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Article ; Online: Native and prosthetic transcatheter aortic valve infective endocarditis due to Lactobacillus rhamnosus.

Bergas, Alba / Rivera, Samuel / Torrecillas, Miriam / Cuervo, Guillermo

Enfermedades infecciosas y microbiologia clinica (English ed.)

2022 Volume 40, Issue 7, Page(s) 402–404

MeSH term(s)	Aortic Valve/surgery ; Endocarditis ; Endocarditis, Bacterial/complications ; Humans ; Lactobacillus rhamnosus
Language	English
Publishing date	2022-07-29
Publishing country	Spain
Document type	Case Reports
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2021.05.018
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Article: An Ocean between the Waves: Trends in Antimicrobial Consumption in Hospitalized Patients with COVID-19.

Durà-Miralles, Xavier / Abelenda-Alonso, Gabriela / Bergas, Alba / Laporte-Amargós, Júlia / Sastre-Escolà, Enric / Padullés, Ariadna / Carratalà, Jordi / Gudiol, Carlota

Antibiotics (Basel, Switzerland)

2024 Volume 13, Issue 1

Abstract: We assessed the antibiotic use in SARS-CoV-2-infected patients during four different waves of the COVID-19 pandemic, as well as its trends over the period and associated risk factors. We performed a cross-sectional retrospective analysis nested in a ... ...

Abstract	We assessed the antibiotic use in SARS-CoV-2-infected patients during four different waves of the COVID-19 pandemic, as well as its trends over the period and associated risk factors. We performed a cross-sectional retrospective analysis nested in a prospectively collected cohort of hospitalized adult patients with COVID-19 at a university hospital in Spain. A total of 2415 patients were included in this study, among whom 1120 corresponded to the first wave. The highest percentage of patients receiving some sort of antibiotic treatment was higher during the first wave (77.6%) than during the others; nevertheless, our calculation of the average DOT (days of antibiotic treatment) per 100 patient days of stay found that the highest antibiotic prescription rate corresponded to the second pandemic wave (61.61 DOT/100 patient days), which was associated with a higher ICU admission rate and a lower SpO
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics13010055
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Article ; Online: Native and prosthetic transcatheter aortic valve infective endocarditis due to Lactobacillus rhamnosus.

Bergas, Alba / Rivera, Samuel / Torrecillas, Miriam / Cuervo, Guillermo

Enfermedades infecciosas y microbiologia clinica (English ed.)

2021

Language	Spanish
Publishing date	2021-07-02
Publishing country	Spain
Document type	Case Reports
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimc.2021.05.012
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Article ; Online: Relapsing Haemothorax as an Unusual Presentation of Primary Angiosarcoma of the Spleen.

Bergas, Alba / Escrihuela-Vidal, Francesc / Fernández Calvo, Davinia / Capdevila Pons, Olga / Corbella, Xavier

European journal of case reports in internal medicine

2020 Volume 7, Issue 12, Page(s) 1944

Abstract: Spontaneous haemothorax (SH) is a rare subcategory of haemothorax that involves the accumulation of blood within the pleural space in the absence of trauma. SH especially occurs in middle-aged or elderly patients, but data are usually limited to case ... ...

Abstract	Spontaneous haemothorax (SH) is a rare subcategory of haemothorax that involves the accumulation of blood within the pleural space in the absence of trauma. SH especially occurs in middle-aged or elderly patients, but data are usually limited to case reports and case series. Coagulopathy, aneurysm or aortic dissection, Rendu-Osler-Weber syndrome and malignancy have to be considered among the causes of SH. Aim: We describe a case of primary angiosarcoma of the spleen presenting as relapsing haemothorax. Results: An 81-year-old woman was referred to our hospital because of a 2-month history of relapsing haemothorax after the performance of urgent splenectomy due to active bleeding from large spleen cysts. No evidence of neoplasm was seen after pathological examination of the spleen. On admission, left haemothorax and 2 new cystic masses in the thoracic wall were documented, both in close relation to the scars of previous surgery and chest tubes. After excision of 1 mass, histological examination revealed angiosarcoma, and a final diagnosis of primary angiosarcoma of the spleen with postsurgical metastatic dissemination to the thorax and pleura was made. Conclusion: Primary angiosarcoma should be included in the differential diagnosis of haemorrhagic spleen cysts. Clinical diagnosis and management usually requires splenectomy, but it should be carefully planned in order to avoid local metastatic dissemination or haematogenous spread of the tumour. Learning points: The differential diagnosis of spleen cysts must include malignant conditions.Despite its absolute rarity, angiosarcoma is considered the most common primary non-haematolymphoid splenic malignancy and has a poor prognosis.Splenectomy is usually required for a prompt diagnosis of primary angiosarcoma of the spleen, but it needs to be performed with extreme caution to avoid metastatic dissemination.
Language	English
Publishing date	2020-10-29
Publishing country	Italy
Document type	Journal Article
ISSN	2284-2594
ISSN (online)	2284-2594
DOI	10.12890/2020_001944
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Article: Increasing Gram-Negative Catheter-Related Bloodstream Infection in Cancer Patients.

Laporte-Amargos, Julia / Sastre, Enric / Bergas, Alba / Pomares, Helena / Paviglianiti, Annalisa / Rodriguez-Arias, Marisol / Pallares, Natalia / Badia-Tejero, Ana Maria / Pons-Oltra, Paula / Carratalà, Jordi / Gudiol, Carlota

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 2

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2023-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12020228
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Article: The Etiology, Antibiotic Therapy and Outcomes of Bacteremic Skin and Soft-Tissue Infections in Onco-Hematological Patients.

Castelli, Valeria / Sastre-Escolà, Enric / Puerta-Alcalde, Pedro / Huete-Álava, Leyre / Laporte-Amargós, Júlia / Bergas, Alba / Chumbita, Mariana / Marín, Mar / Domingo-Domenech, Eva / Badia-Tejero, Ana María / Pons-Oltra, Paula / García-Vidal, Carolina / Carratalà, Jordi / Gudiol, Carlota

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 12

Abstract: Objectives: to assess the current epidemiology, antibiotic therapy and outcomes of onco- hematological patients with bacteremic skin and soft-tissue infections (SSTIs), and to identify the risk factors for Gram-negative bacilli (GNB) infection and for ... ...

Abstract	Objectives: to assess the current epidemiology, antibiotic therapy and outcomes of onco- hematological patients with bacteremic skin and soft-tissue infections (SSTIs), and to identify the risk factors for Gram-negative bacilli (GNB) infection and for early and overall mortality. Methods: episodes of bacteremic SSTIs occurring in cancer patients at two hospitals were prospectively recorded and retrospectively analyzed. Results: Of 164 episodes of bacteremic SSTIs, 53% occurred in patients with solid tumors and 47% with hematological malignancies. GNB represented 45.5% of all episodes, led by Conclusions: GNB bacteremic SSTI was common, particularly if corticosteroid therapy or skin necrosis. IEAT was frequent in resistant bacteria infections. Mortality occurred mainly in older patients with septic shock, resistant bacteria and IEAT. These results might guide empirical antibiotic therapy in this high-risk population.
Language	English
Publishing date	2023-12-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12121722
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Article ; Online: Impact of Empirical Antibiotic Regimens on Mortality in Neutropenic Patients with Bloodstream Infection Presenting with Septic Shock.

Antimicrobial agents and chemotherapy

2021 Volume 66, Issue 2, Page(s) e0174421

Abstract: We analyzed risk factors for mortality in febrile neutropenic patients with bloodstream infections (BSI) presenting with septic shock and assessed the impact of empirical antibiotic regimens. A multicenter retrospective study (2010 to 2019) of two ... ...

Abstract	We analyzed risk factors for mortality in febrile neutropenic patients with bloodstream infections (BSI) presenting with septic shock and assessed the impact of empirical antibiotic regimens. A multicenter retrospective study (2010 to 2019) of two prospective cohorts compared BSI episodes in patients with or without septic shock. Multivariate analysis was performed to identify independent risk factors for mortality in episodes with septic shock. Of 1,563 patients with BSI, 257 (16%) presented with septic shock. Those patients with septic shock had higher mortality than those without septic shock (55% versus 15%,
MeSH term(s)	Aged ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; Humans ; Prospective Studies ; Retrospective Studies ; Sepsis/drug therapy ; Shock, Septic/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-11-29
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.01744-21
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

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Article ; Online: Immunomodulatory therapy, risk factors and outcomes of hospital-acquired bloodstream infection in patients with severe COVID-19 pneumonia: a Spanish case-control matched multicentre study (BACTCOVID).

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2021 Volume 27, Issue 11, Page(s) 1685–1692

Abstract: Objectives: The effect of the use of immunomodulatory drugs on the risk of developing hospital-acquired bloodstream infection (BSI) in patients with COVID-19 has not been specifically assessed. We aim to identify risk factors for, and outcomes of, BSI ... ...

Abstract	Objectives: The effect of the use of immunomodulatory drugs on the risk of developing hospital-acquired bloodstream infection (BSI) in patients with COVID-19 has not been specifically assessed. We aim to identify risk factors for, and outcomes of, BSI among hospitalized patients with severe COVID-19 pneumonia. Methods: We performed a severity matched case-control study (1:1 ratio) nested in a large multicentre prospective cohort of hospitalized adults with COVID-19. Cases with BSI were identified from the cohort database. Controls were matched for age, sex and acute respiratory distress syndrome. A Cox proportional hazard ratio model was performed. Results: Of 2005 patients, 100 (4.98%) presented 142 episodes of BSI, mainly caused by coagulase-negative staphylococci, Enterococcus faecalis and Pseudomonas aeruginosa. Polymicrobial infection accounted for 23 episodes. The median time from admission to the first episode of BSI was 15 days (IQR 9-20), and the most frequent source was catheter-related infection. The characteristics of patients with and without BSI were similar, including the use of tocilizumab, corticosteroids, and combinations. In the multivariate analysis, the use of these immunomodulatory drugs was not associated with an increased risk of BSI. A Cox proportional hazard ratio (HR) model showed that after adjusting for the time factor, BSI was associated with a higher in-hospital mortality risk (HR 2.59; 1.65-4.07; p < 0.001). Discussion: Hospital-acquired BSI in patients with severe COVID-19 pneumonia was uncommon and the use of immunomodulatory drugs was not associated with its development. When adjusting for the time factor, BSI was associated with a higher mortality risk.
MeSH term(s)	Adult ; Bacteremia/drug therapy ; Bacteremia/epidemiology ; COVID-19/drug therapy ; COVID-19/epidemiology ; Case-Control Studies ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Hospitals ; Humans ; Immunomodulation ; Prospective Studies ; Risk Factors ; Spain/epidemiology
Language	English
Publishing date	2021-07-07
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2021.06.041
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with

Albasanz-Puig, Adaia / Durà-Miralles, Xavier / Laporte-Amargós, Júlia / Mussetti, Alberto / Ruiz-Camps, Isabel / Puerta-Alcalde, Pedro / Abdala, Edson / Oltolini, Chiara / Akova, Murat / Montejo, José Miguel / Mikulska, Malgorzata / Martín-Dávila, Pilar / Herrera, Fabián / Gasch, Oriol / Drgona, Lubos / Morales, Hugo Manuel Paz / Brunel, Anne-Sophie / García, Estefanía / Isler, Burcu /

Microorganisms

2022 Volume 10, Issue 4

Abstract: To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with Pseudomonas aeruginosa (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco- ... ...

Abstract	To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with Pseudomonas aeruginosa (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco-hematological patients with PA bloodstream infection (BSI) (2006−2018). The effect of appropriate empirical combination therapy, appropriate monotherapy and inappropriate empirical antibiotic therapy [IEAT] on 30-day case-fatality was assessed only in patients with PA bacteremic pneumonia. Among 1017 PA BSI episodes, pneumonia was the source of BSI in 294 (28.9%). Among those, 52 (17.7%) were caused by a multidrug-resistant (MDR) strain and 68 (23.1%) received IEAT, mainly when the infection was caused by an MDR strain [38/52 (73.1%) vs. 30/242 (12.4%); p < 0.001]. The 30-day case-fatality rate was higher in patients with PA bacteremic pneumonia than in those with PA BSI from other sources (55.1% vs. 31.4%; p < 0.001). IEAT was associated with increased 30-day case-fatality (aHR 1.44 [95%CI 1.01−2.03]; p = 0.042), whereas the use of appropriate combination empirical treatment was independently associated with improved survival (aHR 0.46 [95%CI 0.27−0.78]; p = 0.004). Appropriate empirical monotherapy was not associated with improved overall survival (aHR 1.25 [95%CI 0.76−2.05]; p = 0.39). Combination antibiotic empirical therapy should be administered promptly in febrile neutropenic patients with suspected pneumonia as the source of infection.
Language	English
Publishing date	2022-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10040733
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Article ; Online: Real-Life Use of Ceftolozane/Tazobactam for the Treatment of Bloodstream Infection Due to Pseudomonas aeruginosa in Neutropenic Hematologic Patients: a Matched Control Study (ZENITH Study).

Bergas, Alba / Albasanz-Puig, Adaia / Fernández-Cruz, Ana / Machado, Marina / Novo, Andrés / van Duin, David / Garcia-Vidal, Carolina / Hakki, Morgan / Ruiz-Camps, Isabel / Del Pozo, José Luis / Oltolini, Chiara / DeVoe, Catherine / Drgona, Lubos / Gasch, Oriol / Mikulska, Malgorzata / Martín-Dávila, Pilar / Peghin, Maddalena / Vázquez, Lourdes / Laporte-Amargós, Júlia /

Durà-Miralles, Xavier / Pallarès, Natàlia / González-Barca, Eva / Álvarez-Uría, Ana / Puerta-Alcalde, Pedro / Aguilar-Company, Juan / Carmona-Torre, Francisco / Clerici, Teresa Daniela / Doernberg, Sarah B / Petrikova, Lucía / Capilla, Silvia / Magnasco, Laura / Fortún, Jesús / Castaldo, Nadia / Carratalà, Jordi / Gudiol, Carlota

Microbiology spectrum

2022 Volume 10, Issue 3, Page(s) e0229221

Abstract: We sought to assess the characteristics and outcomes of neutropenic hematologic patients with Pseudomonas aeruginosa (PA) bloodstream infection (BSI) treated with ceftolozane-tazobactam (C/T). We conducted a multicenter, international, matched-cohort ... ...

Abstract	We sought to assess the characteristics and outcomes of neutropenic hematologic patients with Pseudomonas aeruginosa (PA) bloodstream infection (BSI) treated with ceftolozane-tazobactam (C/T). We conducted a multicenter, international, matched-cohort study of PA BSI episodes in neutropenic hematologic patients who received C/T. Controls were patients with PA BSI treated with other antibiotics. Risk factors for overall 7-day and 30-day case fatality rates were analyzed. We compared 44 cases with 88 controls. Overall, 91% of episodes were caused by multidrug-resistant (MDR) strains. An endogenous source was the most frequent BSI origin (35.6%), followed by pneumonia (25.8%). There were no significant differences in patient characteristics between groups. C/T was given empirically in 11 patients and as definitive therapy in 41 patients. Treatment with C/T was associated with less need for mechanical ventilation (13.6% versus 33.3%;
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cephalosporins/therapeutic use ; Cohort Studies ; Drug Resistance, Multiple, Bacterial ; Humans ; Microbial Sensitivity Tests ; Neutropenia/complications ; Neutropenia/drug therapy ; Pneumonia/drug therapy ; Pseudomonas Infections/drug therapy ; Pseudomonas aeruginosa ; Sepsis/drug therapy ; Tazobactam/pharmacology ; Tazobactam/therapeutic use
Chemical Substances	Anti-Bacterial Agents ; Cephalosporins ; ceftolozane (37A4IES95Q) ; Tazobactam (SE10G96M8W)
Language	English
Publishing date	2022-04-27
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02292-21
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