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Article: Laparoscopy management for spontaneous bladder rupture: a case report.

Celotti, Simone / Benuzzi, Laura / Ceriani, Chiara / D'Amore, Piero / Foschi, Diego / Del Re, Luca

Journal of surgical case reports

2021 Volume 2021, Issue 1, Page(s) rjaa570

Abstract: We present a case of a 79-year-old man with lower abdominal pain and negative Blumberg sign. An indwelling bladder catheter was inserted for urinary retention due to a tight phimosis 2 months earlier. A contrast-enhanced computed tomography scan revealed ...

Abstract	We present a case of a 79-year-old man with lower abdominal pain and negative Blumberg sign. An indwelling bladder catheter was inserted for urinary retention due to a tight phimosis 2 months earlier. A contrast-enhanced computed tomography scan revealed a huge gastrectasia and small bowel distention due to a suspected adherent bridle. The clinical signs and the laboratory tests were highly suspicious for bowel obstruction and emergency surgery was indicated. Exploratory laparoscopy showed a bladder hole tamponade by an ileum loop. The perforation was sutured laparoscopically and the patient was discharged on the 14th postoperative day. In our case, emergency laparoscopic exploration was useful for the diagnosis and the treatment of spontaneous bladder rupture. We hope this case report can be useful to give these patients better outcomes. Notably we would like to emphasize that the presence of a urinary catheter can be a risk factor for intraperitoneal bladder rupture.
Language	English
Publishing date	2021-01-18
Publishing country	England
Document type	Case Reports
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjaa570
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Article ; Online: Comparison between level 1 and level 2 trauma centers for the management of splenic blunt trauma.

Sammartano, Fabrizio / Ferrara, Francesco / Benuzzi, Laura / Baldi, Caterina / Conalbi, Valeria / Bini, Roberto / Cimbanassi, Stefania / Chiara, Osvaldo / Stella, Marco

Cirugia espanola

2022 Volume 101, Issue 7, Page(s) 472–481

Abstract: Introduction: The management of blunt splenic trauma has evolved in the last years, from mainly operative approach to the non-operative management (NOM). The aim of this study is to investigate whether trauma center (TC) designation (level 1 and level 2) ...

Abstract	Introduction: The management of blunt splenic trauma has evolved in the last years, from mainly operative approach to the non-operative management (NOM). The aim of this study is to investigate whether trauma center (TC) designation (level 1 and level 2) affects blunt splenic trauma management. Methods: A retrospective analysis of blunt trauma patients with splenic injury admitted to 2 Italian TCs, Niguarda (level 1) and San Carlo Borromeo (level 2), was performed, receiving either NOM or emergency surgical treatment, from January 1, 2015 to December 31, 2020. Univariate comparison was performed between the two centers, and multivariate analysis was carried out to find predictive factors associated with NOM and splenectomy. Results: 181 patients were included in the study, 134 from level 1 and 47 from level 2 TCs. The splenectomy/emergency laparotomy ratio was inferior at level 1 TC for high-grade splenic injuries (30.8% for level 1 and 100% for level 2), whose patients presented higher incidence of other injuries. Splenic NOM failure was registered in only one case (3.3%). At multivariate analysis, systolic pressure, spleen organ injury scale (OIS) and injury severity score (ISS) resulted significant predictive factors for NOM, and only spleen OIS was predictive factor for splenectomy (Odds Ratio 0.14, 0.04-0.49 CI 95%, P < .01). Conclusion: Both level 1 and 2 trauma centers demonstrated application of NOM with a high rate of success with some management difference in the treatment and outcome of patients with splenic injuries between the two types of TCs.
MeSH term(s)	Humans ; Spleen/surgery ; Spleen/injuries ; Trauma Centers ; Retrospective Studies ; Splenectomy ; Abdominal Injuries/epidemiology ; Abdominal Injuries/surgery ; Wounds, Nonpenetrating/surgery
Language	English
Publishing date	2022-07-23
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.cireng.2022.07.012
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Article: Negative Pressure Wound Therapy for the Treatment of Fournier's Gangrene: A Rare Case with Rectal Fistula and Systematic Review of the Literature.

Altomare, Michele / Benuzzi, Laura / Molteni, Mattia / Virdis, Francesco / Spota, Andrea / Cioffi, Stefano Piero Bernardo / Reitano, Elisa / Renzi, Federica / Chiara, Osvaldo / Sesana, Giovanni / Cimbanassi, Stefania

Journal of personalized medicine

2022 Volume 12, Issue 10

Abstract: Fournier's gangrene (FG) is a Necrotizing Soft Tissue Infection (NSTI) of the perineal region characterized by high morbidity and mortality even if appropriately treated. The main treatment strategies are surgical debridement, broad-spectrum antibiotics, ...

Abstract	Fournier's gangrene (FG) is a Necrotizing Soft Tissue Infection (NSTI) of the perineal region characterized by high morbidity and mortality even if appropriately treated. The main treatment strategies are surgical debridement, broad-spectrum antibiotics, hyperbaric oxygen therapy, NPWT (Negative Pressure Wound Therapy), and plastic surgery reconstruction. We present the case of a 50-year-old woman with an NSTI of the abdomen, pelvis, and perineal region associated with a rectal fistula referred to our department. After surgical debridement and a diverting blow-out colostomy, an NPWT system composed of two sponges connected by a bridge through a rectal fistula was performed. Our target was to obtain healing in a lateral-to-medial direction instead of depth-to-surface to prevent the enlargement of the rectal fistula, promoting granulation tissue growth towards the rectum. This eso-endo-NPWT technique allowed for the primary suture of the perineal wounds bilaterally, simultaneously treating the rectal fistula and the perineum lesions. A systematic review of the literature underlines the spreading of NPWT and its effects.
Language	English
Publishing date	2022-10-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12101695
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Article: Regenerative Medicine to Improve Outcomes of Ventral Hernia Reconstruction (REPAIR Study) Phase 1: Find the Best Decellularization Protocol for the Human Dermis.

Altomare, Michele / Ferrario, Luca / Benuzzi, Laura / Tosca, Marta Cecilia / Gipponi, Marta / Khodri, Imam / Sesana, Giovanni / Cimbanassi, Stefania / Cioffi, Stefano Piero Bernardo / Spota, Andrea / Bini, Roberto / Chiara, Osvaldo / Mingoli, Andrea

Journal of personalized medicine

2022 Volume 12, Issue 9

Abstract: Background: Tissue regeneration is a complex process that allows wounds to heal. Many options are currently available to help human skin repair and to reduce the recurrence of hernias. The aim of this study is to analyze the best decellularization ... ...

Abstract	Background: Tissue regeneration is a complex process that allows wounds to heal. Many options are currently available to help human skin repair and to reduce the recurrence of hernias. The aim of this study is to analyze the best decellularization protocol for allogenic human dermal tissues. Methods: Dermal flaps from donors were used and compared with a control group. Each flap was subjected to seven different decellularization protocols and washed with a sequence of five solutions. The samples were then subjected to four control tests (such as Nile Red), and long-term contacts were analyzed to assess whether the decellularized dermis samples could support the growth of human fibroblasts. Results: All the samples had an average residual viability of 60%. Except for one sample, the decellularization treatments were able to reduce cell viability significantly. The Nile Red test showed a significant reduction in phospholipid content (mean 90%, p-value < 0.05) in all treatments. The cell growth increased in a linear manner. As described in the literature, sodium-dodecyl-sulfate (SDS) caused an interference between the test and the detergent. Conclusions: This paper shows the first step to finding the best decellularization protocol for allografting human dermal tissues. Further biocompatibility tests and DNA quantification are necessary.
Language	English
Publishing date	2022-08-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12091411
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Article ; Online: Comment on the article "Age and liver transplantation".

Ferla, Fabio / Lauterio, Andrea / De Carlis, Riccardo / Di Sandro, Stefano / Petrucciani, Niccolò / Benuzzi, Laura / De Carlis, Luciano

Journal of hepatology

2019 Volume 70, Issue 6, Page(s) 1305–1306

MeSH term(s)	Liver Transplantation
Language	English
Publishing date	2019-03-02
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2019.02.007
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Article: From a Philosophical Framework to a Valid Prognostic Staging System of the New "Comprehensive Assessment" for Transplantable Hepatocellular Carcinoma.

Di Sandro, Stefano / Bagnardi, Vincenzo / Cucchetti, Alessandro / Lauterio, Andrea / De Carlis, Riccardo / Benuzzi, Laura / Danieli, Maria / Botta, Francesca / Centonze, Leonardo / Najjar, Marc / De Carlis, Luciano

Cancers

2019 Volume 11, Issue 6

Abstract: The comprehensive assessment of the transplantable tumor (TT) proposed and included in the last Italian consensus meeting still deserve validation. All consecutive patients with hepatocellular carcinoma (HCC) listed for liver transplant (LT) between ... ...

Abstract	The comprehensive assessment of the transplantable tumor (TT) proposed and included in the last Italian consensus meeting still deserve validation. All consecutive patients with hepatocellular carcinoma (HCC) listed for liver transplant (LT) between January 2005 and December 2015 were post-hoc classified by the tumor/patient stage as assessed at the last re-staging-time (ReS-time) before LT as follow: high-risk-class (HRC) = stages TT
Language	English
Publishing date	2019-05-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers11060741
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Article: The current role of laparoscopic resection for HCC: a systematic review of past ten years.

Di Sandro, Stefano / Danieli, Maria / Ferla, Fabio / Lauterio, Andrea / De Carlis, Riccardo / Benuzzi, Laura / Buscemi, Vincenzo / Pezzoli, Isabella / De Carlis, Luciano

Translational gastroenterology and hepatology

2018 Volume 3, Page(s) 68

Abstract: The use of laparoscopic liver resection (LLR) has progressively spread in the last 10 years. Several studies have shown the superiority of LLR to open liver resection (OLR) in term of perioperative outcomes. With this review, we aim to systematically ... ...

Abstract	The use of laparoscopic liver resection (LLR) has progressively spread in the last 10 years. Several studies have shown the superiority of LLR to open liver resection (OLR) in term of perioperative outcomes. With this review, we aim to systematically assess short-term and long-term major outcomes in patients who underwent LLR for hepatocellular carcinoma (HCC) in order to illustrate the advantages of minimally invasive liver surgery. Through an advanced PubMed research, we selected all retrospective, prospective, and comparative clinical trials reporting short-term and long-term outcomes of any series of patients with diagnosis of HCC who underwent laparoscopic or robotic resection. Reviews, meta-analyses, or case reports were excluded. None of the patients included in this review has received a previous locoregional treatment for the same tumor nor has undergone a laparoscopic-assisted procedure. We considered morbidity and mortality for evaluation of major short-term outcomes, and overall survival (OS) and disease-free survival (DFS) for evaluation of long-term outcomes. A total of 1,501 patients from 17 retrospective studies were included, 15 studies compare LLR with OLR. Propensity-score matching (PSM) analysis was used in 11 studies (975 patients). The majority of the studies included patients with good liver function and a single HCC. Cirrhosis at pathology ranged from 33% to 100%. Overall mortality and morbidity ranges were 0-2.4% and 4.9-44% respectively, with most of the complications being Clavien-Dindo grade I or II (range: 3.9-23.3%
Language	English
Publishing date	2018-09-18
Publishing country	China
Document type	Journal Article ; Review
ISSN	2415-1289
ISSN	2415-1289
DOI	10.21037/tgh.2018.08.05
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Article ; Online: Minor laparoscopic liver resection for Hepatocellular Carcinoma is safer than minor open resection, especially for less compensated cirrhotic patients: Propensity score analysis.

Di Sandro, Stefano / Bagnardi, Vincenzo / Najjar, Marc / Buscemi, Vincenzo / Lauterio, Andrea / De Carlis, Riccardo / Danieli, Maria / Pinotti, Enrico / Benuzzi, Laura / De Carlis, Luciano

Surgical oncology

2018 Volume 27, Issue 4, Page(s) 722–729

Abstract: Background: Laparoscopic liver resection (LLR) has gained significant popularity over the last 10 years. First experiences of LLR compared to open liver resection (OLR) reported a similar survival and a better safety profile for LLR.: Materials and ... ...

Abstract	Background: Laparoscopic liver resection (LLR) has gained significant popularity over the last 10 years. First experiences of LLR compared to open liver resection (OLR) reported a similar survival and a better safety profile for LLR. Materials and methods: This is a retrospective analysis of prospectively collected data of all consecutive patients treated by liver resection for HCC on liver cirrhosis between January 2005 and March 2017. The choice of procedure (LLR vs OLR) was generally based on tumor localization, history of previous upper abdominal surgery and patient's preference. The type of resection and indication for surgery were unrelated to the adopted technique. Based on pre-operative variables and confirmed cirrhosis, a 1:1 propensity score matching (PSM) model was developed to compare outcomes of LLR and OLR in patients with HCC. Outcomes of interest included morbidity, mortality and long-term cure potential. Results: After-PSM, the LLR group demonstrated better perioperative results including: lower complication rate (50.7% in OLR vs 29.3% in LLR, p = 0.0035), significantly lower intra-operative blood loss (200 ml in OLR vs 150 ml in LLR, p = 0.007) and shorter hospital length of stay (median 9 days in OLR vs 7 days in LLR, p = 0.0018). Moreover there was no significant difference between the two groups in 3-year survival (76%, CI: 60%-86% in LLR vs 68%, CI: 55%-79% in OLR, p = 0.32) or recurrence-free survival rates (44%, CI: 28%-58%, vs 44%, CI: 31%-57%, p = 0.94). Conclusions: Minor LLR appeared significantly safer compared to minor OLR for HCC. LLR was associated with fewer post-operative complication, lower operative blood loss and a shorter hospital stay along with similar survival and recurrence-free survival rates.
MeSH term(s)	Aged ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Female ; Follow-Up Studies ; Hepatectomy/mortality ; Humans ; Laparoscopy ; Length of Stay ; Liver Cirrhosis/complications ; Liver Cirrhosis/pathology ; Liver Cirrhosis/surgery ; Liver Neoplasms/complications ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Male ; Postoperative Complications ; Prognosis ; Propensity Score ; Prospective Studies ; Retrospective Studies ; Survival Rate
Language	English
Publishing date	2018-10-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1107810-8
ISSN	1879-3320 ; 0960-7404
ISSN (online)	1879-3320
ISSN	0960-7404
DOI	10.1016/j.suronc.2018.10.001
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Article ; Online: 30-Day Morbidity and Mortality of Bariatric Surgery During the COVID-19 Pandemic: a Multinational Cohort Study of 7704 Patients from 42 Countries.

Singhal, Rishi / Ludwig, Christian / Rudge, Gavin / Gkoutos, Georgios V / Tahrani, Abd / Mahawar, Kamal / Pędziwiatr, Michał / Major, Piotr / Zarzycki, Piotr / Pantelis, Athanasios / Lapatsanis, Dimitris P / Stravodimos, Georgios / Matthys, Chris / Focquet, Marc / Vleeschouwers, Wouter / Spaventa, Antonio G / Zerrweck, Carlos / Vitiello, Antonio / Berardi, Giovanna /

Musella, Mario / Sanchez-Meza, Alberto / Cantu, Felipe J / Mora, Fernando / Cantu, Marco A / Katakwar, Abhishek / Reddy, D Nageshwar / Elmaleh, Haitham / Hassan, Mohammad / Elghandour, Abdelrahman / Elbanna, Mohey / Osman, Ahmed / Khan, Athar / Layani, Laurent / Kiran, Nalini / Velikorechin, Andrey / Solovyeva, Maria / Melali, Hamid / Shahabi, Shahab / Agrawal, Ashish / Shrivastava, Apoorv / Sharma, Ankur / Narwaria, Bhavya / Narwaria, Mahendra / Raziel, Asnat / Sakran, Nasser / Susmallian, Sergio / Karagöz, Levent / Akbaba, Murat / Pişkin, Salih Zeki / Balta, Ahmet Ziya / Senol, Zafer / Manno, Emilio / Iovino, Michele Giuseppe / Qassem, Mohamed / Arana-Garza, Sebastián / Povoas, Heitor P / Vilas-Boas, Marcos Leão / Naumann, David / Super, Jonathan / Li, Alan / Ammori, Basil J / Balamoun, Hany / Salman, Mohammed / Nasta, Amrit Manik / Goel, Ramen / Sánchez-Aguilar, Hugo / Herrera, Miguel F / Abou-Mrad, Adel / Cloix, Lucie / Mazzini, Guilherme Silva / Kristem, Leonardo / Lazaro, Andre / Campos, Jose / Bernardo, Joaquín / González, Jesús / Trindade, Carlos / Viveiros, Octávio / Ribeiro, Rui / Goitein, David / Hazzan, David / Segev, Lior / Beck, Tamar / Reyes, Hernán / Monterrubio, Jerónimo / García, Paulina / Benois, Marine / Kassir, Radwan / Contine, Alessandro / Elshafei, Moustafa / Aktas, Sueleyman / Weiner, Sylvia / Heidsieck, Till / Level, Luis / Pinango, Silvia / Ortega, Patricia Martinez / Moncada, Rafael / Valenti, Victor / Vlahović, Ivan / Boras, Zdenko / Liagre, Arnaud / Martini, Francesco / Juglard, Gildas / Motwani, Manish / Saggu, Sukhvinder Singh / Al Moman, Hazem / López, Luis Adolfo Aceves / Cortez, María Angelina Contreras / Zavala, Rodrigo Aceves / D'Haese, Christine / Kempeneers, Ivo / Himpens, Jacques / Lazzati, Andrea / Paolino, Luca / Bathaei, Sarah / Bedirli, Abdulkadir / Yavuz, Aydın / Büyükkasap, Çağrı / Özaydın, Safa / Kwiatkowski, Andrzej / Bartosiak, Katarzyna / Walędziak, Maciej / Santonicola, Antonella / Angrisani, Luigi / Iovino, Paola / Palma, Rossella / Iossa, Angelo / Boru, Cristian Eugeniu / De Angelis, Francesco / Silecchia, Gianfranco / Hussain, Abdulzahra / Balchandra, Srivinasan / Coltell, Izaskun Balciscueta / Pérez, Javier Lorenzo / Bohra, Ashok / Awan, Altaf K / Madhok, Brijesh / Leeder, Paul C / Awad, Sherif / Al-Khyatt, Waleed / Shoma, Ashraf / Elghadban, Hosam / Ghareeb, Sameh / Mathews, Bryan / Kurian, Marina / Larentzakis, Andreas / Vrakopoulou, Gavriella Zoi / Albanopoulos, Konstantinos / Bozdag, Ahemt / Lale, Azmi / Kirkil, Cuneyt / Dincer, Mursid / Bashir, Ahmad / Haddad, Ashraf / Hijleh, Leen Abu / Zilberstein, Bruno / de Marchi, Danilo Dallago / Souza, Willy Petrini / Brodén, Carl Magnus / Gislason, Hjörtur / Shah, Kamran / Ambrosi, Antonio / Pavone, Giovanna / Tartaglia, Nicola / Kona, S Lakshmi Kumari / Kalyan, K / Perez, Cesar Ernesto Guevara / Botero, Miguel Alberto Forero / Covic, Adrian / Timofte, Daniel / Maxim, Madalina / Faraj, Dashti / Tseng, Larissa / Liem, Ronald / Ören, Gürdal / Dilektasli, Evren / Yalcin, Ilker / AlMukhtar, Hudhaifa / Al Hadad, Mohammed / Mohan, Rasmi / Arora, Naresh / Bedi, Digvijaysingh / Rives-Lange, Claire / Chevallier, Jean-Marc / Poghosyan, Tigran / Sebbag, Hugues / Zinaï, Lamia / Khaldi, Saadi / Mauchien, Charles / Mazza, Davide / Dinescu, Georgiana / Rea, Bernardo / Pérez-Galaz, Fernando / Zavala, Luis / Besa, Anais / Curell, Anna / Balibrea, Jose M / Vaz, Carlos / Galindo, Luis / Silva, Nelson / Caballero, José Luis Estrada / Sebastian, Sergio Ortiz / Marchesini, João Caetano Dallegrave / da Fonseca Pereira, Ricardo Arcanjo / Sobottka, Wagner Herbert / Fiolo, Felipe Eduardo / Turchi, Matias / Coelho, Antonio Claudio Jamel / Zacaron, Andre Luis / Barbosa, André / Quinino, Reynaldo / Menaldi, Gabriel / Paleari, Nicolás / Martinez-Duartez, Pedro / de Aragon Ramírez de Esparza, Gabriel Martínez / Esteban, Valentin Sierra / Torres, Antonio / Garcia-Galocha, Jose Luis / Josa, Miguel / Pacheco-Garcia, Jose Manuel / Mayo-Ossorio, Maria Angeles / Chowbey, Pradeep / Soni, Vandana / de Vasconcelos Cunha, Hercio Azevedo / Castilho, Michel Victor / Ferreira, Rafael Meneguzzi Alves / Barreiro, Thiago Alvim / Charalabopoulos, Alexandros / Sdralis, Elias / Davakis, Spyridon / Bomans, Benoit / Dapri, Giovanni / Van Belle, Koenraad / Takieddine, Mazen / Vaneukem, Pol / Karaca, Esma Seda Akalın / Karaca, Fatih Can / Sumer, Aziz / Peksen, Caghan / Savas, Osman Anil / Chousleb, Elias / Elmokayed, Fahad / Fakhereldin, Islam / Aboshanab, Hany Mohamed / Swelium, Talal / Gudal, Ahmad / Gamloo, Lamees / Ugale, Ayushka / Ugale, Surendra / Boeker, Clara / Reetz, Christian / Hakami, Ibrahim Ali / Mall, Julian / Alexandrou, Andreas / Baili, Efstratia / Bodnar, Zsolt / Maleckas, Almantas / Gudaityte, Rita / Guldogan, Cem Emir / Gundogdu, Emre / Ozmen, Mehmet Mahir / Thakkar, Deepti / Dukkipati, Nandakishore / Shah, Poonam Shashank / Shah, Shashank Subhashchandra / Shah, Simran Shashank / Adil, Md Tanveer / Jambulingam, Periyathambi / Mamidanna, Ravikrishna / Whitelaw, Douglas / Jain, Vigyan / Veetil, Deepa Kizhakke / Wadhawan, Randeep / Torres, Max / Tinoco, Tabata / Leclercq, Wouter / Romeijn, Marleen / van de Pas, Kelly / Alkhazraji, Ali K / Taha, Safwan A / Ustun, Murat / Yigit, Taner / Inam, Aatif / Burhanulhaq, Muhammad / Pazouki, Abdolreza / Eghbali, Foolad / Kermansaravi, Mohammad / Jazi, Amir Hosein Davarpanah / Mahmoudieh, Mohsen / Mogharehabed, Neda / Tsiotos, Gregory / Stamou, Konstantinos / Barrera Rodriguez, Francisco J / Rojas Navarro, Marco A / Torres, Omar MOhamed / Martinez, Sergio Lopez / Tamez, Elda Rocio Maltos / Millan Cornejo, Gustavo A / Flores, Jose Eduardo Garcia / Mohammed, Diya Aldeen / Elfawal, Mohamad Hayssam / Shabbir, Asim / Guowei, Kim / So, Jimmy By / Kaplan, Elif Tuğçe / Kaplan, Mehmet / Kaplan, Tuğba / Pham, DangTuan / Rana, Gurteshwar / Kappus, Mojdeh / Gadani, Riddish / Kahitan, Manish / Pokharel, Koshish / Osborne, Alan / Pournaras, Dimitri / Hewes, James / Napolitano, Errichetta / Chiappetta, Sonja / Bottino, Vincenzo / Dorado, Evelyn / Schoettler, Axel / Gaertner, Daniel / Fedtke, Katharina / Aguilar-Espinosa, Francisco / Aceves-Lozano, Saul / Balani, Alessandro / Nagliati, Carlo / Pennisi, Damiano / Rizzi, Andrea / Frattini, Francesco / Foschi, Diego / Benuzzi, Laura / Parikh, Chirag / Shah, Harshil / Pinotti, Enrico / Montuori, Mauro / Borrelli, Vincenzo / Dargent, Jerome / Copaescu, Catalin A / Hutopila, Ionut / Smeu, Bogdan / Witteman, Bart / Hazebroek, Eric / Deden, Laura / Heusschen, Laura / Okkema, Sietske / Aufenacker, Theo / den Hengst, Willem / Vening, Wouter / van der Burgh, Yonta / Ghazal, Ahmad / Ibrahim, Hamza / Niazi, Mourad / Alkhaffaf, Bilal / Altarawni, Mohammad / Cesana, Giovanni Carlo / Anselmino, Marco / Uccelli, Matteo / Olmi, Stefano / Stier, Christine / Akmanlar, Tahsin / Sonnenberg, Thomas / Schieferbein, Uwe / Marcolini, Alejandro / Awruch, Diego / Vicentin, Marco / de Souza Bastos, Eduardo Lemos / Gregorio, Samuel Azenha / Ahuja, Anmol / Mittal, Tarun / Bolckmans, Roel / Wiggins, Tom / Baratte, Clément / Wisnewsky, Judith Aron / Genser, Laurent / Chong, Lynn / Taylor, Lillian / Ward, Salena / Hi, Michael W / Heneghan, Helen / Fearon, Naomi / Plamper, Andreas / Rheinwalt, Karl / Geoghegan, Justin / Ng, Kin Cheung / Kaseja, Krzysztof / Kotowski, Maciej / Samarkandy, Tarig A / Leyva-Alvizo, Adolfo / Corzo-Culebro, Lourdes / Wang, Cunchuan / Yang, Wah / Dong, Zhiyong / Riera, Manel / Jain, Rajesh / Hamed, Hosam / Said, Mohammed / Zarzar, Katia / Garcia, Manuel / Türkçapar, Ahmet Gökhan / Şen, Ozan / Baldini, Edoardo / Conti, Luigi / Wietzycoski, Cacio / Lopes, Eduardo / Pintar, Tadeja / Salobir, Jure / Aydin, Cengiz / Atici, Semra Demirli / Ergin, Anıl / Ciyiltepe, Huseyin / Bozkurt, Mehmet Abdussamet / Kizilkaya, Mehmet Celal / Onalan, Nezihe Berrin Dodur / Zuber, Mariana Nabila Binti Ahmad / Wong, Wei Jin / Garcia, Amador / Vidal, Laura / Beisani, Marc / Pasquier, Jorge / Vilallonga, Ramon / Sharma, Sharad / Parmar, Chetan / Lee, Lyndcie / Sufi, Pratik / Sinan, Hüseyin / Saydam, Mehmet

Obesity surgery

2021 Volume 31, Issue 10, Page(s) 4272–4288

Abstract: Background: There are data on the safety of cancer surgery and the efficacy of preventive strategies on the prevention of postoperative symptomatic COVID-19 in these patients. But there is little such data for any elective surgery. The main objectives ... ...

Abstract	Background: There are data on the safety of cancer surgery and the efficacy of preventive strategies on the prevention of postoperative symptomatic COVID-19 in these patients. But there is little such data for any elective surgery. The main objectives of this study were to examine the safety of bariatric surgery (BS) during the coronavirus disease 2019 (COVID-19) pandemic and to determine the efficacy of perioperative COVID-19 protective strategies on postoperative symptomatic COVID-19 rates. Methods: We conducted an international cohort study to determine all-cause and COVID-19-specific 30-day morbidity and mortality of BS performed between 01/05/2020 and 31/10/2020. Results: Four hundred ninety-nine surgeons from 185 centres in 42 countries provided data on 7704 patients. Elective primary BS (n = 7084) was associated with a 30-day morbidity of 6.76% (n = 479) and a 30-day mortality of 0.14% (n = 10). Emergency BS, revisional BS, insulin-treated type 2 diabetes, and untreated obstructive sleep apnoea were associated with increased complications on multivariable analysis. Forty-three patients developed symptomatic COVID-19 postoperatively, with a higher risk in non-whites. Preoperative self-isolation, preoperative testing for SARS-CoV-2, and surgery in institutions not concurrently treating COVID-19 patients did not reduce the incidence of postoperative COVID-19. Postoperative symptomatic COVID-19 was more likely if the surgery was performed during a COVID-19 peak in that country. Conclusions: BS can be performed safely during the COVID-19 pandemic with appropriate perioperative protocols. There was no relationship between preoperative testing for COVID-19 and self-isolation with symptomatic postoperative COVID-19. The risk of postoperative COVID-19 risk was greater in non-whites or if BS was performed during a local peak.
MeSH term(s)	Bariatric Surgery ; COVID-19 ; COVID-19 Testing ; Cohort Studies ; Diabetes Mellitus, Type 2 ; Humans ; Incidence ; Obesity, Morbid/surgery ; Pandemics ; Postoperative Complications/epidemiology ; SARS-CoV-2
Language	English
Publishing date	2021-07-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-021-05493-9
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