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  1. Article: Self-inflicted penetrating chest trauma from solar powered garden light: a case report.

    Murray, Lewis William / Bennetts, Jayme

    Journal of surgical case reports

    2021  Volume 2021, Issue 8, Page(s) rjab320

    Abstract: Penetrating chest trauma is associated with significant morbidity and mortality due to direct injury to vital organs located within the thorax. This is a case of a 53-year-old man who presented with a self-inflicted penetrating chest trauma using a solar ...

    Abstract Penetrating chest trauma is associated with significant morbidity and mortality due to direct injury to vital organs located within the thorax. This is a case of a 53-year-old man who presented with a self-inflicted penetrating chest trauma using a solar powered garden light. The light penetrated the left side of his chest resulting in a haemopneumothorax, diaphragmatic perforation and pericardial haematoma. The patient underwent an urgent explorative thoracotomy for the removal of the garden light, repair of the diaphragmatic perforation and wedge resections of the perforated lung parenchyma. Postoperatively, the patient recovered in the intensive care before being transferred to the psychiatric department.
    Language English
    Publishing date 2021-08-09
    Publishing country England
    Document type Case Reports
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjab320
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  2. Article ; Online: Brian Fowell Buxton (15/04/1940-20/05/2022)-Outstanding Achievements and Personal Memories.

    Bennetts, Jayme / Tatoulis, James / Raman, Jaishankar / Rosenfeldt, Franklin

    Heart, lung & circulation

    2022  Volume 31, Issue 10, Page(s) 1309–1314

    Abstract: Brian F. Buxton, one of Australia's greatest cardiac surgeons, died in May 2022, aged 82 years. In June 2022, a memorial celebration of Brian's life was held in Melbourne, Australia, attended by 550 colleagues and friends from many walks of life-not only ...

    Abstract Brian F. Buxton, one of Australia's greatest cardiac surgeons, died in May 2022, aged 82 years. In June 2022, a memorial celebration of Brian's life was held in Melbourne, Australia, attended by 550 colleagues and friends from many walks of life-not only "medical people" but also friends involved in Brian's sailing and hiking activities. This Special Article includes an introduction from Professor Jayme Bennetts, President of the Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS), an abridged version of a memorial address by Professor James Tatoulis and contributions from two other long-term professional colleagues and personal friends of Buxton, Professor Jaishankar Raman and Professor Franklin Rosenfeldt, founding editor of Heart, Lung and Circulation. Buxton was an outstanding and pioneering surgeon, clinical leader, and good friend to many. The Brian F. Buxton Cardiac and Thoracic Aortic Surgery Unit in Melbourne, Australia, is now so named in honour of his outstanding achievements and as a legacy. Vale Brian F. Buxton.
    MeSH term(s) Australia ; Humans ; New Zealand ; Thoracic Surgery ; Thoracic Surgical Procedures
    Language English
    Publishing date 2022-09-13
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2022.08.007
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  3. Article ; Online: Institutional variation in early mortality following isolated coronary artery bypass graft surgery.

    Patel, Aayush / Ngo, Linh / Woodman, Richard J / Aliprandi-Costa, Bernadette / Bennetts, Jayme / Psaltis, Peter J / Ranasinghe, Isuru

    International journal of cardiology

    2022  Volume 362, Page(s) 35–41

    Abstract: Background: Thirty-day mortality following coronary artery bypass grafting (CABG) is a widely accepted marker for quality of care. Although surgical mortality has declined, the utility of this measure to profile quality has not been questioned. We ... ...

    Abstract Background: Thirty-day mortality following coronary artery bypass grafting (CABG) is a widely accepted marker for quality of care. Although surgical mortality has declined, the utility of this measure to profile quality has not been questioned. We assessed the institutional variation in risk-standardised mortality rates (RSMR) following isolated CABG within Australia and New Zealand (ANZ).
    Methods: We used an administrative dataset from all public and most private hospitals across ANZ to capture all isolated CABG procedures recorded between 2010 and 2015. The primary outcome was all-cause death occurring in-hospital or within 30-days of discharge. Hospital-specific RSMRs and 95% CI were estimated using a hierarchical generalised linear model accounting for differences in patient characteristics.
    Results: Overall, 60,953 patients (mean age 66.1 ± 10.1y, 18.7% female) underwent an isolated CABG across 47 hospitals. The observed early mortality rate was 1.69% (n = 1029) with 81.8% of deaths recorded in-hospital. The risk-adjustment model was developed with good discrimination (C-statistic = 0.81). Following risk-adjustment, a 3.9-fold variation was observed in RSMRs among hospitals (median:1.72%, range:0.84-3.29%). Four hospitals had RSMRs significantly higher than average, and one hospital had RSMR lower than average. When in-hospital mortality alone was considered, the median in-hospital RSMR was 1.40% with a 5.6-fold variation across institutions (range:0.57-3.19%).
    Conclusions: Average mortality following isolated CABG is low across ANZ. Nevertheless, in-hospital and 30-day mortality vary among hospitals, highlighting potential disparities in care quality and the enduring usefulness of 30-day mortality as an outcome measure. Clinical and policy interventions, including participating in clinical quality registries, are needed to standardise CABG care.
    MeSH term(s) Aged ; Coronary Artery Bypass ; Female ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Outcome Assessment, Health Care ; Registries ; Risk Adjustment
    Language English
    Publishing date 2022-04-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2022.04.080
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  4. Article ; Online: 2021 CSANZ and ANZSCTS Position Statement on the Operator and Institutional Requirements for a Transcatheter Aortic Valve Implantation (TAVI) Program in Australia.

    Bennetts, Jayme / Sinhal, Ajay / Walters, Darren / MacIsaac, Andrew / Fayers, Trevor / Lo, Sidney / Almeida, Aubrey / Muller, David W M

    Heart, lung & circulation

    2021  Volume 30, Issue 12, Page(s) 1811–1818

    Abstract: This document establishes the minimum standard for accreditation of institutions and operators as endorsed by the Cardiac Society of Australia and New Zealand (CSANZ) and the Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS). ... ...

    Abstract This document establishes the minimum standard for accreditation of institutions and operators as endorsed by the Cardiac Society of Australia and New Zealand (CSANZ) and the Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS). The original Joint Society Position Statement was ratified in August 2014. This 2021 update replaces the original and serves as a consensus within which the Conjoint Committee for Trancatheter Aortic Valve Implantation (TAVI) Accreditation will function, as recommended by Medical Services Advisory Committee (MSAC) Determination for TAVI. This is not a Guideline Statement but takes into consideration regional, legislative, and health system factors important to establishing requirements for TAVI accreditation in Australia.
    MeSH term(s) Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Australia ; Consensus ; Heart Valve Prosthesis Implantation ; Humans ; Risk Factors ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
    Language English
    Publishing date 2021-09-02
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2021.07.017
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  5. Article ; Online: Effects of RBT-1 on preconditioning response biomarkers in patients undergoing coronary artery bypass graft or heart valve surgery: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial.

    Lamy, Andre / Chertow, Glenn M / Jessen, Michael / Collar, Alonso / Brown, Craig D / Mack, Charles A / Marzouk, Mohamed / Scavo, Vincent / Washburn, T Benton / Savage, David / Smith, Julian / Bennetts, Jayme / Assi, Roland / Shults, Christian / Arghami, Arman / Butler, Javed / Devereaux, P J / Zager, Richard / Wang, Chao /
    Snapinn, Steve / Browne, Austin / Rodriguez, Jeannette / Ruiz, Stacey / Singh, Bhupinder

    EClinicalMedicine

    2024  Volume 68, Page(s) 102364

    Abstract: Background: RBT-1 is a combination drug of stannic protoporfin (SnPP) and iron sucrose (FeS) that elicits a preconditioning response through activation of antioxidant, anti-inflammatory, and iron-scavenging pathways, as measured by heme oxygenase-1 (HO- ... ...

    Abstract Background: RBT-1 is a combination drug of stannic protoporfin (SnPP) and iron sucrose (FeS) that elicits a preconditioning response through activation of antioxidant, anti-inflammatory, and iron-scavenging pathways, as measured by heme oxygenase-1 (HO-1), interleukin-10 (IL-10), and ferritin, respectively. Our primary aim was to determine whether RBT-1 administered before surgery would safely and effectively elicit a preconditioning response in patients undergoing cardiac surgery.
    Methods: This phase 2, double-blind, randomised, placebo-controlled, parallel-group, adaptive trial, conducted in 19 centres across the USA, Canada, and Australia, enrolled patients scheduled to undergo non-emergent coronary artery bypass graft (CABG) and/or heart valve surgery with cardiopulmonary bypass. Patients were randomised (1:1:1) to receive either a single intravenous infusion of high-dose RBT-1 (90 mg SnPP/240 mg FeS), low-dose RBT-1 (45 mg SnPP/240 mg FeS), or placebo within 24-48 h before surgery. The primary outcome was a preoperative preconditioning response, measured by a composite of plasma HO-1, IL-10, and ferritin. Safety was assessed by adverse events and laboratory parameters. Prespecified adaptive criteria permitted early stopping and enrichment. This trial is registered with ClinicalTrials.gov, NCT04564833.
    Findings: Between Aug 4, 2021, and Nov 9, 2022, of 135 patients who were enrolled and randomly allocated to a study group (46 high-dose, 45 low-dose, 44 placebo), 132 (98%) were included in the primary analysis (46 high-dose, 42 low-dose, 44 placebo). At interim, the trial proceeded to full enrollment without enrichment. RBT-1 led to a greater preconditioning response than did placebo at high-dose (geometric least squares mean [GLSM] ratio, 3.58; 95% CI, 2.91-4.41; p < 0.0001) and low-dose (GLSM ratio, 2.62; 95% CI, 2.11-3.24; p < 0.0001). RBT-1 was generally well tolerated by patients. The primary drug-related adverse event was dose-dependent photosensitivity, observed in 12 (26%) of 46 patients treated with high-dose RBT-1 and in six (13%) of 45 patients treated with low-dose RBT-1 (safety population).
    Interpretation: RBT-1 demonstrated a statistically significant cytoprotective preconditioning response and a manageable safety profile. Further research is needed. A phase 3 trial is planned.
    Funding: Renibus Therapeutics, Inc.
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2023.102364
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  6. Article ; Online: Operator and Institutional Requirements for Transcatheter Mitral Valve Therapies in Australia: a CSANZ and ANZSCTS Position Statement.

    Muller, David W M / Almeida, Aubrey / Camuglia, Anthony / Walters, Darren / Passage, Jurgen / Scalia, Gregory M / Bhindi, Ravinay / Lo, Sidney / Bennetts, Jayme / Walton, Antony

    Heart, lung & circulation

    2021  Volume 30, Issue 12, Page(s) 1805–1810

    Abstract: This expert Position Statement is a description of the requirements for Accreditation for transcatheter mitral valve therapy (TMVT) in Australia. The requirements include the need for a multidisciplinary Heart Team review of individual cases, mandatory ... ...

    Abstract This expert Position Statement is a description of the requirements for Accreditation for transcatheter mitral valve therapy (TMVT) in Australia. The requirements include the need for a multidisciplinary Heart Team review of individual cases, mandatory reporting of outcome data to a national TMVT Registry, and accreditation of individuals and institutions by the Conjoint Accreditation Committee, the assigned accreditation authority.
    MeSH term(s) Australia ; Cardiac Catheterization ; Heart Valve Prosthesis Implantation ; Humans ; Mitral Valve/surgery ; Mitral Valve Insufficiency/surgery ; Treatment Outcome
    Language English
    Publishing date 2021-07-12
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2021.07.001
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  7. Article ; Online: Surfactant and lung function following cardiac surgery.

    Govender, Mogeshni / Bihari, Shailesh / Bersten, Andrew D / De Pasquale, Carmine G / Lawrence, Mark D / Baker, Robert A / Bennetts, Jayme / Dixon, Dani-Louise

    Heart & lung : the journal of critical care

    2018  Volume 48, Issue 1, Page(s) 55–60

    Language English
    Publishing date 2018-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193129-5
    ISSN 1527-3288 ; 0147-9563
    ISSN (online) 1527-3288
    ISSN 0147-9563
    DOI 10.1016/j.hrtlng.2018.08.004
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  8. Article: Biofeedback: making the science real.

    Baker, Robert A / Newland, Richard F / Bennetts, Jayme

    The journal of extra-corporeal technology

    2010  Volume 41, Issue 4, Page(s) P38–42

    Abstract: Neurological deficits such as stroke and subtle psychological, cognitive, and behavioral changes are known risks associated with cardiac surgery. These altered neurologic outcomes have a significant impact on patients and their quality of life ... ...

    Abstract Neurological deficits such as stroke and subtle psychological, cognitive, and behavioral changes are known risks associated with cardiac surgery. These altered neurologic outcomes have a significant impact on patients and their quality of life postoperatively. Perioperative events, such as cerebral embolism and decrease in cerebral oxygenation and hypoperfusion have been identified as factors causal in producing adverse neurologic outcomes. More importantly, a number of mechanisms related to operative techniques have been found to cause these adverse events. Identifying practices associated with adverse outcomes and implementing practice changes may benefit clinical outcomes for cardiac surgery patients. Standardizing techniques among clinicians will also achieve continuous quality improvement in the process of care. Optimal intra-operative management systems contribute significantly to ensuring good patient outcomes (i.e., avoiding neurological injury in patients which is an important cause of post-operative morbidity and mortality). Groom and colleagues (2004) have developed a system to obtain a thorough understanding and redesign of the process of care associated with cardiac surgery. They have developed a system that simultaneously measures some embolic activity, cerebral oxygen saturation, and physiologic parameters, as well as uses a video recording device during cardiac surgery. To date, the evaluation of this methodology in a rigorous, prospective manner has not been reported. Our aim is to conduct a randomised clinical trial to evaluate the influence of continuous quality improvement in cardiac surgery using biofeedback (i.e., real time information on physiologic functioning from an integrated monitoring system) to reduce the incidence of potentially adverse events during surgery. By achieving the outcomes of this project, we plan to be able to not only introduce change in our own practice, but provide a framework for other units to introduce change.
    MeSH term(s) Cardiopulmonary Bypass/adverse effects ; Cardiopulmonary Bypass/methods ; Cerebrovascular Disorders/diagnosis ; Cerebrovascular Disorders/etiology ; Cerebrovascular Disorders/prevention & control ; Embolism/diagnosis ; Embolism/etiology ; Embolism/prevention & control ; Humans ; Monitoring, Physiologic/methods ; Risk Assessment/methods
    Language English
    Publishing date 2010-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390977-3
    ISSN 0022-1058
    ISSN 0022-1058
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  9. Article: Surgery for rheumatic heart disease in the Northern Territory, Australia, 1997-2016: what have we gained?

    Doran, James / Canty, David / Dempsey, Karen / Cass, Alan / Kangaharan, Nadarajah / Remenyi, Bo / Brunsdon, Georgie / McDonald, Malcolm / Heal, Clare / Wang, Zhiqiang / Royse, Colin / Royse, Alistair / Mein, Jacqueline / Gray, Nigel / Bennetts, Jayme / Baker, Robert A / Stewart, Maida / Sutcliffe, Steven / Reeves, Benjamin /
    Doran, Upasna / Rankine, Patricia / Fejo, Richard / Heenan, Elisabeth / Jalota, Ripudaman / Ilton, Marcus / Roberts-Thomson, Ross / King, Jason / Wyber, Rosemary / Doran, Jonathan / Webster, Andrew / Hanson, Joshua

    BMJ global health

    2023  Volume 8, Issue 3

    Abstract: Background: Between 1964 and 1996, the 10-year survival of patients having valve replacement surgery for rheumatic heart disease (RHD) in the Northern Territory, Australia, was 68%. As medical care has evolved since then, this study aimed to determine ... ...

    Abstract Background: Between 1964 and 1996, the 10-year survival of patients having valve replacement surgery for rheumatic heart disease (RHD) in the Northern Territory, Australia, was 68%. As medical care has evolved since then, this study aimed to determine whether there has been a corresponding improvement in survival.
    Methods: A retrospective study of Aboriginal patients with RHD in the Northern Territory, Australia, having their first valve surgery between 1997 and 2016. Survival was examined using Kaplan-Meier and Cox regression analysis.
    Findings: The cohort included 281 adults and 61 children. The median (IQR) age at first surgery was 31 (18-42) years; 173/342 (51%) had a valve replacement, 113/342 (33%) had a valve repair and 56/342 (16%) had a commissurotomy. There were 93/342 (27%) deaths during a median (IQR) follow-up of 8 (4-12) years. The overall 10-year survival was 70% (95% CI: 64% to 76%). It was 62% (95% CI: 53% to 70%) in those having valve replacement. There were 204/281 (73%) adults with at least 1 preoperative comorbidity. Preoperative comorbidity was associated with earlier death, the risk of death increasing with each comorbidity (HR: 1.3 (95% CI: 1.2 to 1.5), p<0.001). Preoperative chronic kidney disease (HR 6.5 (95% CI: 3.0 to 14.0) p≤0.001)), coronary artery disease (HR 3.3 (95% CI: 1.3 to 8.4) p=0.012) and pulmonary artery systolic pressure>50 mm Hg before surgery (HR 1.9 (95% CI: 1.2 to 3.1) p=0.007) were independently associated with death.
    Interpretation: Survival after valve replacement for RHD in this region of Australia has not improved. Although the patients were young, many had multiple comorbidities, which influenced long-term outcomes. The increasing prevalence of complex comorbidity in the region is a barrier to achieving optimal health outcomes.
    MeSH term(s) Adult ; Child ; Humans ; Rheumatic Heart Disease/epidemiology ; Rheumatic Heart Disease/surgery ; Rheumatic Heart Disease/complications ; Northern Territory/epidemiology ; Retrospective Studies ; Comorbidity ; Age Factors
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2059-7908
    ISSN 2059-7908
    DOI 10.1136/bmjgh-2023-011763
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  10. Article ; Online: Changes of left ventricular mechanics after trans-catheter aortic valve implantation and surgical aortic valve replacement for severe aortic stenosis: A tissue-tracking cardiac magnetic resonance study.

    Nucifora, Gaetano / Tantiongco, John-Paul / Crouch, Gareth / Bennetts, Jayme / Sinhal, Ajay / Tully, Phillip J / Bradbrook, Craig / Baker, Robert A / Selvanayagam, Joseph B

    International journal of cardiology

    2017  Volume 228, Page(s) 184–190

    Abstract: Background: Left ventricular (LV) mechanics are impaired in patients with severe aortic stenosis (AS). The aim of the present study was to assess their changes early and late after trans-catheter aortic valve implantation (TAVI) and surgical aortic ... ...

    Abstract Background: Left ventricular (LV) mechanics are impaired in patients with severe aortic stenosis (AS). The aim of the present study was to assess their changes early and late after trans-catheter aortic valve implantation (TAVI) and surgical aortic valve replacement (AVR) using cardiac magnetic resonance (CMR) tissue-tracking imaging.
    Methods: In 59 patients with severe AS undergoing either TAVI (n=35) or surgical AVR (n=24), CMR with late gadolinium enhancement (LGE) imaging was performed before and early post-procedure to evaluate LV function and mass, and presence/extent of LGE. A third CMR scan was performed in 29 patients after a mean follow-up of 15±4months. Tissue-tracking analysis was applied to cine CMR images, to assess LV global longitudinal (GLS), circumferential (GCS) and radial (GRS) strains.
    Results: The TAVI and surgical AVR groups were similar with respect to baseline (p=0.14) and early post-procedure (p=0.16) LV ejection fraction. However, baseline LV GLS was significantly impaired in TAVI patients compared to surgical AVR patients (p=0.025). Early post-procedure, TAVI resulted in a significant improvement of LV GLS (p=0.003), while a significant worsening of LV GLS was observed early after surgical AVR (p=0.012). At longer term follow-up, both TAVI and surgical AVR groups experienced a significant reduction of LV mass and a significant improvement of LV myocardial mechanics in all the three directions.
    Conclusions: Treatment-specific differences in the changes of LV myocardial mechanics early after afterload release by TAVI and surgical AVR are present. Later, both interventions are associated with an improvement of LV myocardial deformation, alongside a regression of LV hypertrophy.
    Language English
    Publishing date 2017-02-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2016.11.200
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