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  1. Article ; Online: A novel role for PGE

    Yarboro, Michael T / Boatwright, Naoko / Sekulich, Deanna C / Hooper, Christopher W / Wong, Ting / Poole, Stanley D / Berger, Courtney D / Brown, Alexus J / Jetter, Christopher S / Sucre, Jennifer M S / Shelton, Elaine L / Reese, Jeff

    American journal of physiology. Heart and circulatory physiology

    2023  Volume 325, Issue 4, Page(s) H687–H701

    Abstract: The ductus arteriosus (DA) is a vascular shunt that allows oxygenated blood to bypass the developing lungs in utero. Fetal DA patency requires vasodilatory signaling via the prostaglandin ... ...

    Abstract The ductus arteriosus (DA) is a vascular shunt that allows oxygenated blood to bypass the developing lungs in utero. Fetal DA patency requires vasodilatory signaling via the prostaglandin E
    MeSH term(s) Mice ; Animals ; Infant, Newborn ; Female ; Pregnancy ; Humans ; Ductus Arteriosus/metabolism ; Dinoprostone/metabolism ; Receptors, Prostaglandin E, EP4 Subtype/genetics ; Receptors, Prostaglandin E, EP4 Subtype/metabolism ; Ductus Arteriosus, Patent/genetics ; Mice, Knockout
    Chemical Substances Dinoprostone (K7Q1JQR04M) ; Receptors, Prostaglandin E, EP4 Subtype
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00294.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Molecular and mechanical factors contributing to ductus arteriosus patency and closure.

    Crockett, Stacey L / Berger, Courtney D / Shelton, Elaine L / Reese, Jeff

    Congenital heart disease

    2018  Volume 14, Issue 1, Page(s) 15–20

    Abstract: Regulation of the ductus arteriosus, an essential fetal vessel connecting the pulmonary artery and aorta, is complex. Failure of this vessel to close after birth may result in a persistent left-to-right shunt through the patent ductus arteriosus, a ... ...

    Abstract Regulation of the ductus arteriosus, an essential fetal vessel connecting the pulmonary artery and aorta, is complex. Failure of this vessel to close after birth may result in a persistent left-to-right shunt through the patent ductus arteriosus, a condition associated with significant morbidities. Numerous factors contribute to the shift from fetal ductus patency to postnatal closure, requiring precise coordination of molecular cues with biomechanical forces and underlying genetic influences. Despite significant advances, questions remain regarding signaling dynamics and the natural time course of ductus closure, particularly in preterm neonates. This review highlights the contributions of early investigators and more recent clinician scientists to our understanding of the molecular and mechanical factors that mediate ductus patency and closure.
    MeSH term(s) Cardiac Surgical Procedures/methods ; Ductus Arteriosus/diagnostic imaging ; Ductus Arteriosus, Patent/metabolism ; Ductus Arteriosus, Patent/psychology ; Ductus Arteriosus, Patent/surgery ; Hemodynamics/physiology ; Humans ; Infant, Newborn ; Oxidative Stress/physiology
    Language English
    Publishing date 2018-11-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2274321-2
    ISSN 1747-0803 ; 1747-079X
    ISSN (online) 1747-0803
    ISSN 1747-079X
    DOI 10.1111/chd.12714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6693: Show issues Location:
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  3. Article ; Online: Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness.

    Crockett, Stacey L / Harris, Micah / Boatwright, Naoko / Su, Rachel L / Yarboro, Michael T / Berger, Courtney D / Shelton, Elaine L / Reese, Jeff / Segar, Jeffrey L

    Pediatric research

    2019  Volume 87, Issue 6, Page(s) 991–997

    Abstract: Background: Indomethacin treatment for patent ductus arteriosus (PDA) is associated with acute kidney injury (AKI). Fenoldopam, a dopamine (DA) DA: Methods: DA receptor expression in CD-1 mouse vessels was analyzed by qPCR and immunohistochemistry. ... ...

    Abstract Background: Indomethacin treatment for patent ductus arteriosus (PDA) is associated with acute kidney injury (AKI). Fenoldopam, a dopamine (DA) DA
    Methods: DA receptor expression in CD-1 mouse vessels was analyzed by qPCR and immunohistochemistry. Concentration-response curves were established using pressure myography. Pretreatment with SCH23390 (DA
    Results: DA
    Conclusion(s): DA receptors are present in the ductus but have limited physiologic effects. DA-induced ductus vasoconstriction is mediated via α-adrenergic pathways. The absence of DA
    MeSH term(s) Animals ; Dopamine/metabolism ; Dopamine Agonists/pharmacology ; Ductus Arteriosus/drug effects ; Ductus Arteriosus/metabolism ; Ductus Arteriosus/physiopathology ; Ductus Arteriosus, Patent/drug therapy ; Ductus Arteriosus, Patent/metabolism ; Ductus Arteriosus, Patent/physiopathology ; Female ; Fenoldopam/pharmacology ; Indomethacin/toxicity ; Mice ; Oxygen/toxicity ; Pregnancy ; Receptors, Dopamine D1/agonists ; Receptors, Dopamine D1/metabolism ; Signal Transduction ; Vasoconstriction/drug effects ; Vasodilation/drug effects ; Vasodilator Agents/pharmacology
    Chemical Substances Dopamine Agonists ; Drd1 protein, mouse ; Receptors, Dopamine D1 ; Vasodilator Agents ; Fenoldopam (INU8H2KAWG) ; Oxygen (S88TT14065) ; Dopamine (VTD58H1Z2X) ; Indomethacin (XXE1CET956)
    Language English
    Publishing date 2019-12-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-019-0716-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 564: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 373: Show issues

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