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Article ; Online: End-of-life matters in chronic renal failure.

Berman, Nathaniel

Current opinion in supportive and palliative care

2014 Volume 8, Issue 4, Page(s) 371–377

Abstract: Purpose of review: The population considered eligible for dialysis has expanded dramatically over the past 4 decades, so that a significant proportion of patients receiving renal replacement therapy are elderly, frail and infirm. These patients have an ... ...

Abstract	Purpose of review: The population considered eligible for dialysis has expanded dramatically over the past 4 decades, so that a significant proportion of patients receiving renal replacement therapy are elderly, frail and infirm. These patients have an extremely limited life expectancy and suffer from significant symptom burden, similar to patients with other end-stage organ failure or cancer. As dialysis has been offered more broadly, it is now initiated earlier than in decades past, further adding to cost and patient burden. Recent findings: The trend toward more expansive and intensive care has not been corroborated by robust data. In response, an increasing number of studies has focused on establishing reasonable limits to renal replacement therapy. Multiple authors have explored the role of conservative kidney management for high-risk dialysis patients as an alternative to dialysis, which may offer similar survival and improved quality of life in certain populations. For those who chose dialysis, deferring initiation until the patient becomes symptomatic may be a reasonable. Evidence-based symptom management guidelines for dialysis patients remain largely absent, with few proven approaches. Hospice and palliative care resources remain underutilized. Summary: For a subset of dialysis patients, palliative care and conservative kidney management are appropriate and underutilized. Video abstract: http://links.lww.com/COSPC/A8
MeSH term(s)	Cost of Illness ; Humans ; Kidney Failure, Chronic/economics ; Kidney Failure, Chronic/therapy ; Palliative Care/methods ; Patient-Centered Care ; Quality of Life ; Renal Replacement Therapy/economics ; Renal Replacement Therapy/statistics & numerical data ; Terminal Care/methods ; Time Factors
Language	English
Publishing date	2014-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2633726-5
ISSN	1751-4266 ; 1751-4258
ISSN (online)	1751-4266
ISSN	1751-4258
DOI	10.1097/SPC.0000000000000097
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Zs.A 6946: Show issues

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Article ; Online: Delivery of an at-home transcranial direct current stimulation intervention to mitigate pain in patients with end-stage kidney disease receiving hemodialysis (ESKD/HD).

Van Zyl, Jordan / Knotkova, Helena / Kim, Patricia / Henderson, Charles R / Portenoy, Russell K / Berman, Nathaniel / Frederic, Melissa W / Reid, M Carrington

Frontiers in pain research (Lausanne, Switzerland)

2023 Volume 4, Page(s) 1132625

Abstract: Background: Poorly controlled pain remains a problem for many patients with end-stage kidney disease requiring hemodialysis (ESKD/HD) and customary approaches to pain management (e.g., opioids, non-steroidals) confer substantial risk. Accordingly, non- ... ...

Abstract	Background: Poorly controlled pain remains a problem for many patients with end-stage kidney disease requiring hemodialysis (ESKD/HD) and customary approaches to pain management (e.g., opioids, non-steroidals) confer substantial risk. Accordingly, non-pharmacologic therapies are needed for use in this population. Non-invasive transcranial Direct Current Simulation (tDCS) constitutes a promising nonpharmacologic method for pain management in affected individuals. Aims: This study seeks to: 1) determine the effects of an 8-week course of at-home tDCS vs. sham tDCS on pain intensity, pain interference, medication usage, quality of life, and mood; 2) determine if tDCS effects vary by race/ethnicity; and 3) ascertain patient satisfaction with device use. Methods: This double-blind, randomized, sham-controlled clinical trial will enroll 100 ESKD/HD patients with moderate-to-severe (≥4 on 0-10 scale) chronic pain. The active study intervention consists of 20 min of tDCS delivered over the primary motor cortex 5 days/week for 8 weeks. The comparator is a sham procedure that provides no effective stimulation. The primary outcome analysis will evaluate efficacy of tDCS for pain reduction after two months of stimulation. We will also assess the effects of treatment on analgesic consumption, pain interference, depressed mood, and quality of life. The statistical plan will include fixed classification factors for treatment (vs. sham), clinic sites, and assessment time, and the interaction of these factors adjusting for covariates (e.g., race/ethnicity, pain level). Conclusion: At-home tDCS constitutes a promising nonpharmacologic treatment for pain mitigation in persons with ESKD/HD. This unique RCT could transform the way pain is managed in this vulnerable population. Trial registration: NCT05311956.
Language	English
Publishing date	2023-04-05
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-561X
ISSN (online)	2673-561X
DOI	10.3389/fpain.2023.1132625
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Article: Acute Renal Failure and Jaundice without Methemoglobinemia in a Patient with Phenazopyridine Overdose: Case Report and Review of the Literature.

Holmes, Ian / Berman, Nathaniel / Domingues, Vinicius

Case reports in nephrology

2014 Volume 2014, Page(s) 845372

Abstract: Phenazopyridine is a commonly used urinary analgesic available throughout the United States. Ingestion of large quantities can lead to methemoglobinemia, hemolytic anemia, jaundice, and acute renal failure. We report a case of a 78-year-old male with ... ...

Abstract	Phenazopyridine is a commonly used urinary analgesic available throughout the United States. Ingestion of large quantities can lead to methemoglobinemia, hemolytic anemia, jaundice, and acute renal failure. We report a case of a 78-year-old male with previously normal renal function who developed acute renal failure and jaundice without methemoglobinemia or hyperbilirubinemia after taking nearly 8 g of phenazopyridine over the course of 4 days. Initially presenting with oliguria, the urine output began to increase by day 2 of his admission, and the creatinine peaked 11 days after he began taking phenazopyridine, and he was discharged safely soon after. To our knowledge, this is the first such case of renal failure and jaundice without methemoglobinemia or hemolytic anemia in an adult patient with normal renal function.
Language	English
Publishing date	2014-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2627652-5
ISSN	2090-665X ; 2090-6641
ISSN (online)	2090-665X
ISSN	2090-6641
DOI	10.1155/2014/845372
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Article ; Online: Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension.

Berman, Nathaniel / Hostetter, Thomas

American journal of kidney diseases : the official journal of the National Kidney Foundation

2008 Volume 51, Issue 3, Page(s) 370–372

Language	English
Publishing date	2008-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1053/j.ajkd.2007.12.009
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Zs.A 1669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: More with Less: A Trial of Reduced-Intensity Treatment in Transplant-Ineligible Hemodialysis Patients.

Berman, Nathaniel / Reid, M Carrington / Teresi, Jeanne / Eimicke, Joseph P / Adelman, Ronald

Journal of palliative medicine

2016 Volume 19, Issue 5, Page(s) 503–508

Abstract: Background: An increasing proportion of hemodialysis patients are ineligible for transplant. Often these patients are elderly, with multiple comorbidities and decreased functional status. Such patients may benefit from modified treatment goals to reduce ...

Abstract	Background: An increasing proportion of hemodialysis patients are ineligible for transplant. Often these patients are elderly, with multiple comorbidities and decreased functional status. Such patients may benefit from modified treatment goals to reduce symptom burden. Objective: To demonstrate the feasibility of a trial of reduced-intensity treatment in nontransplantable patients with end-stage renal disease (ESRD). Study design: A 6-week study randomized patients to a reduced-intensity intervention versus usual care. Intervention subjects were treated with liberalized goals for serum phosphorus and parathyroid hormone (PTH) as well as predialysis blood pressure in comparison with usual care subjects. Outcomes included assessed feasibility of recruitment, randomization, and data collection. Setting and population: Sixteen transplant-ineligible hemodialysis patients were recruited from two urban units. Measurements: Blood pressure was recorded weekly, while serum PTH and phosphorus were assessed every 10 days. A quality-of-life measure was administered before and after the trial. Results: Of 300 patients, 51 were eligible and 16 consented. All were randomized and completed the trial. Patients in the intervention group received significantly lower doses of phosphorus binders and vitamin D analogues, and were less likely to have their dry weight reduced. All patient surveys were completed. Conclusions: High-risk hemodialysis patients may benefit from liberalized treatment guidelines but larger studies are necessary.
MeSH term(s)	Comorbidity ; Humans ; Kidney Failure, Chronic ; Parathyroid Hormone ; Phosphorus ; Renal Dialysis
Chemical Substances	Parathyroid Hormone ; Phosphorus (27YLU75U4W)
Language	English
Publishing date	2016-05-02
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	1427361-5
ISSN	1557-7740 ; 1096-6218
ISSN (online)	1557-7740
ISSN	1096-6218
DOI	10.1089/jpm.2015.0338
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Article ; Online: Comparing the Cockcroft-Gault and MDRD equations for calculation of GFR and drug doses in the elderly.

Berman, Nathaniel / Hostetter, Thomas H

Nature clinical practice. Nephrology

2007 Volume 3, Issue 12, Page(s) 644–645

Language	English
Publishing date	2007-12
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	2228557-X
ISSN	1745-8331 ; 1745-8323
ISSN (online)	1745-8331
ISSN	1745-8323
DOI	10.1038/ncpneph0627
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Zs.A 6334: Show issues

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Book ; Conference proceedings: Einmischung erwünscht?

Berman, Nathaniel / Brunkhorst, Hauke

Menschenrechte in einer Welt der Bürgerkriege

(Fischer : ZeitSchriften ; 13586)

1998

Abstract: Juristen, Politologen und ein dänischer UN-Militärbeobachter im Jugoslawienkrieg erörtern in ihren Vorträgen die Problematik von internationalen Militäreinsätzen zur Sicherung des Friedens bzw. zur Verhinderung von Menschenrechtsverletzungen, wie sie ... ...

Institution	Vereinte Nationen Deutschland / Bundeswehr
Event/congress	Konferenz des Kulturwissenschaftlichen Instituts (1995.11)
Author's details	hrsg. von Hauke Brunkhorst. Mit Beitr. von Nathaniel Berman ... Die englischsprachigen Originalbeiträgen wurden übersetzt von Hans Günter Holl
Series title	Fischer : ZeitSchriften ; 13586
Abstract	Juristen, Politologen und ein dänischer UN-Militärbeobachter im Jugoslawienkrieg erörtern in ihren Vorträgen die Problematik von internationalen Militäreinsätzen zur Sicherung des Friedens bzw. zur Verhinderung von Menschenrechtsverletzungen, wie sie seit einigen Jahren durchgeführt werden. Auf hohem theoretischem Argumentationsniveau geht es hierbei um grundsätzliche Positionen in Recht und Politik, wobei natürlich die Beispiele Somalia, Irak, Bosnien u.a. die Diskussion konkretisieren. Die Autoren kommen zu durchaus unterschiedlichen Ergebnissen und leisten einen wichtigen Beitrag zu der notwendigen und aktuellen politischen Debatte. Der Band wendet sich an den gebildeten, politisch interessierten Zeitgenossen, Schüler sind wohl eher überfordert. (2) (Reinhild Khan)
Keywords	Friedenssicherung ; Bürgerkrieg ; Intervention ; Menschenrechte ; Selbstbestimmungsrecht ; Souveränität ; UN ; Vereinte Nationen ; Völkerrecht ; Weltbürgerrecht
Language	German
Size	204 S.
Edition	Orig.-Ausg.
Publisher	Fischer-Taschenbuch Verl
Publishing place	Frankfurt am Main
Document type	Book ; Conference proceedings
ISBN	3596135869 ; 9783596135868
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Conference proceedings: Einmischung erwünscht?

Berman, Nathaniel / Brunkhorst, Hauke

Menschenrechte in einer Welt der Bürgerkriege

(Fischer : ZeitSchriften ; 13586)

1998

Institution	Vereinte Nationen Deutschland / Bundeswehr
Event/congress	Konferenz des Kulturwissenschaftlichen Instituts (1995.11)
Author's details	hrsg. von Hauke Brunkhorst. Mit Beitr. von Nathaniel Berman ... Die englischsprachigen Originalbeiträgen wurden übersetzt von Hans Günter Holl
Series title	Fischer : ZeitSchriften ; 13586
Abstract	Juristen, Politologen und ein dänischer UN-Militärbeobachter im Jugoslawienkrieg erörtern in ihren Vorträgen die Problematik von internationalen Militäreinsätzen zur Sicherung des Friedens bzw. zur Verhinderung von Menschenrechtsverletzungen, wie sie seit einigen Jahren durchgeführt werden. Auf hohem theoretischem Argumentationsniveau geht es hierbei um grundsätzliche Positionen in Recht und Politik, wobei natürlich die Beispiele Somalia, Irak, Bosnien u.a. die Diskussion konkretisieren. Die Autoren kommen zu durchaus unterschiedlichen Ergebnissen und leisten einen wichtigen Beitrag zu der notwendigen und aktuellen politischen Debatte. Der Band wendet sich an den gebildeten, politisch interessierten Zeitgenossen, Schüler sind wohl eher überfordert. (2) (Reinhild Khan)
Keywords	Friedenssicherung ; Bürgerkrieg ; Intervention ; Menschenrechte ; Selbstbestimmungsrecht ; Souveränität ; UN ; Vereinte Nationen ; Völkerrecht ; Weltbürgerrecht
Language	German
Size	204 S.
Edition	Orig.-Ausg.
Publisher	Fischer-Taschenbuch Verl
Publishing place	Frankfurt am Main
Document type	Book ; Conference proceedings
ISBN	3596135869 ; 9783596135868
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: An isolated iliac wing stress fracture in a marathon runner.

Amorosa, Louis F / Serota, Alana C / Berman, Nathaniel / Lorich, Dean G / Helfet, David L

American journal of orthopedics (Belle Mead, N.J.)

2014 Volume 43, Issue 2, Page(s) 74–77

Abstract: Iliac stress fractures are uncommon and are usually insufficiency fractures related to osteoporosis. Only 2 previous case reports of iliac stress fractures in runners that extended into the sacroiliac joint, and 1 previous case of an isolated iliac wing ... ...

Abstract	Iliac stress fractures are uncommon and are usually insufficiency fractures related to osteoporosis. Only 2 previous case reports of iliac stress fractures in runners that extended into the sacroiliac joint, and 1 previous case of an isolated iliac wing stress fracture not involving the sacroiliac joint were found in the English language literature. We report on a second case of an isolated stress fracture of the iliac wing in a female marathon runner and the associated diagnosis of the female athlete triad. Iliac stress fractures can be an occult cause of hip pain in athletes and should be included in the differential diagnosis of hip pain in a marathon runner.
MeSH term(s)	Female ; Fractures, Stress/pathology ; Humans ; Ilium/injuries ; Ilium/pathology ; Running ; Young Adult
Language	English
Publishing date	2014-02
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2365753-4
ISSN	1934-3418 ; 1078-4519
ISSN (online)	1934-3418
ISSN	1078-4519
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Clinical laboratory and imaging evidence for effectiveness of agarose-agarose macrobeads containing stem-like cells derived from a mouse renal adenocarcinoma cell population (RMBs) in treatment-resistant, advanced metastatic colorectal cancer: Evaluation of a biological-systems approach to cancer therapy (U.S. FDA IND-BB 10091; NCT 02046174, NCT 01053013).

Smith, Barry H / Gazda, Lawrence S / Fahey, Thomas J / Nazarian, Angelica / Laramore, Melissa A / Martis, Prithy / Andrada, Zoe P / Thomas, Joanne / Parikh, Tapan / Sureshbabu, Sudipta / Berman, Nathaniel / Ocean, Allyson J / Hall, Richard D / Wolf, David J

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

2018 Volume 30, Issue 1, Page(s) 72–83

Abstract: Objective: The complexity, heterogeneity and capacity of malignant neoplastic cells and tumors for rapid change and evolution suggest that living-cell-based biological-systems approaches to cancer treatment are merited. Testing this hypothesis, the ... ...

Abstract	Objective: The complexity, heterogeneity and capacity of malignant neoplastic cells and tumors for rapid change and evolution suggest that living-cell-based biological-systems approaches to cancer treatment are merited. Testing this hypothesis, the tumor marker, metabolic activity, and overall survival (OS) responses, to the use of one such system, implantable macrobeads [RENCA macrobeads (RMBs)], in phase I and IIa clinical trials in advanced, treatment-resistant metastatic colorectal cancer (mCRC) are described here. Methods: Forty-eight mCRC patients (30 females; 18 males), who had failed all available, approved treatments, underwent RMB implantation (8 RMB/kg body weight) up to 4 times in phase I and phase IIa open-label trials. Physicals, labs [tumor and inflammation markers, lactate dehydrogenase (LDH)] and positron emission tomography-computed tomography (PET-CT) imaging to measure number/volume and metabolic activity of the tumors were performed pre- and 3-month-post-implantation to evaluate safety and initial efficacy (as defined by biological responses). PET-CT maximum standard uptake value (SUV Results: Responses after implantation were characterized by an at least 20% decrease in CEA and/or CA 19-9 in 75% of patients. Fluorodeoxyglucose (FDG)-positive lesions (phase I, 39; 2a, 82) were detected in 37/48 evaluable patients, with 35% stable volume and stable or decreased SUV (10) plus four with necrosis; 10, increased tumor volume, SUV. LDH levels remained stable and low in Responders (R) (d 0-60, 290.4-333.9), but increased steadily in Non-responders (NR) (d 0-60, 382.8-1,278.5) (d 60, P=0.050). Responders to RMBs, indicated by the changes in the above markers, correlated with OS (R mean OS=10.76 months; NR mean OS=4.9 months; P=0.0006). Conclusions: The correlations of the tumor marker, tumor volume and SUV changes on PET-CT, and LDH levels themselves, and with OS, support the concept of a biological response to RMB implantation and the validity of the biological-systems approach to mCRC. A phase III clinical trial is planned.
Language	English
Publishing date	2018-03-15
Publishing country	China
Document type	Journal Article
ZDB-ID	1067584-x
ISSN	1993-0631 ; 1000-9604
ISSN (online)	1993-0631
ISSN	1000-9604
DOI	10.21147/j.issn.1000-9604.2018.01.08
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