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  1. Article: Phage therapy in lung infections caused by multidrug-resistant Pseudomonas aeruginosa - A literature review.

    Eiselt, Vincent A / Bereswill, Stefan / Heimesaat, Markus M

    European journal of microbiology & immunology

    2024  Volume 14, Issue 1, Page(s) 1–12

    Abstract: Pulmonary infections of patients with cystic fibrosis (CF) or in intensive care units are frequently caused by the Gram-negative opportunistic pathogen Pseudomonas aeruginosa. Since these bacteria are commonly inherently multidrug-resistant (MDR) and ... ...

    Abstract Pulmonary infections of patients with cystic fibrosis (CF) or in intensive care units are frequently caused by the Gram-negative opportunistic pathogen Pseudomonas aeruginosa. Since these bacteria are commonly inherently multidrug-resistant (MDR) and hence, antibiotic treatment options are limited, bacteriophages may provide alternative therapeutic and prophylactic measures in the combat of pneumonia caused by P. aeruginosa. This prompted us to perform a comprehensive literature survey of current knowledge regarding effects of phages applied against pulmonary P. aeruginosa infections. The included 23 studies revealed that P. aeruginosa specific phages lyse and eliminate the bacteria even in case of biofilm production in vitro, whereas application to mice and men resulted in mitigated P. aeruginosa induced clinical signs and enhanced survival. Besides distinct host immune responses, no major adverse effects limiting therapeutic and/or prophylactic phage application were noted. However, the immune system and antibiotics generate synergies with phages due to the mutable sensitivity of P. aeruginosa. In conclusion, results summarized in this review provide evidence that phages constitute promising alternative treatment options for lung infections caused by MDR P. aeruginosa. Further studies are needed, however, to underscore the efficacy and safety aspects of phages application to infected patients including immune-compromised individuals.
    Language English
    Publishing date 2024-01-23
    Publishing country Hungary
    Document type Journal Article ; Review
    ZDB-ID 2652327-9
    ISSN 2062-8633 ; 2062-509X
    ISSN (online) 2062-8633
    ISSN 2062-509X
    DOI 10.1556/1886.2023.00060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Phage therapy in prosthetic joint infections caused by Staphylococcus aureus - A literature review.

    Eiselt, Vincent A / Bereswill, Stefan / Heimesaat, Markus M

    European journal of microbiology & immunology

    2024  Volume 14, Issue 2, Page(s) 75–85

    Abstract: Prosthetic joint infections (PJIs) are dreaded arthroplasty complications often caused by Staphylococcus aureus. Due to methicillin-resistant S. aureus (MRSA) strains or biofilm formation, successful treatment remains difficult. Currently, two-stage ... ...

    Abstract Prosthetic joint infections (PJIs) are dreaded arthroplasty complications often caused by Staphylococcus aureus. Due to methicillin-resistant S. aureus (MRSA) strains or biofilm formation, successful treatment remains difficult. Currently, two-stage revision surgery constitutes the gold standard therapy of PJIs, sometimes replaced or supplemented by debridement, antibiotics, and implant retention (DAIR). Given the dire consequences of therapeutic failure, bacteriophage therapy might be another treatment option. Here we provide a comprehensive literature review addressing the efficacy of phages applied against S. aureus as causative agent of PJIs. The included 17 publications had in common that the applied phages proved to be effective against various S. aureus isolates including MRSA even in biofilms. Experiments with mice, rats, rabbits, and moth larvae confirmed favorable features of phage preparations in PJI treatment in vivo; including its synergistic with antibiotics. Case reports of PJI patients unanimously described the bacterial eradication following, alongside other measures, intravenous and intra-articular phage administration. Generally, no major side effects occurred, but in some cases elevated liver transaminases were observed. To conclude, our review compiled promising evidence suggesting the safety and suitability of phage therapy as an adjuvant to DAIR in S. aureus PJIs, and thus, underscores the significance of further research.
    Language English
    Publishing date 2024-03-04
    Publishing country Hungary
    Document type Journal Article ; Review
    ZDB-ID 2652327-9
    ISSN 2062-8633 ; 2062-509X
    ISSN (online) 2062-8633
    ISSN 2062-509X
    DOI 10.1556/1886.2024.00010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Polyphenolic compounds in the combat of foodborne infections - An update on recent evidence.

    Menikheim, Carolin B / Mousavi, Soraya / Bereswill, Stefan / Heimesaat, Markus M

    European journal of microbiology & immunology

    2024  Volume 14, Issue 2, Page(s) 116–125

    Abstract: In recent years, the incidence of food-borne bacterial enteric diseases has increased worldwide causing significant health care and socioeconomic burdens. According to the World Health Organization, there are an estimated 600 million cases of foodborne ... ...

    Abstract In recent years, the incidence of food-borne bacterial enteric diseases has increased worldwide causing significant health care and socioeconomic burdens. According to the World Health Organization, there are an estimated 600 million cases of foodborne illnesses worldwide each year, resulting in 420,000 deaths. Despite intensive efforts to tackle this problem, foodborne pathogenic microorganisms continue to be spread further. Therefore, there is an urgent need to find novel anti-microbial non-toxic compounds for food preservation. One way to tackle this issue may be the usage of polyphenols, which have received increasing attention in the recent years given their pleotropic health-promoting properties. This prompted us to perform a literature search summarizing studies from the past 10 years regarding the potential anti-microbial and disease-alleviating effects of plant-derived phenolic compounds against foodborne bacterial pathogens. The included 16 studies provide evidence that polyphenols show pronounced anti-bacterial and anti-oxidant effects against both Gram-positive and Gram-negative bacterial species. In addition, synergistic anti-microbial effects in combination with synthetic antibiotics were observed. In conclusion, phenolic compounds may be useful as natural anti-microbial agents in the food, agricultural, and pharmaceutical industries in the combat of foodborne infections.
    Language English
    Publishing date 2024-03-25
    Publishing country Hungary
    Document type Journal Article ; Review
    ZDB-ID 2652327-9
    ISSN 2062-8633 ; 2062-509X
    ISSN (online) 2062-8633
    ISSN 2062-509X
    DOI 10.1556/1886.2024.00018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The impact of ketogenic diet on the onset and progression of multiple sclerosis.

    Brockhoff, Jurij D / Bereswill, Stefan / Heimesaat, Markus M

    European journal of microbiology & immunology

    2023  Volume 13, Issue 2, Page(s) 29–36

    Abstract: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by inflammation and neurodegeneration. Current research suggests that diet may influence disease course, severity of symptoms, and quality of life ... ...

    Abstract Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by inflammation and neurodegeneration. Current research suggests that diet may influence disease course, severity of symptoms, and quality of life in MS patients. The ketogenic diet (KD) has been used for more than a century as a therapeutic approach for various medical conditions. It was originally developed in the 1920s as a treatment option for epilepsy, and especially in the last 30 years, has gained popularity for its potential benefits in a variety of neurological conditions other than epilepsy. This prompted us to perform a literature survey regarding the effect of KD on the onset and progression of MS. The here reviewed 15 original research articles including in vitro, preclinical, and clinical studies provide evidence for the safety and feasibility of the KD in MS, showing potential neuroprotective effects and positive impacts on cellular metabolism and disease outcome. Since the literature is limited and most studies were conducted with low numbers of MS patients and rather exploratory in nature, further studies with larger cohorts are needed to gain a better understanding of the mechanisms by which the improvements of the MS disease course are achieved.
    Language English
    Publishing date 2023-09-04
    Publishing country Hungary
    Document type Journal Article ; Review
    ZDB-ID 2652327-9
    ISSN 2062-8633 ; 2062-509X
    ISSN (online) 2062-8633
    ISSN 2062-509X
    DOI 10.1556/1886.2023.00020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Prophylactic Oral Application of Activated Charcoal Mitigates Acute Campylobacteriosis in Human Gut Microbiota-Associated IL-10

    Heimesaat, Markus M / Schabbel, Niklas / Langfeld, Luis Q / Shayya, Nizar W / Mousavi, Soraya / Bereswill, Stefan

    Biomolecules

    2024  Volume 14, Issue 2

    Abstract: The incidence of ... ...

    Abstract The incidence of human
    MeSH term(s) Animals ; Humans ; Mice ; Campylobacter Infections/prevention & control ; Campylobacter Infections/drug therapy ; Charcoal/administration & dosage ; Gastrointestinal Microbiome ; Interleukin-10/genetics ; Mice, Inbred C57BL ; Administration, Oral ; Disease Models, Animal
    Chemical Substances Charcoal (16291-96-6) ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14020141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Oral treatment of human gut microbiota associated IL-10

    Mousavi, Soraya / Foote, Minnja S / Du, Ke / Bandick, Rasmus / Bereswill, Stefan / Heimesaat, Markus M

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1290490

    Abstract: ... Food- ... ...

    Abstract Food-borne
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1290490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Menthol Pretreatment Alleviates

    Heimesaat, Markus M / Langfeld, Luis Q / Schabbel, Niklas / Shayya, Nizar W / Mousavi, Soraya / Bereswill, Stefan

    Biomolecules

    2024  Volume 14, Issue 3

    Abstract: ... ...

    Abstract Human
    MeSH term(s) Humans ; Mice ; Animals ; Interleukin-10/genetics ; Campylobacter jejuni ; Menthol/pharmacology ; Menthol/therapeutic use ; Campylobacter Infections/complications ; Campylobacter Infections/drug therapy ; Campylobacter Infections/microbiology ; Gastrointestinal Microbiome ; Mice, Inbred C57BL ; Enterocolitis/drug therapy ; Enterocolitis/microbiology
    Chemical Substances Interleukin-10 (130068-27-8) ; Menthol (1490-04-6)
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14030290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Carvacrol prophylaxis improves clinical outcome and dampens apoptotic and pro-inflammatory immune responses upon Campylobacter jejuni infection of human microbiota-associated IL-10-/- mice.

    Heimesaat, Markus M / Langfeld, Luis Q / Schabbel, Niklas / Mousavi, Soraya / Bereswill, Stefan

    European journal of microbiology & immunology

    2024  Volume 14, Issue 2, Page(s) 166–179

    Abstract: Incidence rates of human Campylobacter jejuni infections are progressively increasing globally. Since the risk for the development of post-infectious autoimmune diseases correlates with the severity of the preceding enteritis and campylobacteriosis ... ...

    Abstract Incidence rates of human Campylobacter jejuni infections are progressively increasing globally. Since the risk for the development of post-infectious autoimmune diseases correlates with the severity of the preceding enteritis and campylobacteriosis treatment usually involves symptomatic measures, it is desirable to apply antibiotic-independent compounds to treat or even prevent disease. Given its health-promoting including anti-inflammatory properties carvacrol constitutes a promising candidate. This prompted us to test the disease-alleviating including immune-modulatory effects of carvacrol prophylaxis in acute murine campylobacteriosis. Therefore, human gut microbiota-associated IL-10-/- mice were orally challenged with synthetic carvacrol starting a week before C. jejuni infection and followed up until day 6 post-infection. Whereas carvacrol prophylaxis did neither affect gastrointestinal pathogen loads, nor the human commensal gut microbiota composition, it improved the clinical outcome of mice, attenuated colonic epithelial cell apoptosis, and dampened pro-inflammatory immune responses not only in the intestinal tract but also in extra-intestinal organs including the liver and the spleen. In conclusion, our preclinical placebo-controlled intervention study provides convincing evidence that oral carvacrol pretreatment constitutes a promising option to mitigate acute campylobacteriosis and in turn, to reduce the risk for post-infectious complications.
    Language English
    Publishing date 2024-03-11
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 2652327-9
    ISSN 2062-8633 ; 2062-509X
    ISSN (online) 2062-8633
    ISSN 2062-509X
    DOI 10.1556/1886.2024.00009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Molecular Targets in

    Heimesaat, Markus M / Backert, Steffen / Alter, Thomas / Bereswill, Stefan

    Biomolecules

    2023  Volume 13, Issue 3

    Abstract: Human campylobacteriosis results from foodborne infections ... ...

    Abstract Human campylobacteriosis results from foodborne infections with
    MeSH term(s) Humans ; Campylobacter Infections/drug therapy ; Campylobacter Infections/microbiology ; Campylobacter jejuni/physiology ; Communicable Diseases ; Intestines/microbiology ; Gastroenteritis
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13030409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Disease alleviating effects following prophylactic lemon and coriander essential oil treatment in mice with acute campylobacteriosis.

    Mousavi, Soraya / Weschka, Dennis / Bereswill, Stefan / Heimesaat, Markus M

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1154407

    Abstract: Introduction: Given the worldwide increasing prevalence of human : Methods: Therefore, secondary abiotic IL-10: Results and discussion: Six days post-infection, slightly lower pathogen loads were assessed in the colon of mice from the LEM-EO as ... ...

    Abstract Introduction: Given the worldwide increasing prevalence of human
    Methods: Therefore, secondary abiotic IL-10
    Results and discussion: Six days post-infection, slightly lower pathogen loads were assessed in the colon of mice from the LEM-EO as opposed to the COR-EO cohort if compared to placebo counterparts. Prophylactic application of both EOs improved the clinical outcome of acute campylobacteriosis which was paralleled by less distinct pathogen-induced colonic epithelial cell apoptosis. Moreover, mice subjected to LEM-EO and COR-EO prophylaxis displayed lower colonic numbers of macrophages/monocytes and of T lymphocytes, respectively, whereas in both verum groups, basal IL-6 and IFN-γ concentrations were measured in mesenteric lymph nodes on day 6 post-infection. The oral challenge with either EOs resulted in diminished secretion of distinct pro-inflammatory mediators in the kidney as well as serum samples derived from the infected mice. In conclusion, the results from our preclinical
    Language English
    Publishing date 2023-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1154407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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