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  1. AU="Benhamida, Myriam"
  2. AU="Bérubé, Caterina"
  3. AU=Shaykh Ramzi
  4. AU="Chaker, A M"
  5. AU="Connor, Ashton A"
  6. AU="Pruscini, Ilaria"
  7. AU="Diane M. Pascoe"
  8. AU="Hartner, G"
  9. AU="Özgür Akgül"
  10. AU="Paryani, Mohammad Reza"
  11. AU="Lutin, Florence"
  12. AU="Cheung, D Y T"
  13. AU="Shaishta, Naghma"
  14. AU=Zhao Mengyi
  15. AU="Liang, Dejin"
  16. AU="Yeşim YENİ"
  17. AU="Sivlér, Tobias"
  18. AU=Datta Srayan
  19. AU="Masoud Behzadifar"
  20. AU="Jonathan Fuld"
  21. AU="López-Caballero, María Guadalupe"
  22. AU="Rawlinson, Jennifer R"
  23. AU="Priti N Mody-Pan"
  24. AU="Yunusov, Marat S"
  25. AU=Peever John
  26. AU="Khosravi, Majid"
  27. AU="Xiang, La"
  28. AU="Sag, Duygu"
  29. AU="Khatiri Yanehsari, M."
  30. AU="Cooke, Georga"
  31. AU="Stefanello, Bianca"
  32. AU="Cummings, Brian J"
  33. AU=Yu Xiongwu
  34. AU=Greenland Sander
  35. AU=Deanfield John
  36. AU="Vu, Hung"
  37. AU="Soucek, Alexander"
  38. AU="Rihui Su"
  39. AU="Campbell, Steve"

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  1. Artikel: Assessment of a Multiplex LAMP Assay (Eazyplex® CSF Direct M) for Rapid Molecular Diagnosis of Bacterial Meningitis: Accuracy and Pitfalls

    Leroy, Anne-Gaëlle / Persyn, Elise / Gibaud, Sophie-Anne / Crémet, Lise / Le Turnier, Paul / Benhamida, Myriam / Launay, Elise / Guillouzouic, Aurélie / Bémer, Pascale / Corvec, Stéphane / on behalf of the Western French Study Group on Early Bacterial Meningitis

    Microorganisms. 2021 Sept. 01, v. 9, no. 9

    2021  

    Abstract: Background: Automated molecular panels are attractive tools for improving early meningitis diagnosis. This study assessed the Eazyplex® CSF direct M panel (EP), a multiplex real-time Loop-Mediated Isothermal Amplification assay. Methods: From December ... ...

    Abstract Background: Automated molecular panels are attractive tools for improving early meningitis diagnosis. This study assessed the Eazyplex® CSF direct M panel (EP), a multiplex real-time Loop-Mediated Isothermal Amplification assay. Methods: From December 2016 to December 2019, cerebrospinal fluid (CSF) samples were routinely tested with the EP V1.0. CSF parameters and microbiological and clinical data were retrospectively collected. Results: Out of 230 CSF samples, the EP yielded positive, negative, and invalid results for 32 (13.9%) (16 N. meningitidis, nine S. pneumoniae, two S. agalactiae, two E. coli, two H. influenzae, one L. monocytogenes), 182 (79.1%), and 16 (7%) samples, respectively. Among the positive samples, 14 (44%) remained negative in culture (antibiotic therapy before lumbar puncture (n = 11), meningococcal meningitis (n = 3)). High CSF protein concentrations and cellularity were associated with LAMP inhibition, counteracted by centrifugation. The automated software yielded 13 false positive and five false negative results. Amplification curve analysis was necessary and enabled the attainment of positive (PPA) and negative percentage agreement and positive and negative predictive values of 91.4%, 100%, 100%, and 98.3%. Three false negative results remained (two E. coli and one N. meningitidis). E. coli presented the poorest PPA (50%). Conclusion: This work confirms the strong performance of the EP, of particular interest in cases of antibiotic therapy before lumbar puncture.
    Schlagwörter Escherichia coli ; antibiotics ; automation ; centrifugation ; cerebrospinal fluid ; computer software ; loop-mediated isothermal amplification ; meningitis ; therapeutics
    Sprache Englisch
    Erscheinungsverlauf 2021-0901
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9091859
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel ; Online: Retrospective audit of guidelines for investigation and treatment of bronchiolitis: a French perspective.

    Benhamida, Myriam / Bihouee, Tiphaine / Verstraete, Marie / Gras Le Guen, Christèle / Launay, Elise

    BMJ paediatrics open

    2017  Band 1, Heft 1, Seite(n) e000089

    Abstract: Introduction: As the most recent French bronchiolitis guidelines were published in 2000, there is a current overinvestigation and an overtreatment of infants hospitalised with bronchiolitis in France. In 2012, the Group of Pediatric University Hospitals ...

    Abstract Introduction: As the most recent French bronchiolitis guidelines were published in 2000, there is a current overinvestigation and an overtreatment of infants hospitalised with bronchiolitis in France. In 2012, the Group of Pediatric University Hospitals in Western France ('HUGO') proposed new evidence-based clinical practice guidelines in keeping with the latest international guidelines. We hypothesise that the implementation of these guidelines contributed to the quality improvement of the management of bronchiolitis in our hospital. The aim of this study was to determine the impact of these guidelines on the management of bronchiolitis inpatients.
    Methods: This retrospective before/after study design was conducted in the general paediatric unit of a tertiary care French hospital, looking at 1 year before (ie, the winter of 2011-2012) and 1 year after (ie, the winter of 2013-2014) the implementation of the guidelines. Two hundred and eighty bronchiolitis inpatients, all less than 1 year of age, 115 in 2011-2012 and 165 in 2013-2014, were included. The primary outcome we sought to evaluate was the proportion of children administered a diagnostic test associated with a treatment not routinely recommended by the guidelines. As balancing measures, we evaluated the length of stay, the intensive care unit transfer and the readmission rates.
    Results: Following implementation of the guidelines, use of any given treatment associated with a diagnostic test was reduced by 66% (p<0.001). There were major decreases in the use of chest X-ray (86%vs26%, p<0.001), antibiotics (38%vs13%, p<0.001) and corticosteroids (10%vs3%, p=0.011). Balancing measures were not significantly different.
    Conclusions: HUGO guidelines were effective at reducing the administration of unnecessary diagnostic tests and medications. This study was the first step in convincing French paediatricians to streamline their practices until updated national guidelines are published.
    Sprache Englisch
    Erscheinungsdatum 2017-10-12
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2399-9772
    ISSN (online) 2399-9772
    DOI 10.1136/bmjpo-2017-000089
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Reclassifying inconclusive diagnosis for cystic fibrosis with new generation sweat test.

    Nguyen-Khoa, Thao / Hatton, Aurélie / Drummond, David / Aoust, Laura / Schlatter, Joël / Martin, Clémence / Ramel, Sophie / Kiefer, Sébastien / Gachelin, Elsa / Stremler, Nathalie / Cosson, Laure / Gabsi, Asma / Remus, Natascha / Benhamida, Myriam / Hadchouel, Alice / Fajac, Isabelle / Munck, Anne / Girodon, Emmanuelle / Sermet-Gaudelus, Isabelle

    The European respiratory journal

    2022  Band 60, Heft 2

    Mesh-Begriff(e) Chlorides ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Humans ; Sweat
    Chemische Substanzen Chlorides ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Sprache Englisch
    Erscheinungsdatum 2022-08-04
    Erscheinungsland England
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00209-2022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Assessment of a Multiplex LAMP Assay (Eazyplex

    Leroy, Anne-Gaëlle / Persyn, Elise / Gibaud, Sophie-Anne / Crémet, Lise / Le Turnier, Paul / Benhamida, Myriam / Launay, Elise / Guillouzouic, Aurélie / Bémer, Pascale / Corvec, Stéphane / On Behalf Of The Western French Study Group On Early Bacterial Meningitis

    Microorganisms

    2021  Band 9, Heft 9

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2021-09-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9091859
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Über subito bestellen

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