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  1. Article ; Online: Choosing lithium in the perinatal period, lower dose in the first trimester of pregnancy.

    Bergink, Veerle

    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

    2024  Volume 81, Page(s) 66

    MeSH term(s) Pregnancy ; Female ; Humans ; Lithium ; Pregnancy Trimester, First ; Postpartum Period
    Chemical Substances Lithium (9FN79X2M3F)
    Language English
    Publishing date 2024-03-15
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1082947-7
    ISSN 1873-7862 ; 0924-977X
    ISSN (online) 1873-7862
    ISSN 0924-977X
    DOI 10.1016/j.euroneuro.2024.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prevention and treatment of Postpartum Mania, Psychosis, and psychotic depression.

    Bergink, Veerle

    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

    2023  Volume 74, Page(s) 92–94

    MeSH term(s) Female ; Humans ; Mania ; Depression ; Psychotic Disorders/prevention & control ; Bipolar Disorder/drug therapy ; Bipolar Disorder/prevention & control ; Postpartum Period ; Depression, Postpartum/prevention & control
    Language English
    Publishing date 2023-06-22
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1082947-7
    ISSN 1873-7862 ; 0924-977X
    ISSN (online) 1873-7862
    ISSN 0924-977X
    DOI 10.1016/j.euroneuro.2023.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The prevalence of rare diseases in psychiatry.

    Bergink, Veerle

    The lancet. Psychiatry

    2018  Volume 5, Issue 9, Page(s) 693–694

    MeSH term(s) Humans ; Mental Disorders/epidemiology ; Psychiatry ; Rare Diseases/epidemiology
    Language English
    Publishing date 2018-05-17
    Publishing country England
    Document type Journal Article
    ISSN 2215-0374
    ISSN (online) 2215-0374
    DOI 10.1016/S2215-0366(18)30182-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Risks and benefits of pre-delivery taper in pregnant women taking antidepressants.

    Robakis, Thalia K / Miyares, Samantha / Bergink, Veerle

    Acta psychiatrica Scandinavica

    2023  

    Abstract: Background: Serotonin reuptake inhibitors are commonly used for treatment of mental health problems in pregnancy but may cause neonatal adaptation syndrome. It is unknown whether reduction or discontinuation of medication prior to delivery may mitigate ... ...

    Abstract Background: Serotonin reuptake inhibitors are commonly used for treatment of mental health problems in pregnancy but may cause neonatal adaptation syndrome. It is unknown whether reduction or discontinuation of medication prior to delivery may mitigate this effect.
    Methods: We present a case series of 38 women who either tapered their medication prior to delivery or maintained or increased their dose.
    Results: Greater reductions in maternal antidepressant dose just prior to delivery were associated with fewer admissions to the neonatal intensive care unit (NICU) for infants. There was a slightly greater increase in depressive symptoms across delivery for women who tapered, which was not statistically significant.
    Conclusions: NICU admissions may be less frequent among neonates whose mothers tapered their medication prior to delivery. Large prospective randomized trials are needed to further study this practice.
    Language English
    Publishing date 2023-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 103-x
    ISSN 1600-0447 ; 0001-690X
    ISSN (online) 1600-0447
    ISSN 0001-690X
    DOI 10.1111/acps.13593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Postpartum Psychosis: A Proposed Treatment Algorithm.

    Jairaj, Chaitra / Seneviratne, Gertrude / Bergink, Veerle / Sommer, Iris E / Dazzan, Paola

    Focus (American Psychiatric Publishing)

    2024  Volume 22, Issue 1, Page(s) 131–142

    Abstract: Background: Postpartum psychosis (PPP) is a psychiatric emergency that generally warrants acute inpatient care. PPP is marked by the sudden onset of affective and psychotic symptoms with a rapid deterioration in mental state. Evidence suggests that PPP ... ...

    Abstract Background: Postpartum psychosis (PPP) is a psychiatric emergency that generally warrants acute inpatient care. PPP is marked by the sudden onset of affective and psychotic symptoms with a rapid deterioration in mental state. Evidence suggests that PPP is a discrete disorder on the bipolar disorder spectrum with a distinct treatment profile and prognosis.
    Methods: We conducted a PubMed database search for various terms involving PPP and its treatment and included peer-reviewed articles published in English.
    Objective: To provide a treatment algorithm for the management of PPP based on available evidence.
    Results: Pharmacological therapy is the mainstay of PPP management in the acute phase. Evidence points to a combination of antipsychotics and lithium in the acute treatment of PPP. Electroconvulsive therapy can offer a rapid treatment response where required. Lithium appears to have the best evidence for relapse prevention and prophylaxis in PPP. Psychoeducation is essential and psychosocial interventions used in bipolar disorder may be effective in PPP.
    Conclusion: Early detection and prompt treatment with antipsychotics and lithium, followed by maintenance treatment with lithium, is associated with a favourable prognosis in PPP.Reprinted from
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ISSN 1541-4094
    ISSN 1541-4094
    DOI 10.1176/appi.focus.23021033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Management of Lithium Dosing Around Delivery: An Observational Study.

    Molenaar, Nina M / Poels, Eline M P / Robakis, Thalia / Wesseloo, Richard / Bergink, Veerle

    Focus (American Psychiatric Publishing)

    2024  Volume 22, Issue 1, Page(s) 120–125

    Abstract: Objectives: Recommendations on lithium dosing around delivery vary, with several guidelines suggesting that lithium should be discontinued prior to delivery. We aimed to evaluate the validity of these recommendations by investigating 1) maternal lithium ...

    Abstract Objectives: Recommendations on lithium dosing around delivery vary, with several guidelines suggesting that lithium should be discontinued prior to delivery. We aimed to evaluate the validity of these recommendations by investigating 1) maternal lithium blood level changes following delivery, and 2) the association between neonatal lithium blood levels at delivery and neonatal outcomes.
    Methods: In this retrospective observational cohort study, we included women with at least one lithium blood level measurement during the final week of pregnancy and the first postpartum week. For aim 2, we included a subcohort of women with neonates for whom neonatal lithium blood levels (obtained from the umbilical cord or a neonatal vein puncture within 24 hours of delivery) were available.
    Results: There were a total of 233 maternal lithium blood level measurements; 55 (23.6%) in the week before delivery and 178 (76.4%) in the week after. There was no association between time and lithium blood level/dose ratio (Pearson correlation coefficient -0.03,
    Conclusion: Based on our findings, we do not recommend lowering the dosage or discontinuation of lithium prior to delivery. Stable dosing can prevent subtherapeutic lithium serum levels, which is especially important in the postpartum period when relapse risks are highest.Appeared originally in
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ISSN 1541-4094
    ISSN 1541-4094
    DOI 10.1176/appi.focus.23021031
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  7. Article ; Online: Dose response relationship between lithium serum levels during pregnancy and birth outcomes.

    Schrijver, Lisanne / Kamperman, Astrid M / Bijma, Hilmar / van Kamp, Inge L / Wesseloo, Richard / Hoogendijk, Witte J G / Bergink, Veerle / Poels, Eline M P

    Acta psychiatrica Scandinavica

    2024  Volume 149, Issue 4, Page(s) 323–331

    Abstract: Introduction: Lithium use during pregnancy reduces the risk of mood episodes in the perinatal period for women with bipolar disorder. Some previous studies found deleterious effects of intrauterine lithium exposure on birth outcomes, yet little is known ...

    Abstract Introduction: Lithium use during pregnancy reduces the risk of mood episodes in the perinatal period for women with bipolar disorder. Some previous studies found deleterious effects of intrauterine lithium exposure on birth outcomes, yet little is known about a dose response relationship. The current study investigated the influence of maternal lithium serum levels on birth outcomes.
    Methods: This retrospective observational cohort study included women with a bipolar spectrum disorder who were referred to a specialized psychiatric and obstetric outpatient clinic from 2003 to 2019 and used lithium during the entire pregnancy. For 101 pregnancies at least one lithium level during pregnancy was available. A weighted average lithium level was calculated for the entire pregnancy, as well as for each trimester. Detailed information on maternal, obstetric and neonatal outcomes were retrieved from the medical records. Linear and logistic regression models were used to investigate the association between weighted average lithium level and pregnancy duration, birth weight percentiles, preterm birth and large for gestational age births (LGA). In subsequent exploratory analyses, we studied the role of thyroid-stimulating hormone (TSH) and thyroxine (T4) as a mediator in the found associations.
    Results: The weighted average lithium serum level during pregnancy was negatively associated with pregnancy duration and positively with preterm birth, but not with birth weight percentile or LGA. In exploratory analyses, TSH and T4 did not mediate the association between average lithium serum level and pregnancy duration.
    Conclusion: The results of this cohort study during pregnancy indicate a dose response relationship between maternal lithium serum levels and pregnancy duration.
    MeSH term(s) Infant, Newborn ; Pregnancy ; Humans ; Female ; Birth Weight ; Cohort Studies ; Lithium ; Premature Birth/epidemiology ; Retrospective Studies ; Thyrotropin
    Chemical Substances Lithium (9FN79X2M3F) ; Thyrotropin (9002-71-5)
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 103-x
    ISSN 1600-0447 ; 0001-690X
    ISSN (online) 1600-0447
    ISSN 0001-690X
    DOI 10.1111/acps.13663
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  8. Article: Familial risk of postpartum psychosis.

    Kępińska, Adrianna P / Robakis, Thalia K / Humphreys, Keith / Liu, Xiaoqin / Kahn, René S / Munk-Olsen, Trine / Bergink, Veerle / Mahjani, Behrang

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Objective: Postpartum psychosis, a mood disorder triggered by childbirth, is one of the most severe psychiatric conditions, with high risks of suicide and infanticide if untreated. While it is evident that genetic factors play a crucial role in disorder ...

    Abstract Objective: Postpartum psychosis, a mood disorder triggered by childbirth, is one of the most severe psychiatric conditions, with high risks of suicide and infanticide if untreated. While it is evident that genetic factors play a crucial role in disorder risk, the exact extent of their importance is yet to be determined.
    Methods: This cohort study consisted of 1,648,759 women from the Swedish nationwide registers, of whom 2,514 (0.15%) experienced postpartum psychosis within three months of their first-ever childbirth. We estimated the relative recurrence risk of postpartum psychosis for female full siblings and cousins as a measure of familial, genetic, and environmental risk.
    Results: Relative recurrence risk of postpartum psychosis in full siblings was 10.69 (95% CI=6.60-16.26) when adjusted for year of and age at childbirth. Although cousins showed an elevated relative recurrence risk, these results did not reach statistical significance (1.78, 95% CI=0.70-3.62). Despite the higher familial risk of postpartum psychosis among full siblings, the absolute risk for women with an affected sibling is relatively low, estimated at 1.55% within the entire population.
    Conclusions: The observed increased risk of postpartum psychosis in full siblings suggests both genetic and shared environmental influences. However, the lack of significant results in cousins hampers a definitive distinction between these factors. Furthermore, despite increased relative recurrence risk in siblings, their overall likelihood of developing postpartum psychosis remains low. Our study underscores the need for further research to better understand the intricate interplay of genetics and environment in the development of postpartum psychosis.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.20.23292910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Postpartum psychosis: A proposed treatment algorithm.

    Jairaj, Chaitra / Seneviratne, Gertrude / Bergink, Veerle / Sommer, Iris E / Dazzan, Paola

    Journal of psychopharmacology (Oxford, England)

    2023  Volume 37, Issue 10, Page(s) 960–970

    Abstract: Background: Postpartum psychosis (PPP) is a psychiatric emergency that generally warrants acute inpatient care. PPP is marked by the sudden onset of affective and psychotic symptoms with a rapid deterioration in mental state. Evidence suggests that PPP ... ...

    Abstract Background: Postpartum psychosis (PPP) is a psychiatric emergency that generally warrants acute inpatient care. PPP is marked by the sudden onset of affective and psychotic symptoms with a rapid deterioration in mental state. Evidence suggests that PPP is a discrete disorder on the bipolar disorder spectrum with a distinct treatment profile and prognosis.
    Methods: We conducted a PubMed database search for various terms involving PPP and its treatment and included peer-reviewed articles published in English.
    Objective: To provide a treatment algorithm for the management of PPP based on available evidence.
    Results: Pharmacological therapy is the mainstay of PPP management in the acute phase. Evidence points to a combination of antipsychotics and lithium in the acute treatment of PPP. Electroconvulsive therapy can offer a rapid treatment response where required. Lithium appears to have the best evidence for relapse prevention and prophylaxis in PPP. Psychoeducation is essential and psychosocial interventions used in bipolar disorder may be effective in PPP.
    Conclusion: Early detection and prompt treatment with antipsychotics and lithium, followed by maintenance treatment with lithium, is associated with a favourable prognosis in PPP.
    MeSH term(s) Female ; Humans ; Lithium/therapeutic use ; Psychotic Disorders/drug therapy ; Psychotic Disorders/diagnosis ; Bipolar Disorder/drug therapy ; Bipolar Disorder/diagnosis ; Antipsychotic Agents/therapeutic use ; Postpartum Period ; Algorithms
    Chemical Substances Lithium (9FN79X2M3F) ; Antipsychotic Agents
    Language English
    Publishing date 2023-07-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639313-5
    ISSN 1461-7285 ; 0269-8811
    ISSN (online) 1461-7285
    ISSN 0269-8811
    DOI 10.1177/02698811231181573
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  10. Article ; Online: Association between doxycycline use and long-term functioning in patients with schizophrenia.

    de Witte, Lot D / Munk Laursen, Thomas / Corcoran, Cheryl M / Munk-Olsen, Trine / Bergink, Veerle

    Brain, behavior, and immunity

    2023  Volume 117, Page(s) 66–69

    Abstract: Importance and objective: The brain-penetrant tetracycline antibiotics, minocycline and doxycycline, have been proposed as potential candidate drugs for treatment of schizophrenia, based on preclinical studies and clinical trials. A potential long-term ... ...

    Abstract Importance and objective: The brain-penetrant tetracycline antibiotics, minocycline and doxycycline, have been proposed as potential candidate drugs for treatment of schizophrenia, based on preclinical studies and clinical trials. A potential long-term beneficial effect of these antibiotics for schizophrenia patients has not been investigated. This study was designed to determine if redemption of doxycycline prescription in schizophrenia is associated with decreased incidence of disability pension, a proxy for long-term functioning.
    Design: We performed a population-based cohort study with data from schizophrenia patients available through the Danish registers. Survival analysis models with time-varying covariates were constructed to assess incidence rate ratios (IRR) of disability pension after exposure to doxycycline or a non-brain penetrant tetracycline, defined as at least one filled prescription. The analysis was adjusted for age, sex, calendar year, parental psychiatric status and educational level.
    Results: We used data from 11,157 individuals with schizophrenia (4,945 female and 6,212 male; average age 22.4 years old, standard deviation (std) 4.50). 718 of these were exposed to brain-penetrant doxycycline, and 1,498 individuals redeemed a prescription of one or more of the non-brain-penetrant tetracyclines. The average years at risk per person in this cohort was 4.9, and 2,901 individuals received disability pension in the follow-up period. There was a significantly lower incidence rate of disability pension in schizophrenia patients who had redeemed doxycycline compared to patients who did not redeem a prescription of any tetracycline antibiotics (Incidence rate ratio (IRR) 0.68; 95 % CI 0.56, 0.83). There was also a significant lower rate of disability pension in schizophrenia patients who redeemed doxycycline compared to individuals who redeemed a prescription of one of the non-brain penetrant tetracycline antibiotics (IRR 0.69 95 % CI 0.55, 0.87).
    Conclusions: In this observational study, doxycycline exposure is associated with a reduced incidence of disability pension. These data support further studies on the potential long term neuroprotective effects of doxycycline and level of functioning in schizophrenia patients.
    MeSH term(s) Female ; Humans ; Male ; Young Adult ; Anti-Bacterial Agents/therapeutic use ; Cohort Studies ; Doxycycline/therapeutic use ; Minocycline ; Schizophrenia/drug therapy ; Tetracycline
    Chemical Substances Anti-Bacterial Agents ; Doxycycline (N12000U13O) ; Minocycline (FYY3R43WGO) ; Tetracycline (F8VB5M810T)
    Language English
    Publishing date 2023-12-31
    Publishing country Netherlands
    Document type Journal Article ; Observational Study ; Research Support, N.I.H., Extramural
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2023.12.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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