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  1. Article ; Online: Rituximab leading to an atypical presentation of neuroborreliosis and false negative serology.

    Lorentzen, Åslaug Rudjord / Berg, Kristine Karlsrud / Ljøstad, Unn

    Practical neurology

    2023  

    Abstract: Two patients, recently treated with the B-cell-depleting monoclonal antibody, rituximab, had 2-3 months of progressive systemic symptoms; comprehensive investigations did not clarify the diagnosis. Transient radicular pain at disease onset had suggested ... ...

    Abstract Two patients, recently treated with the B-cell-depleting monoclonal antibody, rituximab, had 2-3 months of progressive systemic symptoms; comprehensive investigations did not clarify the diagnosis. Transient radicular pain at disease onset had suggested neuroborreliosis, but seronegativity and an atypical clinical course made this unlikely. However, PCR identified
    Language English
    Publishing date 2023-12-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2170881-2
    ISSN 1474-7766 ; 1474-7758
    ISSN (online) 1474-7766
    ISSN 1474-7758
    DOI 10.1136/pn-2023-003976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Risk factors for SARS-CoV-2 infection: a test-negative case-control study with additional population controls in Norway.

    Sarjomaa, Marjut / Zhang, Chi / Tveten, Yngvar / Kersten, Hege / Reiso, Harald / Eikeland, Randi / Kongerud, Johny / Berg, Kristine Karlsrud / Thilesen, Carina / Nordbø, Svein Arne / Aaberge, Ingeborg S / Vandenbroucke, Jan / Pearce, Neil / Fell, Anne Kristin Moeller

    BMJ open

    2024  Volume 14, Issue 1, Page(s) e073766

    Abstract: Objectives: This study aims to assess risk factors for SARS-CoV-2 infection by combined design; first comparing positive cases to negative controls as determined by PCR testing and then comparing these two groups to an additional prepandemic population ... ...

    Abstract Objectives: This study aims to assess risk factors for SARS-CoV-2 infection by combined design; first comparing positive cases to negative controls as determined by PCR testing and then comparing these two groups to an additional prepandemic population control group.
    Design and setting: Test-negative design (TND), multicentre case-control study with additional population controls in South-Eastern Norway.
    Participants: Adults who underwent SARS-CoV-2 PCR testing between February and December 2020. PCR-positive cases, PCR-negative controls and additional age-matched population controls.
    Primary outcome measures: The associations between various risk factors based on self- reported questionnaire and SARS-CoV-2 infection comparing PCR-positive cases and PCR-negative controls. Using subgroup analysis, the risk factors for both PCR-positive and PCR-negative participants were compared with a population control group.
    Results: In total, 400 PCR-positive cases, 719 PCR-negative controls and 14 509 population controls were included. Male sex was associated with the risk of SARS-CoV-2 infection only in the TND study (OR 1.9, 95% CI 1.4 to 2.6), but not when PCR-positive cases were compared with population controls (OR 1.2, 95% CI 0.9. to 1.5). Some factors were positively (asthma, wood heating) or negatively (hypertension) associated with SARS-CoV-2 infection when PCR-positive cases were compared with population controls, but lacked convincing association in the TND study. Smoking was negatively associated with the risk of SARS-CoV-2 infection in both analyses (OR 0.5, 95% CI 0.3 to 0.8 and OR 0.6, 95% CI 0.4 to 0.8).
    Conclusions: Male sex was a possible risk factor for SARS-CoV-2 infection only in the TND study, whereas smoking was negatively associated with SARS-CoV-2 infection in both the TND study and when using population controls. Several factors were associated with SARS-CoV-2 infection when PCR-positive cases were compared with population controls, but not in the TND study, highlighting the strength of combining case-control study designs during the pandemic.
    MeSH term(s) Adult ; Humans ; Male ; COVID-19/diagnosis ; COVID-19/epidemiology ; Population Control ; Case-Control Studies ; SARS-CoV-2 ; Risk Factors ; Norway/epidemiology
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-073766
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  3. Article ; Online: SARS-CoV-2 antibody persistence after five and twelve months: A cohort study from South-Eastern Norway.

    Sarjomaa, Marjut / Diep, Lien My / Zhang, Chi / Tveten, Yngvar / Reiso, Harald / Thilesen, Carina / Nordbø, Svein Arne / Berg, Kristine Karlsrud / Aaberge, Ingeborg / Pearce, Neil / Kersten, Hege / Vandenbroucke, Jan Paul / Eikeland, Randi / Fell, Anne Kristin Møller

    PloS one

    2022  Volume 17, Issue 8, Page(s) e0264667

    Abstract: Objectives: To assess total antibody levels against Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS CoV-2) spike protein up to 12 months after Coronavirus Disease (COVID-19) infection in non-vaccinated individuals and the possible predictors of ... ...

    Abstract Objectives: To assess total antibody levels against Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS CoV-2) spike protein up to 12 months after Coronavirus Disease (COVID-19) infection in non-vaccinated individuals and the possible predictors of antibody persistence.
    Methods: This is the first part of a prospective multi-centre cohort study.
    Participants: The study included SARS-CoV-2 real-time polymerase chain reaction (RT-PCR) positive and negative participants in South-Eastern Norway from February to December 2020. Possible predictors of SARS-CoV-2 total antibody persistence was assessed. The SARS-CoV-2 total antibody levels against spike protein were measured three to five months after PCR in 391 PCR-positive and 703 PCR-negative participants; 212 PCR-positive participants were included in follow-up measurements at 10 to 12 months. The participants completed a questionnaire including information about symptoms, comorbidities, allergies, body mass index (BMI), and hospitalisation.
    Primary outcome: The SARS-CoV-2 total antibody levels against spike protein three to five and 10 to 12 months after PCR positive tests.
    Results: SARS-CoV-2 total antibodies against spike protein were present in 366 (94%) non-vaccinated PCR-positive participants after three to five months, compared with nine (1%) PCR-negative participants. After 10 to 12 months, antibodies were present in 204 (96%) non-vaccinated PCR-positive participants. Of the PCR-positive participants, 369 (94%) were not hospitalised. The mean age of the PCR-positive participants was 48 years (SD 15, range 20-85) and 50% of them were male. BMI ≥ 25 kg/m2 was positively associated with decreased antibody levels (OR 2.34, 95% CI 1.06 to 5.42). Participants with higher age and self-reported initial fever with chills or sweating were less likely to have decreased antibody levels (age: OR 0.97, 95% CI 0.94 to 0.99; fever: OR 0.33, 95% CI 0.13 to 0.75).
    Conclusion: Our results indicate that the level of SARS-CoV-2 total antibodies against spike protein persists for the vast majority of non-vaccinated PCR-positive persons at least 10 to 12 months after mild COVID-19.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Antibodies, Viral ; COVID-19 ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Norway ; Prospective Studies ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Young Adult
    Chemical Substances Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0264667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Risk factors for SARS-CoV-2 infection: A test-negative case-control study with additional population controls

    Sarjomaa, Marjut / Zhang, Chi / Tveten, Yngvar / Kersten, Hege / Reiso, Harald / Eikeland, Randi / Kongerud, Johny / Berg, Kristine Karlsrud / Thilesen, Carina / Nordbo, Svein Arne / Aaberge, Ingeborg / Vandenbroucke, Jan / Pearce, Neil / Fell, Anne Kristin

    medRxiv

    Abstract: ABSTRACT Objectives: To assess risk factors for SARS-CoV-2 infection by first comparing positive cases with negative controls as determined by polymerase chain reaction (PCR) testing and then comparing these two groups with an additional population ... ...

    Abstract ABSTRACT Objectives: To assess risk factors for SARS-CoV-2 infection by first comparing positive cases with negative controls as determined by polymerase chain reaction (PCR) testing and then comparing these two groups with an additional population control group. Design and setting: Test-negative design (TND), multicentre case-control study with additional population controls in South Eastern Norway. Participants: Adults who underwent SARS-CoV-2 PCR testing between February and December 2020. PCR-positive cases, PCR-negative controls, and additional age-matched population controls. Primary outcome measures: The associations between various risk factors based on self- reported questionnaire and SARS-CoV-2 infection comparing PCR positive cases and PCR- negative controls. Using subgroup analysis, the risk factors were then compared with a population control group. Univariate and multivariate regression analyses were performed. Results: In total, 400 SARS-CoV-2 PCR-positive cases, 719 PCR-negative controls, and 14,509 population controls were included. Male sex was associated with the risk of SARS- CoV-2 infection when PCR-positive cases were compared with PCR-negative controls (OR 1.9, 95% CI 1.4 to 2.6). Age, education level, comorbidities (asthma, diabetes, hypertension), an exercise were not associated with the risk of SARS-CoV-2 infection when PCR-positive cases were compared with PCR-negative controls. In the subgroup analysis comparing PCR- positive cases with age-matched population controls, asthma was associated with the risk of SARS-CoV-2 infection (OR 1.6, 95% CI 1.1 to 2.1). Daily or occasional smoking was negatively associated with the risk of SARS-CoV-2 infection in both analyses (OR 0.5, 95% CI 0.3 to 0.8 and OR 0.55, 95% CI 0.35, to 0.82, respectively). Conclusions: Male sex was a possible risk factor, whereas smoking was negatively associated with the risk of SARS-CoV-2 infection, when comparing PCR-positive cases and PCR- negative controls. Asthma was associated with the risk of SARS-CoV-2 infection when PCR- positive cases were compared with population controls.
    Keywords covid19
    Language English
    Publishing date 2023-03-19
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.03.15.23287300
    Database COVID19

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  5. Article ; Online: SARS-CoV-2 antibody persistence after five and twelve months: A cohort study from South-Eastern Norway

    Sarjomaa, Marjut / Diep, Lien My / Zhang, Chi / Tveten, Yngvar / Reiso, Harald / Thilesen, Carina / Nordbø, Svein Arne / Berg, Kristine Karlsrud / Aaberge, Ingeborg / Pearce, Neil / Kersten, Hege / Vandenbroucke, Jan Paul / Eikeland, Randi / Fell, Anne Kristin Møller

    medRxiv

    Abstract: Objectives: To assess total antibody levels against Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS CoV-2) spike protein up to 12 months after Coronavirus Disease (COVID-19) infection in non-vaccinated individuals and the possible predictors of ... ...

    Abstract Objectives: To assess total antibody levels against Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS CoV-2) spike protein up to 12 months after Coronavirus Disease (COVID-19) infection in non-vaccinated individuals and the possible predictors of antibody persistence. Methods: This is a prospective multi-centre longitudinal cohort study. Participants The study included SARS-CoV-2 real-time polymerase chain reaction (RT-PCR) positive and negative participants in South-Eastern Norway from February to December 2020. Possible predictors of SARS-CoV-2 total antibody persistence was assessed. The SARS-CoV-2 total antibody levels against spike protein were measured three to five months after PCR in 391 PCR-positive and 703 PCR-negative participants; 212 PCR-positive participants were included in follow-up measurements at 10 to 12 months. The participants completed a questionnaire including information about symptoms, comorbidities, allergies, body mass index (BMI), and hospitalisation. Primary outcome The SARS-CoV-2 total antibody levels against spike protein three to five and 10 to 12 months after PCR positive tests. Results: SARS-CoV-2 total antibodies against spike protein were present in 366 (94%) non-vaccinated PCR-positive participants after three to five months, compared with nine (1%) PCR-negative participants. After 10 to 12 months, antibodies were present in 204 (96%) non-vaccinated PCR-positive participants. Of the PCR-positive participants, 369 (94%) were not hospitalised. The mean age of the PCR-positive participants was 48 years (SD 15, range 20-85) and 50% of them were male. BMI ≥ 25 kg/m 2 was positively associated with decreased antibody levels (OR 2.34, 95% CI 1.06 to 5.42). Participants with higher age and self-reported initial fever with chills or sweating were less likely to have decreased antibody levels (age: OR 0.97, 95% CI 0.94 to 0.99; fever: OR 0.33, 95% CI 0.13 to 0.75).   Conclusion Our results indicate that the level of SARS-CoV-2 total antibodies against spike protein persists for the vast majority of non-vaccinated PCR-positive persons at least 10 to 12 months after mild COVID-19.
    Keywords covid19
    Language English
    Publishing date 2022-02-21
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.02.16.22271075
    Database COVID19

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