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Article: La gestion du risque cardiovasculaire du patient age.

Benoît, F

2014 Volume 35, Issue 4, Page(s) 356–360

Abstract: The management of cardiovascular risk in elderly patients should take into account the complexity that characterizes them, including physiological changes, comorbidities, as well as the individual's life expectancy. Up to 70-75 years old the guideline ... ...

Title translation	Management of cardiovascular risk in the elderly patient.
Abstract	The management of cardiovascular risk in elderly patients should take into account the complexity that characterizes them, including physiological changes, comorbidities, as well as the individual's life expectancy. Up to 70-75 years old the guideline for the cardiovascular risk management is well structured. If the estimated risk is determined by using the "SCORE" model or cardiovascular prevention algorithm, the treatment is based on the importance of the risk. Recommendations beyond 75 years of age are not as clear. Although, we have a growing number of studies used to treat older patients, there are only a few recommendations for extreme old ages. The major modifiable risk factors are smoking, hypertension, dyslipidaemia, diabetes, and obesity. For cardiovascular events the impact of the risk factors changes with age and influence the therapeutic management of the risk factors. Some interventions beneficial to young patients may be deleterious to the elderly. In addition, it is better defined for elderly patients with few comorbidities, and greater than 10 years life expectancy, because it tends to model the guidelines known to patients who are younger than 70 years old. This is not true for other patient profiles where only a few recommendations can guide us for optimal care.
MeSH term(s)	Aged ; Aged, 80 and over ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Diabetes Complications ; Dyslipidemias/complications ; Dyslipidemias/therapy ; Humans ; Hypertension/complications ; Hypertension/therapy ; Obesity/complications ; Obesity/therapy ; Risk Factors ; Smoking/adverse effects ; Smoking Cessation
Language	French
Publishing date	2014-09
Publishing country	Belgium
Document type	English Abstract ; Journal Article
ZDB-ID	760217-0
ISSN	0035-3639
ISSN	0035-3639
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Article: The effect of fracture recency on observed 5-year fracture probability: A study based on the FRISBEE cohort.

Iconaru, L / Charles, A / Baleanu, F / Moreau, M / Surquin, M / Benoit, F / Body, J J / Bergmann, P

Bone reports

2023 Volume 18, Page(s) 101660

Abstract: Introduction: Prediction models, especially the FRAX®, are largely used to estimate the fracture risk at ten years, but the current algorithm does not take into account the time elapsed after a fracture. Kanis et al. recently proposed correction factors ...

Abstract	Introduction: Prediction models, especially the FRAX®, are largely used to estimate the fracture risk at ten years, but the current algorithm does not take into account the time elapsed after a fracture. Kanis et al. recently proposed correction factors allowing to adjust the FRAX® score for fracture recency. The objective of this work was to analyze the effect of fracture recency in the FRISBEE cohort. Methods: We identified in the FRISBEE cohort subjects who sustained a validated fracture during the first 5 years following an incident MOF. We calculated their estimated 5-year risk of fracture using FRAX® uncorrected, adjusted for recency and further adjusted for the MOF/hip ratios calibration factors previously derived for the Belgian FRAX®. We compared the fracture risk estimated by FRAX® before and after these corrections to the observed incidence of validated fractures in our cohort. Results: In our ongoing cohort, 376 subjects had a first non-traumatic incident validated MOF after inclusion; 81 had a secondary fracture during the 5 years follow-up period after this index fracture. The FRAX® score significantly under-evaluated the observed incidence of fractures in our cohort by 54.7 % (fracture rate of 9.7 %; 95 % CI, 6.8-12.9 %) if uncorrected (p < 0.001) and by 32.6 % after correction for recency (14.5 %; 95 % CI, 11.1-18.2 %) (p = 0.01). The calibration for MOF/hip ratios improved the prediction (17.5 %; 95 % CI: 13.7-21.4 %) (p = 0.2). After correcting for recency and for calibration, the predicted value was over-evaluated by 22 % (fracture rate of 26.1 %; 95 % CI, 21.6-30.5 %) but this over-evaluation was not significant (p = 0.1). Conclusion: Our data indicate that the correction of the FRAX® score for fracture recency improves fracture prediction. However, correction for calibration and recency tends to overestimate fracture risk in this population of elderly women.
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2821774-3
ISSN	2352-1872
ISSN	2352-1872
DOI	10.1016/j.bonr.2023.101660
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Article ; Online: Are there specific clinical risk factors for the occurrence of multiple fractures? The FRISBEE study.

Charles, A / Iconaru, L / Baleanu, F / Benoit, F / Surquin, M / Mugisha, A / Bergmann, P / Body, J J

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

2023 Volume 34, Issue 3, Page(s) 501–506

Abstract: This study showed additional clinical risk factors for the occurrence of multiple fractures with regards to a single fracture, with often higher hazard ratios. It would be important to include the risk of the occurrence of multiple fractures in future ... ...

Abstract	This study showed additional clinical risk factors for the occurrence of multiple fractures with regards to a single fracture, with often higher hazard ratios. It would be important to include the risk of the occurrence of multiple fractures in future prediction models. Purpose: To identify clinical risk factors (CRFs) which would specifically increase the risk of multiple fractures. Methods: Data of the 3560 postmenopausal women of the FRISBEE study were analysed. The CRFs and the fractures are collected annually. The cohort was divided into three groups: those who had no incident fracture, those who had a single incident fracture and those who had 2 two or more incident fractures (i.e. multiple fractures). Statistical analyses were performed using Cox proportional hazards models. Results: Among the 3560 subjects (followed for 9.1 (7.2-10.6) years), 261 subjects had two or more validated fractures during follow-up (146 were major osteoporotic fractures (MOFs)), 628 had one fracture (435 MOFs), 2671 had no fracture (2979 had no MOF); 157 subjects had two or more central fractures, 389 had only one and 3014 had none. The risk factors for those with multiple fractures at any site were age, history of fracture, history of fall, total hip bone mineral density (BMD), spine BMD and rheumatoid arthritis. For those with multiple MOFs, significant CRFs were age, history of fracture, parental hip fracture, total hip BMD and rheumatoid arthritis. Conclusion: We found in a prospective cohort study that there were more CRFs and higher hazard ratios for the occurrence of multiple fractures than for a single fracture.
MeSH term(s)	Humans ; Female ; Fractures, Multiple ; Prospective Studies ; Hip Fractures/epidemiology ; Hip Fractures/etiology ; Risk Factors ; Osteoporotic Fractures/epidemiology ; Osteoporotic Fractures/etiology ; Bone Density ; Arthritis, Rheumatoid ; Risk Assessment
Language	English
Publishing date	2023-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1064892-6
ISSN	1433-2965 ; 0937-941X
ISSN (online)	1433-2965
ISSN	0937-941X
DOI	10.1007/s00198-022-06663-w
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Article: Comparison of different prognostic scores in estimating short- and long-term mortality in COVID-19 patients above 60 years old in a university hospital in Belgium.

Van Hauwermeiren, C / Claessens, M / Berland, M / Dumoulin, B / Lieten, S / Surquin, M / Benoit, F

European geriatric medicine

2023 Volume 14, Issue 5, Page(s) 1125–1133

Abstract: Background and objectives: Multiple scoring systems were used for risk stratification in COVID-19 patients. The objective was to determine among 6 scores which performed the best in predicting short-and long-term mortality in hospitalized COVID-19 ... ...

Abstract	Background and objectives: Multiple scoring systems were used for risk stratification in COVID-19 patients. The objective was to determine among 6 scores which performed the best in predicting short-and long-term mortality in hospitalized COVID-19 patients ≥ 60 years. Methods: An observational, retrospective cohort study conducted between 21/10/2020 and 20/01/2021. 6 scores were calculated (Clinical Frailty Scale (CFS), Charlson Comorbidity Index (CCI), 4C Mortality Score (4CMS), NEWS score (NEWS), quick-SOFA score (qSOFA), and Quick COVID-19 Severity Index (qCSI)). We included unvaccinated hospitalized patients with COVID-19 ≥ 60 years old in Brugmann hospital, detected by PCR and/or suggestive CT thorax images. Old and nosocomial infections, and patients admitted immediately at the intensive care unit were excluded. Results: 199 patients were included, mean age was 76.2 years (60-99). 47.2% were female. 56 patients (28%) died within 1 year after the first day of hospitalization. The 4CMS predicted the best intrahospital, 30 days and 6 months mortality, with area under the ROC curve (AUROC) 0.695 (0.58-0.81), 0.76 (0.65-0.86) and 0.72 (0.63-0.82) respectively. The CCI came right after with respectively AUROC of 0.69 (0.59-0.79), 0.74 (0.65-0.83) and 0.71 (0.64-0.8). To predict mortality at 12 months after hospitalization, the CCI had the highest AUROC with 0.77 (0.69-0.85), before the 4CMS with 0.69 (0.60-0.79). Discussion: Among 6 scores, the 4CMS was the best to predict intrahospital, 30-day and 6-month mortality. To predict mortality at 12 months, CCI had the best performance before 4CMS. This reflects the importance of considering comorbidities for short- and long-term mortality after COVID 19. Registration: This study was approved by the ethical committee of Brugmann University Hospital (reference CE 2020/228).
Language	English
Publishing date	2023-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2556794-9
ISSN	1878-7657 ; 1878-7649
ISSN (online)	1878-7657
ISSN	1878-7649
DOI	10.1007/s41999-023-00836-4
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Article: A Rare Complication of Internal Jugular Vein Cannulation Following Subcutaneous Implanted Port Placement.

Chacko, Anjo / Kean, Amber / Benoit, Farrah / Patel, Vijaykumar

Cureus

2022 Volume 14, Issue 5, Page(s) e24862

Abstract: Port-a-Cath also known as a subcutaneous implantable catheter is a common device used in patients undergoing drug infusions. Port-a-Cath placements are widely used among cancer patients who need multiple intravenous infusions with chemotherapeutic agents. ...

Abstract	Port-a-Cath also known as a subcutaneous implantable catheter is a common device used in patients undergoing drug infusions. Port-a-Cath placements are widely used among cancer patients who need multiple intravenous infusions with chemotherapeutic agents. The surgical approach to implanting a Port-a-Cath is associated with risks and benefits; however, it may also be associated with serious complications. We describe a rare case of a large right-sided hemothorax following right internal jugular vein cannulation after Port-a-Cath placement. We discuss possible causes of hemothorax in this patient and describe possible factors such as abnormal anatomy of vessels and body habitus contributing to this complication. We also highlight the use of imaging such as ultrasound-guided techniques and the importance of postoperative chest radiographs to screen for possible complications.
Language	English
Publishing date	2022-05-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.24862
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Book: Plastiektoepassingen in de tuinbouw in de Benelux

Benoit, F. / Ceustermans, N.

1983

Author's details	F. Benoit & N. Ceustermans
Language	Dutch
Size	24 Seiten, Diagramme
Publisher	Proefstation voor de Groenteteelt
Publishing place	St.-Katelijne-Waver
Publishing country	Belgium
Document type	Book
HBZ-ID	HT030668525
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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Article: Face à la COVID-19. Mortalité intra-hospitalière chez les patients âgés de plus de 70 ans avec COVID-19 dans un hôpital universitaire en Belgique :l’étude COVID-AgeBru.

Garcia, E / Sanchez-Rodriguez, D / Levy, S / Claessens, M / Van Hauwermeiren, C / Taliha, M / Benoit, F / Surquin, M

Revue medicale de Liege

2022 Volume 77, Issue 3, Page(s) 146–152

Abstract: Objective: We aimed at assessing the association between demographical and clinical data and the intrahospital mortality in older patients with COVID-19 in Belgium.: Methods: Descriptive, retrospective study of consecutive patients admitted to ... ...

Title translation	Factors associated with intrahospital mortality in older patients with COVID-19 in Belgium : The COVID-AgeBru study.
Abstract	Objective: We aimed at assessing the association between demographical and clinical data and the intrahospital mortality in older patients with COVID-19 in Belgium. Methods: Descriptive, retrospective study of consecutive patients admitted to Brugmann university hospital, Brussels (Belgium) due to COVID-19 (Mars-September-2020). Inclusion criteria: Patients aged ≥ 70 years admitted to acute care with a positive PCR-RT test, or a highly indicative computed tomography scan. Exclusion criteria: Patients transferred to another institution during hospitalization. Outcome measure: All-cause intrahospital mortality. Demographic, clinical data, presence of comordibidties and comprehensive geriatric assessment were collected. Adjusted and unadjusted logistic regression were performed. Results: From the 226 eligible patients, 160 (82.7 ± 6.5-year-old; 57.5 % females) met inclusion criteria, from which 67 (42 %) died during hospital stay. The adjusted logistic regression showed an association between intrahospital mortality and increasing age [OR = 1.09 per every year increase (95 % CI 1.02-1.16); p <0.001], type 2 diabetes [OR = 2.75 ( 1.17-6.46); p = 0.021], and acute respiratory distress syndrome (ARDS) [OR = 8.67 ( 3.48-21.61); p < 0.01]. Conclusions: A higher positive association between intrahospital mortality and increasing age, type 2 diabetes, and ARDS was found. The prognosis value of the comprehensive geriatric assessment in older people with COVID-19 in Belgium requires further studies.
MeSH term(s)	Aged ; Aged, 80 and over ; Belgium/epidemiology ; COVID-19 ; Diabetes Mellitus, Type 2 ; Female ; Hospitalization ; Humans ; Male ; Retrospective Studies ; SARS-CoV-2
Language	French
Publishing date	2022-03-08
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	414001-1
ISSN	0370-629X ; 0035-3663
ISSN	0370-629X ; 0035-3663
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Article ; Online: Distribution of Fracture Sites in Postmenopausal Overweight and Obese Women: The FRISBEE Study.

Charles, A / Mugisha, A / Iconaru, L / Baleanu, F / Benoit, F / Surquin, M / Bergmann, P / Body, J J

Calcified tissue international

2022 Volume 111, Issue 1, Page(s) 29–34

Abstract: The association between obesity and fracture sites in postmenopausal women has been little studied. We examined the most common types of fractures in obese and overweight postmenopausal women compared to subjects with a normal BMI in the FRISBEE study, a ...

Abstract	The association between obesity and fracture sites in postmenopausal women has been little studied. We examined the most common types of fractures in obese and overweight postmenopausal women compared to subjects with a normal BMI in the FRISBEE study, a cohort of postmenopausal women followed since 9.1 (7.2-10.6) years. Chi-squared tests and logistic regressions were used to compare the percentages of fracture sites in overweight/obese subjects to subjects with a normal BMI. Their mean (± SD) age was 76.7 ± 6.9 years and their mean BMI was 26.4 ± 4.4. Seven hundred seventy-seven subjects suffered at least one validated fragility fracture with a total of 964 fractures in the whole cohort. Subjects with a BMI higher than 25 had significantly more ankle fractures and less pelvic fractures than subjects with a normal BMI (OR 1.63, 95% CI 1.02-2.56, P = 0.04 and OR 0.55, 95% CI 0.34-0.89, P = 0.01, respectively). There were no significant differences between overweight and obese subjects. Among those older than 75, there were significantly fewer pelvic fractures in overweight/obese subjects (OR 0.49, 95% CI 0.27-0.87, P = 0.01), but before 75, ankle fractures were significantly more frequent in overweight/obese subjects than in subjects with a normal BMI (OR 1.89, 95% CI 1.01-3.57, P = 0.04). In conclusion, the proportion of ankle and pelvic fractures in obese and overweight subjects differs from that in subjects with a normal BMI, but these differences are age dependent. Fracture prevention strategies should take into account the differential effects of excess weight according to age and the site of fracture.
MeSH term(s)	Aged ; Aged, 80 and over ; Ankle Fractures ; Body Mass Index ; Female ; Humans ; Obesity/complications ; Overweight/complications ; Postmenopause ; Risk Factors
Language	English
Publishing date	2022-03-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304266-2
ISSN	1432-0827 ; 0944-0747 ; 0008-0594 ; 0171-967X
ISSN (online)	1432-0827
ISSN	0944-0747 ; 0008-0594 ; 0171-967X
DOI	10.1007/s00223-022-00968-y
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Book: Kunststoffanwendung im belgischen Gartenbau

Benoit, F. / Ceustermans, N.

1982

Title translation	Plastiektoepassingen in de tuinbouw in de Benelux
Author's details	F. Benoit & N. Ceustermans
Language	German
Size	18 Seiten, Diagramme
Publisher	Gesellschaft für Kunststoffe in der Landwirtschaft (GKL)
Publishing place	Erscheinungsort nicht ermittelbar
Publishing country	Germany
Document type	Book
HBZ-ID	HT030668545
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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Article ; Online: A short and simple bedside test to detect cognitive fluctuations in patients with dementia with Lewy bodies.

Segers, Kurt / Benoit, Florence / de Assis Oliveira Rocha, Francisco / Praet, Jean-P / Surquin, Murielle

Acta neurologica Belgica

2023 Volume 123, Issue 3, Page(s) 803–806

Abstract: Background and purpose: The establishment of cognitive fluctuations is important when dementia with Lewy bodies (DLB) is suspected but can be especially difficult in the absence of a caregiver who lives with the patient. We examined the possibility of ... ...

Abstract	Background and purpose: The establishment of cognitive fluctuations is important when dementia with Lewy bodies (DLB) is suspected but can be especially difficult in the absence of a caregiver who lives with the patient. We examined the possibility of using fluctuating scores on a forward (FDS) and a backward digit span (BDS) test as a marker for cognitive fluctuation. Methods: Patients with DLB (21), other forms of dementia (14 with Alzheimer's disease, 8 with vascular dementia) and 20 controls were asked to perform an FDS and BDS twice, with an interval of 20 min. Results: Seventy percent of patients with DLB showed evidence of cognitive fluctuations for at least one test, while less than 10% of controls and patients with other dementias did. Evidence of cognitive fluctuations on at least one of both tests classified 83% of patients correctly (i.e. DLB or not), with a sensitivity of 70% and a specificity of 90%. Conclusions: Repeated forward and backward digit span tests seem a valid, short, easy and inexpensive bedside tool to detect cognitive fluctuations in the diagnostic work-up of DLB, even in the absence of a caregiver, which limits the use of questionnaires.
MeSH term(s)	Humans ; Lewy Body Disease/diagnosis ; Lewy Body Disease/psychology ; Neuropsychological Tests ; Alzheimer Disease/diagnosis ; Alzheimer Disease/psychology ; Dementia, Vascular ; Cognition
Language	English
Publishing date	2023-04-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-023-02260-8
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