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  1. Article ; Online: COVID-19 in patients with paracoccidioidomycosis.

    de Macedo, Priscila Marques / Benko, Lorena Macedo Pestana / Falcão, Eduardo Mastrangelo Marinho / Nosanchuk, Joshua D / Almeida-Paes, Rodrigo / do Valle, Antonio Carlos Francesconi

    PLoS neglected tropical diseases

    2023  Volume 17, Issue 5, Page(s) e0011322

    Abstract: Introduction: In 2020, we reported the first patient with concomitant COVID-19 and paracoccidioidomycosis (PCM). Since then, no other cases have been recorded in the literature. We aim to update information on the occurrence of COVID-19 in patients with ...

    Abstract Introduction: In 2020, we reported the first patient with concomitant COVID-19 and paracoccidioidomycosis (PCM). Since then, no other cases have been recorded in the literature. We aim to update information on the occurrence of COVID-19 in patients with PCM followed at a reference center for infectious diseases at Rio de Janeiro, Brazil.
    Methods: We reviewed the medical records from patients diagnosed with PCM who presented with clinical symptoms, radiological findings, and/or laboratory diagnosis of COVID-19 at any time during their acute or follow-up care. The clinical profiles of these patients were described.
    Results: Between March 2020 and September 2022, we identified six individuals with COVID-19 among the 117 patients with PCM evaluated. The median age was 38 years and the male to female ratio 2:1. Most patients (n = 5) presented for evaluation due to acute PCM. The severity of COVID-19 ranged from mild to severe in acute PCM and only the single patient with chronic PCM died.
    Conclusions: There is a range of disease severity in COVID-19 and PCM co-infection and concomitant disease may represent a severe association, especially in the chronic type of the mycosis with pulmonary involvement. As COVID-19 and chronic PCM share similar clinical aspects and PCM is neglected, it is probable that COVID-19 has been hampering simultaneous PCM diagnosis, which can explain the absence of new co-infection reports. With the continued persistence of COVID-19 globally, these findings further suggest that more attention by providers is necessary to identify co-infections with Paracoccidioides.
    MeSH term(s) Humans ; Male ; Female ; Adult ; Paracoccidioidomycosis/complications ; Paracoccidioidomycosis/diagnosis ; Paracoccidioidomycosis/epidemiology ; Coinfection/complications ; Brazil/epidemiology ; COVID-19/complications ; COVID-19/diagnosis ; Paracoccidioides
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Paracoccidioidomycosis and pregnancy: A 40-year single-center cohort study in the endemic area of Rio de Janeiro, Brazil.

    Benko, Lorena Macedo Pestana / Vieira da Silva, Mariana Evangelista de Souza / Falcão, Eduardo Mastrangelo Marinho / Freitas, Dayvison Francis Saraiva / Calvet, Guilherme Amaral / Almeida, Marcos de Abreu / Almeida-Paes, Rodrigo / Zancopé-Oliveira, Rosely Maria / do Valle, Antonio Carlos Francesconi / de Macedo, Priscila Marques

    PLoS neglected tropical diseases

    2023  Volume 17, Issue 9, Page(s) e0011645

    Abstract: The occurrence of acute paracoccidioidomycosis (PCM) in urban areas of the Rio de Janeiro state, Brazil, has emerged in recent years. Therefore, young populations, including pregnant women, are at a higher risk of infection. Furthermore, young women ... ...

    Abstract The occurrence of acute paracoccidioidomycosis (PCM) in urban areas of the Rio de Janeiro state, Brazil, has emerged in recent years. Therefore, young populations, including pregnant women, are at a higher risk of infection. Furthermore, young women undergoing itraconazole treatment for PCM have increased chances to get pregnant because this medication may reduce the effectiveness of contraceptives. Acute PCM is invasive, reaching abdominal organs, posing a maternal-fetal risk. PCM treatment in pregnant women is also challenging due to the teratogenicity associated with the currently available oral drugs. There are scarce studies on PCM and pregnancy, mainly consisting of case reports and experimental murine models that highlight the severity of this association. We conducted a database research at a PCM reference center in Rio de Janeiro state from 1980 to 2020. We included patients diagnosed with PCM who were pregnant shortly before, at admission, or at any moment of their PCM follow-up care. Data related to pregnancy, childbirth, and the newborn were obtained from the Brazilian official public databases. We also reviewed the epidemiological and clinical features of these patients. During the study period, we identified 18 pregnant patients, with a median age of 26 years (range: 16-38). Among these cases, six (33.3%) were detected in the last 5 years, and 14 (77.8%) presented acute PCM, supporting the recent shift in the epidemiological profile towards acute PCM. Most pregnancies occurred during PCM treatment (n = 11, 61.1%), which led to challenges in the therapeutic management. Maternal-fetal complications occurred in some of these cases, including vaginal bleeding (n = 1), preeclampsia (n = 1), prematurity (n = 2), low birth weight (n = 4), and fetal deaths (n = 2). PCM during pregnancy presents a significant public health concern in the context of the emergence of acute PCM in urban areas.
    MeSH term(s) Humans ; Female ; Animals ; Mice ; Pregnancy ; Adolescent ; Young Adult ; Adult ; Paracoccidioidomycosis/drug therapy ; Paracoccidioidomycosis/epidemiology ; Brazil/epidemiology ; Cohort Studies ; Itraconazole ; Databases, Factual
    Chemical Substances Itraconazole (304NUG5GF4)
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011645
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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