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  1. AU="Bergdall, Valerie"
  2. AU="George Th. Tsangaris"
  3. AU="Maria C Jordan"
  4. AU="Zhang, Zhen-Hai"
  5. AU=Lorenzo-Gomez M F AU=Lorenzo-Gomez M F
  6. AU="Weng, Wei-Chien"
  7. AU="Michael Zauner"
  8. AU="Offin, M."
  9. AU=Burney Ikram A
  10. AU="Sciubba, Adalberto"
  11. AU="Hu, Tony Y"
  12. AU="L'Hoyes, Wouter"
  13. AU="Bernhardt, Sarah M"
  14. AU="Holman, Wayne"
  15. AU="Ghabi, Elie"
  16. AU="Pan, Jia-fu"
  17. AU="Fareed, Zeeshan"
  18. AU="Watkins, A Claire"
  19. AU="Taggart, Michael"
  20. AU="Boone, William J"

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  1. Artikel ; Online: Serum Concentrations of a Long-acting Cat Formulation of Transdermal Buprenorphine in C57BL/6 Mice.

    Emmer, Kathryn M / Chlada, Kaci N / Bergdall, Valerie K

    Journal of the American Association for Laboratory Animal Science : JAALAS

    2023  Band 62, Heft 4, Seite(n) 349–354

    Abstract: Long-acting analgesics such as extended-release buprenorphine are desirable in rodent medicine because they reduce need for administration of additional medication and provide stable drug levels. We measured the serum concentrations of buprenorphine ... ...

    Abstract Long-acting analgesics such as extended-release buprenorphine are desirable in rodent medicine because they reduce need for administration of additional medication and provide stable drug levels. We measured the serum concentrations of buprenorphine after topical administration of a long-acting transdermal buprenorphine (LAT-bup) solution to female C57BL/6 mice. We hypothesized that LAT-bup dosed topically at 40mg/kg would achieve serum drug concentrations of greater than 1ng/mL, which is considered the therapeutic level for adequate analgesia in rodents. LAT-bup administered at 40mg/kg resulted in serum drug concentrations above 1ng/mL for all mice at time points 2, 4, 24, 48, 72, and 96 h (n = 3/time point), as assessed by liquid chromatography-mass spectrometry. No adverse effects were noted when LAT-bup was dosed at either 30mg/kg or 40mg/kg. We conclude that LAT-bup is easily administered to mice and achieves adequate blood levels for 96 h. Further studies evaluating analgesic efficacy are indicated.
    Mesh-Begriff(e) Female ; Mice ; Animals ; Analgesics, Opioid ; Mice, Inbred C57BL ; Buprenorphine ; Pain/drug therapy ; Analgesia
    Chemische Substanzen Analgesics, Opioid ; Buprenorphine (40D3SCR4GZ)
    Sprache Englisch
    Erscheinungsdatum 2023-09-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2769-6677
    ISSN (online) 2769-6677
    DOI 10.30802/AALAS-JAALAS-22-000101
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  2. Artikel ; Online: Comparison of Floor Cleaning and Disinfection Processes in a Research Animal Facility.

    Capria, Vittoria M / Fernandez, Max O / Walker, Mary M / Bergdall, Valerie K

    Journal of the American Association for Laboratory Animal Science : JAALAS

    2022  Band 61, Heft 6, Seite(n) 644–649

    Abstract: Floor cleaning and disinfection are essential components of maintaining animal health status and meeting regulatory requirements in research vivaria. However, best practices for method, frequency, and evaluation techniques have not been established. ... ...

    Abstract Floor cleaning and disinfection are essential components of maintaining animal health status and meeting regulatory requirements in research vivaria. However, best practices for method, frequency, and evaluation techniques have not been established. Reuse of cotton string mop and bucket systems has been implicated in spreading contamination in the human hospital setting. We evaluated 4 different combinations of disinfectant and mop systems commonly used in rodent vivaria. Eight housing rooms were mopped a total of 4 times using one of the following methods: quaternary ammonium compound (QUAT) and cotton string mop (QC), QUAT and microfiber mop (QM), hydrogen peroxide disinfectant (HPD) and cotton string mop (HC), or HPD and microfiber mop (HM). ATP and RODAC samples of the floor were taken before and after mopping. The time to mop each room, floor drying time, and the amount of disinfectant used were recorded. The QC method was associated with significantly more bacterial contamination while all other methods significantly reduced bacterial contamination. The QC method performed significantly worse in reducing bacterial contamination as compared with all other methods when cotton mop heads were reused. All methods except QC significantly reduced ATP levels, with the HC and HM methods being significantly more effective at reducing ATP levels than the QC and QM methods. Costs were similar for the QC, QM, and HM methods. The results of this study indicate that reuse of cotton string mop heads with QUAT increases floor contamination while HPD is effective for up to 3 reuses. Single use microfiber mops were effective with both QUAT and HPD but did not result in more effective cleaning or disinfection than cotton string mops.
    Mesh-Begriff(e) Humans ; Animals ; Disinfection/methods ; Floors and Floorcoverings ; Disinfectants/pharmacology ; Quaternary Ammonium Compounds ; Bacteria ; Adenosine Triphosphate
    Chemische Substanzen Disinfectants ; Quaternary Ammonium Compounds ; Adenosine Triphosphate (8L70Q75FXE)
    Sprache Englisch
    Erscheinungsdatum 2022-11-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2769-6677
    ISSN (online) 2769-6677
    DOI 10.30802/AALAS-JAALAS-22-000042
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  3. Artikel ; Online: Evaluation of Rodent Cage Processing Using Reduced Water Temperatures.

    Walker, Mary M / Harrison, Dianne M / Collins, Toi A / Bergdall, Valerie K

    Journal of the American Association for Laboratory Animal Science : JAALAS

    2021  Band 60, Heft 4, Seite(n) 442–450

    Abstract: Studies published in 1994 and 2000 established a temperature range of 143-180 °F for effective cage sanitization in animal facilities. These 2 studies were, respectively, theoretical and based on experiments using hot water to sanitize bacteria-coated ... ...

    Abstract Studies published in 1994 and 2000 established a temperature range of 143-180 °F for effective cage sanitization in animal facilities. These 2 studies were, respectively, theoretical and based on experiments using hot water to sanitize bacteria-coated test tubes. However, such experimental methods may not capture the practical advantages of modern washing technology or account for the routine use of detergent in cage wash. Moreover, these methods may not translate to the challenges of removing adhered debris and animal waste from the surfaces being sanitized. A sample of highly soiled cage bottoms, half of which were autoclaved with bedding to create challenging cleaning conditions, were processed at 6 combinations of wash and rinse cycles with 125 °F, 140 °F, and 180 °F water with detergent. All cycles were equipped with a data logging device to independently verify temperatures. After washing, cages underwent visual inspection and microbial sampling consisting of organic material detection using ATP detection and Replicate Organism Detection and Counting (RODAC) plates. Cages with any amount of visible debris failed inspection, as did cages that exceeded institutional sanitization thresholds. Results indicate that wash and rinse temperatures of 140 °F for a programmed wash duration of 450 s and rinse of 50 s effectively clean and disinfect both highly soiled and autoclaved cages. Accounting for both steam and electrical energy, these parameters result in an annual savings of $21,867.08 per washer on an equivalent run basis using the current institutional standard of 180 °F.
    Mesh-Begriff(e) Animals ; Housing, Animal ; Rodentia ; Sterilization ; Temperature ; Water
    Chemische Substanzen Water (059QF0KO0R)
    Sprache Englisch
    Erscheinungsdatum 2021-06-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2769-6677
    ISSN (online) 2769-6677
    DOI 10.30802/AALAS-JAALAS-20-000132
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  4. Artikel ; Online: MG53 Mitigates Nitrogen Mustard-Induced Skin Injury.

    Li, Haichang / Li, Zhongguang / Li, Xiuchun / Cai, Chuanxi / Zhao, Serena Li / Merritt, Robert E / Zhou, Xinyu / Tan, Tao / Bergdall, Valerie / Ma, Jianjie

    Cells

    2023  Band 12, Heft 14

    Abstract: Sulfur mustard (SM) and nitrogen mustard (NM) are vesicant agents that cause skin injury and blistering through complicated cellular events, involving DNA damage, free radical formation, and lipid peroxidation. The development of therapeutic approaches ... ...

    Abstract Sulfur mustard (SM) and nitrogen mustard (NM) are vesicant agents that cause skin injury and blistering through complicated cellular events, involving DNA damage, free radical formation, and lipid peroxidation. The development of therapeutic approaches targeting the multi-cellular process of tissue injury repair can potentially provide effective countermeasures to combat vesicant-induced dermal lesions. MG53 is a vital component of cell membrane repair. Previous studies have demonstrated that topical application of recombinant human MG53 (rhMG53) protein has the potential to promote wound healing. In this study, we further investigate the role of MG53 in NM-induced skin injury. Compared with
    Mesh-Begriff(e) Mice ; Humans ; Animals ; Mechlorethamine/toxicity ; Mechlorethamine/metabolism ; Irritants/metabolism ; Keratinocytes/metabolism ; Wound Healing/physiology ; Membrane Proteins/metabolism
    Chemische Substanzen Mechlorethamine (50D9XSG0VR) ; Irritants ; MG53 protein, mouse ; Membrane Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-07-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12141915
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  5. Artikel ; Online: Reuse of Disposable Isolation Gowns in Rodent Facilities during a Pandemic.

    Collins, Toi A / Sparks, Amanda E / Walker, Mary M / Kendall, Lon V / Dobos, Karen M / Bergdall, Valerie K / Hickman-Davis, Judy M

    Journal of the American Association for Laboratory Animal Science : JAALAS

    2021  Band 60, Heft 4, Seite(n) 431–441

    Abstract: Reuse of disposable personal protective equipment is traditionally discouraged, yet in times of heightened medical applications such as the SARS CoV-2 pandemic, it can be difficult to obtain. In this article we examine the reuse of disposable gowns with ... ...

    Abstract Reuse of disposable personal protective equipment is traditionally discouraged, yet in times of heightened medical applications such as the SARS CoV-2 pandemic, it can be difficult to obtain. In this article we examine the reuse of disposable gowns with respect to still providing personnel protection. XR7, a fluorescent powder, was used to track contamination of gowns after manipulation of rodent cages. Mouse cages were treated with XR7 prior to manipulations. Disposable gowns were labeled for single person use and hung in common procedure spaces within the vivarium between usages. A simulated rack change of 140 cages was completed using XR7-treated cages. One individual changed all cages with a break occurring after the first 70 cages, requiring the gown to be removed and reused once. To simulate research activities, 5 individuals accessed 3 XR7-treated cages daily for 5 d. Each mouse in the XR7-treated cages was manipulated at least once before returning cages to the housing room. Disposable gowns were reused 5 times per individual. Gowns, gloves, clothing, bare arms, and hands were scanned for fluorescence before and after removing PPE. Fluorescence was localized to gloves and gown sleeves in closest contact with animals and caging. No fluorescence was detected on underlying clothing, or bare arms and hands after removing PPE. Fluorescence was not detected in procedure spaces where gowns were hung. The lack of fluorescence on personnel or surfaces indicate that gowns can be reused 1 time for routine husbandry tasks and up to 5 times for research personnel. A method for decontamination of used gowns using Vaporized Hydrogen Peroxide (VHP) was also validated for use in areas where animals are considered high risk such as quarantine, or for fragile immunocompromised rodent colonies.
    Mesh-Begriff(e) Animal Technicians ; Animals ; Animals, Laboratory ; Disposable Equipment ; Health Personnel ; Housing, Animal ; Humans ; Mice ; Pandemics/prevention & control ; Personal Protective Equipment ; Protective Clothing
    Sprache Englisch
    Erscheinungsdatum 2021-06-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2769-6677
    ISSN (online) 2769-6677
    DOI 10.30802/AALAS-JAALAS-20-000130
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  6. Artikel: Performance analysis of exam gloves used for aseptic rodent surgery.

    LeMoine, Dana M / Bergdall, Valerie K / Freed, Carrie

    Journal of the American Association for Laboratory Animal Science : JAALAS

    2015  Band 54, Heft 3, Seite(n) 311–316

    Abstract: Aseptic technique includes the use of sterile surgical gloves for survival surgeries in rodents to minimize the incidence of infections. Exam gloves are much less expensive than are surgical gloves and may represent a cost-effective, readily available ... ...

    Abstract Aseptic technique includes the use of sterile surgical gloves for survival surgeries in rodents to minimize the incidence of infections. Exam gloves are much less expensive than are surgical gloves and may represent a cost-effective, readily available option for use in rodent surgery. This study examined the effectiveness of surface disinfection of exam gloves with 70% isopropyl alcohol or a solution of hydrogen peroxide and peracetic acid (HP-PA) in reducing bacterial contamination. Performance levels for asepsis were met when gloves were negative for bacterial contamination after surface disinfection and sham 'exertion' activity. According to these criteria, 94% of HP-PA-disinfected gloves passed, compared with 47% of alcohol-disinfected gloves. In addition, the effect of autoclaving on the integrity of exam gloves was examined, given that autoclaving is another readily available option for aseptic preparation. Performance criteria for glove integrity after autoclaving consisted of: the ability to don the gloves followed by successful simulation of wound closure and completion of stretch tests without tearing or observable defects. Using this criteria, 98% of autoclaved nitrile exam gloves and 76% of autoclaved latex exam gloves met performance expectations compared with the performance of standard surgical gloves (88% nitrile, 100% latex). The results of this study support the use of HP-PA-disinfected latex and nitrile exam gloves or autoclaved nitrile exam gloves as viable cost-effective alternatives to sterile surgical gloves for rodent surgeries.
    Mesh-Begriff(e) 2-Propanol ; Animals ; Animals, Laboratory ; Asepsis ; Disinfection/methods ; Gloves, Protective/economics ; Gloves, Protective/microbiology ; Gloves, Protective/veterinary ; Gloves, Surgical/economics ; Gloves, Surgical/veterinary ; Latex ; Rodentia
    Chemische Substanzen Latex ; 2-Propanol (ND2M416302)
    Sprache Englisch
    Erscheinungsdatum 2015-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1559-6109
    ISSN 1559-6109
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  7. Artikel ; Online: Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development.

    Niu, Hong / Li, Haichang / Guan, Ya / Zhou, Xin / Li, Zhongguang / Zhao, Serana Li / Chen, Peng / Tan, Tao / Zhu, Hua / Bergdall, Valerie / Xu, Xuehong / Ma, Jianjie / Guan, Jianjun

    Bioactive materials

    2022  Band 18, Seite(n) 104–115

    Abstract: MG53 is an essential component of the cell membrane repair machinery, participating in the healing of dermal wounds. Here we develop a novel delivery system using recombinant human MG53 (rhMG53) protein and a reactive oxygen species (ROS)-scavenging gel ... ...

    Abstract MG53 is an essential component of the cell membrane repair machinery, participating in the healing of dermal wounds. Here we develop a novel delivery system using recombinant human MG53 (rhMG53) protein and a reactive oxygen species (ROS)-scavenging gel to treat diabetic wounds. Mice with ablation of MG53 display defective hair follicle structure, and topical application of rhMG53 can promote hair growth in the
    Sprache Englisch
    Erscheinungsdatum 2022-03-16
    Erscheinungsland China
    Dokumenttyp Journal Article
    ISSN 2452-199X
    ISSN (online) 2452-199X
    DOI 10.1016/j.bioactmat.2022.03.017
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  8. Artikel ; Online: MG53 attenuates nitrogen mustard-induced acute lung injury.

    Li, Haichang / Rosas, Lucia / Li, Zhongguang / Bian, Zehua / Li, Xiuchun / Choi, Kyounghan / Cai, Chuanxi / Zhou, Xinyu / Tan, Tao / Bergdall, Valerie / Whitson, Bryan / Davis, Ian / Ma, Jianjie

    Journal of cellular and molecular medicine

    2022  Band 26, Heft 7, Seite(n) 1886–1895

    Abstract: Nitrogen mustard (NM) is an alkylating vesicant that causes severe pulmonary injury. Currently, there are no effective means to counteract vesicant-induced lung injury. MG53 is a vital component of cell membrane repair and lung protection. Here, we show ... ...

    Abstract Nitrogen mustard (NM) is an alkylating vesicant that causes severe pulmonary injury. Currently, there are no effective means to counteract vesicant-induced lung injury. MG53 is a vital component of cell membrane repair and lung protection. Here, we show that mice with ablation of MG53 are more susceptible to NM-induced lung injury than the wild-type mice. Treatment of wild-type mice with exogenous recombinant human MG53 (rhMG53) protein ameliorates NM-induced lung injury by restoring arterial blood oxygen level, by improving dynamic lung compliance and by reducing airway resistance. Exposure of lung epithelial and endothelial cells to NM leads to intracellular oxidative stress that compromises the intrinsic cell membrane repair function of MG53. Exogenous rhMG53 protein applied to the culture medium protects lung epithelial and endothelial cells from NM-induced membrane injury and oxidative stress, and enhances survival of the cells. Additionally, we show that loss of MG53 leads to increased vulnerability of macrophages to vesicant-induced cell death. Overall, these findings support the therapeutic potential of rhMG53 to counteract vesicant-induced lung injury.
    Mesh-Begriff(e) Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; Acute Lung Injury/genetics ; Animals ; Endothelial Cells/metabolism ; Lung/metabolism ; Mechlorethamine/therapeutic use ; Mechlorethamine/toxicity ; Membrane Proteins/metabolism ; Mice ; Recombinant Proteins/metabolism
    Chemische Substanzen MG53 protein, mouse ; Membrane Proteins ; Recombinant Proteins ; Mechlorethamine (50D9XSG0VR)
    Sprache Englisch
    Erscheinungsdatum 2022-02-24
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.16917
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    Zs.A 5752: Hefte anzeigen Standort:
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  9. Artikel ; Online: Institutional animal care and use committee review of clinical studies.

    Kendall, Lon V / Petervary, Nicolette / Bergdall, Valerie K / Page, Rod L / Baneux, Philippe J R

    Journal of the American Veterinary Medical Association

    2018  Band 253, Heft 8, Seite(n) 980–984

    Mesh-Begriff(e) Animal Care Committees ; Animal Experimentation/ethics ; Animal Experimentation/standards ; Animal Welfare ; Animals ; Animals, Laboratory ; Laboratory Animal Science/standards
    Sprache Englisch
    Erscheinungsdatum 2018-10-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 390811-2
    ISSN 1943-569X ; 0003-1488
    ISSN (online) 1943-569X
    ISSN 0003-1488
    DOI 10.2460/javma.253.8.980
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  10. Artikel ; Online: Institutional Animal Care and Use Committee Considerations Regarding the Use of Virus-Induced Carcinogenesis and Oncolytic Viral Models.

    Lewis, Stephanie D / Hickman-Davis, Judy M / Bergdall, Valerie K

    ILAR journal

    2016  Band 57, Heft 1, Seite(n) 86–94

    Abstract: The use of virus-induced carcinogenesis and oncologic experimental animal models is essential in understanding the mechanisms of cancer development to advance prevention, diagnosis, and treatment methods. The Institutional Animal Care and Use Committee ( ... ...

    Abstract The use of virus-induced carcinogenesis and oncologic experimental animal models is essential in understanding the mechanisms of cancer development to advance prevention, diagnosis, and treatment methods. The Institutional Animal Care and Use Committee (IACUC) is responsible for both the complex philosophical and practical considerations associated with animal models of cancer. Animal models of cancer carry their own unique issues that require special consideration from the IACUC. Many of the considerations to be discussed apply to cancer models in general; specific issues related to viral carcinogenesis or oncolytic viruses will be specifically discussed as they arise. Responsible animal use integrates good science, humane care, and regulatory compliance. To meet those standards, the IACUC, in conjunction with the research investigator and attending veterinarian, must address a wide range of issues, including animal model selection, cancer model selection, humane end point considerations, experimental considerations, postapproval monitoring, reporting requirements, and animal management and personnel safety considerations.
    Mesh-Begriff(e) Animal Care Committees ; Animals ; Carcinogenesis ; Disease Models, Animal ; Humans ; Neoplasms/therapy ; Neoplasms/virology ; Oncolytic Virotherapy
    Sprache Englisch
    Erscheinungsdatum 2016
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2192062-X
    ISSN 1930-6180 ; 1084-2020
    ISSN (online) 1930-6180
    ISSN 1084-2020
    DOI 10.1093/ilar/ilv046
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