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Article ; Online: Non-genetic influences on lipoprotein(a) concentrations.

Enkhmaa, Byambaa / Berglund, Lars

2022 Volume 349, Page(s) 53–62

Abstract: An elevated level of lipoprotein(a) [Lp(a)] is a genetically regulated, independent, causal risk factor for cardiovascular disease. However, the extensive variability in Lp(a) levels between individuals and population groups cannot be fully explained by ... ...

Abstract	An elevated level of lipoprotein(a) [Lp(a)] is a genetically regulated, independent, causal risk factor for cardiovascular disease. However, the extensive variability in Lp(a) levels between individuals and population groups cannot be fully explained by genetic factors, emphasizing a potential role for non-genetic factors. In this review, we provide an overview of current evidence on non-genetic factors influencing Lp(a) levels with a particular focus on diet, physical activity, hormones and certain pathological conditions. Findings from randomized controlled clinical trials show that diets lower in saturated fats modestly influence Lp(a) levels and often in the opposing direction to LDL cholesterol. Results from studies on physical activity/exercise have been inconsistent, ranging from no to minimal or moderate change in Lp(a) levels, potentially modulated by age and the type, intensity, and duration of exercise modality. Hormone replacement therapy (HRT) in postmenopausal women lowers Lp(a) levels with oral being more effective than transdermal estradiol; the type of HRT, dose of estrogen and addition of progestogen do not modify the Lp(a)-lowering effect of HRT. Kidney diseases result in marked elevations in Lp(a) levels, albeit dependent on disease stages, dialysis modalities and apolipoprotein(a) phenotypes. In contrast, Lp(a) levels are reduced in liver diseases in parallel with the disease progression, although population studies have yielded conflicting results on the associations between Lp(a) levels and non-alcoholic fatty liver disease. Overall, current evidence supports a role for diet, hormones and related conditions, and liver and kidney diseases in modifying Lp(a) levels.
MeSH term(s)	Cardiovascular Diseases/blood ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/therapy ; Cholesterol, LDL ; Estradiol ; Estrogen Replacement Therapy ; Estrogens ; Exercise ; Female ; Humans ; Lipoprotein(a)/adverse effects ; Lipoprotein(a)/blood ; Lipoprotein(a)/genetics ; Risk Factors
Chemical Substances	Cholesterol, LDL ; Estrogens ; Lipoprotein(a) ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2022-05-21
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2022.04.006
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Article ; Online: Entrepreneurship and innovation in clinical and translational science.

Kimberly, Robert / Berglund, Lars

Journal of clinical and translational science

2022 Volume 6, Issue 1, Page(s) e15

Language	English
Publishing date	2022-02-09
Publishing country	England
Document type	Editorial
ISSN	2059-8661
ISSN (online)	2059-8661
DOI	10.1017/cts.2021.881
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Article ; Online: Tailoring the Holocellulose Fiber/Acrylic Resin Composite Interface with Hydrophobic Carboxymethyl Cellulose to Enhance Optical and Mechanical Properties.

Zha, Li / Yan, Max / Berglund, Lars A / Zhou, Qi

Biomacromolecules

2024

Abstract: Interface engineering is essential for cellulosic fiber-reinforced polymer composites to achieve high strength and toughness. In this study, carboxymethyl cellulose (CMC) functionalized with hydrophobic quaternary ammonium ions (QAs) were utilized to ... ...

Abstract	Interface engineering is essential for cellulosic fiber-reinforced polymer composites to achieve high strength and toughness. In this study, carboxymethyl cellulose (CMC) functionalized with hydrophobic quaternary ammonium ions (QAs) were utilized to modify the interface between holocellulose fibers (HF) and acrylic resin. The wet HF/CMC papers were prepared by vacuum filtration, akin to papermaking, followed by cationic ion exchange with different hydrophobic QAs. Subsequently, the modified papers were dried, impregnated with an acrylic resin monomer, and cured to produce transparent composite films. The effect of the hydrophobic QA moieties on the structure and optical and mechanical properties of the HF/CMC/acrylic resin composites were investigated. The composite film with cetyltrimethylammonium (CTA)-functionalized CMC showed high optical transmittance (87%) with low haze (43%), while the composite film with phenyltrimethylammonium (PTMA)-functionalized CMC demonstrated high Young's modulus of 7.6 GPa and high tensile strength of 180 MPa. These properties are higher than those of the composites prepared through covalent interfacial modification strategies. The results highlighted the crucial role of hydrophobic functionalized CMCs in facilitating homogeneous resin impregnation in the HF fiber network, producing a composite with enhanced interfacial adhesion strength, increased optical transparency, and mechanical strength. This facile use of hydrophobic CMCs as interfacial compatibilizers provides an energy-efficient route for preparing transparent, thin, and flexible composite films favorable in optoelectronic applications.
Language	English
Publishing date	2024-05-07
Publishing country	United States
Document type	Journal Article
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.4c00295
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Thoracolumbar and Lumbopelvic Spinal Alignment During the Barbell Back Squat: A Comparison Between Men and Women.

Bengtsson, Victor / Berglund, Lars / Öhberg, Fredrik / Aasa, Ulrika

International journal of sports physical therapy

2023 Volume 18, Issue 4, Page(s) 820–830

Abstract: Background: Maintaining neutral spinal alignment is considered important when performing the barbell back squat exercise. Since male and female lifters may differ in injury location it is important to examine whether they differ in spinal alignment ... ...

Abstract	Background: Maintaining neutral spinal alignment is considered important when performing the barbell back squat exercise. Since male and female lifters may differ in injury location it is important to examine whether they differ in spinal alignment during the back squat. Objectives: The study aimed to quantify the spinal alignment in the upper and lower lumbar spine during the barbell back squat exercise in male and female lifters. Secondary aims were to compare alignment during the back squat to standing habitual lumbar spine alignment and determine whether male and female lifters differ in these aspects. Study design: Observational, Cross-sectional. Methods: Competitive power- and weightlifters were recruited and performed three repetitions of the barbell back squat exercise using a load equivalent to 70% of their one-repetition maximum. Spinal alignment and range of motion were measured using inertial measurement units placed on the thoracic, lumbar and sacral spine. Data was presented descriptively and comparisons between men and women as well as spinal alignment in four different positions were done with a factorial repeated measures analysis of variance. Results: Twenty-three (14 males, 9 females) were included. During execution of the squat, spinal alignment adjustments in the lumbar spine were made in all three planes of movement, compared to the start position, in both male and female lifters. Compared to their standing habitual posture, all lifters adjusted their upper lumbar spine to a less lordotic position when in the start position of the back squat (standing upright with the barbell on their back). Only male lifters assumed a less lordotic alignment in their lower lumbar spine in the start position compared their habitual posture. Conclusions: Adjustments of spinal alignment, predominantly in the sagittal plane, are made during execution of the back squat in both male and female lifters. Further, lifters adopt a less lordotic alignment with a heavy barbell on their upper back, more so in male than female lifters. In conclusion, it seems that spinal alignment changes noticeably during the barbell back squat. Level of evidence: 3©The Author(s).
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2628664-6
ISSN	2159-2896
ISSN	2159-2896
DOI	10.26603/001c.83942
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High Self-Reported Levels of Pain 1 Year After a Myocardial Infarction Are Related to Long-Term All-Cause Mortality: A SWEDEHEART Study Including 18 376 Patients.

Vixner, Linda / Hambraeus, Kristina / Äng, Björn / Berglund, Lars

Journal of the American Heart Association

2023 Volume 12, Issue 17, Page(s) e029648

Abstract: Background Pain increases the risk for cardiovascular diseases, including myocardial infarction (MI). However, the impact of pain on mortality after MI has not yet been investigated in large studies with long-term follow-up periods. Thus, we aimed to ... ...

Abstract	Background Pain increases the risk for cardiovascular diseases, including myocardial infarction (MI). However, the impact of pain on mortality after MI has not yet been investigated in large studies with long-term follow-up periods. Thus, we aimed to examine various levels of pain severity 1 year after an MI as a potential risk for all-cause mortality. Methods and Results We collected data from 18 376 patients, aged <75 years, who had a registered MI event during the period from 2004 to 2013 and with measurements of potential cardiovascular risk indicators at hospital discharge from the Swedish quality register SWEDEHEART (Swedish Web System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies). Self-reported levels of experienced pain according to EuroQol-5 dimension instrument were recorded in secondary prevention clinics 1 year after hospital discharge. We collected all-cause mortality data up to 8.5 years (median, 3.4 years) after the 1-year visit. The Cox proportional hazard regression was used to estimate hazard ratio (HR) and 95% CI. Moderate pain and extreme pain were reported by 38.2% and 4.5%, respectively, of included patients. There were 1067 deaths. Adjusted HR was 1.35 (95% CI, 1.18-1.55) and 2.06 (95% CI, 1.63-2.60) for moderate and extreme pain, respectively. Pain was a stronger mortality predictor than smoking. Conclusions Pain 1 year after MI is highly prevalent, and its effect on mortality 1 year after MI was found to be more pronounced than smoking. Clinicians managing patients after MI should recognize the need to consider experienced pain when making prognosis or treatment decisions.
MeSH term(s)	Humans ; Self Report ; Myocardial Infarction/complications ; Smoking ; Prognosis ; Patient Discharge ; Registries
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.029648
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Article ; Online: Lp(a) and SARS-CoV-2: A conspiracy of two mysteries.

Enkhmaa, Byambaa / Berglund, Lars

Journal of internal medicine

2021 Volume 291, Issue 1, Page(s) 8–10

MeSH term(s)	COVID-19/blood ; Cardiovascular Diseases ; Humans ; Lipoprotein(a)/blood ; SARS-CoV-2 ; Thromboembolism
Chemical Substances	Lipoprotein(a)
Language	English
Publishing date	2021-10-29
Publishing country	England
Document type	Editorial ; Research Support, N.I.H., Extramural
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.13356
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Article ; Online: Lipoprotein(a) and diet-a challenge for a role of saturated fat in cardiovascular disease risk reduction?

Law, Hayley G / Meyers, Frederick J / Berglund, Lars / Enkhmaa, Byambaa

The American journal of clinical nutrition

2023 Volume 118, Issue 1, Page(s) 23–26

Abstract: In this perspective, we discuss new evidence relating to current dietary recommendations to reduce SFA intake to modulate an individual's global risk of CVD. Although it is well established that lowering dietary SFA intake has a beneficial effect on LDL ... ...

Abstract	In this perspective, we discuss new evidence relating to current dietary recommendations to reduce SFA intake to modulate an individual's global risk of CVD. Although it is well established that lowering dietary SFA intake has a beneficial effect on LDL cholesterol concentrations, findings increasingly indicate an opposite effect on lipoprotein(a) [Lp(a)] concentrations. In recent years, many studies have firmly established a role for an elevated Lp(a) concentration as a genetically regulated, causal, and prevalent risk factor for CVD. However, there is less awareness of the effect of dietary SFA intake on Lp(a) concentrations. This study discusses this issue and highlights the contrasting effect of reducing dietary SFA intake on LDL cholesterol and Lp(a), 2 highly atherogenic lipoproteins. This calls attention to the need for precision nutrition approaches that move beyond a "one-size-fits-all" approach. To illustrate the contrast, we describe the dynamic contributions of Lp(a) and LDL cholesterol concentrations to CVD risk during interventions with a low-SFA diet, with the hope that this will stimulate further studies and discussions regarding dietary management of CVD risk.
MeSH term(s)	Humans ; Dietary Fats/pharmacology ; Cholesterol, LDL ; Lipoprotein(a) ; Cardiovascular Diseases/prevention & control ; Fatty Acids ; Diet ; Risk Reduction Behavior
Chemical Substances	Dietary Fats ; Cholesterol, LDL ; Lipoprotein(a) ; Fatty Acids
Language	English
Publishing date	2023-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	280048-2
ISSN	1938-3207 ; 0002-9165
ISSN (online)	1938-3207
ISSN	0002-9165
DOI	10.1016/j.ajcnut.2023.05.017
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Article ; Online: Acetylation of Nanocellulose: Miscibility and Reinforcement Mechanisms in Polymer Nanocomposites.

Wohlert, Jakob / Chen, Pan / Berglund, Lars A / Lo Re, Giada

ACS nano

2023 Volume 18, Issue 3, Page(s) 1882–1891

Abstract: The improvement of properties in nanocomposites obtained by topochemical surface modification, e.g., acetylation, of the nanoparticles is often ascribed to ... ...

Abstract	The improvement of properties in nanocomposites obtained by topochemical surface modification, e.g., acetylation, of the nanoparticles is often ascribed to improved
Language	English
Publishing date	2023-12-04
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c04872
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Article ; Online: Lumbopelvic movement control in powerlifters with and without low back pain.

Larsson, Hampus / Strömbäck, Edit / Schau, Mikael / Johansson, Susanna / Berglund, Lars

Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine

2023 Volume 65, Page(s) 74–82

Abstract: Objectives: To measure lumbopelvic movement control in powerlifters with and without low back pain (LBP).: Design: Quantitative Cross-sectional.: Participants: Twelve powerlifters with LBP and 28 powerlifters without LBP.: Setting: Powerlifters ...

Abstract	Objectives: To measure lumbopelvic movement control in powerlifters with and without low back pain (LBP). Design: Quantitative Cross-sectional. Participants: Twelve powerlifters with LBP and 28 powerlifters without LBP. Setting: Powerlifters were recruited in nine different cities and filmed while performing a movement control test battery. Main outcome measures: Lumbopelvic movement control test battery consisting of seven tests, with a possible score between 0 and 13. The tests were rated by a physical therapist blinded to the group allocation and comparisons of the frequency of current/incorrect tests between groups were calculated. Results: There was no statistically significant difference in the movement control test battery between the powerlifters with LBP (Median = 7.0, (2-11)) and powerlifters without LBP (Median = 6.0, (1-10)) (P = 0.59). There were no statistically significant differences between groups when the individual movement control tests were analyzed separately. Conclusions: The lack of significant differences between groups indicates that performance in lumbopelvic movement control test might not be associated with LBP in powerlifters. More studies on associations between LBP and movement control and other body functions are needed to guide assessment and treatment of powerlifters with LBP and for investigation of possible risk factors for LBP in powerlifters.
MeSH term(s)	Humans ; Low Back Pain/therapy ; Lumbosacral Region ; Cross-Sectional Studies ; Movement ; Risk Factors
Language	English
Publishing date	2023-12-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2008604-0
ISSN	1873-1600 ; 1466-853X
ISSN (online)	1873-1600
ISSN	1466-853X
DOI	10.1016/j.ptsp.2023.11.006
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Article ; Online: Transparent Wood Biocomposite of Well-Dispersed Dye Content for Fluorescence and Lasing Applications.

Höglund, Martin / Baitenov, Adil / Berglund, Lars A / Popov, Sergei

ACS applied optical materials

2023 Volume 1, Issue 5, Page(s) 1043–1051

Abstract: Aggregation-induced quenching often restricts emissive performance of optically active solid materials with embedded fluorescent dyes. Delignified and nanoporous wood readily adsorbs organic dyes and is investigated as a host material for rhodamine 6G ( ... ...

Abstract	Aggregation-induced quenching often restricts emissive performance of optically active solid materials with embedded fluorescent dyes. Delignified and nanoporous wood readily adsorbs organic dyes and is investigated as a host material for rhodamine 6G (R6G). High concentration of R6G (>35 mM) is achieved in delignified wood without any ground-state dye aggregation. To evaluate emissive performance, a solid-state random dye laser is prepared using the dye-doped wood substrates. The performance in terms of lasing threshold and efficiency was improved with increased dye content due to the ability of delignified wood to disperse R6G.
Language	English
Publishing date	2023-05-15
Publishing country	United States
Document type	Journal Article
ISSN	2771-9855
ISSN (online)	2771-9855
DOI	10.1021/acsaom.3c00100
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