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Article ; Online: Periapical Cyst and Odontogenic Remnants on Osseous Mandibulectomy Margins: Two Diagnostic Pitfalls.

Roy, Simon F / Berdugo, Jérémie

International journal of surgical pathology

2020 Volume 28, Issue 5, Page(s) 507–509

Abstract: In this article, we describe 2 high-stake diagnostic pitfalls that occurred in a single patient having undergone partial glossectomy and marginal mandibulectomy for invasive squamous cell carcinoma. Margins were grossly uninvolved. Histopathology showed ... ...

Abstract	In this article, we describe 2 high-stake diagnostic pitfalls that occurred in a single patient having undergone partial glossectomy and marginal mandibulectomy for invasive squamous cell carcinoma. Margins were grossly uninvolved. Histopathology showed a moderately differentiated squamous cell carcinoma. Microscopic evaluation of margins was challenging, as the inferior osseous margin submitted en face showed spongiotic epithelium with mixed chronic and acute inflammation, representing a periapical cyst after correlation with the gross examination. Another section of the osseous margin showed a small non-atypical epithelial nest, consistent with an odontogenic epithelial rest. We wish to raise awareness of these diagnostic pitfalls as a bone margin with such epithelial foci could be misinterpreted as positive, with serious therapeutic consequences.
MeSH term(s)	Aged ; Glossectomy ; Humans ; Male ; Mandibular Osteotomy ; Margins of Excision ; Odontogenic Cysts/pathology ; Radicular Cyst/pathology ; Squamous Cell Carcinoma of Head and Neck/pathology ; Squamous Cell Carcinoma of Head and Neck/surgery ; Tongue Neoplasms/pathology ; Tongue Neoplasms/surgery
Language	English
Publishing date	2020-02-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1336393-1
ISSN	1940-2465 ; 1066-8969
ISSN (online)	1940-2465
ISSN	1066-8969
DOI	10.1177/1066896920905085
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Article: 59 The positive effect of the use of recombinant equine chorionic gonadotrophin for ovarian stimulation for

Bandeo, A / Konrad, J L / Berdugo, J / Ibaña, P / Vallejos, N / Maldonado Vargas, P / Crudeli, G

Reproduction, fertility, and development

2022 Volume 34, Issue 2, Page(s) 265

Language	English
Publishing date	2022-03-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1019913-5
ISSN	1448-5990 ; 1031-3613
ISSN (online)	1448-5990
ISSN	1031-3613
DOI	10.1071/RDv34n2Ab59
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Article ; Online: Locoregionally Advanced, BRAF V600L-Positive, Mucosal Melanoma of the Hypopharynx Treated With a Combination of

Lampasona, Giovanni / Noujaim, Jonathan / Gologan, Olga / Berdugo, Jeremie / Maniakas, Anastasios

JCO precision oncology

2022 Volume 6, Page(s) e2100561

MeSH term(s)	Humans ; Hypopharynx ; Melanoma/drug therapy ; Mitogen-Activated Protein Kinase Kinases ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins B-raf/genetics
Chemical Substances	Protein Kinase Inhibitors ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2)
Language	English
Publishing date	2022-06-16
Publishing country	United States
Document type	Journal Article
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.21.00561
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Article ; Online: RB1, p16, and Human Papillomavirus in Oropharyngeal Squamous Cell Carcinoma.

Berdugo, Jérémie / Rooper, Lisa M / Chiosea, Simion I

Head and neck pathology

2021 Volume 15, Issue 4, Page(s) 1109–1118

Abstract: While P16 immunohistochemistry (IHC) is a well-established surrogate marker of Human Papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (OSCC), Retinoblastoma 1 (RB1) loss may lead to p16 overexpression in the absence of HPV. We determined the ...

Abstract	While P16 immunohistochemistry (IHC) is a well-established surrogate marker of Human Papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (OSCC), Retinoblastoma 1 (RB1) loss may lead to p16 overexpression in the absence of HPV. We determined the proportion of p16-positive/HPV-negative OSCC with RB1 loss and other alterations in RB1/p16 pathway, and tested RB1 IHC as a prognostic biomarker for OSCC, along with the 8th edition of AJCC staging manual. P16 and RB1 IHC and HPV DNA in situ hybridization (ISH) were performed on 257 OSCC. High risk HPV RNA ISH, RB1 fluorescence in situ hybridization (FISH), and next generation sequencing (NGS) were done on p16-positive/HPV DNA ISH-negative OSCC. Disease free survival (DFS) was used as an endpoint. In the entire cohort and in p16-positive (n = 184) and p16-negative (n = 73) subgroups, AJCC 8th edition staging correlated with DFS (p < 0.01). RB1 IHC showed RB1 loss in p16-positive OSCC only (79/184, 43%). RB1 loss by IHC is associated with a better DFS, without providing additional prognostic information for patients with p16-positive OSCC. HPV RNA ISH was positive in 12 of 14 HPV DNA ISH-negative cases. RB1 IHC showed loss in 10 of 15 HPV DNA ISH-negative cases and in 1 of 2 HPV RNA ISH-negative cases. Overall, only one case of p16-positive/HPV RNA ISH-negative OSCC showed RB1 loss by IHC (1/184, 0.5%). Of the 10 p16-positive and HPV DNA ISH-negative cases with RB1 loss by IHC, 2 had RB1 hemizygous deletion and 3 showed Chromosome 13 monosomy by FISH. No RB1 mutations were detected by NGS. Other molecular alterations in p16-positive/HPV DNA ISH-negative cases included TP53 and TERT mutations and DDX3X loss. HPV-independent RB1 inactivation rarely results in false positive p16 IHC. RB1 inactivation by high risk HPV E7 oncoprotein may co-exist with RB1 deletion. RB1 loss is a favorable prognosticator and occurs exclusively in p16-positive OSCC. The 8th edition of the AJCC staging manual satisfactorily predicts DFS of OSCC patients.
MeSH term(s)	Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/virology ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; DNA, Viral/genetics ; Disease-Free Survival ; E2F1 Transcription Factor/genetics ; Female ; Genome, Viral ; High-Throughput Nucleotide Sequencing ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Middle Aged ; Oropharyngeal Neoplasms/mortality ; Oropharyngeal Neoplasms/pathology ; Oropharyngeal Neoplasms/virology ; Papillomaviridae/genetics ; RNA, Viral/genetics
Chemical Substances	CDKN2A protein, human ; Cyclin-Dependent Kinase Inhibitor p16 ; DNA, Viral ; E2F1 Transcription Factor ; RNA, Viral
Language	English
Publishing date	2021-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2407834-7
ISSN	1936-0568 ; 1936-055X
ISSN (online)	1936-0568
ISSN	1936-055X
DOI	10.1007/s12105-021-01317-5
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Article: Esophagitis as a complication of the combination of lenvatinib and pembrolizumab for advanced endometrial cancer: A case report.

Fellouah, Massine / Auclair, Marie-Hélène / Fortin, Suzanne / Berdugo, Jérémie / de Guerké, Lara

Gynecologic oncology reports

2023 Volume 49, Page(s) 101235

Abstract: Background: Pembrolizumab is a monoclonal antibody targeting the programmed cell death protein 1 (PD-1). It is used in the management and treatment of various oncologic conditions. To name a few: refractory and advanced melanoma, non-small cell lung ... ...

Abstract	Background: Pembrolizumab is a monoclonal antibody targeting the programmed cell death protein 1 (PD-1). It is used in the management and treatment of various oncologic conditions. To name a few: refractory and advanced melanoma, non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), renal cell carcinoma and gastric cancer. It is also approved for metastatic mismatch repair deficient (dMMR) endometrial carcinoma after failure of front-line chemotherapy. Lenvatinib is an oral multikinase inhibitor that targets vascular endothelial growth factor receptors 1-3, fibroblast growth factor receptors 1-4, platelet-derived growth factor receptor-a, RET, and KIT. The combination of lenvatinib and pembrolizumab has proven to be more effective together than as monotherapy. Here, we present the case of a patient who probably developed lenvatinib-related esophagitis, a complication not previously described in the literature to our knowledge.Case presentation.We describe a 65 years old female with metastatic endometrial cancer who presented dysphagia after a few months of lenvatinib plus pembrolizumab treatment. Upper endoscopy results revealed a very fragile upper esophageal mucosa with mucosal lacerations, consistent with grade 2 esophagitis. The biopsy showed esophagitis with mixed lymphocytic and eosinophilic inflammation and apoptotic component. Pembrolizumab was then stopped pending the results of the biopsy, following the recommendations of the gastroenterologist. Dysphagia, however, remained unchanged. In the meantime, the lenvatinib had to be stopped due to a dental procedure, and the patient noted a marked improvement in her symptoms. After discussion with the gastroenterologist, pembrolizumab was resumed and lenvatinib was suspended. The patient was also started on a PPI twice daily since the first digestive exploration. 1 month later, upper endoscopy showed complete recovery, the patient's symptoms improved, and lenvatinib was resumed. However, symptoms of dysphagia resumed a few days later. Lenvatinib was finally resumed at a reduced dose without reappearance in her symptoms. Conclusions: We present a case of oesophagitis as a likely complication of lenvatinib for advanced endometrial cancer. The initiation of PPI and dose reduction of the lenvatinib allowed the patient to successfully go back on treatment.
Language	English
Publishing date	2023-06-28
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2818505-5
ISSN	2352-5789
ISSN	2352-5789
DOI	10.1016/j.gore.2023.101235
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Article ; Online: Epstein-Barr Virus-Associated Lymphoepithelial Carcinoma Arising in a Salivary Sebaceous Lymphadenoma.

Wong, Jahg / Gologan, Olga / Ahmad, Khouloud / Seethala, Raja R / Berdugo, Jérémie

Head and neck pathology

2023 Volume 17, Issue 3, Page(s) 871–876

Abstract: Background: Lymphadenomas are rare benign tumors of the major salivary glands that are further classified as sebaceous and non-sebaceous. No association with viruses has been reported so far. Little is known about the mechanisms that allow lymphadenomas ...

Abstract	Background: Lymphadenomas are rare benign tumors of the major salivary glands that are further classified as sebaceous and non-sebaceous. No association with viruses has been reported so far. Little is known about the mechanisms that allow lymphadenomas to undergo malignant transformation. Among these rare instances, there has never been a malignant transformation to Epstein-Barr virus (EBV)-associated lymphoepithelial carcinoma. Methods: Clinical data of the reported case were retrieved from the patient's electronic medical record. Hematoxylin & eosin-stained slides, immunohistochemical tests, and in situ hybridization performed for routine diagnostic purposes were reviewed. Results: We report a salivary gland sebaceous lymphadenoma in which the luminal components were mostly replaced by malignant epithelial cells with markedly atypical nuclear features. Presence of EBV was demonstrated in all components by EBER. The morphological and immunohistochemical findings were consistent with a lymphoepithelial carcinoma arising from a sebaceous lymphadenoma. Conclusion: We report the first case of an Epstein-Barr virus-associated lymphoepithelial carcinoma arising from a sebaceous lymphadenoma.
MeSH term(s)	Humans ; Herpesvirus 4, Human/genetics ; Epstein-Barr Virus Infections/complications ; Carcinoma, Squamous Cell/pathology ; Salivary Gland Neoplasms/pathology ; In Situ Hybridization ; Parotid Neoplasms/pathology
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2407834-7
ISSN	1936-0568 ; 1936-055X
ISSN (online)	1936-0568
ISSN	1936-055X
DOI	10.1007/s12105-023-01546-w
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Article ; Online: Learning curve for completely thoracoscopic anatomic sublobar resection.

Rakovich, George / Belahmira, Ghizlane / Woodall, William H / Berdugo, Jeremie

Minerva surgery

2021 Volume 77, Issue 2, Page(s) 101–108

Abstract: Background: Minimally invasive anatomic sublobar resection is increasingly being considered as an alternative to lobectomy in selected cases. However, this remains a technically challenging procedure and only 5 studies evaluating learning curves have ... ...

Abstract	Background: Minimally invasive anatomic sublobar resection is increasingly being considered as an alternative to lobectomy in selected cases. However, this remains a technically challenging procedure and only 5 studies evaluating learning curves have been published to date. The aim of this study was to evaluate a single surgeon's learning curve for completely thoracoscopic anatomic sublobar resection. Methods: A retrospective review was conducted of all thoracoscopic anatomic sublobar resections by one surgeon proficient in VATS lobectomy between January 2015 and January 2020. The primary outcome was operative time. Secondary outcomes were perioperative complications, duration of chest tube drainage and length of stay. Results: There were 67 thoracoscopic anatomic sublobar resections performed in 66 patients. A Time-series plot and Cumulative Sum analysis of operative times showed a drop off after case 32, suggesting achievement of competency. After case 32, mean operative times were decreased (128.59±32.42 min. vs. 153.63±40.16 min, P=0.013) and there was a trend toward decreased blood loss (124.26±76.0 vs. 175.0±141.99 mL, P=0.073). A percentage 13.6% of patients had postoperative complications other than air leak and 88,9% of these were Clavien-Dindo class 1-2; postoperative complications were evenly distributed before and after case 32. Cumlulative Sum curves for the duration of chest tube drainage and length of stay did not show any significant change during the study period. Conclusions: This study suggests that for a surgeon proficient in VATS lobectomy, competency in completely thoracoscopic anatomic sublobar resection can be achieved after 32 cases and can be accomplished in a way that does not compromise perioperative outcomes.
MeSH term(s)	Humans ; Learning Curve ; Lung Neoplasms/complications ; Pneumonectomy/adverse effects ; Postoperative Complications/etiology ; Thoracic Surgery, Video-Assisted/adverse effects ; Treatment Outcome
Language	English
Publishing date	2021-08-02
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3067899-7
ISSN	2724-5438
ISSN (online)	2724-5438
DOI	10.23736/S2724-5691.21.08895-X
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Article ; Online: Real-World Experience with a Human Fibrinogen Concentrate: Clinical Data from Adult and Pediatric Patients Requiring Fibrinogen for Bleeding Control and Prevention.

Stéphan, Francois / Gutermann, Loriane / Bourget, Stéphanie / Djabarouti, Sarah / Berdugo, Johanna / Fardini, Yann / Clerson, Pierre / Hébert, Guillaume / Belmokhtar, Chafké

Journal of clinical pharmacology

2023 Volume 63, Issue 11, Page(s) 1186–1196

Abstract: Human fibrinogen concentrate (Fibryga) received temporary approval for fibrinogen replacement therapy in France (2017), with subsequent full approval for congenital and acquired hypofibrinogenemia. We evaluated real-world use for on-demand treatment of ... ...

Abstract	Human fibrinogen concentrate (Fibryga) received temporary approval for fibrinogen replacement therapy in France (2017), with subsequent full approval for congenital and acquired hypofibrinogenemia. We evaluated real-world use for on-demand treatment of bleeding and prophylaxis to enhance our knowledge on fibrinogen concentrate as an option for fibrinogen replacement. Data were retrospectively collected from adult and pediatric patients with fibrinogen deficiency. The primary end point was indication for fibrinogen concentrate use; the secondary end point was treatment success for on-demand treatment/perioperative prophylaxis. The study included 150 adult (median age, 62 years; range, 18-94 years) and 50 pediatric (median age, 3 years; range, 0.01-17 years) patients with acquired fibrinogen deficiency. Fibrinogen concentrate was administered to 47.3% for nonsurgical bleeding, 22.7% for surgical bleeding, and 30.0% for perioperative prophylaxis in adult patients, and to 4.0% for surgical bleeding and 96.0% for perioperative prophylaxis in pediatric patients. Cardiac surgeries accounted for 79.5%/75.0% perioperative prophylaxis and 82.4%/100.0% surgical bleeding cases in adult/pediatric patients, respectively. The mean ± standard deviation (SD, median) total fibrinogen doses were 3.06 ± 1.69 g (32.61 mg/kg), 2.09 ± 1.36 g (22.99 mg/kg), and 2.36 ± 1.25 g (29.67 mg/kg) for adult nonsurgical bleeding, surgical bleeding, and perioperative prophylaxis, respectively; doses of 0.75 ± 0.35 g (47.64 mg/kg) and 0.83 ± 0.62 g (55.56 mg/kg) were used for pediatric surgical bleeding and perioperative prophylaxis, respectively. Treatment success was 85.7%/97.1/93.3% in adults and 50.0%/87.5% in pediatrics for nonsurgical bleeding (adults only), surgical bleeding, and perioperative prophylaxis, respectively. Fibrinogen concentrate demonstrated favorable effectiveness and safety across the age groups. This study contributes to evidence supporting fibrinogen concentrate for bleeding control/prevention in real-world clinical practice, particularly for patients with acquired fibrinogen deficiency.
Language	English
Publishing date	2023-07-30
Publishing country	England
Document type	Journal Article
ZDB-ID	188980-1
ISSN	1552-4604 ; 0091-2700 ; 0021-9754
ISSN (online)	1552-4604
ISSN	0091-2700 ; 0021-9754
DOI	10.1002/jcph.2291
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Article ; Online: Sebaceous Epithelial-Myoepithelial Carcinoma With Aggressive Behavior and Evidence of Preexisting Pleomorphic Adenoma.

Ngo, Marie-Hélène / Krishnan, Vimal / Piché, Jean / Berdugo, Jérémie

International journal of surgical pathology

2020 Volume 29, Issue 5, Page(s) 524–528

Abstract: Epithelial-myoepithelial carcinoma (EMCA) is a rare low-grade carcinoma of the salivary glands with multiple morphological variants. One such variant, sebaceous EMCA (SEMCA), has been reported in the literature. Distinguishing it from other tumors such ... ...

Abstract	Epithelial-myoepithelial carcinoma (EMCA) is a rare low-grade carcinoma of the salivary glands with multiple morphological variants. One such variant, sebaceous EMCA (SEMCA), has been reported in the literature. Distinguishing it from other tumors such as sebaceous carcinoma is crucial, as SEMCA typically behaves more indolently. We present a case of a SEMCA in the right parotid of a 71-year-old man that shows features of aggressive behavior such as facial nerve invasion and extraparenchymal extension. Also, we report evidence of preexisting pleomorphic adenoma within this tumor.
MeSH term(s)	Adenocarcinoma, Sebaceous/diagnosis ; Adenocarcinoma, Sebaceous/pathology ; Adenocarcinoma, Sebaceous/surgery ; Adenoma, Pleomorphic/diagnosis ; Adenoma, Pleomorphic/pathology ; Adenoma, Pleomorphic/surgery ; Aged ; Humans ; Male ; Neoplasms, Complex and Mixed/diagnosis ; Neoplasms, Complex and Mixed/pathology ; Neoplasms, Complex and Mixed/surgery ; Parotid Gland/diagnostic imaging ; Parotid Gland/pathology ; Parotid Gland/surgery ; Parotid Neoplasms/diagnosis ; Parotid Neoplasms/pathology ; Parotid Neoplasms/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2020-12-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1336393-1
ISSN	1940-2465 ; 1066-8969
ISSN (online)	1940-2465
ISSN	1066-8969
DOI	10.1177/1066896920980804
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Article: 11 Effect of breed type on production of bovine embryos: Experience in Paraguay

Arreseigor, C / Arza-Spinzi, F / Sanchez, P / Berdugo, J. A / Konrad, J. L / Maldondo-Vargas, P

Reproduction, fertility, and development. 2021, v. 33, no. 2

2021

Abstract: One of the parameters that has the most influence on invitro embryo production programs is the number of oocytes obtained in each follicular aspiration session (ovum pickup; OPU). A significant impact of the breed of the donor on this parameter has been ... ...

Abstract	One of the parameters that has the most influence on invitro embryo production programs is the number of oocytes obtained in each follicular aspiration session (ovum pickup; OPU). A significant impact of the breed of the donor on this parameter has been reported. The objective of this work was to compare the parameters of an invitro embryo production program of cows of different breeds in Paraguay. A total of 4811 OPU sessions were performed between 2016 and 2019 in cows classified according to breed and type. Beef-type breeds: Nelore (Bos indicus): n=1569; Aberdeen Angus (Bos taurus): n=1276; and Brangus (Cross): n=182 OPU, and Gyr (Bos indicus): n=1086; dairy breeds: Holstein (Bos taurus): n=401, and Girolando (Cross): n=297. The oocytes were aspirated and transported to the same laboratory located in Asunción, Paraguay. The invitro embryo production protocol was similar in all types. Bull semen tested for IVF was used. The number of oocytes, percentage viability, and percentage embryo production were evaluated. Additionally, the mean and standard deviation of the variables were calculated to show the efficiency of the processes, according to the production aptitude of the donors (meat or milk) and the breed type (Bos indicus, Bos taurus, or crosses). Continuous data were analysed with ANOVA and Tukey’s post hoc comparisons. Categorical data were analysed using Chi-squared at a significance level of 0.05. In this work, the production aptitude had no significant effect over the studied variables. However, some significant differences were found considering the breed type of the oocyte donor cow, as shown in Table 1. When crosses with the pure breeds are compared with their crosses, we found that Brangus produced more pregnancies and a greater number of oocytes/OPU compared with Angus (P<0.05). When the same comparison was made between Girolando and Holstein, no significant differences were found. The results show that Bos indicus breeds and their crosses have a greater capacity to produce more oocytes and embryos and that Bos indicus and crossbreeds were more efficient in producing pregnancies (2-fold) per OPU session than Bos taurus breeds. Additionally, crossing with meat indicus breeds generates better quality embryos and increases efficiency in the system of embryo production. Table 1. Comparison of embryo production parameters Item Breed type Bos indicus Cross Bos taurus Oocytes/OPU (mean±SD) 29.8±2.7a 26.3±7.8a 14.6±1.4b Viable oocytes, % 64.7±3a 64.6±3.4a 60.1±3.1a Embryo produced/OPU, % 35.2±4.7a 32.8±9.4a 26.2±4a Embryo/OPU 6.9±1.7a 5.4±1.7a 2.3±0.4b Pregnancy rate, % 29.6±5.5a 33.1±6.3a 25.3±5a Pregnancies/OPU 2.1±0.9a 1.9±1a 0.6±0.2b a,bValues within a row different letters differ (P<0.05).
Keywords	Angus ; Brangus ; Girolando ; Holstein ; Nellore ; cows ; meat ; milk ; oocytes ; pregnancy rate ; semen ; standard deviation ; viability ; zebu ; Paraguay
Language	English
Size	p. 113.
Publishing place	CSIRO Publishing
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1019913-5
ISSN	1448-5990 ; 1031-3613
ISSN (online)	1448-5990
ISSN	1031-3613
DOI	10.1071/RDv33n2Ab11
Database	NAL-Catalogue (AGRICOLA)

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