj Fibiger / Voss, Thomas Schmidt / Magnusson, Nils Erik / Svart, Mads Vadsted / Jessen, Niels / Møller, Niels

    The Journal of clinical endocrinology and metabolism

    2020  Volume 105, Issue 12

    Abstract: Aims: Hypoglycemia hinders optimal glycemic management in type 1 diabetes (T1D). Long diabetes duration and hypoglycemia impair hormonal counter-regulatory responses to hypoglycemia. Our study was designed to test whether (1) the metabolic responses and ...

    Abstract Aims: Hypoglycemia hinders optimal glycemic management in type 1 diabetes (T1D). Long diabetes duration and hypoglycemia impair hormonal counter-regulatory responses to hypoglycemia. Our study was designed to test whether (1) the metabolic responses and insulin sensitivity are impaired, and (2) whether they are affected by short-lived antecedent hypoglycemia in participants with T1D.
    Materials and methods: In a randomized, crossover, 2x2 factorial design, 9 male participants with T1D and 9 comparable control participants underwent 30 minutes of hypoglycemia (p-glucose < 2.9 mmol/L) followed by a euglycemic clamp on 2 separate interventions: with and without 30 minutes of hypoglycemia the day before the study day.
    Results: During both interventions insulin sensitivity was consistently lower, while counter-regulatory hormones were reduced, with 75% lower glucagon and 50% lower epinephrine during hypoglycemia in participants with T1D, who also displayed 40% lower lactate and 5- to 10-fold increased ketone body concentrations following hypoglycemia, whereas palmitate and glucose turnover, forearm glucose uptake, and substrate oxidation did not differ between the groups. In participants with T1D, adipose tissue phosphatase and tensin homolog (PTEN) content, hormone-sensitive lipase (HSL) phosphorylation, and muscle glucose transporter type 4 (GLUT4) content were decreased compared with controls. And antecedent hypoglycemic episodes lasting 30 minutes did not affect counter-regulation or insulin sensitivity.
    Conclusions: Participants with T1D displayed insulin resistance and impaired hormonal counter-regulation during hypoglycemia, whereas glucose and fatty acid fluxes were intact and ketogenic responses were amplified. We observed subtle alterations of intracellular signaling and no effect of short-lived antecedent hypoglycemia on subsequent counter-regulation. This plausibly reflects the presence of insulin resistance and implies that T1D is a condition with defective hormonal but preserved metabolic responsiveness to short-lived hypoglycemia.
    MeSH term(s) Adult ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Cross-Over Studies ; Denmark ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/metabolism ; Diabetes Mellitus, Type 1/pathology ; Glucose Clamp Technique/methods ; Humans ; Hypoglycemia/chemically induced ; Hypoglycemia/metabolism ; Insulin/administration & dosage ; Insulin/adverse effects ; Insulin Resistance ; Lipid Metabolism/drug effects ; Male ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Recurrence ; Subcutaneous Fat, Abdominal/drug effects ; Subcutaneous Fat, Abdominal/metabolism ; Subcutaneous Fat, Abdominal/pathology ; Young Adult
    Chemical Substances Blood Glucose ; Insulin
    Language English
    Publishing date 2020-08-19
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgaa645
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  7. Article ; Online: Hyperpolarized [1-

    Bengtsen, Mads Bisgaard / Hansen, Esben Søvsø Szocska / Tougaard, Rasmus Stilling / Lyhne, Mads Dam / Rittig, Nikolaj Fibiger / Støy, Julie / Jessen, Niels / Mariager, Christian Østergaard / Stødkilde-Jørgensen, Hans / Møller, Niels / Laustsen, Christoffer

    Experimental physiology

    2021  Volume 106, Issue 12, Page(s) 2412–2422

    Abstract: New findings: What is the central question of this study? Is it possible to combine the hyperpolarized magnetic resonance technique and the hyperinsulinaemic clamp method in order to evaluate skeletal muscle metabolism in a large animal model? What is ... ...

    Abstract New findings: What is the central question of this study? Is it possible to combine the hyperpolarized magnetic resonance technique and the hyperinsulinaemic clamp method in order to evaluate skeletal muscle metabolism in a large animal model? What is the main finding and its importance? The logistical set-up is possible, and we found substantial increments in glucose infusion rates representing skeletal muscle glucose uptake but no differences in ratios of [1-
    Abstract: In skeletal muscle, glucose metabolism is tightly regulated by the reciprocal relationship between insulin and adrenaline, with pyruvate being at the intersection of both pathways. Hyperpolarized magnetic resonance (hMR) is a new approach to gain insights into these pathways, and human trials involving hMR and skeletal muscle metabolism are imminent. We aimed to combine the hyperinsulinaemic clamp technique and hMR in a large animal model resembling human physiology. Fifteen anaesthetized pigs were randomized to saline (control group), hyperinsulinaemic euglycaemic clamp technique (HE group) or hyperinsulinaemic hypoglycaemic clamp technique (HH group). Skeletal muscle metabolism was evaluated by hyperpolarized [1-
    MeSH term(s) Animals ; Glucose Clamp Technique ; Hypoglycemic Agents/metabolism ; Insulin/metabolism ; Models, Animal ; Muscle, Skeletal/metabolism ; Pyruvic Acid/metabolism ; Swine
    Chemical Substances Hypoglycemic Agents ; Insulin ; Pyruvic Acid (8558G7RUTR)
    Language English
    Publishing date 2021-11-15
    Publishing country England
    Document type Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP089782
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