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  1. Article ; Online: Documenting the Recovery of Vascular Services in European Centres Following the Initial COVID-19 Pandemic Peak: Results from a Multicentre Collaborative Study.

    Benson, Ruth A

    EJVES vascular forum

    2022  Volume 57, Page(s) 28–34

    Abstract: Objective: To document the recovery of vascular services in Europe following the first COVID-19 pandemic peak.: Methods: An online structured vascular service survey with repeated data entry between 23 March and 9 August 2020 was carried out. Unit ... ...

    Abstract Objective: To document the recovery of vascular services in Europe following the first COVID-19 pandemic peak.
    Methods: An online structured vascular service survey with repeated data entry between 23 March and 9 August 2020 was carried out. Unit level data were collected using repeated questionnaires addressing modifications to vascular services during the first peak (March - May 2020, "period 1"), and then again between May and June ("period 2") and June and July 2020 ("period 3"). The duration of each period was similar. From 2 June, as reductions in cases began to be reported, centres were first asked if they were in a region still affected by rising cases, or if they had passed the peak of the first wave. These centres were asked additional questions about adaptations made to their standard pathways to permit elective surgery to resume.
    Results: The impact of the pandemic continued to be felt well after countries' first peak was thought to have passed in 2020. Aneurysm screening had not returned to normal in 21.7% of centres. Carotid surgery was still offered on a case by case basis in 33.8% of centres, and only 52.9% of centres had returned to their normal aneurysm threshold for surgery. Half of centres (49.4%) believed their management of lower limb ischaemia continued to be negatively affected by the pandemic. Reduced operating theatre capacity continued in 45.5% of centres. Twenty per cent of responding centres documented a backlog of at least 20 aortic repairs. At least one negative swab and 14 days of isolation were the most common strategies used for permitting safe elective surgery to recommence.
    Conclusion: Centres reported a broad return of services approaching pre-pandemic "normal" by July 2020. Many introduced protocols to manage peri-operative COVID-19 risk. Backlogs in cases were reported for all major vascular surgeries.
    Language English
    Publishing date 2022-10-20
    Publishing country England
    Document type Journal Article
    ISSN 2666-688X
    ISSN (online) 2666-688X
    DOI 10.1016/j.ejvsvf.2022.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Aneurysm Screening: The Next Generation Demands Couture, Not Prêt-à-Porter.

    Kindon, Andy J / Benson, Ruth A

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2024  

    Language English
    Publishing date 2024-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2024.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The COvid-19 Vascular sERvice (COVER) Study: An International Vascular and Endovascular Research Network (VERN) Collaborative Study Assessing the Provision, Practice, and Outcomes of Vascular Surgery During the COVID-19 Pandemic

    Benson, Ruth A

    Eur. j. vasc. endovasc. surg

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #438280
    Database COVID19

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  4. Article ; Online: The COvid-19 Vascular sERvice (COVER) Study

    Benson, Ruth A.

    European Journal of Vascular and Endovascular Surgery ; ISSN 1078-5884

    An International Vascular and Endovascular Research Network (VERN) Collaborative Study Assessing the Provision, Practice, and Outcomes of Vascular Surgery During the COVID-19 Pandemic

    2020  

    Keywords Surgery ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.ejvs.2020.04.039
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The persistent challenges faced by vascular surgery services during the UK coronavirus pandemic: a snapshot qualitative survey.

    Nandhra, S / Benson, R A

    Annals of the Royal College of Surgeons of England

    2021  Volume 104, Issue 5, Page(s) 385–388

    Abstract: Introduction: The coronavirus (COVID-19) pandemic continues to affect the NHS. The Vascular and Endovascular Research Network (VERN) COvid Vascular sERvice (COVER) study has prospectively shown the significant global impact of the COVID-19 pandemic on ... ...

    Abstract Introduction: The coronavirus (COVID-19) pandemic continues to affect the NHS. The Vascular and Endovascular Research Network (VERN) COvid Vascular sERvice (COVER) study has prospectively shown the significant global impact of the COVID-19 pandemic on vascular surgery. The aim of this study is to investigate the way in which this second wave has affected surgeons' ability to treat patients with urgent vascular conditions, using contemporaneous snapshot data from 30 UK vascular centres.
    Methods: This is a contemporary (18-28 January 2021) re-run of the Tier 1 COVER survey. This used closed and open questions, related to centres' provision of common vascular services, threshold for treatment, imaging, screening, staff and theatre availability, multidisciplinary team input, clinics, personal protective equipment, vaccination policies and case-backlogs. The survey was disseminated to clinicians via email. A service reduction score was calculated.
    Results: Forty-two complete responses were received from 30 vascular centres (England, Northern Ireland, Scotland and Wales). Overall, 56.7% of units are performing only urgent procedures. The threshold for abdominal aortic aneurysm (AAA) repair has increased in the majority of UK centres (60%). One in six AAA screening programmes have stopped all screening activity: 30% having a significantly reduced programme and only half running as normal. Waiting lists are increasing for AAA, lower limb revascularisation and venous disease.
    Conclusion: Overall, these data suggest that vascular care in the NHS is facing unprecedented pressures due to COVID-19. Vascular stakeholders will have to urgently address these issues in the coming months.
    Study registration number: ISRCTN 80453162 (registered prospectively).
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Humans ; Pandemics/prevention & control ; SARS-CoV-2 ; United Kingdom/epidemiology ; Vascular Surgical Procedures
    Language English
    Publishing date 2021-12-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2021.0202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Outcomes of Vascular and Endovascular Interventions Performed During the Coronavirus Disease 2019 (COVID-19) Pandemic.

    Benson, Ruth A / Nandhra, Sandip

    Annals of surgery

    2020  Volume 273, Issue 4, Page(s) 630–635

    Abstract: Objective: The aim of the COVER Study is to identify global outcomes and decision making for vascular procedures during the pandemic.: Background data: During its initial peak, there were many reports of delays to vital surgery and the release of ... ...

    Abstract Objective: The aim of the COVER Study is to identify global outcomes and decision making for vascular procedures during the pandemic.
    Background data: During its initial peak, there were many reports of delays to vital surgery and the release of several guidelines advising later thresholds for vascular surgical intervention for key conditions.
    Methods: An international multi-center observational study of outcomes after open and endovascular interventions.
    Results: In an analysis of 1103 vascular intervention (57 centers in 19 countries), 71.6% were elective or scheduled procedures. Mean age was 67 ± 14 years (75.6% male). Suspected or confirmed COVID-19 infection was documented in 4.0%. Overall, in-hospital mortality was 11.0% [aortic interventions mortality 15.2% (23/151), amputations 12.1% (28/232), carotid interventions 10.7% (11/103), lower limb revascularisations 9.8% (51/521)]. Chronic obstructive pulmonary disease [odds ratio (OR) 2.02, 95% confidence interval (CI) 1.30-3.15] and active lower respiratory tract infection due to any cause (OR 24.94, 95% CI 12.57-241.70) ware associated with mortality, whereas elective or scheduled cases were lower risk (OR 0.4, 95% CI 0.22-0.73 and 0.60, 95% CI 0.45-0.98, respectively. After adjustment, antiplatelet (OR 0.503, 95% CI: 0.273-0.928) and oral anticoagulation (OR 0.411, 95% CI: 0.205-0.824) were linked to reduced risk of in-hospital mortality.
    Conclusions: Mortality after vascular interventions during this period was unexpectedly high. Suspected or confirmed COVID-19 cases were uncommon. Therefore an alternative cause, for example, recommendations for delayed surgery, should be considered. The vascular community must anticipate longer term implications for survival.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Testing ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/surgery ; Clinical Decision-Making/methods ; Endovascular Procedures/mortality ; Endovascular Procedures/statistics & numerical data ; Female ; Global Health ; Hospital Mortality ; Humans ; Logistic Models ; Male ; Middle Aged ; Pandemics ; Prospective Studies ; Treatment Outcome ; Vascular Surgical Procedures/mortality ; Vascular Surgical Procedures/statistics & numerical data
    Language English
    Publishing date 2020-11-27
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000004722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Study protocol for COvid-19 Vascular sERvice (COVER) study: The impact of the COVID-19 pandemic on the provision, practice and outcomes of vascular surgery.

    Benson, Ruth A / Nandhra, Sandip

    PloS one

    2020  Volume 15, Issue 12, Page(s) e0243299

    Abstract: Background: The novel Coronavirus Disease 2019 (COVID-19) pandemic is having a profound impact on global healthcare. Shortages in staff, operating theatre space and intensive care beds has led to a significant reduction in the provision of surgical care. ...

    Abstract Background: The novel Coronavirus Disease 2019 (COVID-19) pandemic is having a profound impact on global healthcare. Shortages in staff, operating theatre space and intensive care beds has led to a significant reduction in the provision of surgical care. Even vascular surgery, often insulated from resource scarcity due to its status as an urgent specialty, has limited capacity due to the pandemic. Furthermore, many vascular surgical patients are elderly with multiple comorbidities putting them at increased risk of COVID-19 and its complications. There is an urgent need to investigate the impact on patients presenting to vascular surgeons during the COVID-19 pandemic.
    Methods and analysis: The COvid-19 Vascular sERvice (COVER) study has been designed to investigate the worldwide impact of the COVID-19 pandemic on vascular surgery, at both service provision and individual patient level. COVER is running as a collaborative study through the Vascular and Endovascular Research Network (VERN), an independent, international vascular research collaborative with the support of numerous national and international organisations). The study has 3 'Tiers': Tier 1 is a survey of vascular surgeons to capture longitudinal changes to the provision of vascular services within their hospital; Tier 2 captures data on vascular and endovascular procedures performed during the pandemic; and Tier 3 will capture any deviations to patient management strategies from pre-pandemic best practice. Data submission and collection will be electronic using online survey tools (Tier 1: SurveyMonkey® for service provision data) and encrypted data capture forms (Tiers 2 and 3: REDCap® for patient level data). Tier 1 data will undergo real-time serial analysis to determine longitudinal changes in practice, with country-specific analyses also performed. The analysis of Tier 2 and Tier 3 data will occur on completion of the study as per the pre-specified statistical analysis plan.
    MeSH term(s) COVID-19/epidemiology ; Endovascular Procedures/statistics & numerical data ; Health Impact Assessment/statistics & numerical data ; Humans ; Internet ; Operating Rooms/statistics & numerical data ; SARS-CoV-2 ; Specialties, Surgical/statistics & numerical data ; Surgeons ; Surveys and Questionnaires ; Vascular Surgical Procedures/statistics & numerical data
    Language English
    Publishing date 2020-12-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0243299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The effect of abatacept on T-cell activation is not long-lived

    da Rosa, Larissa C / Scales, Hannah E / Benson, Robert A / Brewer, James M / McInnes, Iain B / Garside, Paul

    Discovery immunology

    2024  Volume 3, Issue 1, Page(s) kyad029

    Abstract: Abatacept, a co-stimulatory blocker comprising the extracellular portion of human CTLA-4 linked to the Fc region of IgG1, is approved for the treatment of rheumatoid arthritis. By impairing the interaction between CD28 on T cells and CD80/CD86 on APCs, ... ...

    Abstract Abatacept, a co-stimulatory blocker comprising the extracellular portion of human CTLA-4 linked to the Fc region of IgG1, is approved for the treatment of rheumatoid arthritis. By impairing the interaction between CD28 on T cells and CD80/CD86 on APCs, its mechanisms of action include the suppression of follicular T helper cells (preventing the breach of self-tolerance in B cells), inhibition of cell cycle progression holding T cells in a state described as 'induced naïve' and reduction in DC conditioning. However, less is known about how long these inhibitory effects might last, which is a critical question for therapeutic use in patients. Herein, employing a murine model of OVA-induced DTH, we demonstrate that the effect of abatacept is short-lived
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ISSN 2754-2483
    ISSN (online) 2754-2483
    DOI 10.1093/discim/kyad029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A vascular multi-arm multi-stage trial to prevent groin wound surgical site infection: A feasibility survey.

    Popplewell, Matthew A / Gwilym, Brenig L / Benson, Ruth A / Juszczak, Maciej / Bosanquet, David / Pinkney, Thomas D / Chetter, Ian / Wall, Michael

    International wound journal

    2023  Volume 20, Issue 8, Page(s) 2998–3005

    Abstract: Surgical site infection (SSI) is common following arterial surgery involving a groin incision. There is a lack of evidence regarding interventions to prevent groin wound SSI, therefore, a survey of vascular clinicians was undertaken to assess current ... ...

    Abstract Surgical site infection (SSI) is common following arterial surgery involving a groin incision. There is a lack of evidence regarding interventions to prevent groin wound SSI, therefore, a survey of vascular clinicians was undertaken to assess current opinion and practice, equipoise and feasibility of a randomised controlled trial (RCT). Participants at the Vascular Society of Great Britain and Ireland 2021 Annual Scientific Meeting were surveyed regarding three separate interventions designed to prevent SSI in the groin; impregnated incise drapes, diakylcarbomoyl chloride dressings and antibiotic impregnated collagen sponges. Results were collated via an online survey using the Research Electronic Data Capture platform. Seventy-five participants completed the questionnaire, most were consultant vascular surgeons (50/75, 66.7%). The majority agree that groin wound SSI is a major problem (73/75, 97.3%), and would be content using either of the three interventions (51/61, 83.6%) and had clinical equipoise to randomise patients to any of the three interventions versus standard of care (70/75, 93.3%). There was some reluctance to not use impregnated incise drapes as may be considered "standard of care". Groin wound SSI is perceived as major problem in vascular surgery, and a multicentre RCT of three preventative interventions appears acceptable to vascular surgeons.
    MeSH term(s) Humans ; Groin/surgery ; Surgical Wound Infection/prevention & control ; Feasibility Studies ; Vascular Surgical Procedures/adverse effects ; Surveys and Questionnaires ; Surgical Wound
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2170920-8
    ISSN 1742-481X ; 1742-4801
    ISSN (online) 1742-481X
    ISSN 1742-4801
    DOI 10.1111/iwj.14170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Regarding "Comparing the efficacy of shunting approaches and cerebral monitoring during carotid endarterectomy using a national database".

    Fisher, Owain / Benson, Ruth A / Imray, Christopher H E

    Journal of vascular surgery

    2019  Volume 69, Issue 2, Page(s) 626

    MeSH term(s) Brain Ischemia ; Carotid Arteries ; Endarterectomy, Carotid ; Humans
    Language English
    Publishing date 2019-01-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2018.09.056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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