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  1. Article ; Online: Molecular Immunology in Bacterial Vaccine Discovery.

    Berisio, Rita

    Cells

    2022  Volume 11, Issue 23

    Abstract: The global threat of antimicrobial resistance (AMR) poses a difficult challenge, as underscored by the World Health Organization (WHO), which identifies AMR as one of the three greatest threats to human health [ ... ]. ...

    Abstract The global threat of antimicrobial resistance (AMR) poses a difficult challenge, as underscored by the World Health Organization (WHO), which identifies AMR as one of the three greatest threats to human health [...].
    Language English
    Publishing date 2022-11-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11233803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Understanding Molecular Actors of SARS-CoV-2 Virulence to Tackle COVID-19 Outbreak.

    Berisio, Rita

    Cells

    2022  Volume 11, Issue 22

    Abstract: COVID-19 (coronavirus disease 2019) is a threatening disease caused by the novel enveloped, positive-sense, single-stranded RNA beta-coronavirus, denoted as SARS-CoV-2 [ ... ]. ...

    Abstract COVID-19 (coronavirus disease 2019) is a threatening disease caused by the novel enveloped, positive-sense, single-stranded RNA beta-coronavirus, denoted as SARS-CoV-2 [...].
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Virulence ; RNA ; Disease Outbreaks
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2022-11-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11223597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Virulence Factors in

    Berisio, Rita / Ruggiero, Alessia

    Biomolecules

    2023  Volume 13, Issue 8

    Abstract: Tuberculosis (TB) remains one of the main causes of death by infection, especially in immunocompromised patients [ ... ]. ...

    Abstract Tuberculosis (TB) remains one of the main causes of death by infection, especially in immunocompromised patients [...].
    MeSH term(s) Humans ; Virulence Factors ; Tuberculosis ; Immunocompromised Host
    Chemical Substances Virulence Factors
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13081201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular Biomarkers of Disease for Diagnosis and Drug Development.

    Berisio, Rita

    Current medicinal chemistry

    2019  Volume 26, Issue 24, Page(s) 4498–4500

    MeSH term(s) Bacterial Infections/diagnosis ; Biomarkers/analysis ; Humans ; Neoplasms/diagnosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-12-01
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/092986732624190927115301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Molecular Biomarkers of Disease for Diagnosis and Drug Development.

    Berisio, Rita

    Current medicinal chemistry

    2019  Volume 26, Issue 11, Page(s) 1922–1923

    MeSH term(s) Bacteria/chemistry ; Bacterial Infections/diagnosis ; Bacterial Infections/physiopathology ; Biomarkers/analysis ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/physiology ; Drug Development ; Humans ; Neoplasms/diagnosis ; Neoplasms/physiopathology
    Chemical Substances Biomarkers ; Biomarkers, Tumor
    Language English
    Publishing date 2019-07-22
    Publishing country United Arab Emirates
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/092986732611190628090938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: PGRS domain structures: Doomed to sail the mycomembrane.

    Berisio, Rita / Delogu, Giovanni

    PLoS pathogens

    2022  Volume 18, Issue 9, Page(s) e1010760

    Abstract: The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS "sailing" model as a ... ...

    Abstract The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS "sailing" model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-terminus.
    MeSH term(s) Antigens, Bacterial/metabolism ; Artificial Intelligence ; Bacterial Proteins/metabolism ; Cell Wall/metabolism ; Mycobacterium tuberculosis/metabolism
    Chemical Substances Antigens, Bacterial ; Bacterial Proteins
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1010760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: HtpG-A Major Virulence Factor and a Promising Vaccine Antigen against

    Berisio, Rita / Barra, Giovanni / Napolitano, Valeria / Privitera, Mario / Romano, Maria / Squeglia, Flavia / Ruggiero, Alessia

    Biomolecules

    2024  Volume 14, Issue 4

    Abstract: Tuberculosis (TB) is the leading global cause of death f rom an infectious bacterial agent. Therefore, limiting its epidemic spread is a pressing global health priority. The chaperone-like protein HtpG ... ...

    Abstract Tuberculosis (TB) is the leading global cause of death f rom an infectious bacterial agent. Therefore, limiting its epidemic spread is a pressing global health priority. The chaperone-like protein HtpG of
    MeSH term(s) Mycobacterium tuberculosis/immunology ; Antigens, Bacterial/immunology ; Antigens, Bacterial/chemistry ; Virulence Factors/immunology ; Virulence Factors/chemistry ; Humans ; Tuberculosis Vaccines/immunology ; Bacterial Proteins/immunology ; Bacterial Proteins/chemistry ; Tuberculosis/immunology ; Tuberculosis/prevention & control ; Tuberculosis/microbiology ; Animals ; Molecular Chaperones/immunology ; Molecular Chaperones/chemistry ; Molecular Chaperones/metabolism
    Chemical Substances Antigens, Bacterial ; Virulence Factors ; Tuberculosis Vaccines ; Bacterial Proteins ; Molecular Chaperones
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14040471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Structural Basis of PE_PGRS Polymorphism, a Tool for Functional Modulation.

    Kramarska, Eliza / De Maio, Flavio / Delogu, Giovanni / Berisio, Rita

    Biomolecules

    2023  Volume 13, Issue 5

    Abstract: Background: The mycobacterial PE_PGRS protein family is present only in pathogenic strains of the genus mycobacterium, such as : Methods: We made extensive use of AlphaFold2.0 computations and coupled them with sequence distribution phylogenetic and ... ...

    Abstract Background: The mycobacterial PE_PGRS protein family is present only in pathogenic strains of the genus mycobacterium, such as
    Methods: We made extensive use of AlphaFold2.0 computations and coupled them with sequence distribution phylogenetic and frequency analyses, and antigenic predictions.
    Results: Modeling of several polymorphic forms of PE_PGRS33, the prototype of the PE_PGRS family and sequence analyses allowed us to predict the structural impact of mutations/deletions/insertions present in the most frequent variants. These analyses well correlate with the observed frequency and with the phenotypic features of the described variants.
    Conclusions: Here, we provide a thorough description of structural impacts of the observed polymorphism of PE_PGRS33 protein and we correlate predicted structures to the known fitness of strains containing specific variants. Finally, we also identify protein variants associated with bacterial evolution, showing sophisticated modifications likely endowed with a gain-of-function role during bacterial evolution.
    MeSH term(s) Mycobacterium tuberculosis/metabolism ; Phylogeny ; Bacterial Proteins/metabolism ; Polymorphism, Genetic ; Mutation
    Chemical Substances Bacterial Proteins
    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13050812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Editorial: Molecular determinants of bacterial diseases.

    Berisio, Rita

    Current medicinal chemistry

    2015  Volume 22, Issue 14, Page(s) 1640–1641

    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteria/cytology ; Bacteria/drug effects ; Bacteria/enzymology ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2015-04-22
    Publishing country United Arab Emirates
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/092986732214150424103419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Editorial: cell processes in bacterial diseases.

    Berisio, Rita

    Protein and peptide letters

    2012  Volume 19, Issue 10, Page(s) 1011–1012

    MeSH term(s) Animals ; Bacterial Infections/immunology ; Bacterial Infections/pathology ; Cell Physiological Phenomena ; Host-Pathogen Interactions ; Humans
    Language English
    Publishing date 2012-04-15
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1280776-x
    ISSN 1875-5305 ; 0929-8665
    ISSN (online) 1875-5305
    ISSN 0929-8665
    DOI 10.2174/092986612802762624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4452: Show issues Location:
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