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  1. Article ; Online: A guide to mycetisms: A toxicological and preventive overview.

    Benvenuti, Mirko / Zotti, Mirca / La Maestra, Sebastiano

    Medical mycology

    2024  Volume 62, Issue 4

    Abstract: Fungi are often considered a delicacy and are primarily cultivated and harvested, although numerous species are responsible for intoxication due to toxin content. Foodborne diseases are a significant public health concern, causing approximately 420 000 ... ...

    Abstract Fungi are often considered a delicacy and are primarily cultivated and harvested, although numerous species are responsible for intoxication due to toxin content. Foodborne diseases are a significant public health concern, causing approximately 420 000 deaths and 600 million morbidities yearly, of which mushroom poisoning is one of the leading causes. Epidemiological data on non-cultivated mushroom poisoning in individual countries are often unrepresentative, as intoxication rarely requires emergency intervention. On the other hand, the lack of specialist knowledge among medical personnel about the toxicological manifestations of mushroom consumption may result in ineffective therapeutic interventions. This work aims to provide an easy-to-consult and wide-ranging tool useful for better understanding the variability of mushroom intoxications, the associated symptoms, and the main treatments for the most severe cases, given the absence of a complete species mapping tool toxic. Moreover, we establish an effective collection network that describes the incidence of mushroom poisonings by reporting the species and associated toxicological manifestations for each case. In conclusion, we highlight the need to establish appropriate primary prevention interventions, such as training the affected population and increasing consultancy relationships between mycological experts and specialised healthcare personnel.
    MeSH term(s) Humans ; Mushroom Poisoning/prevention & control ; Mushroom Poisoning/epidemiology ; Agaricales/chemistry
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1421796-x
    ISSN 1460-2709 ; 1369-3786
    ISSN (online) 1460-2709
    ISSN 1369-3786
    DOI 10.1093/mmy/myae033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comet-FISH analysis of urothelial cells. A screening opportunity for bladder cancer?

    La Maestra, Sebastiano / Benvenuti, Mirko / D'Agostini, Francesco / Micale, Rosanna T

    Expert review of molecular diagnostics

    2023  Volume 23, Issue 8, Page(s) 653–663

    Abstract: Introduction: Bladder cancer (BCa) is the most frequent cancer of the urinary tract, with more than 500,000 reported cases and nearly 200,000 related deaths yearly. Cystoscopy is the standard examination used for the initial diagnosis and follow-up of ... ...

    Abstract Introduction: Bladder cancer (BCa) is the most frequent cancer of the urinary tract, with more than 500,000 reported cases and nearly 200,000 related deaths yearly. Cystoscopy is the standard examination used for the initial diagnosis and follow-up of BCa in the noninvasive stage. However, the American Cancer Society does not include BCa screening in its list of recommended cancer screenings.
    Areas covered: Recently, several urine-based bladder tumor markers (UBBTMs) that identify genomic, transcriptomic, epigenetic, or protein alterations have been introduced, some of which have been approved by the Food and Drug Administration (FDA) to improve its diagnosis and surveillance. Several biomarkers have been found in the tissues and blood of individuals with BCa or predisposed to develop the disease, further enriching our information.
    Expert opinion: From a prevention perspective, alkaline Comet-FISH could be a valuable tool with broad potential for clinical application. Furthermore, a comet assay could be more beneficial for diagnosing and monitoring bladder cancer and determining individual susceptibility. Thus, we recommend further studies to understand the potential of this combined assay in the general population as a potential screening test and in patients initiated into the diagnostic process.
    MeSH term(s) Humans ; Comet Assay ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/analysis ; Early Detection of Cancer ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/pathology ; Cystoscopy
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2023-06-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2112530-2
    ISSN 1744-8352 ; 1473-7159
    ISSN (online) 1744-8352
    ISSN 1473-7159
    DOI 10.1080/14737159.2023.2227381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Photoprotective and Anti-Aging Properties of the Apical Frond Extracts from the Mediterranean Seaweed

    Mirata, Serena / Asnaghi, Valentina / Chiantore, Mariachiara / Salis, Annalisa / Benvenuti, Mirko / Damonte, Gianluca / Scarfì, Sonia

    Marine drugs

    2023  Volume 21, Issue 5

    Abstract: There is a growing interest in using brown algal extracts thanks to the bioactive substances they produce for adaptation to the marine benthic environment. We evaluated the anti-aging and photoprotective properties of two types of extracts (50%-ethanol ... ...

    Abstract There is a growing interest in using brown algal extracts thanks to the bioactive substances they produce for adaptation to the marine benthic environment. We evaluated the anti-aging and photoprotective properties of two types of extracts (50%-ethanol and DMSO) obtained from different portions, i.e., apices and thalli, of the brown seaweed,
    MeSH term(s) Seaweed/chemistry ; Polyphenols ; Phaeophyceae/chemistry ; Flavonoids/chemistry ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/chemistry
    Chemical Substances Polyphenols ; Flavonoids ; Antioxidants ; Plant Extracts
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21050306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays.

    Parodi, Alice / Righetti, Giada / Pesce, Emanuela / Salis, Annalisa / Tomati, Valeria / Pastorino, Cristina / Tasso, Bruno / Benvenuti, Mirko / Damonte, Gianluca / Pedemonte, Nicoletta / Cichero, Elena / Millo, Enrico

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 3

    Abstract: Cystic fibrosis (CF) is a genetic disease affecting the lungs and pancreas and causing progressive damage. CF is caused by mutations abolishing the function of CFTR, a protein whose role is chloride's mobilization in the epithelial cells of various ... ...

    Abstract Cystic fibrosis (CF) is a genetic disease affecting the lungs and pancreas and causing progressive damage. CF is caused by mutations abolishing the function of CFTR, a protein whose role is chloride's mobilization in the epithelial cells of various organs. Recently a therapy focused on small molecules has been chosen as a main approach to contrast CF, designing and synthesizing compounds acting as misfolding (correctors) or defective channel gating (potentiators). Multi-drug therapies have been tested with different combinations of the two series of compounds. Previously, we designed and characterized two series of correctors, namely, hybrids, which were conceived including the aminoarylthiazole (AAT) core, merged with the benzodioxole carboxamide moiety featured by VX-809. In this paper, we herein proceeded with molecular modeling studies guiding the design of a new third series of hybrids, featuring structural variations at the thiazole moiety and modifications on position 4. These derivatives were tested in different assays including a YFP functional assay on models F508del-CFTR CFBE41o-cells, alone and in combination with VX-445, and by using electrophysiological techniques on human primary bronchial epithelia to demonstrate their F508del-CFTR corrector ability. This study is aimed (i) at identifying three molecules (
    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15030274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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