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Article ; Online: Are the solutions to radiotherapy side effects on the gastrointestinal tract right at our doorstep?

Berliner, Christoph

2021 Volume 74, Page(s) 103687

MeSH term(s)	Clinical Decision-Making ; Diagnostic Imaging/methods ; Disease Management ; Disease Susceptibility ; Gastrointestinal Tract/pathology ; Gastrointestinal Tract/radiation effects ; Humans ; Neoplasms/complications ; Neoplasms/radiotherapy ; Prognosis ; Radiation Injuries/diagnosis ; Radiation Injuries/etiology ; Radiation Injuries/prevention & control ; Radiation Injuries/therapy ; Radiotherapy/adverse effects ; Radiotherapy/methods
Language	English
Publishing date	2021-11-12
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2021.103687
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Article ; Online: Prostataspezifische Membranantigen-Positronenemissionstomographie (PSMA-PET) für Urologen – wann und welcher Tracer?

Berliner, Christoph / Kesch, Claudia / Fendler, Wolfgang P / Eiber, Matthias / Maurer, Tobias

Der Urologe. Ausg. A

2022 Volume 61, Issue 4, Page(s) 384–391

Abstract: Background: Prostate-specific membrane antigen positron emission tomography (PSMA PET) is increasingly replacing conventional imaging for staging of prostate cancer. A major challenge is its appropriate use and correct interpretation.: Objectives: ... ...

Title translation	Prostate-specific membrane antigen positron emission tomography (PSMA PET) for urologists-when and which tracer?
Abstract	Background: Prostate-specific membrane antigen positron emission tomography (PSMA PET) is increasingly replacing conventional imaging for staging of prostate cancer. A major challenge is its appropriate use and correct interpretation. Objectives: How and when is PSMA PET used in patient care to optimally direct therapy? Materials and methods: Systematic presentation and discussion of the current state of knowledge, guidelines and expert knowledge on PSMA PET with a summary of ongoing studies. Conclusion: PSMA PET is the new standard for systemic staging of prostate cancer, enabling precision patient care with novel local, oligometastatic, and systemic treatment approaches.
MeSH term(s)	Humans ; Male ; Neoplasm Staging ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/methods ; Prostate/diagnostic imaging ; Prostate/pathology ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Urologists
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	German
Publishing date	2022-02-09
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	204041-4
ISSN	1433-0563 ; 0340-2592 ; 0375-4685
ISSN (online)	1433-0563
ISSN	0340-2592 ; 0375-4685
DOI	10.1007/s00120-022-01766-y
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Article: A Retrospective Multicenter Analysis of the Incidence of Bone-Only Disease at PSMA PET/CT in Castration Resistant Prostate Cancer Patients.

Serani, Francesca / Fendler, Wolfgang P / Castellucci, Paolo / Berliner, Christoph / Barbato, Francesco / Herrmann, Ken / Farolfi, Andrea / Fanti, Stefano

Cancers

2023 Volume 15, Issue 8

Abstract: PSMA PET/CT has unprecedented accuracy for localization of initial or recurrent prostate cancer (PC), which can be applied in a metastasis-directed therapy approach. PSMA PET/CT (PET) also has a role in the selection of patients for metastasis-directed ... ...

Abstract	PSMA PET/CT has unprecedented accuracy for localization of initial or recurrent prostate cancer (PC), which can be applied in a metastasis-directed therapy approach. PSMA PET/CT (PET) also has a role in the selection of patients for metastasis-directed therapy or radioligand therapy and therapy assessment in CRPC patients. The purpose of this multicenter retrospective study was to determine the incidence of bone-only metastasis in CRPC patients who underwent PSMA PET/CT for restaging, as well as identifying potential predictors of bone-only PET positivity. The study analyzed data from 179 patients from two centers in Essen and Bologna. Results showed that 20.1% of the patients had PSMA uptake only in the bone, with the most frequent lesions located in the vertebrae, ribs, and hip bone. Half half of the patients showed oligo disease in bone and may benefit from a bone-metastasis-directed therapy. Initial positive nodal status and solitary ADT were shown to be negative predictors of osseous metastasis. The role of PSMA PET/TC in this patient population needs to be further explored in terms of its role in the evaluation and adoption of bone-specific therapies.
Language	English
Publishing date	2023-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15082208
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Article ; Online: Delayed Imaging Improves Lesion Detectability in [

Berliner, Christoph / Steinhelfer, Lisa / Chantadisai, Maythinee / Kroenke, Markus / Koehler, Daniel / Pose, Randi / Bannas, Peter / Knipper, Sophie / Eiber, Matthias / Maurer, Tobias

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2023 Volume 64, Issue 7, Page(s) 1036–1042

Abstract: Our objective was to compare the ability to detect histopathologically confirmed lymph node metastases by early and delayed [ ...

Abstract	Our objective was to compare the ability to detect histopathologically confirmed lymph node metastases by early and delayed [
MeSH term(s)	Male ; Humans ; Prostate/pathology ; Positron Emission Tomography Computed Tomography/methods ; Retrospective Studies ; Neoplasm Recurrence, Local ; Prostatic Neoplasms/pathology ; Single Photon Emission Computed Tomography Computed Tomography ; Gallium Radioisotopes
Chemical Substances	Gallium Radioisotopes
Language	English
Publishing date	2023-05-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.122.265252
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Article ; Online: PSMA hybrid imaging in prostate cancer - current applications and perspectives.

Koehler, Daniel / Berliner, Christoph / Shenas, Farzad / Karimzadeh, Amir / Apostolova, Ivayla / Klutmann, Susanne / Adam, Gerhard / Sauer, Markus

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

2023 Volume 195, Issue 11, Page(s) 1001–1008

Abstract: Background: Prostate cancer (PCa) is the most common malignancy in men and the second most common tumor-associated cause of death in the male population in Germany. Prostate-specific membrane antigen (PSMA)-targeted hybrid imaging using positron ... ...

Title translation	PSMA-Hybridbildgebung in der Diagnostik des Prostatakarzinoms – aktuelle Anwendungen und Perspektiven.
Abstract	Background: Prostate cancer (PCa) is the most common malignancy in men and the second most common tumor-associated cause of death in the male population in Germany. Prostate-specific membrane antigen (PSMA)-targeted hybrid imaging using positron emission tomography (PET) in combination with CT or MRI represents a comparably new method that gained increasing importance in the diagnostic process of PCa in recent years. Method: Current applications of PSMA hybrid imaging were summarized according to the German and European guidelines on PCa. New developments were elaborated based on a literature review of PubMed conducted in 10/22. Results: PSMA-PET/CT demonstrated higher detection rates for metastases in high-risk PCa and recurrent PCa after primary therapy than established imaging methods (CT, MRI, and bone scan). Despite promising results from prospective trials in both scenarios and substantial influence on clinical decision making, data regarding the influence of PSMA-PET on PCa-specific and overall survival are still lacking. Hence, PSMA PET/CT is recommended with a "weak" strength rating in most situations. However, its importance in new treatment options like metastasis-directed therapy or PSMA-radioligand therapy expands the scope of PSMA-PET in the clinical routine. Conclusion: PSMA-targeting hybrid imaging represents the most sensitive diagnostic test in several stages of PCa and allows the development of new treatment strategies. Prospective studies are needed to evaluate the influence of PSMA-PET on patient survival. Key points: · PSMA-PET/CT is superior to conventional imaging in the primary staging of high-risk prostate cancer.. · PSMA hybrid imaging can detect metastases in patients with biochemical recurrence at low PSA values.. · Clinical decision making is frequently influenced by results of PSMA-PET/CT.. Citation format: · Koehler D, Berliner C, Shenas F et al. PSMA hybrid imaging in prostate cancer - current applications and perspectives. Fortschr Röntgenstr 2023; 195: 1001 - 1008.
MeSH term(s)	Humans ; Male ; Positron Emission Tomography Computed Tomography/methods ; Prospective Studies ; Prostatic Neoplasms/pathology ; Magnetic Resonance Imaging ; Germany
Language	German
Publishing date	2023-06-22
Publishing country	Germany
Document type	Review ; Journal Article
ZDB-ID	554830-5
ISSN	1438-9010 ; 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
ISSN (online)	1438-9010
ISSN	0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
DOI	10.1055/a-2088-9543
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Article: Thymic hyperplasia after mRNA based Covid-19 vaccination.

von Tresckow, Julia / von Tresckow, Bastian / Reinhardt, H Christian / Herrmann, Ken / Berliner, Christoph

Radiology case reports

2021 Volume 16, Issue 12, Page(s) 3744–3745

Abstract: Reactive lymphadenopathy with increased 18F-Fluordeoxyglucose uptake in positron emission tomography/computed tomography scans is known after mRNA vaccination (BNT162B2, mRNA-1273) against severe acute respiratory syndrome coronavirus type 2. Besides ... ...

Abstract	Reactive lymphadenopathy with increased 18F-Fluordeoxyglucose uptake in positron emission tomography/computed tomography scans is known after mRNA vaccination (BNT162B2, mRNA-1273) against severe acute respiratory syndrome coronavirus type 2. Besides this, increased 18F-Fluordeoxyglucose uptake in the thymus might occur after mRNA vaccination as shown in our case of a young patient with mantle cell lymphoma. Especially in patients with lymphoma but also in other patients with cancer it is critical to distinguish between immune responses and involvement of the disease to avoid inadequate treatment decisions.
Language	English
Publishing date	2021-08-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2021.08.050
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Article ; Online: Oldies (but Goldies): Die Peritonealszintigrafie bei Peritonealdialyse.

Berliner, Christoph / Boss, Kristina / Pape, Anke / Kribben, Andreas / Fendler, Wolfgang / Herrmann, Ken

Nuklearmedizin. Nuclear medicine

2021 Volume 60, Issue 6, Page(s) 450–453

Title translation	Oldies (but Goldies): Peritoneal Scintigraphy in Chronic Peritoneal Dialysis Patients.
MeSH term(s)	Humans ; Peritoneal Dialysis/adverse effects ; Radionuclide Imaging
Language	German
Publishing date	2021-08-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2030804-8
ISSN	2567-6407 ; 0029-5566
ISSN (online)	2567-6407
ISSN	0029-5566
DOI	10.1055/a-1542-6247
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Article: Evaluation of [

Koehler, Daniel / Sauer, Markus / Karimzadeh, Amir / Apostolova, Ivayla / Klutmann, Susanne / Adam, Gerhard / Knipper, Sophie / Maurer, Tobias / Berliner, Christoph

EJNMMI research

2022 Volume 12, Issue 1, Page(s) 66

Abstract: Background: PSMA PET/CT is the recommended imaging test in cases with prostate-specific antigen (PSA) recurrence after primary therapy of prostate cancer (PCa). However, imaging protocols remain a topic of active research. The aim of the presented study ...

Abstract	Background: PSMA PET/CT is the recommended imaging test in cases with prostate-specific antigen (PSA) recurrence after primary therapy of prostate cancer (PCa). However, imaging protocols remain a topic of active research. The aim of the presented study was to examine the impact of additional late scans of the pelvis in [ Methods: A total of 297 patients (median PSA 0.35 ng/ml, interquartile range (IQR) 0.2-0.8) who underwent early whole-body [ Results: One hundred and thirty-four (45.1%) [ Conclusions: Additional late scans of the pelvis in [
Language	English
Publishing date	2022-10-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2619892-7
ISSN	2191-219X
ISSN	2191-219X
DOI	10.1186/s13550-022-00938-3
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Article: PSMA hybrid imaging in prostate cancer – current applications and perspectives

Koehler, Daniel / Berliner, Christoph / Shenas, Farzad / Karimzadeh, Amir / Apostolova, Ivayla / Klutmann, Susanne / Adam, Gerhard / Sauer, Markus

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

2023 Volume 195, Issue 11, Page(s) 1001–1008

Abstract	Background: Prostate cancer (PCa) is the most common malignancy in men and the second most common tumor-associated cause of death in the male population in Germany. Prostate-specific membrane antigen (PSMA)-targeted hybrid imaging using positron emission tomography (PET) in combination with CT or MRI represents a comparably new method that gained increasing importance in the diagnostic process of PCa in recent years. Method: Current applications of PSMA hybrid imaging were summarized according to the German and European guidelines on PCa. New developments were elaborated based on a literature review of PubMed conducted in 10/22. Results: PSMA-PET/CT demonstrated higher detection rates for metastases in high-risk PCa and recurrent PCa after primary therapy than established imaging methods (CT, MRI, and bone scan). Despite promising results from prospective trials in both scenarios and substantial influence on clinical decision making, data regarding the influence of PSMA-PET on PCa-specific and overall survival are still lacking. Hence, PSMA PET/CT is recommended with a “weak” strength rating in most situations. However, its importance in new treatment options like metastasis-directed therapy or PSMA-radioligand therapy expands the scope of PSMA-PET in the clinical routine. Conclusion: PSMA-targeting hybrid imaging represents the most sensitive diagnostic test in several stages of PCa and allows the development of new treatment strategies. Prospective studies are needed to evaluate the influence of PSMA-PET on patient survival. Key Points: PSMA-PET/CT is superior to conventional imaging in the primary staging of high-risk prostate cancer. PSMA hybrid imaging can detect metastases in patients with biochemical recurrence at low PSA values. Clinical decision making is frequently influenced by results of PSMA-PET/CT. Citation Format: Koehler D, Berliner C, Shenas F et al. PSMA hybrid imaging in prostate cancer – current applications and perspectives. Fortschr Röntgenstr 2023; 195: 1001 – 1008 ; Hintergrund: Das Prostatakarzinom (PCa) ist das häufigste Malignom des Mannes und die zweithäufigste krebsbedingte Todesursache der männlichen Bevölkerung in Deutschland. Die Bildgebung des prostataspezifischen Membranantigens (PSMA) mittels Hybridverfahren wie der Positronen-Emissions-Tomografie (PET) in Kombination mit der CT oder MRT stellt eine vergleichsweise neue Methode dar, die in den letzten Jahren zunehmend an Bedeutung in der Diagnostik des PCa gewonnen hat. Methode: Aktuelle Anwendungen der PSMA-Hybridbildgebung wurden basierend auf den deutschen und europäischen Leitlinien zum Thema Prostatakarzinom erörtert und um neue Entwicklungen basierend auf einer Literaturrecherche in PubMed aus 10/22 ergänzt. Ergebnisse: Die PSMA-PET/CT weist sowohl im Primärstaging von Hochrisikoprostatakarzinomen als auch beim Rezidiv nach Primärtherapie höhere Detektionsraten von Metastasen als die etablierten Methoden (CT, MRT und Skelettszintigrafie) auf. Trotz vielversprechender Ergebnisse prospektiver Studien in beiden Szenarien und dem deutlichen Einfluss der PSMA-PET auf Therapieentscheidungen liegen aktuell noch keine Analysen bezüglich ihres Einflusses auf das PCa-spezifische Überleben und das Gesamtüberleben vor. Daher wird in den meisten Situationen eine „kann“-Empfehlung für die PSMA-PET/CT ausgesprochen. Neue Behandlungsstrategien wie die metastasengerichtete Therapie oder die PSMA-Radioligandentherapie erweitern jedoch bereits jetzt schon den Einsatzbereich der PSMA-PET und verankern sie weiter im klinischen Alltag. Schlussfolgerung: Die PSMA-Hybridbildgebung stellt in verschiedenen Stadien des PCa die sensitivste Staging-Methode dar und ermöglicht damit die Entwicklung neuer Behandlungskonzepte. Prospektive Analysen sind jedoch notwendig, um ihren Einfluss auf das Patientenüberleben zu evaluieren. Kernaussagen: Die PSMA-PET/CT ist der konventionellen Bildgebung beim Staging von Hochrisikoprostatakarzinomen überlegen. Im biochemischen Rezidiv kann die PSMA-Hybridbildgebung bereits bei niedrigen PSA-Werten Filiae erkennen. Therapieentscheidungen werden häufig durch Erkenntnisse aus der PSMA-PET/CT beeinflusst. Zitierweise: Koehler D, Berliner C, Shenas F et al. PSMA hybrid imaging in prostate cancer – current applications and perspectives. Fortschr Röntgenstr 2023; 195: 1001 – 1008
Keywords	prostate ; PET-CT ; metastases ; PET ; staging ; prostate ; PET-CT ; metastases ; PET ; staging
Language	English
Publishing date	2023-06-22
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	554830-5
ISSN	1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
ISSN (online)	1438-9010
ISSN	1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
DOI	10.1055/a-2088-9543
Database	Thieme publisher's database

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Article: Oldies (but Goldies): Die Peritonealszintigrafie bei Peritonealdialyse

Berliner, Christoph / Boss, Kristina / Pape, Anke / Kribben, Andreas / Fendler, Wolfgang / Herrmann, Ken

Nuklearmedizin - NuclearMedicine

2021 Volume 60, Issue 06, Page(s) 450–453

Language	German
Publishing date	2021-08-25
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2030804-8
ISSN	2567-6407 ; 0029-5566
ISSN (online)	2567-6407
ISSN	0029-5566
DOI	10.1055/a-1542-6247
Database	Thieme publisher's database

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