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  1. AU="Benmeziane, Keltouma"
  2. AU="Barik, Saroj K."
  3. AU="Madhurima Basu" AU="Madhurima Basu"
  4. AU="Polanska, Nikola"
  5. AU="Stephane Cullati"
  6. AU="Held, Noelle A"
  7. AU="Zhu, Simeng"
  8. AU="Hantour, Naima"
  9. AU="Bo Shopsin"
  10. AU="Reese, Samario"
  11. AU="Retamal, Catalina"
  12. AU="Lee-Wing, Matthew"
  13. AU="Dostálová, I"
  14. AU=McCloskey Kayleigh A
  15. AU="Dharmarajan, Arun"
  16. AU="Stebel, Luigi"
  17. AU=Amico Patrizia
  18. AU="Kojev, Aslan"
  19. AU="Zhiyu Wang"
  20. AU="Shannon C Peyton"
  21. AU="Shiltsev, V."
  22. AU="Edward S. Debnam"
  23. AU="Freeston, Sarah L"
  24. AU="Bertolucci, S."
  25. AU="de Barros, Rosires M B"
  26. AU="Carr, Crystal C"
  27. AU="Davies, Mark Lloyd"
  28. AU=St Gelais Corine
  29. AU=Engstrom Malitta
  30. AU="Hongo, Akane"
  31. AU="Krykorková, I"
  32. AU=Yan Bing
  33. AU="Nakos, Konstantinos"
  34. AU="Schreiner, Ryan"
  35. AU=Pltz T
  36. AU="Akhmanova, Anna" AU="Akhmanova, Anna"
  37. AU="Goretsky, Anton"
  38. AU="Cordoza, Makayla L"
  39. AU=Midoux Patrick AU=Midoux Patrick
  40. AU="Mundt, H M"
  41. AU=Tsivitse Susan

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  1. Artikel ; Online: Isolation and phenotypic characterization of human and nonhuman primate intestinal lamina propria mononuclear cells.

    Benmeziane, Keltouma / Delache, Benoit / Langlois, Sébastien / Scarlatti, Gabriella / Le Grand, Roger / Cavarelli, Mariangela

    STAR protocols

    2022  Band 3, Heft 4, Seite(n) 101815

    Abstract: Isolation of viable immune cells from tissues is critically important to characterize cellular and molecular processes during homeostasis and disease. Here, we provide an optimized protocol to achieve high yields of viable intestinal lamina propria ... ...

    Abstract Isolation of viable immune cells from tissues is critically important to characterize cellular and molecular processes during homeostasis and disease. Here, we provide an optimized protocol to achieve high yields of viable intestinal lamina propria mononuclear cells (LPMCs). We describe steps for intestinal tissue collection from humans and nonhuman primates, followed by mechanical disruption and enzymatic digestion. Furthermore, we detail characterization of the mononuclear phagocyte (MP) subtypes by flow cytometry analysis. The protocol is repeatable and scalable for downstream applications. For complete details on the use and execution of this protocol, please refer to Cavarelli et al. (2022).
    Mesh-Begriff(e) Animals ; Humans ; Intestinal Mucosa ; Flow Cytometry/methods ; Leukocytes ; Primates
    Sprache Englisch
    Erscheinungsdatum 2022-11-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101815
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The localization, origin, and impact of platelets in the tumor microenvironment are tumor type-dependent.

    Le Chapelain, Ophélie / Jadoui, Soumaya / Gros, Angèle / Barbaria, Samir / Benmeziane, Keltouma / Ollivier, Véronique / Dupont, Sébastien / Solo Nomenjanahary, Mialitiana / Mavouna, Sabrina / Rogozarski, Jasmina / Mawhin, Marie-Anne / Caligiuri, Giuseppina / Delbosc, Sandrine / Porteu, Françoise / Nieswandt, Bernhard / Mangin, Pierre H / Boulaftali, Yacine / Ho-Tin-Noé, Benoit

    Journal of experimental & clinical cancer research : CR

    2024  Band 43, Heft 1, Seite(n) 84

    Abstract: Background: How platelets interact with and influence the tumor microenvironment (TME) remains poorly characterized.: Methods: We compared the presence and participation of platelets in the TME of two tumors characterized by highly different TME, ... ...

    Abstract Background: How platelets interact with and influence the tumor microenvironment (TME) remains poorly characterized.
    Methods: We compared the presence and participation of platelets in the TME of two tumors characterized by highly different TME, PyMT AT-3 mammary tumors and B16F1 melanoma.
    Results: We show that whereas firmly adherent platelets continuously line tumor vessels of both AT-3 and B16F1 tumors, abundant extravascular stromal clusters of platelets from thrombopoietin-independent origin were present only in AT-3 mammary tumors. We further show that platelets influence the angiogenic and inflammatory profiles of AT-3 and B16F1 tumors, though with very different outcomes according to tumor type. Whereas thrombocytopenia increased bleeding in both tumor types, it further caused severe endothelial degeneration associated with massive vascular leakage, tumor swelling, and increased infiltration of cytotoxic cells, only in AT-3 tumors.
    Conclusions: These results indicate that while platelets are integral components of solid tumors, their localization and origin in the TME, as well as their impact on its shaping, are tumor type-dependent.
    Mesh-Begriff(e) Animals ; Humans ; Tumor Microenvironment ; Mammary Neoplasms, Animal
    Sprache Englisch
    Erscheinungsdatum 2024-03-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 803138-1
    ISSN 1756-9966 ; 0392-9078
    ISSN (online) 1756-9966
    ISSN 0392-9078
    DOI 10.1186/s13046-024-03001-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Intestinal immunological events of acute and resolved SARS-CoV-2 infection in non-human primates.

    Hua, Stéphane / Latha, Krishna / Marlin, Romain / Benmeziane, Keltouma / Bossevot, Laetitia / Langlois, Sébastien / Relouzat, Francis / Dereuddre-Bosquet, Nathalie / Le Grand, Roger / Cavarelli, Mariangela

    Mucosal immunology

    2023  Band 17, Heft 1, Seite(n) 25–40

    Abstract: SARS-CoV-2 infection has been associated with intestinal mucosal barrier damage, leading to microbial and endotoxin translocation, heightened inflammatory responses, and aggravated disease outcomes. This study aimed to investigate the immunological ... ...

    Abstract SARS-CoV-2 infection has been associated with intestinal mucosal barrier damage, leading to microbial and endotoxin translocation, heightened inflammatory responses, and aggravated disease outcomes. This study aimed to investigate the immunological mechanisms associated with impaired intestinal barrier function. We conducted a comprehensive analysis of gut damage and inflammation markers and phenotypic characterization of myeloid and lymphoid populations in the ileum and colon of SARS-CoV-2-exposed macaques during both the acute and resolved infection phases. Our findings revealed a significant accumulation of terminally differentiated and activated CD4+ and CD8+ T cells, along with memory B cells, within the gastrointestinal tract up to 43 days after exposure to SARS-CoV-2. This robust infection-induced immune response was accompanied by a notable depletion of plasmacytoid dendritic cells, myeloid dendritic cells, and macrophages, particularly affecting the colon during the resolved infection phase. Additionally, we identified a population of CX3CR1
    Mesh-Begriff(e) Animals ; COVID-19/pathology ; SARS-CoV-2 ; Intestinal Mucosa ; Inflammation ; Primates
    Sprache Englisch
    Erscheinungsdatum 2023-10-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2411370-0
    ISSN 1935-3456 ; 1933-0219
    ISSN (online) 1935-3456
    ISSN 1933-0219
    DOI 10.1016/j.mucimm.2023.10.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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