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Article: Looking into the Eyes to See the Heart of Chronic Kidney Disease Patients.

Kislikova, Maria / Gaitán-Valdizán, Jorge Javier / Parra Blanco, José Antonio / García Unzueta, María Teresa / Rodríguez Vidriales, María / Escagedo Cagigas, Clara / Piñera Haces, Vicente Celestino / Valentín Muñoz, María de la Oliva / Benito Hernández, Adalberto / Ruiz San Millan, Juan Carlos / Rodrigo Calabia, Emilio

Life (Basel, Switzerland)

2024 Volume 14, Issue 4

Abstract: In patients with chronic kidney disease (CKD), the main cause of morbidity and mortality is cardiovascular disease (CVD). Both coronary artery calcium scoring by computed tomography (CT) and optical coherence tomography (OCT) are used to identify ... ...

Abstract	In patients with chronic kidney disease (CKD), the main cause of morbidity and mortality is cardiovascular disease (CVD). Both coronary artery calcium scoring by computed tomography (CT) and optical coherence tomography (OCT) are used to identify patients at increased risk for ischemic heart disease, thereby indicating a higher cardiovascular risk profile. Our study aimed to investigate the utility of these techniques in the CKD population. In patients with CKD, OCT was used to measure the choroidal thickness (CHT) and the thickness of the peripapillary retinal nerve fiber layer (pRNFL). A total of 127 patients were included, including 70 men (55%) with an estimated glomerular filtration rate (eGFR) of 39 ± 30 mL/min/1.73 m
Language	English
Publishing date	2024-04-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life14040533
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Article: Torque Teno Virus Load Predicts Opportunistic Infections after Kidney Transplantation but Is Not Associated with Maintenance Immunosuppression Exposure.

Cañamero, Lucía / Benito-Hernández, Adalberto / González, Elena / Escagedo, Clara / Rodríguez-Vidriales, María / García-Saiz, María Del Mar / Valero, Rosalía / Belmar, Lara / de Cos, María Angeles / Francia, María Victoria / Ruiz, Juan Carlos / Rodrigo, Emilio

Biomedicines

2023 Volume 11, Issue 5

Abstract: Measuring the non-pathogenic Torque Teno Virus (TTV) load allows assessing the net immunosuppressive state after kidney transplantation (KTx). Currently, it is not known how exposure to maintenance immunosuppression affects TTV load. We hypothesized that ...

Abstract	Measuring the non-pathogenic Torque Teno Virus (TTV) load allows assessing the net immunosuppressive state after kidney transplantation (KTx). Currently, it is not known how exposure to maintenance immunosuppression affects TTV load. We hypothesized that TTV load is associated with the exposure to mycophenolic acid (MPA) and tacrolimus. We performed a prospective study including 54 consecutive KTx. Blood TTV load was measured by an in-house PCR at months 1 and 3. Together with doses and trough blood levels of tacrolimus and MPA, we calculated the coefficient of variability (CV), time in therapeutic range (TTR) and concentration/dose ratio (C/D) of tacrolimus, and the MPA-area under the curve (AUC-MPA) at the third month. TTV load at the first and third month discriminated those patients at risk of developing opportunistic infections between months 1 and 3 (AUC-ROC 0.723, 95%CI 0.559-0.905,
Language	English
Publishing date	2023-05-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11051410
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Article ; Online: Growth Differentiation Factor 15 Is Superior to Troponin I in the Evaluation of Kidney Transplant Candidates.

de Cos Gomez, Marina / Garcia Unzueta, Maria Teresa / Benito Hernandez, Adalberto / Aguilera Fernandez, Alejandro / Perez Arnedo, Mario / Lopez Del Moral Cuesta, Covadonga / Kislikova, Maria / Valero San Cecilio, Rosalia / Ruiz San Millan, Juan Carlos / Rodrigo Calabia, Emilio

American journal of nephrology

2022 Volume 53, Issue 2-3, Page(s) 118–128

Abstract: Introduction: Pretransplant cardiac troponin I (cTNI) has demonstrated its predicting value in survival after kidney transplant. Growth differentiation factor 15 (GDF-15) is a biomarker currently studied as a predictor of mortality and cardiovascular ... ...

Abstract	Introduction: Pretransplant cardiac troponin I (cTNI) has demonstrated its predicting value in survival after kidney transplant. Growth differentiation factor 15 (GDF-15) is a biomarker currently studied as a predictor of mortality and cardiovascular events (CVE) in different scenarios. The aim of this study was to compare the utility of these two biomarkers in the prediction of events after kidney transplant. Methods: We included 359 kidney transplants performed in our center between 2005 and 2015. cTNI and GDF-15 were measured on stored serum samples obtained pretransplant. Results: Median GDF-15 was 5,346.4 pg/mL, and cTNI was 5.6 ng/L. After follow-up, 77 (21.5%) patients died, and the incidence of cerebrovascular accident (CVA), acute coronary syndrome (ACS), and major adverse CVEs (MACE) was 6.38%, 12.68%, and 20.56%, respectively. Patients were stratified in tertiles according to GDF-15 and cTNT levels. By multivariate cox regression analysis including both biomarkers and different clinical characteristics, we found a significant relation between GDF-15 and mortality, CVAs, and MACE (highest tertile hazard ratio [HR] 2.2 95% confidence interval [CI] [1.2-4.1], p = 0.01, HR 9.7 CI 95% [2.2-43.1], p = 0.003 and HR 2.7 CI 95% [1.4-5.1], p = 0.002). On the contrary, posttransplant ACS was related to cTNI (highest cTNI tertile HR 3.2 CI 95% [1.5-7.3], p = 0.003). Discussion: Our study indicates the potential utility of GDF-15 as a mortality and CVE predictor after kidney transplant and its superiority compared to cTNI. By contrast, probably due to its tissue specificity, cardiac troponin showed a stronger correlation with acute coronary events. Although more studies are needed to confirm our findings, these two molecules could be used in conjunction with other tools to predict adverse events after transplant and ideally find strategies to minimize them.
MeSH term(s)	Biomarkers ; Growth Differentiation Factor 15 ; Humans ; Kidney Transplantation/adverse effects ; Prognosis ; Troponin I ; Troponin T
Chemical Substances	Biomarkers ; Growth Differentiation Factor 15 ; Troponin I ; Troponin T
Language	English
Publishing date	2022-02-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604540-6
ISSN	1421-9670 ; 0250-8095
ISSN (online)	1421-9670
ISSN	0250-8095
DOI	10.1159/000521781
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Article ; Online: Measurement of galactosyl-deficient IgA1 by the monoclonal antibody KM55 contributes to predicting patients with IgA nephropathy with high risk of long-term progression.

Martín-Penagos, Luis / Fernández-Fresnedo, Gema / Benito-Hernández, Adalberto / Mazón, Jaime / de Cos, Marina / Oviedo, María Victoria / San Segundo, David / López-Hoyos, Marcos / Gómez-Román, Javier / Ruiz, Juan Carlos / Rodrigo, Emilio

Nefrologia

2021 Volume 41, Issue 3, Page(s) 311–320

Abstract: Background and objective: About 25% of patients with IgA nephropathy (IgAN) progress to stage 5 chronic kidney disease (CKD) after years of evolution. Various tools have been developed in recent years designed to predict which of the patients will had ... ...

Abstract	Background and objective: About 25% of patients with IgA nephropathy (IgAN) progress to stage 5 chronic kidney disease (CKD) after years of evolution. Various tools have been developed in recent years designed to predict which of the patients will had poorer outcomes. The value of circulating galactosyl-deficient IgA1 (Gd-IgA1) has been related to a worse evolution of IgAN in several studies. There are also some publications that relate higher APRIL values with a worse evolution. Recently, a new method has been developed that allows measuring the value of circulating Gd-IgA1 in a simpler way than those previously available. The objective of this study is to analyze the influence of circulating Gd-IgA1, measured by this method, on the progression of IgAN. Materials and methods: Forty-nine patients with a diagnosis of IgAN demonstrated by renal biopsy were selected in our center, without having received prior immunosuppressive treatment, for whom frozen serum was available. The median follow-up was 4 years. Gd-IgA1 was measured by lectin-independent ELISA with the monoclonal antibody KM55 (IgA1 kit Cat. No. 30111694. IBL Int., Hamburg, Germany). Likewise, APRIL levels were also measured in these patients. Results: 19 (38.8%) patients reached stage 5 CKD. The fourth quartile of circulating Gd-IgA1 was related to a higher cumulative risk of reaching stage 5 CKD in the Kaplan-Meier analysis (risk at the 5th year 39.4% vs. 24.3%, log rank p=0.019). The Gd-IgA1 value was related to an increased risk of CKD stage 5 (HR 1.147, 95% CI 1.035-1.270, p=0.009), regardless of glomerular filtration rate, proteinuria, the percentage of sclerosed glomeruli and the value of segmental sclerosis. We did not find significant differences in the APRIL values. Conclusions: The value of circulating Gd-IgA1 measured by the monoclonal antibody KM55 is related to a worse evolution of patients with IgAN independently of other variables, so it could be included in the study of patients to improve the prediction of the risk of disease progression.
MeSH term(s)	Antibodies, Monoclonal ; Galactose ; Glomerulonephritis, IGA ; Humans ; Immunoglobulin A ; Lectins ; Renal Insufficiency, Chronic
Chemical Substances	Antibodies, Monoclonal ; Immunoglobulin A ; Lectins ; Galactose (X2RN3Q8DNE)
Language	English
Publishing date	2021-07-28
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefroe.2021.06.004
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Article ; Online: La determinación de IgA1 galactosil deficiente mediante el anticuerpo monoclonal KM55 contribuye a predecir a los pacientes con nefropatía IgA con alto riesgo de progresión a largo plazo.

Nefrologia

2021 Volume 41, Issue 3, Page(s) 311–320

Title translation	Measurement of galactosyl-deficient IgA1 by the monoclonal antibody KM55 contributes to predicting patients with IgA nephropathy with high risk of long-term progression.
Abstract	Background and objective: About 25% of patients with IgA nephropathy (IgAN) progress to stage 5 chronic kidney disease (CKD) after years of evolution. Various tools have been developed in recent years designed to predict which of the patients will had poorer outcomes. The value of circulating galactosyl-deficient IgA1 (Gd-IgA1) has been related to a worse evolution of IgAN in several studies. There are also some publications that relate higher APRIL values with a worse evolution. Recently, a new method has been developed that allows measuring the value of circulating Gd-IgA1 in a simpler way than those previously available. The objective of this study is to analyze the influence of circulating Gd-IgA1, measured by this method, on the progression of IgAN. Materials and methods: Forty-nine patients with a diagnosis of IgAN demonstrated by renal biopsy were selected in our center, without having received prior immunosuppressive treatment, for whom frozen serum was available. The median follow-up was 4 years. Gd-IgA1 was measured by lectin-independent ELISA with the monoclonal antibody KM55 (IgA1 kit Cat. No. 30111694. IBL Int., Hamburg, Germany). Likewise, APRIL levels were also measured in these patients. Results: 19 (38.8%) patients reached stage 5 CKD. The fourth quartile of circulating Gd-IgA1 was related to a higher cumulative risk of reaching stage 5 CKD in the Kaplan-Meier analysis (risk at the 5th year 39.4% vs. 24.3%, log rank p=0.019). The Gd-IgA1 value was related to an increased risk of CKD stage 5 (HR 1.147, 95% CI 1.035-1.270, p=0.009), regardless of glomerular filtration rate, proteinuria, the percentage of sclerosed glomeruli and the value of segmental sclerosis. We did not find significant differences in the APRIL values. Conclusions: The value of circulating Gd-IgA1 measured by the monoclonal antibody KM55 is related to a worse evolution of patients with IgAN independently of other variables, so it could be included in the study of patients to improve the prediction of the risk of disease progression.
MeSH term(s)	Adult ; Aged ; Antibodies, Monoclonal/blood ; Disease Progression ; Female ; Glomerulonephritis, IGA/blood ; Humans ; Immunoglobulin A/immunology ; Male ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Risk Assessment ; Time Factors
Chemical Substances	Antibodies, Monoclonal ; Immunoglobulin A ; galactosyl-deficient IgA1
Language	Spanish
Publishing date	2021-03-23
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefro.2020.12.011
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Article ; Online: Urinary Plasminogen Activator Inhibitor-1: A Biomarker of Acute Tubular Injury.

Paniagua-Sancho, María / Quiros, Yaremi / Casanova, Alfredo G / Blanco-Gozalo, Víctor / Agüeros-Blanco, Consuelo / Benito-Hernández, Adalberto / Ramos-Barron, María A / Gómez-Alamillo, Carlos / Arias, Manuel / Sancho-Martínez, Sandra M / López-Hernández, Francisco J

American journal of nephrology

2021 Volume 52, Issue 9, Page(s) 714–724

Abstract: Introduction: Acute kidney injury (AKI) is a threatening, multiaetiological syndrome encompassing a variety of forms and damage patterns. AKI lacks sufficiently specific diagnostic tools to evaluate the distinct combination of pathophysiological events ... ...

Abstract	Introduction: Acute kidney injury (AKI) is a threatening, multiaetiological syndrome encompassing a variety of forms and damage patterns. AKI lacks sufficiently specific diagnostic tools to evaluate the distinct combination of pathophysiological events underlying each case, which limits personalized and optimized handling. Therefore, a pathophysiological diagnosis based on new urinary biomarkers is sought for practical (readiness and noninvasiveness) and conceptual reasons, as the urine is a direct product of the kidneys. However, biomarkers found in the urine may also have extrarenal origin, thus conveying pathophysiological information from other organs or tissues. Urinary plasminogen activator inhibitor-1 (PAI-1) has been associated to AKI, although its origin and traffic to the urine are not known. Methods: Herein, we studied the blood or renal origin of urinary PAI-1 (uPAI-1) in experimental AKI in Wistar rats, by means of the in situ renal perfusion method. For this purpose, urine was collected while the kidneys of rats with AKI showing increased uPAI-1 excretion, and controls, were in situ perfused with a saline solution. Results: Our results show that during perfusion, PAI-1 remained in the urine of AKI rats, suggesting that renal cells shed this protein directly to the urine. PAI-1 is also significantly increased in the urine of AKI patients. Its low correlation with other urinary markers such as NGAL or NAG suggests that PAI-1 provides complementary and distinct phenotypical information. Conclusion: In conclusion, uPAI-1 is a biomarker produced by damaged kidneys following AKI, whose precise pathophysiological meaning in AKI needs to be further investigated.
MeSH term(s)	Acute Kidney Injury/urine ; Adult ; Aged ; Animals ; Biomarkers/urine ; Female ; Humans ; Kidney Tubules ; Male ; Middle Aged ; Plasminogen Activator Inhibitor 1/urine ; Rats ; Rats, Wistar
Chemical Substances	Biomarkers ; Plasminogen Activator Inhibitor 1 ; SERPINE1 protein, human
Language	English
Publishing date	2021-09-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604540-6
ISSN	1421-9670 ; 0250-8095
ISSN (online)	1421-9670
ISSN	0250-8095
DOI	10.1159/000518455
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Article ; Online: Urinary C-X-C Motif Chemokine 10 Is Related to Acute Graft Lesions Secondary to T Cell- and Antibody-Mediated Damage.

Arnau, Alvaro / Benito-Hernández, Adalberto / Ramos-Barrón, María Angeles / García-Unzueta, María Teresa / Gómez-Román, José Javier / Gómez-Ortega, José María / López-Hoyos, Marcos / San Segundo, David / Ruiz, Juan Carlos / Rodrigo, Emilio

Annals of transplantation

2021 Volume 26, Page(s) e929491

Abstract: BACKGROUND Non-invasive biomarkers of graft rejection are needed to optimize the management and outcomes of kidney transplant recipients. Urinary excretion of IFN-g-related chemokine CXCL10 is clearly associated with clinical and subclinical T cell- ... ...

Abstract	BACKGROUND Non-invasive biomarkers of graft rejection are needed to optimize the management and outcomes of kidney transplant recipients. Urinary excretion of IFN-g-related chemokine CXCL10 is clearly associated with clinical and subclinical T cell-mediated graft inflammation, but its relationship with antibody-mediated damage has not been fully addressed. Further, the variables influencing levels of urinary CXCL10 excretion are unknown. MATERIAL AND METHODS A total of 151 kidney graft biopsies (92 surveillance and 59 indication biopsies) and 151 matched urine samples obtained before biopsy were prospectively analyzed. T cell-mediated rejection (TCMR) and antibody-mediated rejection (AbMR) were defined according to the 2017 Banff classification criteria. Urinary CXCL10 levels were measured by ELISA and corrected by urinary creatinine. RESULTS Banff scores 't', 'i', 'g', and 'ptc' were significantly related to urinary CXCL10 levels. Multivariate analysis showed that 't' (ß=0.107, P=0.001) and 'ptc' (ß=0.093, P=0.002) were significantly associated with urinary CXCL10. Donor-specific antibodies (DSAs) were related to the high excretion of urinary CXCL10 at 1 year after transplantation (odds ratio [OR] 17.817, P=0.003). Urinary CXCL10 showed good discrimination ability for AbMR (AUC-ROC 0.760, P=0.001). The third tertile of urinary CXCL10 remained significantly associated with AbMR (OR 4.577, 95% confidence interval 1.799-11.646, P=0.001) after multivariate regression analysis. CONCLUSIONS DSA was the only variable clearly related to high urinary CXCL10 levels. Urinary CXCL10 is a good non-invasive candidate biomarker of AbMR and TCMR, supplying information independent of renal function and other variables normally used to monitor kidney transplants.
MeSH term(s)	Adult ; Antibodies/immunology ; Chemokine CXCL10/urine ; Female ; Graft Rejection/immunology ; Humans ; Kidney Transplantation/adverse effects ; Male ; Middle Aged ; T-Lymphocytes/immunology
Chemical Substances	Antibodies ; CXCL10 protein, human ; Chemokine CXCL10
Language	English
Publishing date	2021-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484710-3
ISSN	2329-0358 ; 1425-9524
ISSN (online)	2329-0358
ISSN	1425-9524
DOI	10.12659/AOT.929491
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Zs.A 5093: Show issues

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Article ; Online: Urinary CXCL10 specifically relates to HLA-DQ eplet mismatch load in kidney transplant recipients.

San Segundo, David / Guiral-Foz, Sandra A / Benito-Hernández, Adalberto / Fernández, André Renaldo / Arnau, Alvaro / Valero, Rosalía / Ramos-Barrón, María Angeles / García-Unzueta, María Teresa / Gómez-Ortega, José María / López-Hoyos, Marcos / Ruiz, Juan Carlos / Rodrigo, Emilio

Transplant immunology

2021 Volume 70, Page(s) 101494

Abstract: Background: Urinary CXCL10 (uCXCL10) is associated with graft inflammation and graft survival, but the factors related to its excretion are not well known. HLA molecular matching at epitope level allow estimating the "dissimilarity" between donor and ... ...

Abstract	Background: Urinary CXCL10 (uCXCL10) is associated with graft inflammation and graft survival, but the factors related to its excretion are not well known. HLA molecular matching at epitope level allow estimating the "dissimilarity" between donor and recipient HLA more precisely, being better related to further transplant outcomes. The relationship between uCXCL10 and HLA molecular mismatch has not been previously explored. Methods: HLA class I and class II typing of some 65 recipients and their donors was retrospectively performed by high resolution sequence-specific-primer (Life Technologies, Brown Deer, WI). The HLA-Matchmaker 3.1 software was used to assess eplet matching. Urine samples collected on the day of the 1-year surveillance biopsy were available of these 65 patients. uCXCL10 was measured using a commercial enzyme-linked immunoassay kit. Results: 1-year uCXCL10 was independently associated with HLA-DQB1 eplet mismatch load (β 0.300, 95%CI 0.010-0.058, p = 0.006). Kidney transplant recipients with a HLA-DQB1 eplet mismatch load >3 showed higher values of uCXCL10 at 1-year (p = 0.018) than those with ≤3. Patients with a HLA-DQB1 eplet mismatch load >3 with subclinical AbMR had significantly higher levels of the logarithm of 1-year uCXCL10 (No AbMR 0.88, IQR 0.37; AbMR 1.38, IQR 0.34, p = 0.002) than those without AbMR. Conclusions: uCXCL10 specifically relates to HLA-DQ eplet mismatch load. This relationship can partly explain the previously reported association between uCXCL10 excretion and graft inflammation. An adequate evaluation of any potential non-invasive biomarker, such as uCXCL10, must take into account the HLA molecular mismatch.
MeSH term(s)	Animals ; Chemokine CXCL10 ; Deer ; Graft Rejection ; Graft Survival ; HLA Antigens ; HLA-DQ Antigens/genetics ; Histocompatibility Testing ; Humans ; Kidney Transplantation ; Retrospective Studies ; Tissue Donors ; Transplant Recipients
Chemical Substances	CXCL10 protein, human ; Chemokine CXCL10 ; HLA Antigens ; HLA-DQ Antigens
Language	English
Publishing date	2021-11-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1160846-8
ISSN	1878-5492 ; 0966-3274
ISSN (online)	1878-5492
ISSN	0966-3274
DOI	10.1016/j.trim.2021.101494
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Zs.A 3784: Show issues

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Article: Urinary KIM-1 Correlates with the Subclinical Sequelae of Tubular Damage Persisting after the Apparent Functional Recovery from Intrinsic Acute Kidney Injury.

Cuesta, Cristina / Fuentes-Calvo, Isabel / Sancho-Martinez, Sandra M / Valentijn, Floris A / Düwel, Annette / Hidalgo-Thomas, Omar A / Agüeros-Blanco, Consuelo / Benito-Hernández, Adalberto / Ramos-Barron, María A / Gómez-Alamillo, Carlos / Arias, Manuel / Nguyen, Tri Q / Goldschmeding, Roel / Martínez-Salgado, Carlos / López-Hernández, Francisco J

Biomedicines

2022 Volume 10, Issue 5

Abstract: Acute kidney injury (AKI) poses an increased risk factor for new AKI episodes, progression to chronic kidney disease, and death. A worsened evolution has been linked to an incomplete renal repair beyond the apparent functional recovery based on plasma ... ...

Abstract	Acute kidney injury (AKI) poses an increased risk factor for new AKI episodes, progression to chronic kidney disease, and death. A worsened evolution has been linked to an incomplete renal repair beyond the apparent functional recovery based on plasma creatinine (pCr) normalization. However, structural sequelae pass largely unnoticed due to the absence of specific diagnostic tools. The urinary kidney injury molecule 1 (KIM-1) participates in renal tissue damage and repair and is proposed as a biomarker of early and subclinical AKI. Thus, we study in this paper the evolution of KIM-1 urinary excretion alongside renal tissue sequelae after an intrinsic AKI episode induced by cisplatin in Wistar rats. Creatinine clearance, pCr, proteinuria and the fractional excretion of Na
Language	English
Publishing date	2022-05-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10051106
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Article ; Online: A proliferation-inducing ligand increase precedes IgA nephropathy recurrence in kidney transplant recipients.

Martín-Penagos, Luis / Benito-Hernández, Adalberto / San Segundo, David / Sango, Cristina / Azueta, Ainara / Gómez-Román, Javier / Fernández-Fresnedo, Gema / López-Hoyos, Marcos / Ruiz, Juan C / Rodrigo, Emilio

Clinical transplantation

2019 Volume 33, Issue 4, Page(s) e13502

Abstract: Background: IgA nephropathy (IgAN) may recur in kidney transplant recipients. B-cell-activating factor (BAFF), a proliferation-inducing ligand (APRIL), and α-defensins are involved in the pathogenesis of native IgAN; however, their role on IgAN ... ...

Abstract	Background: IgA nephropathy (IgAN) may recur in kidney transplant recipients. B-cell-activating factor (BAFF), a proliferation-inducing ligand (APRIL), and α-defensins are involved in the pathogenesis of native IgAN; however, their role on IgAN recurrence has not been previously analyzed. Methods: Thirty-five patients with IgAN who received a kidney transplant in our center between January 1, 1993, and December 31, 2015, were included. Recurrence was diagnosed and ruled out in 14 and 11 patients, respectively, by indication biopsies. Pre-transplant, 6-month, 1-, 3-, and 5-year sera selected to measure BAFF, APRIL, and defensin by ELISA. Results: Six months post-transplantation, APRIL levels (300.1 vs 1203.8 pg/mL, P = 0.033) and the mean APRIL values from 6 months to 3 years (409.8 vs 1258.0 pg/mL, P = 0.003) were higher in recurrent patients. Both 6-month APRIL levels (AUC-ROC 0.753, P = 0.033) and mean APRIL values (AUC-ROC 0.844, P = 0.004) discriminated patients with recurrence risk. By logistic regression, APRIL at 6 months (P = 0.044) and mean APRIL (P = 0.021) related to the risk of IgAN recurrence independently. Neither BAFF nor defensin related to recurrence. Conclusions: Serum APRIL increased at 6 months and mean APRIL remained higher the first 3 years in patients in whom IgAN was going to recur.
MeSH term(s)	Adult ; B-Cell Activating Factor/blood ; Biomarkers/blood ; Female ; Follow-Up Studies ; Glomerulonephritis, IGA/blood ; Glomerulonephritis, IGA/pathology ; Glomerulonephritis, IGA/surgery ; Graft Rejection/blood ; Graft Rejection/diagnosis ; Graft Rejection/etiology ; Graft Survival ; Humans ; Kidney Transplantation/adverse effects ; Longitudinal Studies ; Male ; Middle Aged ; Postoperative Complications ; Prognosis ; Prospective Studies ; Recurrence ; Risk Factors ; Tumor Necrosis Factor Ligand Superfamily Member 13/blood
Chemical Substances	B-Cell Activating Factor ; Biomarkers ; TNFSF13 protein, human ; TNFSF13B protein, human ; Tumor Necrosis Factor Ligand Superfamily Member 13
Language	English
Publishing date	2019-03-11
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.13502
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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Order via subito

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Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito