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  1. Article ; Online: Editorial: Diagnosis of zoonoses: Relevance of BSL3 and BSL4 facilities.

    Berger, Kavita / Garbuglia, Anna Rosa

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 1052082

    MeSH term(s) Animals ; Humans ; Zoonoses/diagnosis ; Laboratories
    Language English
    Publishing date 2022-10-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.1052082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Emerging and Enabling Technologies in Biodefense

    Berger, Kavita M.

    Defense Against Biological Attacks

    Abstract: The emergence of new biotechnologies provides great promise for biodefense, especially for key objectives of biosurveillance and early warning, microbial forensics, risk and threat assessment, horizon scanning in biotechnology, and medical countermeasure ...

    Abstract The emergence of new biotechnologies provides great promise for biodefense, especially for key objectives of biosurveillance and early warning, microbial forensics, risk and threat assessment, horizon scanning in biotechnology, and medical countermeasure (MCM) development, scale-up, and delivery. Understanding and leveraging the newly developed capabilities afforded by emerging biotechnologies require knowledge about cutting-edge research and its real or proposed application(s), the process through which biotechnologies advance, and the educational and research infrastructure that promotes multi-disciplinary science. Innovation in research and technology development are driven by sector-specific needs and the convergence of the physical, chemical, material, computer, engineering, and/or life sciences. Biotechnologies developed for other sectors could be applied to biodefense, especially if the individuals involved are able to innovate in concept design and development. Of all biodefense objectives, biosurveillance seems to have reaped the most benefit from emerging biotechnologies, specifically the integration and analysis of diverse clinical, biological, demographic, and other relevant data. More recently, scientists have begun applying synthetic biology, genomics, and microfluidics to the development of new products and platforms for MCMs. Unlike these objectives, investments in microbial forensics have been few, limiting its ability to harness biotechnology advances for collecting and analyzing data. Looking to the future, emerging biotechnologies can provide new opportunities for enhancing biodefense by addressing capability gaps.
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1007/978-3-030-03053-7_13
    Database COVID19

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  3. Article ; Online: What life scientists should know about security threats.

    Berger, Kavita M

    Science (New York, N.Y.)

    2016  Volume 354, Issue 6317, Page(s) 1237–1239

    MeSH term(s) Academies and Institutes ; Biohazard Release/prevention & control ; Biological Science Disciplines ; Humans ; Knowledge ; Malpractice ; Research Personnel/psychology ; Risk Assessment ; Security Measures ; Universities
    Keywords covid19
    Language English
    Publishing date 2016-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aaf9334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: National and Transnational Security Implications of Asymmetric Access to and Use of Biological Data.

    Berger, Kavita M / Schneck, Phyllis A

    Frontiers in bioengineering and biotechnology

    2019  Volume 7, Page(s) 21

    Abstract: Biology and biotechnology have changed dramatically during the past 20 years, in part because of increases in computational capabilities and use of engineering principles to study biology. The advances in supercomputing, data storage capacity, and cloud ... ...

    Abstract Biology and biotechnology have changed dramatically during the past 20 years, in part because of increases in computational capabilities and use of engineering principles to study biology. The advances in supercomputing, data storage capacity, and cloud platforms enable scientists throughout the world to generate, analyze, share, and store vast amounts of data, some of which are biological and much of which may be used to understand the human condition, agricultural systems, evolution, and environmental ecosystems. These advances and applications have enabled: (1) the emergence of data science, which involves the development of new algorithms to analyze and visualize data; and (2) the use of engineering approaches to manipulate or create new biological organisms that have specific functions, such as production of industrial chemical precursors and development of environmental bio-based sensors. Several biological sciences fields harness the capabilities of computer, data, and engineering sciences, including synthetic biology, precision medicine, precision agriculture, and systems biology. These advances and applications are not limited to one country. This capability has economic and physical consequences, but is vulnerable to unauthorized intervention. Healthcare and genomic information of patients, information about pharmaceutical and biotechnology products in development, and results of scientific research have been stolen by state and non-state actors through infiltration of databases and computer systems containing this information. Countries have developed their own policies for governing data generation, access, and sharing with foreign entities, resulting in asymmetry of data sharing. This paper describes security implications of asymmetric access to and use of biological data.
    Language English
    Publishing date 2019-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2019.00021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Promoting biosecurity by professionalizing biosecurity.

    Moritz, Rebecca L / Berger, Kavita M / Owen, Barbara R / Gillum, David R

    Science (New York, N.Y.)

    2020  Volume 367, Issue 6480, Page(s) 856–858

    MeSH term(s) Containment of Biohazards/methods ; Humans ; Professional Practice
    Keywords covid19
    Language English
    Publishing date 2020-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aba0376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Biosecurity Implications for the Synthesis of Horsepox, an Orthopoxvirus.

    DiEuliis, Diane / Berger, Kavita / Gronvall, Gigi

    Health security

    2017  Volume 15, Issue 6, Page(s) 629–637

    Abstract: This article examines the biosecurity and biodefense implications resulting from the recent creation of horsepox virus, a noncirculating (extinct) species of orthopoxvirus. Here we examine the technical aspects of the horsepox virus synthesis and ... ...

    Abstract This article examines the biosecurity and biodefense implications resulting from the recent creation of horsepox virus, a noncirculating (extinct) species of orthopoxvirus. Here we examine the technical aspects of the horsepox virus synthesis and conclude that orthopox synthesis experiments currently remain technically challenging-and will continue to be so, even once this work is published in the scientific literature. This limits potential misuse by some types of nefarious actors. We also examine the implications of one stated purpose for the recreation of horsepox virus: the development of a smallpox vaccine. If the development is successful, it could take advantage of US government incentives for the priority FDA review of medical countermeasures (MCMs) against biosecurity threats. However, if this case leads to the determination that this incentive is counterproductive for security, the newly created priority review voucher program should be more clearly defined or limited based on need. Limiting the program could have costs that require further consideration, however, as general incentives for biodefense medical countermeasure development are required for MCMs to be available. Finally, while the recreation of horsepox virus was not technically trivial, nor was it cell-free, this experiment was a de facto demonstration of already-assumed scientific capabilities. The ability to recreate horsepox, or smallpox, will remain no matter what policy controls are put into place. It will be impossible to close off all avenues for nefarious misuse of gene synthesis, or misuse of biological materials more broadly. As a result, we advocate for the implementation of policy, regulations, and guidance that will make illicit recreation harder, more burdensome, more detectable, and, thus, more preventable without having sweeping negative consequences for the research enterprise. As part of our biosecurity efforts, we must also encourage and enable scientists to participate actively and to do all they can to safeguard their technical fields from irresponsible or illicit actions.
    MeSH term(s) Biohazard Release/prevention & control ; Communicable Diseases, Emerging/prevention & control ; Humans ; Orthopoxvirus/genetics ; Smallpox/immunology ; Smallpox/prevention & control ; Smallpox Vaccine/genetics ; Vaccinia/genetics
    Chemical Substances Smallpox Vaccine
    Language English
    Publishing date 2017-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2823049-8
    ISSN 2326-5108 ; 2326-5094
    ISSN (online) 2326-5108
    ISSN 2326-5094
    DOI 10.1089/hs.2017.0081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online ; Conference proceedings: Biological safety training as a component of personnel reliability

    Berger, Kavita Marfatia

    workshop report

    2009  

    Abstract: This workshop is one of four workshops on biosecurity education. At the workshop, participants discussed similarities and differences in infrastructure, oversight and personnel training between biosafety level 3 (BSL-3) and biosafety level 4 (BSL-4) ... ...

    Institution American Association for the Advancement of Science
    Author's details prepared by Kavita Marfatia Berger ... [et al.]
    Abstract This workshop is one of four workshops on biosecurity education. At the workshop, participants discussed similarities and differences in infrastructure, oversight and personnel training between biosafety level 3 (BSL-3) and biosafety level 4 (BSL-4) laboratories.
    MeSH term(s) Laboratories/standards ; Safety Management
    Keywords United States
    Language English
    Publisher American Association for the Advancement of Science
    Publishing place Washington, DC
    Document type Book ; Online ; Conference proceedings
    Note Title from PDF t.p.
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article ; Online: Biodefense Policy Analysis-A Systems-based Approach.

    DiEuliis, Diane / Rao, Venkat / Billings, Emily A / Meyer, Corey B / Berger, Kavita

    Health security

    2019  Volume 17, Issue 2, Page(s) 83–99

    Abstract: Understanding the overall biosecurity and biodefense policy landscape, the relationships between policies and their effects on each other, and the mechanisms for leveraging advances in science and technology to enhance defensive capabilities is crucial ... ...

    Abstract Understanding the overall biosecurity and biodefense policy landscape, the relationships between policies and their effects on each other, and the mechanisms for leveraging advances in science and technology to enhance defensive capabilities is crucial for ensuring that policy strategies address long-standing gaps and challenges. To date, policy analyses have been conducted primarily on single issues, which limits analyses of broader effects of policies, particularly after implementation. Here we describe the first-ever systems-based analysis of the US biosecurity and biodefense policy landscape to analyze functional relationships between policies, including examination of the unintended positive or negative consequences of policy actions. This analysis revealed a striking bifurcation of the US policy landscape for countering biological threats, with one grouping of policies focused on prevention of theft, diversion, or deliberate malicious use of biological sciences knowledge, skills, materials, and technologies (ie, biosecurity) and a second grouping on development of capabilities and knowledge to assess, detect, monitor, respond to, and attribute biological threats (ie, biodefense). An analysis of indirect effects demonstrated that policies within groups may result in mutual benefit, but policies in different groups may counteract each other, limiting achievement of the policy objectives in either group. The current policy landscape predominantly focuses on pathogens and toxins, having limited focus on rapidly changing biotechnologies with potential to positively contribute to biodefense capabilities or introduce unknown and/or unacceptable security risk. Based on our analyses, we present actions for implementing biosecurity and biodefense policy in the United States that intends to harness the benefits of science and technology while also minimizing potential risks. This article synthesizes and highlights the major findings and conclusions from the detailed analyses, which can be found in the full report ( http://www.gryphonscientific.com/biosecurity-policy/ ).
    MeSH term(s) Biotechnology/legislation & jurisprudence ; Bioterrorism/legislation & jurisprudence ; Bioterrorism/prevention & control ; Humans ; Policy Making ; Security Measures/legislation & jurisprudence ; Systems Analysis ; United States
    Language English
    Publishing date 2019-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2823049-8
    ISSN 2326-5108 ; 2326-5094
    ISSN (online) 2326-5108
    ISSN 2326-5094
    DOI 10.1089/hs.2018.0082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: New rules for biosecurity.

    Berger, Kavita M / Leshner, Alan I

    Science (New York, N.Y.)

    2009  Volume 324, Issue 5931, Page(s) 1117

    MeSH term(s) Biomedical Research ; Containment of Biohazards ; Government Regulation ; International Cooperation ; Public Policy ; Security Measures/legislation & jurisprudence ; United States
    Keywords covid19
    Language English
    Publishing date 2009-05-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1176543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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