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Article: Dermatofibrosarcoma Protuberans of the Vulva: A Review of the MITO Rare Cancer Group.

Mancari, Rosanna / Cioffi, Raffaella / Magazzino, Francescapaola / Attademo, Laura / Sant'angelo, Miriam / Taccagni, Gianluca / Mangili, Giorgia / Pignata, Sandro / Bergamini, Alice

Cancers

2024 Volume 16, Issue 1

Abstract: Background: Vulvar dermatofibrosarcoma protuberans is an extremely rare disease. Its rarity can hamper the quality of treatment; deeper knowledge is necessary to plan appropriate management. The purpose of this review is to analyse the data reported in ... ...

Abstract	Background: Vulvar dermatofibrosarcoma protuberans is an extremely rare disease. Its rarity can hamper the quality of treatment; deeper knowledge is necessary to plan appropriate management. The purpose of this review is to analyse the data reported in the literature to obtain evidence regarding appropriate disease management. Methods: We made a systematic search of the literature, including the terms "dermatofibrosarcoma protuberans", "vulva", and "vulvar", alone or in combination. We selected articles published in English from two electronic databases, PubMed and MEDLINE, and we analysed their reference lists to include other potentially relevant studies. Results: We selected 39 articles, with a total of 68 cases reported; they were retrospective case reports and case series. Dermatofibrosarcoma protuberans of the vulva tends towards local recurrence; an early and timely pathological diagnosis, together with an appropriate surgical approach, are of utmost importance to ensure free margins and maximise the curative potential. Conclusions: Even if this is an indolent disease and it generally shows a good prognosis, appropriate management may help in reducing the rate of local recurrences that may hamper patients' quality of life. Management by a multidisciplinary team is highly recommended.
Language	English
Publishing date	2024-01-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16010222
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Article ; Online: Sentinel lymph node biopsy in open surgery for gynecological malignancies.

Bocciolone, Luca / Candotti, Giorgio / Cioffi, Raffaella / Rabaiotti, Emanuela / Bergamini, Alice / Candiani, Massimo

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2023 Volume 33, Issue 4, Page(s) 636–637

MeSH term(s)	Female ; Humans ; Sentinel Lymph Node Biopsy ; Genital Neoplasms, Female/surgery ; Genital Neoplasms, Female/pathology ; Lymph Nodes/pathology ; Sentinel Lymph Node/surgery ; Sentinel Lymph Node/pathology ; Uterine Cervical Neoplasms/pathology ; Lymph Node Excision ; Neoplasm Staging
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2022-003898
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Article ; Online: Ovarian failure risk in post-pubertal patients with cancer: a prognostic model.

Cioffi, Raffaella / Fais, Maria Luisa / Bergamini, Alice / Vanni, Valeria Stella / Pagliardini, Luca / Papaleo, Enrico / Mangili, Giorgia / Candiani, Massimo

Future oncology (London, England)

2022 Volume 18, Issue 19, Page(s) 2391–2400

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Cohort Studies ; Doxorubicin/therapeutic use ; Female ; Fertility Preservation ; Humans ; Neoplasms/complications ; Neoplasms/diagnosis ; Neoplasms/drug therapy ; Prognosis ; Retrospective Studies
Chemical Substances	Doxorubicin (80168379AG)
Language	English
Publishing date	2022-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2274956-1
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon-2022-0078
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Article: Current Evidence on Immunotherapy for Gestational Trophoblastic Neoplasia (GTN).

Mangili, Giorgia / Sabetta, Giulia / Cioffi, Raffaella / Rabaiotti, Emanuela / Candotti, Giorgio / Pella, Francesca / Candiani, Massimo / Bergamini, Alice

Cancers

2022 Volume 14, Issue 11

Abstract: Background: Gestational trophoblastic disease includes a rare group of benign and malignant tumors derived from abnormal trophoblastic proliferation. Malignant forms are called gestational trophoblastic neoplasia (GTN) and include invasive mole, ... ...

Abstract	Background: Gestational trophoblastic disease includes a rare group of benign and malignant tumors derived from abnormal trophoblastic proliferation. Malignant forms are called gestational trophoblastic neoplasia (GTN) and include invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. Standard treatment of GTN is chemotherapy. The regimen of choice mainly depends on the FIGO prognostic score. Low-risk and high-risk GTN is treated with single-agent or multiagent chemotherapy, respectively. In the case of chemoresistance, immunotherapy may represent a new therapeutic strategy. Methods: Literature obtained from searches on PubMed concerning GTN and immunotherapy was reviewed. Results: Programmed cell death 1 (PD-1) and its ligands (PD-L1/2) are expressed in GTN. Published data on PD-1/PD-L1 inhibitors alone in GTN were available for 51 patients. Pembrolizumab is an anti-PD-1 inhibitor used in chemoresistant forms of GTN. In the TROPHIMMUN trial, Avelumab, a monoclonal antibody inhibiting PD-L1, showed promising results only in patients with GTN resistant to monochemotherapy. Conversely, in patients with resistance to multiagent chemotherapy, treatment with Avelumab was discontinued due to severe toxicity and disease progression. The association of Camrelizumab and Apatinib could represent a different treatment for forms of GTN refractory to polychemotherapy or for relapses. Conclusions: Anti-PD-1 or anti-PD-L1 might represent an important new treatment strategy for the management of chemoresistant/refractory GTN.
Language	English
Publishing date	2022-06-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14112782
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Article ; Online: A prospective, observational study of chemotherapy-induced ovarian damage on follicular reserve and maturation.

Cioffi, Raffaella / Cervini, Laura / Taccagni, Gianluca / Papaleo, Enrico / Pagliardini, Luca / Bergamini, Alice / Ferrari, Stefano / Mangili, Giorgia / Candiani, Massimo

Archives of gynecology and obstetrics

2022 Volume 306, Issue 5, Page(s) 1723–1729

Abstract: Background: Chemotherapy negatively affects gonadal function, often resulting in premature ovarian failure (POF) due to ovarian reserve depletion. Mechanisms of gonadotoxicity, such as primordial follicle overactivation and "burnout", remain to be ... ...

Abstract	Background: Chemotherapy negatively affects gonadal function, often resulting in premature ovarian failure (POF) due to ovarian reserve depletion. Mechanisms of gonadotoxicity, such as primordial follicle overactivation and "burnout", remain to be established. Ovarian tissue cryopreservation (OTC) before treatment plays an important role in safeguarding fertility. Methods: This is a prospective observational study that aims to evaluate the feasibility of OTC after chemotherapeutic treatment initiation. Patients were divided into 2 groups depending on whether they received chemotherapy before the harvesting procedure (Group 1) or not (Group 2). The main outcomes of this study are serum anti-Mullerian hormone (AMH) levels and histological follicular counts on ovarian tissue biopsies. Results: Between 2012 and 2020, 79 patients underwent OTC at our Hospital. Follicular counts from the ovarian biopsies of 30 post-pubertal patients and respective serum AMH levels were included in the analysis. AMH levels did not significantly differ between the 2 groups (P = 0.70) as well as the number of primordial follicles (P = 0.73). Ovarian biopsies of patients from Group 1 showed a higher number of primary follicles (P = 0.04) and atretic follicles (P = 0.05) with respect to Group 2. Conclusions: In conclusion, OTC appears to be feasible even after the start of chemotherapeutic treatment, since in treated patients, the main ovarian reserve indicators (number of primordial follicles and serum AMH levels) were not significantly reduced compared to untreated patients. The "burnout" theory of chemotherapeutic damage to the ovary seems to be supported by the higher number of primary follicles found in the ovaries of patients who received chemotherapy before OTC.
MeSH term(s)	Anti-Mullerian Hormone ; Antineoplastic Agents/adverse effects ; Female ; Humans ; Ovarian Follicle ; Ovarian Reserve ; Ovary/pathology ; Prospective Studies
Chemical Substances	Antineoplastic Agents ; Anti-Mullerian Hormone (80497-65-0)
Language	English
Publishing date	2022-07-14
Publishing country	Germany
Document type	Journal Article ; Observational Study
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-022-06692-0
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Article ; Online: Granulosa cell tumors (GCTs) of the ovary: What is the role of radiotherapy?

Barcellini, Amelia / Mangili, Giorgia / Fodor, Andrei / Secondino, Simona / Zerbetto, Flavia / Charalampopoulou, Alexandra / Pignata, Sandro / Orlandi, Ester / Bergamini, Alice

Critical reviews in oncology/hematology

2022 Volume 181, Page(s) 103889

Abstract: Granulosa cell tumors of the ovary have an indolent behavior and a good prognosis, but a high incidence of local recurrence after surgery. The best treatment in the recurrent setting is unclear and randomized clinical trials on the management in the ... ...

Abstract	Granulosa cell tumors of the ovary have an indolent behavior and a good prognosis, but a high incidence of local recurrence after surgery. The best treatment in the recurrent setting is unclear and randomized clinical trials on the management in the recurrent setting are lacking. The role of radiotherapy is controversial in adjuvant settings and unknown in case of relapse after surgery. This review aims to summarize the level of evidence of the role of radiation treatments for granulosa cell tumors of the ovary.
Language	English
Publishing date	2022-11-26
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	605680-5
ISSN	1879-0461 ; 0737-9587 ; 1040-8428
ISSN (online)	1879-0461
ISSN	0737-9587 ; 1040-8428
DOI	10.1016/j.critrevonc.2022.103889
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Article ; Online: Management of recurrent ovarian cancer: when platinum-based regimens are not a therapeutic option.

Bergamini, Alice / Bocciolone, Luca / Fodor, Andrei / Candiani, Massimo / Mangili, Giorgia

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2019 Volume 29, Issue 9, Page(s) 1431–1436

Abstract: Ovarian cancer relapses have been traditionally classified according to the platinum-free interval, leading to an arbitrary categorization of possible scenarios and treatment options. Its relevance in assessing treatment strategies has been revised in ... ...

Abstract	Ovarian cancer relapses have been traditionally classified according to the platinum-free interval, leading to an arbitrary categorization of possible scenarios and treatment options. Its relevance in assessing treatment strategies has been revised in the last several years, as the panorama is constantly changing in the era of personalized medicine and targeted therapies. Factors to be considered while defining the best management of recurrent disease, and, consequently, the available treatment alternatives are increasing. Platinum remains one of the milestones of ovarian cancer treatment, but for some patients it might not be an ideal choice for several reasons other than limited platinum sensitivity. This review aims to analyze the scenarios in which platinum is not considered suitable in the management of patients with recurrent ovarian cancer, and the currently available alternatives.
MeSH term(s)	Antineoplastic Agents, Hormonal/therapeutic use ; Carcinoma, Ovarian Epithelial/drug therapy ; Carcinoma, Ovarian Epithelial/radiotherapy ; Doxorubicin/analogs & derivatives ; Doxorubicin/therapeutic use ; Female ; Humans ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/radiotherapy ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/radiotherapy ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Polyethylene Glycols/therapeutic use ; Randomized Controlled Trials as Topic ; Topotecan/therapeutic use
Chemical Substances	Antineoplastic Agents, Hormonal ; Poly(ADP-ribose) Polymerase Inhibitors ; liposomal doxorubicin ; Polyethylene Glycols (3WJQ0SDW1A) ; Topotecan (7M7YKX2N15) ; Doxorubicin (80168379AG)
Language	English
Publishing date	2019-09-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2019-000624
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Article: Endometriosis-Related Ovarian Cancers: Evidence for a Dichotomy in the Histogenesis of the Two Associated Histotypes.

Bergamini, Alice / Mangili, Giorgia / Ambrosi, Alessandro / Taccagni, Gianluca / Rabaiotti, Emanuela / Bocciolone, Luca / Candotti, Giorgio / Cioffi, Raffaella / Pella, Francesca / Sabetta, Giulia / Saponaro, Costanza / Candiani, Massimo

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 8

Abstract: Evidence indicates that different pathways of malignant degeneration underlie the development of endometriosis-associated ovarian tumors of endometrioid and clear cell histotypes. The aim of this study was to compare data from patients affected by these ... ...

Abstract	Evidence indicates that different pathways of malignant degeneration underlie the development of endometriosis-associated ovarian tumors of endometrioid and clear cell histotypes. The aim of this study was to compare data from patients affected by these two histotypes to investigate the hypothesis of a dichotomy in the histogenesis of these tumors. Clinical data and tumor characteristics of 48 patients who were diagnosed with either pure clear cell ovarian cancer and mixed endometrioid-clear cell ovarian cancer arising from endometriosis (ECC,
Language	English
Publishing date	2023-04-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13081425
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Article ; Online: CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses.

Bove, Camilla / Arcangeli, Silvia / Falcone, Laura / Camisa, Barbara / El Khoury, Rita / Greco, Beatrice / De Lucia, Anna / Bergamini, Alice / Bondanza, Attilio / Ciceri, Fabio / Bonini, Chiara / Casucci, Monica

Journal for immunotherapy of cancer

2023 Volume 11, Issue 1

Abstract: Background: To date, T cells redirected with CD19-specific chimeric antigen receptors (CAR) have gained impressive success in B-cell malignancies. However, treatment failures are common and the occurrence of severe toxicities, such as cytokine release ... ...

Abstract	Background: To date, T cells redirected with CD19-specific chimeric antigen receptors (CAR) have gained impressive success in B-cell malignancies. However, treatment failures are common and the occurrence of severe toxicities, such as cytokine release syndrome (CRS), still limits the full exploitation of this approach. Therefore, the development of cell products with improved therapeutic indexes is highly demanded. Methods: In this project, we investigated how CD4 and CD8 populations cooperate during CD19 CAR-T cell responses and what is their specific role in CRS development. To this aim, we took advantage of immunodeficient mice reconstituted with a human immune system (HuSGM3) and engrafted with the B-cell acute lymphoblastic leukemia cell line NALM-6, a model that allows to thoroughly study efficacy and toxicity profiles of CD19 CAR-T cell products. Results: CD4 CAR-T cells showed superior proliferation and activation potential, which translated into stronger stimulation of myeloid cells, the main triggers of adverse events. Accordingly, toxicity assessment in HuSGM3 mice identified CD4 CAR-T cells as key contributors to CRS development, revealing a safer profile when they harbor CARs embedded with 4-1BB, rather than CD28. By comparing differentially co-stimulated CD4:CD8 1:1 CAR-T cell formulations, we observed that CD4 cells shape the overall expansion kinetics of the infused product and are crucial for maintaining long-term responses. Interestingly, the combination of CD4.BBz with CD8.28z CAR-T cells resulted in the lowest toxicity, without impacting antitumor efficacy. Conclusions: Taken together, these data point out that the rational design of improved adoptive T-cell therapies should consider the biological features of CD4 CAR-T cells, which emerged as crucial for maintaining long-term responses but also endowed by a higher toxic potential.
MeSH term(s)	Humans ; Mice ; Animals ; Cytokine Release Syndrome/etiology ; Immunotherapy, Adoptive/methods ; CD4-Positive T-Lymphocytes ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma ; Burkitt Lymphoma ; Antigens, CD19
Chemical Substances	Antigens, CD19
Language	English
Publishing date	2023-01-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2022-005878
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Article: Radiation Therapy for Gestational Trophoblastic Neoplasia: Forward-Looking Lessons Learnt.

Barcellini, Amelia / Fodor, Andrei / Charalampopoulou, Alexandra / Cassani, Chiara / Locati, Laura Deborah / Cioffi, Raffaella / Bergamini, Alice / Pignata, Sandro / Orlandi, Ester / Mangili, Giorgia

Cancers

2023 Volume 15, Issue 19

Abstract: Gestational trophoblastic neoplasia (GTN) includes several rare malignant diseases occurring after pregnancy: invasive moles, choriocarcinoma, placental site trophoblastic tumours, and epithelioid trophoblastic tumours. Multidisciplinary protocols ... ...

Abstract	Gestational trophoblastic neoplasia (GTN) includes several rare malignant diseases occurring after pregnancy: invasive moles, choriocarcinoma, placental site trophoblastic tumours, and epithelioid trophoblastic tumours. Multidisciplinary protocols including multi-agent chemotherapy, surgery, and occasionally radiotherapy achieve good outcomes for some high-risk metastatic patients. In this narrative review of the published studies on the topic, we have tried to identify the role of radiotherapy. The available studies are mainly small, old, and retrospective, with incomplete data regarding radiotherapy protocols delivering low doses (which can make this disease appear radioresistant in some cases despite high response rates with palliative doses) to wide fields (whole-brain, whole-liver, etc.), which can increase toxicity. Studies considering modern techniques are needed to overcome these limitations and determine the full potential of radiotherapy beyond its antihemorrhagic and palliative roles.
Language	English
Publishing date	2023-09-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15194817
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