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  1. Article ; Online: Analysis of tryptophan metabolites and related compounds in human and murine tissue: development and validation of a quantitative and semi-quantitative method using high resolution mass spectrometry.

    Abujrais, Sandy / Ubhayasekera, S J Kumari A / Bergquist, Jonas

    Analytical methods : advancing methods and applications

    2024  Volume 16, Issue 7, Page(s) 1074–1082

    Abstract: This study explores the metabolic differences between human and murine plasma in addition to differences between murine subcutaneous and visceral white adipose tissue. A quantitative and semi-quantitative targeted method was developed and validated for ... ...

    Abstract This study explores the metabolic differences between human and murine plasma in addition to differences between murine subcutaneous and visceral white adipose tissue. A quantitative and semi-quantitative targeted method was developed and validated for this purpose. The quantitative method includes tryptophan and its metabolites in addition to tyrosine, phenylalanine, taurine, B vitamins, neopterin, cystathionine and hypoxanthine. While the semi-quantitative method includes; 3-indoleacetic acid, 5-hydroxyindoleacetic acid, acetylcholine, asymmetric dimethylarginine, citrulline and methionine. Sample preparation was based on protein precipitation, while quantification was conducted using ultrahigh-performance liquid chromatography coupled to a quadrupole Orbitrap tandem mass spectrometer with electrospray ionization in the parallel reaction monitoring (PRM) mode. The low limit of quantification for all metabolites ranged from 1 to 200 ng mL
    MeSH term(s) Humans ; Mice ; Animals ; Tryptophan/metabolism ; Chromatography, High Pressure Liquid/methods ; Tandem Mass Spectrometry/methods ; Tyrosine ; Phenylalanine
    Chemical Substances Tryptophan (8DUH1N11BX) ; Tyrosine (42HK56048U) ; Phenylalanine (47E5O17Y3R)
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d3ay01959d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Leveraging the power of mass spectrometry to unravel complex brain pathologies.

    Bergquist, Jonas

    Clinical mass spectrometry (Del Mar, Calif.)

    2019  Volume 14 Pt B, Page(s) 63–65

    Language English
    Publishing date 2019-08-21
    Publishing country Netherlands
    Document type Editorial
    ISSN 2376-9998
    ISSN (online) 2376-9998
    DOI 10.1016/j.clinms.2019.08.002
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  3. Article: Perspective: Drawing on Findings From Critical Illness to Explain Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

    Stanculescu, Dominic / Bergquist, Jonas

    Frontiers in medicine

    2022  Volume 9, Page(s) 818728

    Abstract: We propose an initial explanation for how myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) could originate and perpetuate by drawing on findings from critical illness research. Specifically, we combine emerging findings regarding (a) ... ...

    Abstract We propose an initial explanation for how myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) could originate and perpetuate by drawing on findings from critical illness research. Specifically, we combine emerging findings regarding (a) hypoperfusion and endotheliopathy, and (b) intestinal injury in these illnesses with our previously published hypothesis about the role of (c) pituitary suppression, and (d) low thyroid hormone
    Language English
    Publishing date 2022-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.818728
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  4. Article ; Online: Research and education in analytical chemistry - industrial and academic perspectives from a survey conducted in Sweden.

    Bergquist, Jonas / Emmer, Åsa / Farbrot, Anne / Turner, Charlotta

    Analytical and bioanalytical chemistry

    2023  Volume 415, Issue 12, Page(s) 2151–2161

    Language English
    Publishing date 2023-03-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-023-04661-3
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    In stock of ZB MED Bonn / Germany

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  5. Article ; Online: Proteomics to Understand the Degenerative Matter.

    Bergquist, Jonas

    Free radical biology & medicine

    2014  Volume 75 Suppl 1, Page(s) S10

    Abstract: No matter what we do, eat or practice - sooner or later we all will start loosing our abilities to control our bodily functions, maintain muscle control and innervations. Most of us will grow old and degrade by natural causes, while some of us ... ...

    Abstract No matter what we do, eat or practice - sooner or later we all will start loosing our abilities to control our bodily functions, maintain muscle control and innervations. Most of us will grow old and degrade by natural causes, while some of us unfortunately will be affected by fast or slow progressive diseases or even have accidents with traumas that will initiate dramatic degenerative effects. We have recently demonstrated that a shotgun proteomic approach coupled with relative quantitative dimethyl labeling (DML) method can analyze the global changes in the human brain and skeletal muscle proteome. Very limited amount of material (biopsy) is needed for comparison. The underlying objective of our studies are to identify potential protein biomarkers related to the development of degeneration but also to be able to get in detail structural characteristics of protein modifications that are initiated by disease. These proteins are involved in several biological processes including fundamental brain function, muscle development and contraction, metabolic process, enzyme activity, glycolysis, regulation of apoptosis and transport activity. We have identified a number of different factors behind this phenomenon that also reveals new knowledge about the natural aging.
    Language English
    Publishing date 2014-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2014.10.853
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2109: Show issues Location:
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  6. Article: Theory: Treatments for Prolonged ICU Patients May Provide New Therapeutic Avenues for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

    Stanculescu, Dominic / Larsson, Lars / Bergquist, Jonas

    Frontiers in medicine

    2021  Volume 8, Page(s) 672370

    Abstract: We here provide an overview of treatment trials ... ...

    Abstract We here provide an overview of treatment trials for
    Language English
    Publishing date 2021-05-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.672370
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  7. Article: Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

    Stanculescu, Dominic / Larsson, Lars / Bergquist, Jonas

    Frontiers in medicine

    2021  Volume 8, Page(s) 628029

    Abstract: Here the hypothesis is advanced that maladaptive mechanisms that prevent recovery in some intensive care unit (ICU) patients may also underlie Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Specifically, these mechanisms are: (a) ... ...

    Abstract Here the hypothesis is advanced that maladaptive mechanisms that prevent recovery in some intensive care unit (ICU) patients may also underlie Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Specifically, these mechanisms are: (a) suppression of the pituitary gland's
    Language English
    Publishing date 2021-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.628029
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  8. Article ; Online: Toward ovarian cancer screening with protein biomarkers using dried, self-sampled cervico-vaginal fluid.

    Hedlund Lindberg, Julia / Widgren, Anna / Ivansson, Emma / Gustavsson, Inger / Stålberg, Karin / Gyllensten, Ulf / Sundfeldt, Karin / Bergquist, Jonas / Enroth, Stefan

    iScience

    2024  Volume 27, Issue 2, Page(s) 109001

    Abstract: Early detection is key for increased survival in ovarian cancer, but no general screening program exists today due to lack of biomarkers and overall cost versus benefit over traditional clinical methods. Here, we used dried cervico-vaginal fluid (CVF) as ...

    Abstract Early detection is key for increased survival in ovarian cancer, but no general screening program exists today due to lack of biomarkers and overall cost versus benefit over traditional clinical methods. Here, we used dried cervico-vaginal fluid (CVF) as sampling matrix coupled with mass spectrometry for detection of protein biomarkers. We find that self-collected CVF on paper cards yields robust results and is suitable for high-throughput proteomics. Artificial intelligence-based methods were used to identify an 11-protein panel that separates cases from controls. In validation data, the panel achieved a sensitivity of 0.97 (95% CI 0.91-1.00) at a specificity of 0.67 (0.40-0.87). Analyses of samples collected prior to development of symptoms indicate that the panel is informative also of future risk of disease. Dried CVF is used in cervical cancer screening, and our results opens the possibility for a screening program also for ovarian cancer, based on self-collected CVF samples.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109001
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  9. Article ; Online: Silica Particles Trigger the Exopolysaccharide Production of Harsh Environment Isolates of Growth-Promoting Rhizobacteria and Increase Their Ability to Enhance Wheat Biomass in Drought-Stressed Soils.

    Fetsiukh, Anastasiia / Conrad, Julian / Bergquist, Jonas / Timmusk, Salme

    International journal of molecular sciences

    2021  Volume 22, Issue 12

    Abstract: In coming decades, drought is expected to expand globally owing to increased evaporation and reduced rainfall. Understanding, predicting, and controlling crop plants' rhizosphere has the potential to manipulate its responses to environmental stress. Our ... ...

    Abstract In coming decades, drought is expected to expand globally owing to increased evaporation and reduced rainfall. Understanding, predicting, and controlling crop plants' rhizosphere has the potential to manipulate its responses to environmental stress. Our plant growth-promoting rhizobacteria (PGPR) are isolated from a natural laboratory, 'The Evolution Canyon', Israel, (EC), from the wild progenitors of cereals, where they have been co-habituating with their hosts for long periods of time. The study revealed that commercial TM50 silica particles (SN) triggered the PGPR production of exopolysaccharides (EPS) containing D-glucuronate (D-GA). The increased EPS content increased the PGPR water-holding capacity (WHC) and osmotic pressure of the biofilm matrix, which led to enhanced plant biomass in drought-stressed growth environments. Light- and cryo-electron- microscopic studies showed that, in the presence of silica (SN) particles, bacterial morphology is changed, indicating that SNs are associated with significant reprogramming in bacteria. The findings encourage the development of large-scale methods for isolate formulation with natural silicas that ensure higher WHC and hyperosmolarity under field conditions. Osmotic pressure involvement of holobiont cohabitation is also discussed.
    MeSH term(s) Bacteria/classification ; Bacteria/isolation & purification ; Bacteria/metabolism ; Droughts ; Polysaccharides, Bacterial/metabolism ; Rhizosphere ; Silicon Dioxide/pharmacology ; Soil/chemistry ; Soil Microbiology ; Triticum/drug effects ; Triticum/growth & development ; Triticum/metabolism
    Chemical Substances Polysaccharides, Bacterial ; Soil ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2021-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22126201
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  10. Article ; Online: Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth.

    Akhter, Tansim / Hedeland, Mikael / Bergquist, Jonas / Ubhayasekera, Kumari / Larsson, Anders / Kullinger, Merit / Skalkidou, Alkistis

    American journal of reproductive immunology (New York, N.Y. : 1989)

    2023  Volume 90, Issue 3, Page(s) e13767

    Abstract: Problem: The exact biochemical mechanisms that initiate labor are not yet fully understood. Nitric oxide is a potent relaxant of uterine smooth muscles until labor starts, and its precursor is L-arginine. Asymmetric (ADMA) and symmetric (SDMA) ... ...

    Abstract Problem: The exact biochemical mechanisms that initiate labor are not yet fully understood. Nitric oxide is a potent relaxant of uterine smooth muscles until labor starts, and its precursor is L-arginine. Asymmetric (ADMA) and symmetric (SDMA) dimethylarginines, are potent NO-inhibitors. However, arginines (dimethylarginines and L-arginine) are scarcely studied in relation to labor and childbirth. We aimed to investigate arginines in women with spontaneous (SLVB) and induced (ILVB) term labor with vaginal birth and in women undergoing elective caesarean section (ECS).
    Method of study: Women at gestational week 16-18 were recruited to the population-based prospective cohort study BASIC at the Uppsala University Hospital, Sweden. Plasma samples taken at start of labor were analyzed for arginines, from SLVB (n = 45), ILVB (n = 45), and ECS (n = 45), using Ultra-High Performance Liquid Chromatography. Between-group differences were assessed using Kruskal-Wallis and Mann-Whitney U-test.
    Results: Women with SLVB and ILVB had higher levels of ADMA (p < .0001), SDMA (p < .05) and lower L-arginines (p < .01), L-arginine/ADMA (p < .0001), and L-arginine/SDMA (p < .01, respectively <.001) compared to ECS. However, ILVB had higher ADMA (p < .0001) and lower L-arginine (p < .01), L-arginine/ADMA (p < .0001), and L-arginine/SDMA (p < .01) compared to SLVB. Results are adjusted for gestational length at birth and cervical dilatation at sampling.
    Conclusion: Our novel findings of higher levels of dimethylarginines in term vaginal births compared to ECS give insights into the biochemical mechanisms of labor. These findings might also serve as a basis for further studies of arginines in complicated pregnancies and labor.
    MeSH term(s) Pregnancy ; Infant, Newborn ; Female ; Humans ; Cesarean Section ; Prospective Studies ; Parturition ; Delivery, Obstetric ; Arginine
    Chemical Substances Arginine (94ZLA3W45F)
    Language English
    Publishing date 2023-08-28
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604542-x
    ISSN 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
    ISSN (online) 1600-0897
    ISSN 0271-7352 ; 8755-8920 ; 1046-7408
    DOI 10.1111/aji.13767
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    Zs.A 1653: Show issues Location:
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