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  1. Article ; Online: Career lasting influences.

    Bennink, Jack R

    Monoclonal antibodies in immunodiagnosis and immunotherapy

    2014  Volume 33, Issue 3, Page(s) 199

    MeSH term(s) Academies and Institutes/history ; Allergy and Immunology/history ; Antibodies, Monoclonal/immunology ; History, 20th Century ; History, 21st Century ; Immunity, Cellular/immunology ; Virology/history ; Virology/methods
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2014-06-03
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2167-9436
    ISSN (online) 2167-9436
    DOI 10.1089/mab.2014.0004
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  2. Article ; Online: Slowing Influenza Virus Evolution: A Role for Multiple Synergistic Antiviral Specificities in Vaccination Strategies.

    Lafont, Bernard A P / Bennink, Jack R

    Viral immunology

    2020  Volume 33, Issue 3, Page(s) 197–200

    MeSH term(s) Antibodies, Viral/immunology ; Antigens, Viral/genetics ; Antigens, Viral/immunology ; Evolution, Molecular ; Humans ; Influenza Vaccines/immunology ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Orthomyxoviridae/genetics ; Orthomyxoviridae/immunology ; Vaccination
    Chemical Substances Antibodies, Viral ; Antigens, Viral ; Influenza Vaccines
    Language English
    Publishing date 2020-04-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 639075-4
    ISSN 1557-8976 ; 0882-8245
    ISSN (online) 1557-8976
    ISSN 0882-8245
    DOI 10.1089/vim.2019.0167
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    Zs.A 2227: Show issues Location:
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  3. Article: Making the connection: antibody responsiveness and MHC genes.

    Bennink, Jack R

    Journal of immunology (Baltimore, Md. : 1950)

    2004  Volume 173, Issue 3, Page(s) 1499

    MeSH term(s) Allergy and Immunology/history ; Animals ; Antibody Formation/genetics ; H-2 Antigens/genetics ; H-2 Antigens/history ; H-2 Antigens/immunology ; History, 20th Century ; Humans ; Major Histocompatibility Complex
    Chemical Substances H-2 Antigens
    Language English
    Publishing date 2004-05-20
    Publishing country United States
    Document type Comment ; Historical Article ; Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.173.3.1499
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  4. Article ; Online: Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity.

    Altman, Meghan O / Bennink, Jack R / Yewdell, Jonathan W / Herrin, Brantley R

    eLife

    2015  Volume 4

    Abstract: Immunoglobulins (Igs) are a crown jewel of jawed vertebrate evolution. Through recombination and mutation of small numbers of genes, Igs can specifically recognize a vast variety of natural and man-made organic molecules. Jawless vertebrates evolved a ... ...

    Abstract Immunoglobulins (Igs) are a crown jewel of jawed vertebrate evolution. Through recombination and mutation of small numbers of genes, Igs can specifically recognize a vast variety of natural and man-made organic molecules. Jawless vertebrates evolved a parallel system of humoral immunity, which recognizes antigens not with Ig, but with a structurally unrelated receptor called the variable lymphocyte receptor B (VLRB). We exploited the convergent evolution of Ig and VLRB antibodies (Abs) to investigate if intrinsic chemical features of foreign proteins determine their antigenicity and immunogenicity. Surprisingly, we find lamprey VLRB and mouse Ig responses to influenza A virus are extremely similar. Each focuses ~80% of the response on hemagglutinin (HA), mainly through recognition of the major antigenic sites in the HA globular head domain. Our findings predict basic conservation of Ab responses to protein antigens, strongly supporting the use of animal models for understanding human Ab responses to viruses and protein immunogens.
    MeSH term(s) Adaptive Immunity ; Animals ; Antigens, Viral/immunology ; Fish Diseases/immunology ; Fish Proteins/genetics ; Fish Proteins/immunology ; Influenza A virus/immunology ; Lampreys/immunology ; Lymphocytes/immunology ; Mice ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/veterinary ; Receptors, Immunologic/genetics ; Receptors, Immunologic/immunology
    Chemical Substances Antigens, Viral ; Fish Proteins ; Receptors, Immunologic
    Language English
    Publishing date 2015-08-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.07467
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  5. Article ; Online: Emetine optimally facilitates nascent chain puromycylation and potentiates the ribopuromycylation method (RPM) applied to inert cells.

    David, Alexandre / Bennink, Jack R / Yewdell, Jonathan W

    Histochemistry and cell biology

    2012  Volume 139, Issue 3, Page(s) 501–504

    Abstract: We previously described the ribopuromyclation method (RPM) to visualize and quantitate translating ribosomes in fixed and permeabilized cells by standard immunofluorescence. RPM is based on puromycylation of nascent chains bound to translating ribosomes ... ...

    Abstract We previously described the ribopuromyclation method (RPM) to visualize and quantitate translating ribosomes in fixed and permeabilized cells by standard immunofluorescence. RPM is based on puromycylation of nascent chains bound to translating ribosomes followed by detection of puromycylated nascent chains with a puromycin-specific mAb. We now demonstrate that emetine optimally enhances nascent chain puromycylation, and describe a modified RPM protocol for identifying ribosome-bound nascent chains in metabolically inert permeabilized cells.
    MeSH term(s) Cell Membrane Permeability ; Emetine/pharmacology ; HeLa Cells ; Humans ; Protein Modification, Translational/drug effects ; Puromycin/metabolism ; Ribosomes/drug effects ; Ribosomes/metabolism
    Chemical Substances Puromycin (4A6ZS6Q2CL) ; Emetine (X8D5EPO80M)
    Language English
    Publishing date 2012-12-11
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 1222930-1
    ISSN 1432-119X ; 0301-5564 ; 0948-6143
    ISSN (online) 1432-119X
    ISSN 0301-5564 ; 0948-6143
    DOI 10.1007/s00418-012-1063-8
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  6. Article ; Online: From optical bench to cageside: intravital microscopy on the long road to rational vaccine design.

    Hickman, Heather D / Bennink, Jack R / Yewdell, Jonathan W

    Immunological reviews

    2011  Volume 239, Issue 1, Page(s) 209–220

    Abstract: No antiviral vaccine is perfect. For some important pathogens, there are no effective vaccines. Many current vaccines are based on the working principles of Jenner and Pasteur, that is, empiric administration of attenuated or inactivated forms of the ... ...

    Abstract No antiviral vaccine is perfect. For some important pathogens, there are no effective vaccines. Many current vaccines are based on the working principles of Jenner and Pasteur, that is, empiric administration of attenuated or inactivated forms of the pathogen. Tapping the full potential of vaccination requires a thorough understanding of the mechanism of immune activation by pathogens and their individual components. Though the rate of discovery continues to accelerate, the complexity of the immune system is daunting, particularly when integrated into the overall physiology of the host. Here, we review the application of multiphoton microscopy to examine host-pathogen interactions, focusing on our recent efforts to understand mouse CD8(+) T-cell responses to viruses at the level of cellular interactions in lymph nodes draining the infection site. We also discuss our recent efforts to understand the influence of the sympathetic nervous system on antiviral immunity, with the ultimate goal of appreciating the traditional elements of immunity as just one facet of the total organismal response to infection and immunization.
    MeSH term(s) Animals ; B-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Dendritic Cells/immunology ; Drug Design ; Host-Pathogen Interactions ; Humans ; Lymph Nodes/immunology ; Lymphocyte Activation ; Mice ; Microscopy, Fluorescence, Multiphoton ; Sympathetic Nervous System/physiology ; Viral Vaccines ; Virus Diseases/immunology ; Virus Diseases/prevention & control
    Chemical Substances Viral Vaccines
    Language English
    Publishing date 2011-01-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/j.1600-065X.2010.00973.x
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  7. Article ; Online: Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands.

    Dolan, Brian P / Bennink, Jack R / Yewdell, Jonathan W

    Cellular and molecular life sciences : CMLS

    2011  Volume 68, Issue 9, Page(s) 1481–1489

    Abstract: It has been 15 years since we proposed the defective ribosomal product (DRiP) hypothesis to explain the rapid presentation of viral peptides by MHC class I molecules on the surface of infected cells. Here, we review the evidence for the contribution of ... ...

    Abstract It has been 15 years since we proposed the defective ribosomal product (DRiP) hypothesis to explain the rapid presentation of viral peptides by MHC class I molecules on the surface of infected cells. Here, we review the evidence for the contribution of DRiPs to antigen processing, pointing to the uncertainties regarding the physical nature of DRiPs, and emphasizing recent findings suggesting that peptide generation is a specialized process involving compartmentalized translation.
    MeSH term(s) Antigen Presentation/immunology ; Endoplasmic Reticulum/immunology ; Endoplasmic Reticulum/metabolism ; Histocompatibility Antigens Class I/biosynthesis ; Histocompatibility Antigens Class I/immunology ; Humans ; Protein Biosynthesis ; Virus Diseases/immunology
    Chemical Substances Histocompatibility Antigens Class I
    Language English
    Publishing date 2011-03-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-011-0656-z
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  8. Article ; Online: PD-1 Blockade Promotes Epitope Spreading in Anticancer CD8

    Memarnejadian, Arash / Meilleur, Courtney E / Shaler, Christopher R / Khazaie, Khashayarsha / Bennink, Jack R / Schell, Todd D / Haeryfar, S M Mansour

    Journal of immunology (Baltimore, Md. : 1950)

    2017  Volume 199, Issue 9, Page(s) 3348–3359

    Abstract: The interactions between programmed death-1 (PD-1) and its ligands hamper tumor-specific ... ...

    Abstract The interactions between programmed death-1 (PD-1) and its ligands hamper tumor-specific CD8
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/pathology ; Cell Death/genetics ; Cell Death/immunology ; Cell Line, Tumor ; Epitopes/genetics ; Epitopes/immunology ; Female ; Immunity, Cellular ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; Mice ; Neoplasm Proteins/genetics ; Neoplasm Proteins/immunology ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/immunology ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/immunology ; Signal Transduction/genetics ; Signal Transduction/immunology
    Chemical Substances Epitopes ; IFNG protein, mouse ; Neoplasm Proteins ; Pdcd1 protein, mouse ; Programmed Cell Death 1 Receptor ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2017-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1700643
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  9. Article: The promise of siRNAs for the treatment of influenza.

    Bennink, Jack R / Palmore, Tara N

    Trends in molecular medicine

    2004  Volume 10, Issue 12, Page(s) 571–574

    Abstract: Current WHO reports on the Asian avian influenza virus outbreaks are poignant reminders of the potential for the emergence of highly virulent strains of influenza A virus (IAV) and the fact that it remains a scourge on human health. As IAV drifts and ... ...

    Abstract Current WHO reports on the Asian avian influenza virus outbreaks are poignant reminders of the potential for the emergence of highly virulent strains of influenza A virus (IAV) and the fact that it remains a scourge on human health. As IAV drifts and shifts its genetic and antigenic composition, it presents an ever-changing challenge for vaccines and antiviral medications. Short-interfering RNAs (siRNAs) are the latest class of potential antiviral therapeutics to be developed. Recent reports using siRNAs in mice suggest that they hold great promise for the prevention and treatment of IAV infections.
    MeSH term(s) Animals ; Antiviral Agents/therapeutic use ; Humans ; Influenza A virus/genetics ; Influenza, Human/drug therapy ; Mice ; RNA Interference/physiology ; RNA, Small Interfering/therapeutic use
    Chemical Substances Antiviral Agents ; RNA, Small Interfering
    Language English
    Publishing date 2004-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2004.10.004
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  10. Article ; Online: Caught in the act: intravital multiphoton microscopy of host-pathogen interactions.

    Hickman, Heather D / Bennink, Jack R / Yewdell, Jonathan W

    Cell host & microbe

    2009  Volume 5, Issue 1, Page(s) 13–21

    Abstract: Intravital multiphoton microscopy provides a unique opportunity to discover and characterize biological phenomena in the natural context of living organisms. Here we provide an overview of multiphoton microscopy with particular attention to its ... ...

    Abstract Intravital multiphoton microscopy provides a unique opportunity to discover and characterize biological phenomena in the natural context of living organisms. Here we provide an overview of multiphoton microscopy with particular attention to its application for studying host-pathogen interactions.
    MeSH term(s) Host-Pathogen Interactions ; Microscopy, Fluorescence, Multiphoton ; Pathology/methods
    Language English
    Publishing date 2009-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2008.12.007
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