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  1. Article ; Online: Duke STAR Program.

    Benjamin, Daniel K

    Journal of the Pediatric Infectious Diseases Society

    2023  Volume 12, Issue Supplement_2, Page(s) S1–S2

    Language English
    Publishing date 2023-12-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piad096
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  2. Article ; Online: Lessons Learned From the COVID-19 Pandemic in K-12 Education.

    Zimmerman, Kanecia O / Benjamin, Daniel K

    Pediatrics

    2023  Volume 152, Issue Suppl 1

    MeSH term(s) Humans ; Pandemics ; COVID-19 ; Educational Status
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2023-060352O
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  3. Article ; Online: Author Response: Other Factors Potentially Contributing to the Number of Secondary Infections.

    Boutzoukas, Angelique E / Benjamin, Daniel K

    Pediatrics

    2022  Volume 150, Issue 1

    MeSH term(s) Coinfection ; Humans
    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2022-057636B
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  4. Article ; Online: An Innovative Approach to Building an Effective and Efficient Pediatric Trial Network.

    Randell, Rachel L / Benjamin, Daniel K / Greenberg, Rachel G

    Hospital pediatrics

    2022  Volume 12, Issue 9, Page(s) e309–e311

    MeSH term(s) Child ; Clinical Trials as Topic ; Humans
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ISSN 2154-1671
    ISSN (online) 2154-1671
    DOI 10.1542/hpeds.2022-006811
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  5. Article ; Online: School Safety, Masking, and the Delta Variant.

    Boutzoukas, Angelique E / Zimmerman, Kanecia O / Benjamin, Daniel K

    Pediatrics

    2021  

    Language English
    Publishing date 2021-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2021-054396
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  6. Article ; Online: From Research to Policy: Reopening K-12 Schools in North Carolina During the COVID-19 Pandemic.

    Zimmerman, Kanecia O / Jackman, Jennifer G / Benjamin, Daniel K

    Pediatrics

    2021  Volume 149, Issue 12 Suppl 2

    Abstract: School-aged children experienced substantial challenges to health and well-being as a result of school-building closures due to the coronavirus disease 2019 pandemic. In hopes of supporting equitable and safe school reopening for every student across ... ...

    Abstract School-aged children experienced substantial challenges to health and well-being as a result of school-building closures due to the coronavirus disease 2019 pandemic. In hopes of supporting equitable and safe school reopening for every student across North Carolina (NC) and improving child health, researchers from Duke University and the University at North Carolina at Chapel Hill established the ABC Science Collaborative (ABCs) in July 2020. The ABCs collected data related to in-school severe acute respiratory syndrome coronavirus 2 transmission and adherence to mitigation strategies. These data were presented to NC government officials, including the NC Department of Health and Human Services, the NC Department of Public Instruction, and Democratic and Republican representatives from the NC General Assembly. These data-sharing practices led to the implementation of in-person school legislation in early 2021 in which in-person school access for every student was required, the full-time in-person reopening of NC public schools was supported, and weekly reporting to the ABCs of coronavirus disease 2019 infections from >1 000 000 children and adults was required.
    MeSH term(s) Academic Medical Centers ; COVID-19/diagnosis ; COVID-19/prevention & control ; COVID-19 Testing ; Communicable Disease Control/organization & administration ; Community-Institutional Relations ; Humans ; North Carolina ; Pandemics ; Return to School ; Schools
    Language English
    Publishing date 2021-10-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2021-054268E
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  7. Article ; Online: SARS-CoV-2 Infections and Incidence at a North Carolina Pre-Kindergarten-12 School During In-Person Education: August 2020 to January 2021.

    Thakkar, Pavan V / Zimmerman, Kanecia O / Benjamin, Daniel K / Kalu, Ibukunoluwa C

    The Journal of school health

    2022  Volume 92, Issue 5, Page(s) 461–468

    Abstract: Background: School closures were initially believed to mitigate SARS-CoV-2, but instead may have had a limited role in reducing community SARS-CoV-2 transmission. We describe a single school's experience with in-person education during the COVID-19 ... ...

    Abstract Background: School closures were initially believed to mitigate SARS-CoV-2, but instead may have had a limited role in reducing community SARS-CoV-2 transmission. We describe a single school's experience with in-person education during the COVID-19 pandemic.
    Methods: From August 17, 2020 through January 23, 2021, we conducted a prospective study at a private pre-kindergarten through 12th grade (PreK-12) school in North Carolina. The school employed numerous SARS-CoV-2 mitigation measures, including mandatory masking and physical distancing without mandated laboratory screening tests. We analyzed de-identified contact tracing data collected by the school.
    Results: Seventy-five primary cases were reported among the 2110 students, faculty, and staff during the study period. Twenty-one (28%) of the primary cases were on-campus during their infectious periods; however, no classroom close-contacts subsequently reported a positive SARS-CoV-2 test result. Two secondary cases likely resulted from unmasked exposure at a school athletic event. There was no correlation between community incidence and secondary transmission in the school.
    Conclusions: Despite high rates of SARS-CoV-2 community incidence during the study period, routine mitigation practices including daily health screenings, mandatory face coverings, and efficient contact tracing contributed to minimal secondary SARS-CoV-2 transmission within an urban PreK-12 school. The limited school-associated transmission occurred when masks were not used during athletic events.
    MeSH term(s) COVID-19/epidemiology ; Child, Preschool ; Humans ; Incidence ; North Carolina/epidemiology ; Pandemics ; Prospective Studies ; SARS-CoV-2 ; Schools
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 952835-0
    ISSN 1746-1561 ; 0022-4391
    ISSN (online) 1746-1561
    ISSN 0022-4391
    DOI 10.1111/josh.13148
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  8. Article ; Online: Remdesivir: Preliminary Data and Clinical Use Versus Recommended Use.

    Boutzoukas, Angelique E / Benjamin, Daniel K / Zimmerman, Kanecia O

    Pediatrics

    2021  Volume 147, Issue 5

    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; Humans ; Preliminary Data
    Chemical Substances remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2021-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2021-050212
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  9. Article: Comparative Effectiveness of Dual- Versus Mono-Sedative Therapy on Opioid Administration, Sedative Administration, and Sedation Level in Mechanically Ventilated, Critically Ill Children.

    Zimmerman, Kanecia O / Westreich, Daniel / Funk, Michele Jonsson / Benjamin, Daniel K / Turner, David / Stürmer, Til

    The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

    2023  Volume 28, Issue 5, Page(s) 409–416

    Abstract: Objective: We estimated the effect of early initiation of dual therapy vs monotherapy on drug administration and related outcomes in mechanically ventilated, critically ill children.: Methods: We used the electronic medical record at a single ... ...

    Abstract Objective: We estimated the effect of early initiation of dual therapy vs monotherapy on drug administration and related outcomes in mechanically ventilated, critically ill children.
    Methods: We used the electronic medical record at a single tertiary medical center to conduct an active comparator, new user cohort study. We included children <18 years of age who were exposed to a sedative or analgesic within 6 hours of intubation. We used stabilized inverse probability of treatment weighting to account for confounding at baseline. We estimated the average effect of initial dual therapy vs monotherapy on outcomes including cumulative opioid, benzodiazepine, and dexmedetomidine dosing; sedation scores; time to double the opioid or benzodiazepine infusion rate; initiation of neuromuscular blockade within the first 7 days of follow-up; time to extubation; and 7-day all-cause in-hospital death.
    Results: The cohort included 640 patients. Children receiving dual therapy received 0.03 mg/kg (95% CI, 0.02-0.04) more dexmedetomidine over the first 7 days after initiation of mechanical ventilation than did monotherapy patients. Dual therapy patients had similar sedation scores, time to double therapy, initiation of neuromuscular blockade, and time to extubation as monotherapy patients. Dual therapy patients had a lower incidence of death.
    Conclusions: In this study, initial dual therapy compared with monotherapy does not reduce overall drug administration during mechanical ventilation. The identified effect of dual therapy on mortality deserves further investigation.
    Language English
    Publishing date 2023-10-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3028543-4
    ISSN 1551-6776
    ISSN 1551-6776
    DOI 10.5863/1551-6776-28.5.409
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  10. Article ; Online: Use of vasopressors for septic shock in the neonatal intensive care unit.

    Foote, Henry P / Benjamin, Daniel K / Greenberg, Rachel G / Clark, Reese H / Hornik, Christoph P

    Journal of perinatology : official journal of the California Perinatal Association

    2023  Volume 43, Issue 10, Page(s) 1274–1280

    Abstract: Objective: To describe outcomes for infants in the neonatal intensive care unit with septic shock based on the vasopressor administered.: Methods: This is a multicenter cohort study of infants with an episode of septic shock. We evaluated the primary ...

    Abstract Objective: To describe outcomes for infants in the neonatal intensive care unit with septic shock based on the vasopressor administered.
    Methods: This is a multicenter cohort study of infants with an episode of septic shock. We evaluated the primary outcomes of mortality and pressor-free days alive in the first week after shock using multivariable logistic and Poisson regressions.
    Results: We identified 1592 infants. Mortality was 50%. Dopamine was the most used vasopressor (92% of episodes) and hydrocortisone was co-administered with a vasopressor in 38% of episodes. Compared to infants treated with dopamine alone, adjusted odds of mortality were significantly higher for those treated with epinephrine alone (aOR 4.7 [95% CI: 2.3-9.2]). Adjuvant hydrocortisone was associated with significantly lower adjusted odds of mortality (aOR 0.60 [0.42-0.86]) CONCLUSIONS: The use of epinephrine as either a solo agent or in combination therapy was associated with significantly worse outcomes, while adjuvant hydrocortisone was associated with decreased mortality.
    MeSH term(s) Infant, Newborn ; Humans ; Shock, Septic/drug therapy ; Shock, Septic/complications ; Hydrocortisone/therapeutic use ; Dopamine/therapeutic use ; Intensive Care Units, Neonatal ; Cohort Studies ; Vasoconstrictor Agents/therapeutic use ; Epinephrine/therapeutic use ; Intensive Care Units ; Retrospective Studies
    Chemical Substances Hydrocortisone (WI4X0X7BPJ) ; Dopamine (VTD58H1Z2X) ; Vasoconstrictor Agents ; Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 645021-0
    ISSN 1476-5543 ; 0743-8346
    ISSN (online) 1476-5543
    ISSN 0743-8346
    DOI 10.1038/s41372-023-01667-8
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