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  1. Book ; Online: Fast Facts : Biosimilars

    Cornes, Paul / Bennett, David J.

    (Fast facts)

    2018  

    Abstract: Biosimilars have been in clinical use for more than 10 years, and evidence from more than 700 million patient-days’ exposure shows that approved biosimilars can be used as safely and effectively as their originator biologics. And yet concerns about these ...

    Author's details Paul Cornes, David Bennett
    Series title Fast facts
    Abstract Biosimilars have been in clinical use for more than 10 years, and evidence from more than 700 million patient-days’ exposure shows that approved biosimilars can be used as safely and effectively as their originator biologics. And yet concerns about these drugs persist, particularly in therapy areas where they are recent additions to the formulary. It is vital to address these concerns so that clinicians can prescribe biosimilars with confidence, realizing substantial cost savings and improving patient access to effective treatments. 'Fast Facts: Biosimilars' provides a comprehensive yet concise explanation of biosimilars: what they are, how they are regulated, and how they are used in clinical practice. It is ideal for healthcare professionals and decision makers who want to understand biosimilars and the key concerns and controversies around these valuable products. Contents: 1 - An introduction to biologics and biosimilars 2 - Why do we need biosimilars? 3 - How is the quality of biosimilars assured? 4 - How is the efficacy and safety of biosimilars ensured? 5 - What has been the experience with biosimilars to date? 6 - The future of biosimilar medicines 7 - How do I use biosimilar medicines?
    Keywords Pharmaceutical biotechnology
    Subject code 615.19
    Language English
    Size 1 online resource (72 pages) :, illustrations.
    Publisher Health Press Ltd
    Publishing place Abingdon, Oxford, England
    Document type Book ; Online
    Note Includes index.
    ISBN 1-910797-68-5 ; 1-910797-67-7 ; 978-1-910797-68-6 ; 978-1-910797-67-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Successful agricultural innovation in emerging economies

    Bennett, David J. / Jennings, Richard C.

    new genetic technologies for global food production

    2013  

    Author's details ed. by David J. Bennett ; Richard C. Jennings
    Keywords Agriculture ; Crop improvement ; Food crops/Biotechnology
    Language English
    Size XXVIII, 427 S. : Ill., graph. Darst., Kt.
    Publisher Cambridge Univ. Press
    Publishing place Cambridge u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017460684
    ISBN 978-1-107-02670-4 ; 1-107-02670-9
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    138/232 available for loan (reading room) Freihandmagazin (U1)

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  3. Article ; Online: Selective Synthesis of 1-Dialkylamino-2-alkylbicyclo-[1.1.1]pentanes.

    Ma, Xiaoshen / Han, Yongxin / Bennett, David J

    Organic letters

    2020  Volume 22, Issue 22, Page(s) 9133–9138

    Abstract: Compared to the abundance of methodologies accessing 1-substituted and 1,3-disubstuted bicyclo[1.1.1] pentanes (BCPs), the synthetic accessibility of BCPs with substitutions at the methylene position has been limited. Herein, we report a selective ... ...

    Abstract Compared to the abundance of methodologies accessing 1-substituted and 1,3-disubstuted bicyclo[1.1.1] pentanes (BCPs), the synthetic accessibility of BCPs with substitutions at the methylene position has been limited. Herein, we report a selective synthesis of 1-dialkylamino-2-alkylbicyclo[1.1.1]pentanes from prefunctionalized starting materials. We also achieved further functionalizations of these 1,2-disubstituted BCPs and developed a synthesis of these compounds with minimum necessity of chromatographic purifications starting from 1,3-dichloroacetone. Finally, we also detailed the synthesis of a 1,2,3-trisubstituted BCP analogue.
    Language English
    Publishing date 2020-11-10
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.0c03612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Successful agricultural innovation in emerging economies

    Bennett, David J

    new genetic technologies for global food production

    2013  

    Author's details ed. by David J. Bennett
    Keywords Agriculture ; Crop improvement ; Food crops/Biotechnology ; Landwirtschaft ; Pflanzenbau ; Innovation ; Gentechnik ; Grüne Gentechnik ; Ernährungssicherung ; Agrarwissenschaft ; Schwellenländer ; Welt
    Language English
    Size XXVIII, 427 S., graph. Darst., Kt.
    Publisher Cambridge Univ. Press
    Publishing place Cambridge u.a.
    Document type Book
    Note Enth. 25 Beitr. ; Includes index
    ISBN 9781107026704 ; 1107026709
    Database ECONomics Information System

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  5. Article: Widespread innervation of motoneurons by spinal V3 neurons globally amplifies locomotor output in mice.

    Zhang, Han / Deska-Gauthier, Dylan / MacKay, Colin S / Hari, Krishnapriya / Lucas-Osma, Ana M / Borowska-Fielding, Joanna / Letawsky, Reese L / Akay, Turgay / Fenrich, Keith K / Bennett, David J / Zhang, Ying

    bioRxiv : the preprint server for biology

    2024  

    Abstract: While considerable progress has been made in understanding the neuronal circuits that underlie the patterning of locomotor behaviours such as walking, less is known about the circuits that amplify motoneuron output to enable adaptable increases in muscle ...

    Abstract While considerable progress has been made in understanding the neuronal circuits that underlie the patterning of locomotor behaviours such as walking, less is known about the circuits that amplify motoneuron output to enable adaptable increases in muscle force across different locomotor intensities. Here, we demonstrate that an excitatory propriospinal neuron population (V3 neurons, Sim1
    Language English
    Publishing date 2024-03-17
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.15.585199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intrinsic motoneuron properties in typical human development.

    Mohammadalinejad, Ghazaleh / Afsharipour, Babak / Yacyshyn, Alex / Duchcherer, Jennifer / Bashuk, Jack / Bennett, Erin / Pearcey, Gregory E P / Negro, Francesco / Quinlan, Katharina A / Bennett, David J / Gorassini, Monica A

    The Journal of physiology

    2024  Volume 602, Issue 9, Page(s) 2061–2087

    Abstract: Motoneuron properties and their firing patterns undergo significant changes throughout development and in response to neuromodulators such as serotonin. Here, we examined the age-related development of self-sustained firing and general excitability of ... ...

    Abstract Motoneuron properties and their firing patterns undergo significant changes throughout development and in response to neuromodulators such as serotonin. Here, we examined the age-related development of self-sustained firing and general excitability of tibialis anterior motoneurons in a young development (7-17 years), young adult (18-28 years) and adult (32-53 years) group, as well as in a separate group of participants taking selective serotonin reuptake inhibitors (SSRIs, aged 11-28 years). Self-sustained firing, as measured by ΔF, was larger in the young development (∼5.8 Hz, n = 20) compared to the young adult (∼4.9 Hz, n = 13) and adult (∼4.8 Hz, n = 8) groups, consistent with a developmental decrease in self-sustained firing mediated by persistent inward currents (PIC). ΔF was also larger in participants taking SSRIs (∼6.5 Hz, n = 9) compared to their age-matched controls (∼5.3 Hz, n = 26), consistent with increased levels of spinal serotonin facilitating the motoneuron PIC. Participants in the young development and SSRI groups also had higher firing rates and a steeper acceleration in initial firing rates (secondary ranges), consistent with the PIC producing a steeper acceleration in membrane depolarization at the onset of motoneuron firing. In summary, both the young development and SSRI groups exhibited increased intrinsic motoneuron excitability compared to the adults, which, in the young development group, was also associated with a larger unsteadiness in the dorsiflexion torque profiles. We propose several intrinsic and extrinsic factors that affect both motoneuron PICs and cell discharge which vary during development, with a time course similar to the changes in motoneuron firing behaviour observed in the present study. KEY POINTS: Neurons in the spinal cord that activate muscles in the limbs (motoneurons) undergo increases in excitability shortly after birth to help animals stand and walk. We examined whether the excitability of human ankle flexor motoneurons also continues to change from child to adulthood by recording the activity of the muscle fibres they innervate. Motoneurons in children and adolescents aged 7-17 years (young development group) had higher signatures of excitability that included faster firing rates and more self-sustained activity compared to adults aged ≥18 years. Participants aged 11-28 years of age taking serotonin reuptake inhibitors had the highest measures of motoneuron excitability compared to their age-matched controls. The young development group also had more unstable contractions, which might partly be related to the high excitability of the motoneurons.
    MeSH term(s) Humans ; Motor Neurons/physiology ; Motor Neurons/drug effects ; Adult ; Adolescent ; Female ; Male ; Child ; Young Adult ; Middle Aged ; Action Potentials/physiology ; Muscle, Skeletal/physiology ; Muscle, Skeletal/growth & development ; Muscle, Skeletal/innervation ; Selective Serotonin Reuptake Inhibitors/pharmacology
    Chemical Substances Selective Serotonin Reuptake Inhibitors
    Language English
    Publishing date 2024-03-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP285756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.65: Show issues Location:
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  7. Article ; Online: A Selective Synthesis of 2,2-Difluorobicyclo[1.1.1]pentane Analogues: "BCP-F

    Ma, Xiaoshen / Sloman, David L / Han, Yongxin / Bennett, David J

    Organic letters

    2019  Volume 21, Issue 18, Page(s) 7199–7203

    Abstract: The bicyclo[1.1.1]pentane (BCP) motif has been utilized as bioisosteres in drug candidates to replace phenyl, ...

    Abstract The bicyclo[1.1.1]pentane (BCP) motif has been utilized as bioisosteres in drug candidates to replace phenyl,
    Language English
    Publishing date 2019-07-11
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.9b02026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Locomotor-related propriospinal V3 neurons produce primary afferent depolarization and modulate sensory transmission to motoneurons.

    Lin, Shihao / Hari, Krishnapriya / Black, Sophie / Khatmi, Aysan / Fouad, Karim / Gorassini, Monica A / Li, Yaqing / Lucas-Osma, Ana M / Fenrich, Keith K / Bennett, David J

    Journal of neurophysiology

    2023  Volume 130, Issue 4, Page(s) 799–823

    Abstract: When a muscle is stretched, sensory feedback not only causes reflexes but also leads to a depolarization of sensory afferents throughout the spinal cord (primary afferent depolarization, PAD), readying the whole limb for further disturbances. This ... ...

    Abstract When a muscle is stretched, sensory feedback not only causes reflexes but also leads to a depolarization of sensory afferents throughout the spinal cord (primary afferent depolarization, PAD), readying the whole limb for further disturbances. This sensory-evoked PAD is thought to be mediated by a trisynaptic circuit, where sensory input activates first-order excitatory neurons that activate GABAergic neurons that in turn activate GABA
    MeSH term(s) Animals ; Mice ; Motor Neurons ; Spinal Cord ; Axons ; GABAergic Neurons ; Glutamic Acid
    Chemical Substances Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80161-6
    ISSN 1522-1598 ; 0022-3077
    ISSN (online) 1522-1598
    ISSN 0022-3077
    DOI 10.1152/jn.00482.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Post-activation depression from primary afferent depolarization (PAD) produces extensor H-reflex suppression following flexor afferent conditioning.

    Metz, Krista / Matos, Isabel Concha / Hari, Krishnapriya / Bseis, Omayma / Afsharipour, Babak / Lin, Shihao / Singla, Rahul / Fenrich, Keith K / Li, Yaqing / Bennett, David J / Gorassini, Monica A

    The Journal of physiology

    2023  Volume 601, Issue 10, Page(s) 1925–1956

    Abstract: Suppression of the extensor H-reflex by flexor afferent conditioning is thought to be produced by a long-lasting inhibition of extensor Ia afferent terminals via ... ...

    Abstract Suppression of the extensor H-reflex by flexor afferent conditioning is thought to be produced by a long-lasting inhibition of extensor Ia afferent terminals via GABA
    MeSH term(s) Animals ; Mice ; H-Reflex/physiology ; Receptors, GABA-A ; Neurons, Afferent/physiology ; Motor Neurons/physiology ; Muscle, Skeletal ; Electric Stimulation
    Chemical Substances Receptors, GABA-A
    Language English
    Publishing date 2023-04-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP283706
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  10. Article ; Online: General access to cubanes as benzene bioisosteres.

    Wiesenfeldt, Mario P / Rossi-Ashton, James A / Perry, Ian B / Diesel, Johannes / Garry, Olivia L / Bartels, Florian / Coote, Susannah C / Ma, Xiaoshen / Yeung, Charles S / Bennett, David J / MacMillan, David W C

    Nature

    2023  Volume 618, Issue 7965, Page(s) 513–518

    Abstract: The replacement of benzene rings with ... ...

    Abstract The replacement of benzene rings with sp
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06021-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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