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  1. Book ; Online: Solidarische Mittelvergabe

    Rodatz, Christoph / Atzpodien, Uta / Berens, Christian / Brohn, Sebastian / Bründl, Anna / Hera, M Hasan / Kotzerke, Moritz

    Neue Perspektiven für die Zusammenarbeit in der freien Kunstszene

    (Public Interest Design)

    2023  

    Series title Public Interest Design
    Keywords Theatre management ; Management & management techniques ; Central government policies ; Solidarität ; Fördermittel ; Förderung ; Fördermittelvergabe ; Juryverfahren ; Kunst ; Freie Kunst ; Darstellende Kunst ; Kultur ; Geld ; Prekarisierung ; Kunstförderung ; Theater ; Kulturmanagement ; Theatermanagement ; Kulturpolitik ; Zivilgesellschaft ; Solidarity ; Subsidies ; Promotion ; Funding ; Jury Procedure ; Art ; Free Art ; Performing Arts ; Culture ; Money ; Precarity ; Art Promotion ; Theatre ; Cultural Management ; Theatre Management ; Cultural Policy ; Civil Society
    Language German
    Size 1 electronic resource (284 pages)
    Publisher transcript Verlag
    Publishing place Bielefeld
    Document type Book ; Online
    Note German
    HBZ-ID HT030381737
    ISBN 9783837668520 ; 3837668525
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Chronic inflammation in conditions associated with a deficient clearance of dying and dead cells, their remnants, and intracellular constituents

    Herrmann, Martin / Gaipl, Udo S. / Lauber, Kirsten / Berens, Christian / Munoz, Luis Enrique

    2015  

    Abstract: In multicellular organisms, states with a high degree of tissue turnover like embryogenesis, development, and adult tissue homeostasis need an instantaneous, tightly regulated and immunologically silent clearance of these dying cells to ensure ... ...

    Abstract In multicellular organisms, states with a high degree of tissue turnover like embryogenesis, development, and adult tissue homeostasis need an instantaneous, tightly regulated and immunologically silent clearance of these dying cells to ensure appropriate development of the embryo and adult tissue remodelling. The proper and swift clearance of apoptotic cells is essential to prevent cellular leakage of damage associated molecular patterns (DAMPs) which would lead to the stimulation of inflammatory cytokine responses. In addition to the clearance of apoptotic cells (efferocytosis), backup mechanisms are required to cope with DAMPs (HMGB-1, DNA, RNA, S100 molecules, ATP and adenosine) and other intracellular material (uric acid, intracellular proteins and their aggregates) released from cells, that were not properly cleared and have entered the stage of secondary necrosis. Furthermore, under certain pathologic conditions (e.g.-

    gout, cancer, diabetes) non-apoptotic cell death may transiently occur (NETosis, necroptosis, pyroptosis) which generates material that also has to be cleared to avoid overloading tissues with non-functional cellular waste. Efficient efferocytosis is therefore indispensable for normal tissue turnover and homeostasis. The characterization of various signalling pathways that regulate this complex and evolutionary conserved process has shed light on new pathogenetic mechanisms of many diseases. Impaired clearance promotes initiation of autoimmunity as well as the perpetuation of chronic inflammation, but may also foster anti-tumor immunity under certain microenvironmental conditions. Immunological tolerance is continuously being challenged by the presence of post-apoptotic remnants in peripheral lymphoid tissues. Besides the autoimmune phenotype of chronic inflammatory rheumatoid disorders a plethora of pathologies have been associated with defects in genes involved in clearance, e.g.-

    atherosclerosis, cancer, gout, diabetes, some forms of blindness, neuropathy, schizophrenia and Alzheimer's disease. The main goal of this research topic is to collect contributions from various disciplines committed to studying pathogenetic mechanisms of the aforementioned disorders and dealing with alterations in the clearance of dying and dead cells, their remnants, and their constituents that leak out after membrane rupture. Integrating the combined collection of knowledge on efferocytosis and clearance of dead cells and their derived waste from different fields of research in physiology and pathophysiology could improve the molecular understanding of these increasingly prevalent diseases and may ultimately result in new therapeutic strategies
    Keywords Medicine (General) ; Immunologic diseases. Allergy
    Size 1 electronic resource (73 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020091796
    ISBN 9782889196012 ; 2889196011
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Thesis: Identifizierung und Charakterisierung von Aminosäureabschnitten des Tn10-kodierten Tet-Repressors, die für Dimerisierung, DNA-Bindung und Induktion durch Tetracyclin wichtig sind

    Berens, Christian

    1994  

    Author's details vorgelegt von Christian Berens
    Keywords Genexpression ; Vektor ; Escherichia coli ; Transposon Tn 10 ; Tetracyclinrepressor
    Subject Tet-Repressor ; Tetracyclin-Repressor ; Colibakterium ; Kolibakterium ; E. coli ; Vektor-DNS ; Genetischer Vektor ; Klonierungsvektor ; Vektor-DNA
    Language German
    Size IV, 107 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Diss., 1994
    HBZ-ID HT006632999
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    95 D 3005 order for loan Magazin

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  4. Article ; Online: Shigatoxin-bildende Escherichia coli [(STEC, syn. Verotoxin-bildende E. coli (VTEC)] ; Shiga toxin-producing E. coli (Vero toxin-producing E. coli)

    Berens, Christian / Barth, Stefanie / Menge, Christian

    2023  

    Keywords Text ; ddc:630 ; FLI-Information -- Tiergesundheit -- Jahresbericht -- Shigatoxin-bildende Escherichia coli -- STEC -- Verotoxin-bildende Escherichia coli -- VTEC -- Deutschland
    Language German
    Publishing date 2023-12-21
    Publisher Friedrich-Loeffler-Inst.
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article: Comparative Genomic Analysis of Antimicrobial-Resistant

    González-Santamarina, Belén / Weber, Michael / Menge, Christian / Berens, Christian

    Microorganisms

    2022  Volume 10, Issue 9

    Abstract: South American camelids (SAC) are increasingly kept in Europe in close contact with humans and other livestock species and can potentially contribute to transmission chains of epizootic, zoonotic and antimicrobial-resistant (AMR) agents from and to ... ...

    Abstract South American camelids (SAC) are increasingly kept in Europe in close contact with humans and other livestock species and can potentially contribute to transmission chains of epizootic, zoonotic and antimicrobial-resistant (AMR) agents from and to livestock and humans. Consequently, SAC were included as livestock species in the new European Animal Health Law. However, the knowledge on bacteria exhibiting AMR in SAC is too scarce to draft appropriate monitoring and preventive programs. During a survey of SAC holdings in central Germany, 39
    Language English
    Publishing date 2022-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10091697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Audio / Video ; Online: Identifying persistent quinolone and cephalosporin resistant Escherichia coli strains along the pork production chain in Thuringian pigsties

    Pfeifer, Nicola / Weber, Michael / Barth, Stefanie / Berens, Christian / Menge, Christian

    2023  

    Keywords Text ; ddc:630
    Language English
    Publishing date 2023-05-23
    Publishing country de
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Online: Supplementary material Comparative Genomic Analysis of Antimicrobial-Resistant Escherichia coli from South American Camelids in Central Germany

    González-Santamarina, Belén / Weber, Michael / Menge, Christian / Berens, Christian

    2023  

    Keywords Text ; ddc:570 ; escherichia coli ; genomics
    Language English
    Publishing date 2023-06-14
    Publisher Zenodo
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Comparative Genomic Analysis of Antimicrobial-Resistant Escherichia coli from South American Camelids in Central Germany

    González-Santamarina, Belén / Weber, Michael / Menge, Christian / Berens, Christian

    Microorganisms. 2022 Aug. 24, v. 10, no. 9

    2022  

    Abstract: South American camelids (SAC) are increasingly kept in Europe in close contact with humans and other livestock species and can potentially contribute to transmission chains of epizootic, zoonotic and antimicrobial-resistant (AMR) agents from and to ... ...

    Abstract South American camelids (SAC) are increasingly kept in Europe in close contact with humans and other livestock species and can potentially contribute to transmission chains of epizootic, zoonotic and antimicrobial-resistant (AMR) agents from and to livestock and humans. Consequently, SAC were included as livestock species in the new European Animal Health Law. However, the knowledge on bacteria exhibiting AMR in SAC is too scarce to draft appropriate monitoring and preventive programs. During a survey of SAC holdings in central Germany, 39 Escherichia coli strains were isolated from composite fecal samples by selecting for cephalosporin or fluoroquinolone resistance and were here subjected to whole-genome sequencing. The data were bioinformatically analyzed for strain phylogeny, detection of pathovars, AMR genes and plasmids. Most (33/39) strains belonged to phylogroups A and B1. Still, the isolates were highly diverse, as evidenced by 28 multi-locus sequence types. More than half of the isolates (23/39) were genotypically classified as multidrug resistant. Genes mediating resistance to trimethoprim/sulfonamides (22/39), aminoglycosides (20/39) and tetracyclines (18/39) were frequent. The most common extended-spectrum-β-lactamase gene was blaCTX₋M₋₁ (16/39). One strain was classified as enteropathogenic E. coli. The positive results indicate the need to include AMR bacteria in yet-to-be-established animal disease surveillance protocols for SAC.
    Keywords Camelidae ; aminoglycosides ; animal health ; antibiotic resistance ; cephalosporins ; disease surveillance ; enteropathogenic Escherichia coli ; epizootic diseases ; fluoroquinolones ; genes ; genomics ; livestock ; multilocus sequence typing ; multiple drug resistance ; pathovars ; phylogeny ; plasmids ; surveys ; trimethoprim ; Germany
    Language English
    Dates of publication 2022-0824
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10091697
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Shigatoxin-bildende Escherichia coli [(STEC, syn. Verotoxin-bildende E. coli (VTEC)] ; Shiga toxin-producing E. coli (Vero toxin-producing E. coli)

    Barth, Stefanie / Berens, Christian / Menge, Christian

    2022  

    Keywords Text ; ddc:630 ; Tiergesundheit -- Jahresbericht -- Shigatoxin-bildende Escherichia coli -- STEC -- Verotoxin-bildende Escherichia coli -- VTEC -- Deutschland
    Language German
    Publishing date 2022-12-22
    Publisher Friedrich-Loeffler-Inst.
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: Shiga Toxin-Producing E. coli in Animals: Detection, Characterization, and Virulence Assessment.

    Barth, Stefanie A / Bauerfeind, Rolf / Berens, Christian / Menge, Christian

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2291, Page(s) 19–86

    Abstract: Cattle and other ruminants are primary reservoirs for Shiga toxin-producing Escherichia coli (STEC) strains which have a highly variable, but unpredictable, pathogenic potential for humans. Domestic swine can carry and shed STEC, but only STEC strains ... ...

    Abstract Cattle and other ruminants are primary reservoirs for Shiga toxin-producing Escherichia coli (STEC) strains which have a highly variable, but unpredictable, pathogenic potential for humans. Domestic swine can carry and shed STEC, but only STEC strains producing the Shiga toxin (Stx) 2e variant and causing edema disease in piglets are considered pathogens of veterinary medical interest. In this chapter, we present general diagnostic workflows for sampling livestock animals to assess STEC prevalence, magnitude, and duration of host colonization. This is followed by detailed method protocols for STEC detection and typing at genetic and phenotypic levels to assess the relative virulence exerted by the strains.
    MeSH term(s) Animals ; Cattle ; Cattle Diseases/diagnosis ; Cattle Diseases/metabolism ; Cattle Diseases/microbiology ; Escherichia coli Infections/diagnosis ; Escherichia coli Infections/metabolism ; Escherichia coli Infections/microbiology ; Escherichia coli Infections/veterinary ; Shiga Toxin 2/metabolism ; Shiga-Toxigenic Escherichia coli/classification ; Shiga-Toxigenic Escherichia coli/isolation & purification ; Shiga-Toxigenic Escherichia coli/metabolism ; Shiga-Toxigenic Escherichia coli/pathogenicity ; Swine ; Swine Diseases/diagnosis ; Swine Diseases/metabolism ; Swine Diseases/microbiology
    Chemical Substances Shiga Toxin 2
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1339-9_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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