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Article: Site-Specific Volumetric Skeletal Changes in Women with a Distal Forearm Fracture.

Wihlborg, Axel / Bergström, Karin / Bergström, Ingrid / Gerdhem, Paul

Journal of osteoporosis

2021 Volume 2021, Page(s) 1578543

Abstract: Purpose: To assess site-specific volumetric bone and muscle changes, as well as demographic and biochemical changes, in postmenopausal women with a low-energy distal forearm fracture.: Methods: In a cross-sectional case-control study, postmenopausal ... ...

Abstract	Purpose: To assess site-specific volumetric bone and muscle changes, as well as demographic and biochemical changes, in postmenopausal women with a low-energy distal forearm fracture. Methods: In a cross-sectional case-control study, postmenopausal women with a distal forearm fracture were compared with age- and gender-matched controls. In total, 203 postmenopausal women (104 cases and 99 controls), with a mean age of 65 years, were included. Measurements included peripheral quantitative computed tomography (pQCT) and dual-energy X-ray absorptiometry (DXA) as well as blood sampling and questionnaires. Results: Forearm trabecular volumetric BMD and total BMD assessed with pQCT were significantly lower in fracture cases compared to controls ( Conclusion: A distal forearm fracture was associated with site-specific and central bone changes. Postmenopausal women with fracture had a larger bone area in combination with a thinner cortex and lower site-specific total BMD. In addition, women with fracture had a higher activity level, an increased occurrence of previous fall accidents, and a high prevalence of vertebral fractures. Forearm muscle composition, PTH, and 25OHD were not associated with forearm fracture. Fracture preventive measures following a low-energy distal forearm fracture seem beneficial.
Language	English
Publishing date	2021-09-30
Publishing country	United States
Document type	Journal Article
ISSN	2090-8059
ISSN	2090-8059
DOI	10.1155/2021/1578543
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Article ; Online: Parathyroid Hormone Disturbances in Postmenopausal Women with Distal Forearm Fracture.

Wihlborg, Axel / Bergström, Karin / Gerdhem, Paul / Bergström, Ingrid

World journal of surgery

2021 Volume 46, Issue 1, Page(s) 128–135

Abstract: Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder with a wide range of adverse effects, such as osteoporosis. Many women are not diagnosed due to asymptomatic disease or vague symptoms but are still at risk of severe adverse ... ...

Abstract	Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder with a wide range of adverse effects, such as osteoporosis. Many women are not diagnosed due to asymptomatic disease or vague symptoms but are still at risk of severe adverse effects. Early identification of patients with PHPT is therefore of importance. The aim of this study was to determine PHPT prevalence among postmenopausal women with a distal forearm fracture. Methods: Recruitment was conducted in conjunction with the occurrence of a distal forearm fracture at Karolinska University Hospital. In total, 161 postmenopausal women were included in a cross-sectional study with repeated evaluations. Analyzes of serum calcium, ionized calcium, phosphate, parathyroid hormone (PTH), and vitamin D were performed. Diagnosis of PHPT was based on clinical evaluations and biochemical definitions of serum calcium and PTH in coherence with previous population prevalence reports. Results: Mean age was 64.7 (9.5) years, serum calcium 2.33 (0.10) mmol/L, ionized calcium 1.25 (0.05) mmol/L and PTH 54 (26) ng/L. PTH was elevated in 32 (20%) women. In total, 11 (6.8%) women were diagnosed with PHPT; 6 with classical PHPT and 5 with mild PHPT. The prevalence of PHPT was significantly increased compared to the population prevalence of 3.4% (p = 0.022). Conclusion: Screening postmenopausal women in conjunction with low-energy distal forearm fracture revealed a large number of women with parathyroid disturbance. Evaluation of parathyroid hormone and calcium status in this group of patients seems beneficial.
MeSH term(s)	Calcium ; Cross-Sectional Studies ; Female ; Forearm ; Humans ; Hyperparathyroidism, Primary ; Middle Aged ; Parathyroid Hormone ; Postmenopause
Chemical Substances	Parathyroid Hormone ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-10-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-021-06331-w
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Zs.A 1336: Show issues

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Article ; Online: Reply to "Comment on aortic size predicts aortic dissection in Turner syndrome - A 25-year prospective cohort study" by Salman Khazaei.

Thunström, Sofia / Thunström, Erik / Naessén, Sabine / Berntorp, Kerstin / Kitlinski, Margareta Laczna / Ekman, Bertil / Wahlberg, Jeanette / Bergström, Ingrid / Bech-Hanssen, Odd / Krantz, Emily / Laine, Christine M / Bryman, Inger / Landin-Wilhelmsen, Kerstin

International journal of cardiology

2023 Volume 380, Page(s) 56

MeSH term(s)	Humans ; Turner Syndrome/complications ; Turner Syndrome/diagnosis ; Prospective Studies ; Aortic Dissection/diagnostic imaging ; Aortic Dissection/etiology ; Aorta
Language	English
Publishing date	2023-03-11
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2023.03.007
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Zs.A 1673: Show issues

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Article ; Online: Lower pain and higher muscular strength in immigrant women with vitamin D deficiency following vitamin D treatment.

Englund, Marianne / Persson, Jan / Bergström, Ingrid

International journal of circumpolar health

2017 Volume 76, Issue 1, Page(s) 1340547

Abstract: Background: Vitamin D deficiency is common among immigrants in the Nordic region. It may lead to osteomalacia with severe musculoskeletal pain. There are reports that vitamin D deficiency without osteomalacia may lead to pain but little is known of the ... ...

Abstract	Background: Vitamin D deficiency is common among immigrants in the Nordic region. It may lead to osteomalacia with severe musculoskeletal pain. There are reports that vitamin D deficiency without osteomalacia may lead to pain but little is known of the effect of treatment. Objective: To investigate whether a moderate dose of cholecalciferol and calcium improves strength and pain in a group of vitamin D deficient women. Design: Twentyfive immigrant women with vitamin D deficiency diagnosed during pregnancy were treated postpartum with a daily dose of 1,600 IU cholecalciferol and 1,000 mg of calcium. They were examined at the start of treatment and again after 3 months of treatement and the results were statistically compared. Setting: Southern parts of Stockholm. Main outcome measures: Serum 25-hydroyvitamin D (25(OH)D), serum-parathyroid hormone (PTH), pain measured by a visual analogue scale (VAS), musculoskeletal strength by performance on a chair stand test (seconds), and bone tenderness by pressure algometer (kilo-Pascal). Results: Following the treatment, the 21 women attending had lowered cm in VAS, improved musculoskeletal strength, - and 25(OH)D levels were normalized. Conclusions: A moderate dose of vitamin D normalized l vitamin D levels, improved muscular strength and reduced pain in this group of vitamin D deficient immigrant women.
MeSH term(s)	Adult ; Dose-Response Relationship, Drug ; Emigrants and Immigrants/statistics & numerical data ; Female ; Humans ; Low Back Pain/drug therapy ; Middle Aged ; Muscle Strength ; Nutritional Status ; Sweden ; Treatment Outcome ; Vitamin D/administration & dosage ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/drug therapy ; Women's Health ; Young Adult
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article
ZDB-ID	1386707-6
ISSN	2242-3982 ; 1239-9736
ISSN (online)	2242-3982
ISSN	1239-9736
DOI	10.1080/22423982.2017.1340547
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Zs.A 2467: Show issues

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Article ; Online: Autoimmune Disease in Turner Syndrome in Sweden: An up to 25 Years' Controlled Follow-up Study.

Naessén, Sabine / Eliasson, Malin / Berntorp, Kerstin / Kitlinski, Margareta / Trimpou, Penelope / Amundson, Emily / Thunström, Sofia / Ekman, Bertil / Wahlberg, Jeanette / Karlsson, Anders / Isaksson, Magnus / Bergström, Ingrid / Levelind, Carina / Bryman, Inger / Landin-Wilhelmsen, Kerstin

The Journal of clinical endocrinology and metabolism

2023 Volume 109, Issue 2, Page(s) e602–e612

Abstract: Context: Turner syndrome (TS) is the most common chromosomal aberration in women; it is the result of structural or numeric abnormalities in the X chromosome. Autoimmune hypothyroidism has been recognized as one of the more prominent disorders ... ...

Abstract	Context: Turner syndrome (TS) is the most common chromosomal aberration in women; it is the result of structural or numeric abnormalities in the X chromosome. Autoimmune hypothyroidism has been recognized as one of the more prominent disorders associated with TS. Objective: This work aimed to study the prevalence of autoimmune diseases in TS. Methods: A cross-sectional, longitudinal, 25-year follow-up study was conducted of patients from adult Turner centers at the University Hospitals, Sweden. During 1994 to 2020, a total of 503 women aged 16 to 71 years with TS were evaluated consecutively every fifth year according to national guidelines. A random population sample of women, n = 401, aged 25 to 44 years, from the World Health Organization Monitoring of Trends and Determinants for Cardiovascular Disease (MONICA) project served as controls. Serum thyrotropin, free thyroxine, vitamin B12, antithyroid peroxidase (anti-TPO), and antitransglutaminase antibodies were measured. Results: Mean follow-up time (years) was 16 ± 7 for patients and 13 ± 1 for controls. From study start, the prevalence increased in TS for hypothyroidism 40% to 58%, vitamin B12 deficiency 5% to 12%, celiac disease 4% to 7%, positive anti-TPO 26% to 41%, and antitransglutaminase antibodies 6% to 8% (P < .0001 vs controls). Type 1 diabetes and Addison disease were rare. The only interrelationship was between hypothyroidism and vitamin B12 deficiency, both in TS and controls. No association between autoimmune disease and karyotype, antecedent growth hormone treatment, or ongoing estrogen hormone replacement, was seen in TS. Conclusion: In women with TS up to older than 80 years, more than half developed hypothyroidism, mainly autoimmune, during follow-up. Awareness of vitamin B12 deficiency and celiac disease throughout life is also recommended in women with TS.
MeSH term(s)	Adult ; Humans ; Female ; Turner Syndrome/epidemiology ; Follow-Up Studies ; Sweden/epidemiology ; Celiac Disease/epidemiology ; Cross-Sectional Studies ; Addison Disease ; Antibodies ; Hypothyroidism ; Vitamin B 12 Deficiency
Chemical Substances	Antibodies
Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgad566
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Uh III Zs.134: Show issues

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Article ; Online: Bone health in adolescents with idiopathic scoliosis.

Diarbakerli, Elias / Savvides, Panayiotis / Wihlborg, Axel / Abbott, Allan / Bergström, Ingrid / Gerdhem, Paul

The bone & joint journal

2020 Volume 102-B, Issue 2, Page(s) 268–272

Abstract: Aims: Idiopathic scoliosis is the most common spinal deformity in adolescents and children. The aetiology of the disease remains unknown. Previous studies have shown a lower bone mineral density in individuals with idiopathic scoliosis, which may ... ...

Abstract	Aims: Idiopathic scoliosis is the most common spinal deformity in adolescents and children. The aetiology of the disease remains unknown. Previous studies have shown a lower bone mineral density in individuals with idiopathic scoliosis, which may contribute to the causation. The aim of the present study was to compare bone health in adolescents with idiopathic scoliosis with controls. Methods: We included 78 adolescents with idiopathic scoliosis (57 female patients) at a mean age of 13.7 years (8.5 to 19.6) and 52 age- and sex-matched healthy controls (39 female patients) at a mean age of 13.8 years (9.1 to 17.6). Mean skeletal age, estimated according to the Tanner-Whitehouse 3 system (TW3), was 13.4 years (7.4 to 17.8) for those with idiopathic scoliosis, and 13.1 years (7.4 to 16.5) for the controls. Mean Cobb angle for those with idiopathic scoliosis was 29° (SD 11°). All individuals were scanned with dual energy x-ray absorptiometry (DXA) and peripheral quantitative CT (pQCT) of the left radius and tibia to assess bone density. Statistical analyses were performed with independent-samples Results: Compared with controls, adolescents with idiopathic scoliosis had mean lower DXA values in the left femoral neck (0.94 g/cm Conclusion: In the present study, idiopathic scoliosis patients seemed to have lower BMD at central skeletal sites and less evident differences at peripheral skeletal sites when compared with controls. Cite this article:
MeSH term(s)	Absorptiometry, Photon ; Adolescent ; Bone Density ; Bone Diseases, Metabolic/complications ; Bone Diseases, Metabolic/diagnostic imaging ; Child ; Female ; Femur Neck/diagnostic imaging ; Humans ; Male ; Radius/diagnostic imaging ; Scoliosis/diagnostic imaging ; Scoliosis/etiology ; Tibia/diagnostic imaging ; Tomography, X-Ray Computed ; Young Adult
Language	English
Publishing date	2020-02-07
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	2697156-2
ISSN	2049-4408 ; 2049-4394
ISSN (online)	2049-4408
ISSN	2049-4394
DOI	10.1302/0301-620X.102B2.BJJ-2019-1016.R1
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Zs.A 6989: Show issues

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Article ; Online: From being restrained to recapturing vitality: non-western immigrant women's experiences of undergoing vitamin D treatment after childbirth.

Qvist, Ninni / Bergström, Ingrid / Åkerstedt, Torbjörn / Persson, Jan / Konradsen, Hanne / Forss, Anette

International journal of qualitative studies on health and well-being

2019 Volume 14, Issue 1, Page(s) 1632111

Abstract: ... ...

Abstract	Purpose
MeSH term(s)	Adult ; Africa/ethnology ; Delivery, Obstetric/rehabilitation ; Emigrants and Immigrants ; Europe, Eastern/ethnology ; Female ; Humans ; Interviews as Topic ; Middle East/ethnology ; Qualitative Research ; South America/ethnology ; Sweden ; Vitamin D/administration & dosage ; Vitamin D/analogs & derivatives ; Women's Health
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2019-06-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2232726-5
ISSN	1748-2631 ; 1748-2623
ISSN (online)	1748-2631
ISSN	1748-2623
DOI	10.1080/17482631.2019.1632111
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Article ; Online: Aortic size predicts aortic dissection in Turner syndrome - A 25-year prospective cohort study.

Thunström, Sofia / Thunström, Erik / Naessén, Sabine / Berntorp, Kerstin / Laczna Kitlinski, Margareta / Ekman, Bertil / Wahlberg, Jeanette / Bergström, Ingrid / Bech-Hanssen, Odd / Krantz, Emily / Laine, Christine M / Bryman, Inger / Landin-Wilhelmsen, Kerstin

International journal of cardiology

2022 Volume 373, Page(s) 47–54

Abstract: Background: Women with Turner syndrome (TS) have an increased risk of aortic dissection. The current recommended cutoff to prevent aortic dissection in TS is an aortic size index (ASI) of ≥2.5 cm/m: Methods: A prospective, observational study in ... ...

Abstract	Background: Women with Turner syndrome (TS) have an increased risk of aortic dissection. The current recommended cutoff to prevent aortic dissection in TS is an aortic size index (ASI) of ≥2.5 cm/m Methods: A prospective, observational study in Sweden, of women with TS, n = 400, all evaluated with echocardiography of the aorta and data on medical history for up to 25 years. Receiver operating characteristic (ROC) curves, sensitivity and specificity were calculated for the absolute ascending aortic diameter (AAD), ascending ASI and TS specific z-score. Results: There were 12 patients (3%) with aortic dissection. ROC curves demonstrated that absolute AAD and TS specific z-score were superior to ascending ASI in predicting aortic dissection. The best cutoff for absolute AAD was 3.3 cm and 2.12 for the TS specific z-score, respectively, with a sensitivity of 92% for both. The ascending ASI cutoff of 2.5 cm/m Conclusions: In Turner syndrome, absolute AAD and TS-specific z-score were more reliable predictors for aortic dissection than ASI. Care should be taken before and during pregnancy.
MeSH term(s)	Pregnancy ; Humans ; Female ; Turner Syndrome/complications ; Turner Syndrome/epidemiology ; Prospective Studies ; Aorta/diagnostic imaging ; Aortic Dissection/diagnostic imaging ; Aortic Dissection/epidemiology ; Aortic Dissection/etiology ; Aortic Coarctation
Language	English
Publishing date	2022-11-21
Publishing country	Netherlands
Document type	Observational Study ; Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2022.11.023
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Zs.A 1673: Show issues

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Article ; Online: Sparing effect of peritoneal dialysis vs hemodialysis on BMD changes and its impact on mortality.

Iseri, Ken / Qureshi, Abdul Rashid / Ripsweden, Jonaz / Heimbürger, Olof / Barany, Peter / Bergström, Ingrid B / Stenvinkel, Peter / Brismar, Torkel B / Lindholm, Bengt

Journal of bone and mineral metabolism

2020 Volume 39, Issue 2, Page(s) 260–269

Abstract: Introduction: Bone loss in end stage renal disease (ESRD) patients associates with fractures, vascular calcification, cardiovascular disease (CVD) and increased mortality. We investigated factors associated with changes of bone mineral density (ΔBMD) ... ...

Abstract	Introduction: Bone loss in end stage renal disease (ESRD) patients associates with fractures, vascular calcification, cardiovascular disease (CVD) and increased mortality. We investigated factors associated with changes of bone mineral density (ΔBMD) during the initial year on dialysis therapy and associations of ΔBMD with subsequent mortality in ESRD patients initiating dialysis. Materials and methods: In 242 ESRD patients (median age 55 years, 61% men) starting dialysis with peritoneal dialysis (PD; n = 138) or hemodialysis (HD; n = 104), whole-body dual-energy X-ray absorptiometry (DXA), body composition, nutritional status and circulating biomarkers were assessed at baseline and 1 year after dialysis start. We used multivariate linear regression analysis to determine factors associated with ΔBMD, and fine and gray competing risk analysis to determine associations of ΔBMD with subsequent mortality risk. Results: BMD decreased significantly in HD patients (significant reductions of BMD Conclusions: PD had beneficial effect compared with HD on BMD changes during first year of dialysis therapy. Better preservation of BMD, especially in bone sites rich in cortical bone, associated with lower subsequent mortality. BMD in cortical bone may have stronger association with clinical outcome than BMD in trabecular bone.
MeSH term(s)	Absorptiometry, Photon ; Body Composition ; Body Mass Index ; Bone Density ; Cardiovascular Diseases/complications ; Female ; Hand Strength ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/diagnostic imaging ; Kidney Failure, Chronic/physiopathology ; Male ; Middle Aged ; Multivariate Analysis ; Peritoneal Dialysis/mortality ; Regression Analysis ; Renal Dialysis/mortality ; Risk Assessment
Language	English
Publishing date	2020-09-04
Publishing country	Japan
Document type	Comparative Study ; Journal Article
ZDB-ID	1295123-7
ISSN	1435-5604 ; 0914-8779
ISSN (online)	1435-5604
ISSN	0914-8779
DOI	10.1007/s00774-020-01144-8
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Zs.A 4894: Show issues

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Article ; Online: Observational study of vitamin D levels and pain in pregnant immigrant women living in Sweden.

Bergström, Ingrid / Palmér, Mats / Persson, Jan / Blanck, Agneta

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

2014 Volume 30, Issue 1, Page(s) 74–77

Abstract: The aim was to determine the prevalence of vitamin D insufficiency in pregnant immigrant women assessed by the levels of 25-hydroxyvitamin D, parathyroid hormone (PTH) and alkaline phosphatase (ALP) as well as the correlation to musculoskeletal pain. ... ...

Abstract	The aim was to determine the prevalence of vitamin D insufficiency in pregnant immigrant women assessed by the levels of 25-hydroxyvitamin D, parathyroid hormone (PTH) and alkaline phosphatase (ALP) as well as the correlation to musculoskeletal pain. Sixty-eight pregnant immigrant women were included. Fifty-one native Swedish pregnant women served as controls. 25-hydroxyvitamin D, PTH, ALP and musculoskeletal pain, rated on a visual analogue scale, were analyzed in all women in gestational week 12 and in the immigrant women at 6-12 months postpartum. A significantly higher proportion of immigrant women (77.9%) had levels of 25-hydroxyvitamin D <25 nmol/l compared with 3.9% in controls. Of the immigrant women, 29.4% had 25-hydroxyvitamin D levels <12 nmol/l, but none of the controls. Musculoskeletal pain evaluated with a visual analogue scale (VAS) was significantly higher for the immigrant women than for the controls at gestational week 12. However, no within group correlation was seen between 25-hydroxyvitamin D levels, PTH or ALP and pain. A significant negative correlation between changes in 25-hydroxyvitamin D and pain from gestational week 12 to postpartum was observed. Hypovitaminosis D is prevalent in immigrant women living in Sweden. There is an indication that pain might be associated with hypovitaminosis D.
MeSH term(s)	Adolescent ; Adult ; Case-Control Studies ; Emigrants and Immigrants/statistics & numerical data ; Female ; Humans ; Nutritional Status ; Pain/blood ; Pain/complications ; Pain/epidemiology ; Pregnancy ; Pregnancy Complications/blood ; Pregnancy Complications/epidemiology ; Pregnant Women ; Sweden/epidemiology ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/epidemiology ; Young Adult
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2014-01
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	639237-4
ISSN	1473-0766 ; 0951-3590
ISSN (online)	1473-0766
ISSN	0951-3590
DOI	10.3109/09513590.2013.856408
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