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  1. AU="Bermudez-Lekerika, Paola"
  2. AU="Ter Hoeve, Natalie D"
  3. AU="Yang, X-D"
  4. AU="Jerry J Shih"
  5. AU=Kapil Vikas
  6. AU="Sanda Cosarca"
  7. AU=Murthy J M K
  8. AU="Ward Chiasson, Stephanie"
  9. AU="Kinsella, Paul"
  10. AU="Alyaqout, Khaled"
  11. AU="J Joshua Smith"
  12. AU="Kotak, Dinesh"
  13. AU="Michael Holland"
  14. AU="Pauline, Staelen"
  15. AU="Mouna Esmaeilzadeh"
  16. AU=Congreve Miles
  17. AU="Li, Yunfeng" AU="Li, Yunfeng"
  18. AU="Shankar, Ganesh"
  19. AU="Ruginsk, Silvia G"
  20. AU="Aquilante, Francesco"
  21. AU="Dillon, Robert C"
  22. AU="Yuan Qu"
  23. AU="Dufour, A"
  24. AU="Hannus, Jill"
  25. AU="Rieber, Julia"
  26. AU="Gulmuradov, Tashpulat"
  27. AU="Romeu Fontanillas, Teresa"
  28. AU="Fleming, Renée"
  29. AU="Cao, Fang"
  30. AU="Sally J L Moore"
  31. AU="Moreno, Yolanda"
  32. AU="Vasiliy Ya. Kolyuchkin"

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  1. Artikel ; Online: Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems.

    Bermudez-Lekerika, Paola / Crump, Katherine B / Wuertz-Kozak, Karin / Le Maitre, Christine L / Gantenbein, Benjamin

    Gels (Basel, Switzerland)

    2024  Band 10, Heft 5

    Abstract: The negatively charged extracellular matrix plays a vital role in intervertebral disc tissues, providing specific cues for cell maintenance and tissue hydration. Unfortunately, suitable biomimetics for intervertebral disc regeneration are lacking. Here, ... ...

    Abstract The negatively charged extracellular matrix plays a vital role in intervertebral disc tissues, providing specific cues for cell maintenance and tissue hydration. Unfortunately, suitable biomimetics for intervertebral disc regeneration are lacking. Here, sulfated alginate was investigated as a 3D culture material due to its similarity to the charged matrix of the intervertebral disc. Precursor solutions of standard alginate, or alginate with 0.1% or 0.2% degrees of sulfation, were mixed with primary human nucleus pulposus cells, cast, and cultured for 14 days. A 0.2% degree of sulfation resulted in significantly decreased cell density and viability after 7 days of culture. Furthermore, a sulfation-dependent decrease in DNA content and metabolic activity was evident after 14 days. Interestingly, no significant differences in cell density and viability were observed between surface and core regions for sulfated alginate, unlike in standard alginate, where the cell number was significantly higher in the core than in the surface region. Due to low cell numbers, phenotypic evaluation was not achieved in sulfated alginate biomaterial. Overall, standard alginate supported human NP cell growth and viability superior to sulfated alginate; however, future research on phenotypic properties is required to decipher the biological properties of sulfated alginate in intervertebral disc cells.
    Sprache Englisch
    Erscheinungsdatum 2024-05-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels10050330
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The bone morphogenetic protein 2 analogue L51P enhances spinal fusion in combination with BMP2 in an in vivo rat tail model.

    Gantenbein, Benjamin / Oswald, Katharina A C / Erbach, Georg F / Croft, Andreas S / Bermudez-Lekerika, Paola / Strunz, Franziska / Bigdon, Sebastian F / Albers, Christoph E

    Acta biomaterialia

    2024  Band 177, Seite(n) 148–156

    Abstract: Bone morphogenic protein 2 (BMP2) is known to induce osteogenesis and is applied clinically to enhance spinal fusion despite adverse effects. BMP2 needs to be used in high doses to be effective due to the presence of BMP2 inhibitors. L51P is a BMP2 ... ...

    Abstract Bone morphogenic protein 2 (BMP2) is known to induce osteogenesis and is applied clinically to enhance spinal fusion despite adverse effects. BMP2 needs to be used in high doses to be effective due to the presence of BMP2 inhibitors. L51P is a BMP2 analogue that acts by inhibition of BMP2 inhibitors. Here, we hypothesized that mixtures of BMP2 and L51P could achieve better spinal fusion outcomes regarding ossification. To test whether mixtures of both cytokines are sufficient to improve ossification, 45 elderly Wistar rats (of which 21 were males) were assigned to seven experimental groups, all which received spinal fusion surgery, including discectomy at the caudal 4-5 level using an external fixator and a porous β-tricalcium phosphate (βTCP) carrier. These βTCP carriers were coated with varying concentrations of BMP2 and L51P. X-rays were taken immediately after surgery and again six and twelve weeks post-operatively. Histological sections and µCT were analyzed after twelve weeks. Spinal fusion was assessed using X-ray, µCT and histology according to the Bridwell scale by voxel-based quantification and a semi-quantitative histological score, respectively. The results were congruent across modalities and revealed high ossification for high-dose BMP2 (10 µg), while PBS induced no ossification. Low-dose BMP2 (1 µg) or 10 µg L51P alone did not induce relevant bone formation. However, all combinations of low-dose BMP2 with L51P (1 µg + 1/5/10 µg) were able to induce similar ossificationas high-dose BMP2. These results are of high clinical relevance, as they indicate L51P is sufficient to increase the efficacy of BMP2 and thus lower the required dose for spinal fusion. STATEMENT OF SIGNIFICANCE: Spinal fusion surgery is frequently applied to treat spinal pathologies. Bone Morphogenic Protein-2 (BMP2) has been approved by the U .S. Food and Drug Administration (FDA-) and by the "Conformité Européenne" (CE)-label. However, its application is expensive and high concentrations cause side-effects. This research targets the improvement of the efficacy of BMP2 in spinal fusion surgery.
    Mesh-Begriff(e) Humans ; Male ; Rats ; Animals ; Aged ; Female ; Bone Morphogenetic Protein 2/pharmacology ; Rats, Wistar ; Spinal Fusion/methods ; Tail ; Osteogenesis ; Transforming Growth Factor beta/pharmacology
    Chemische Substanzen Bone Morphogenetic Protein 2 ; Transforming Growth Factor beta ; BMP2 protein, human
    Sprache Englisch
    Erscheinungsdatum 2024-02-06
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2024.01.039
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Inhibition of the extracellular signal-regulated kinase pathway reduces the inflammatory component in nucleus pulposus cells.

    Tekari, Adel / Marazza, Alessandro / Crump, Katherine / Bermudez-Lekerika, Paola / Gantenbein, Benjamin

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society

    2022  Band 40, Heft 10, Seite(n) 2362–2371

    Abstract: Intervertebral disc (IVD) degeneration is a spinal disorder that triggers an inflammatory response and subsequent development of spinal pseudoarthrosis. The aim of the present study is to elucidate the role of the extracellular signal-regulated kinase ( ... ...

    Abstract Intervertebral disc (IVD) degeneration is a spinal disorder that triggers an inflammatory response and subsequent development of spinal pseudoarthrosis. The aim of the present study is to elucidate the role of the extracellular signal-regulated kinase (ERK) pathway in inflammation-induced IVD cells. Inflammatory human nucleus pulposus (NP) cells (NPCs) were induced using tumor necrosis factor-α and the ERK pathway was blocked using a selective molecule-based inhibitor U0126. Gene expression of catabolic and anabolic markers, proinflammatory, and NPCs markers was investigated. The enzymatic activity of matrix metalloproteinases (MMP)2/MMP9 was determined by gelatin zymography and nitrite production was assessed by Griess reaction. The NPC metabolic activity and viability were assessed using resazurin sodium-salt and live/dead assays, and subsequently, the specificity of U0126 on ERK1/2 signaling was determined. The catabolic enzyme MMP3 (p = 0.0001) and proinflammatory cytokine interleukin 6 (p = 0.036) were downregulated by U0126 in NPCs under inflammatory conditions. A significant increase of the cytokeratin 19 (p = 0.0031) was observed, suggesting a partial and possible recovery of the NP phenotype. U0126 does not seem to have an effect on prostaglandin production, aggrecanases, or other anabolic genes. We confirmed that U0126 selectively blocks the ERK phosphorylation and only affects the cell metabolic activity without the reduction of viable cells. Inhibition of ERK signaling downregulates important metalloproteinases and proinflammatory cytokines, and upregulates some NP markers, suggesting its potential to treat IVD degeneration.
    Mesh-Begriff(e) Butadienes ; Cytokines/metabolism ; Extracellular Matrix/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gelatin/metabolism ; Gelatin/pharmacology ; Humans ; Interleukin-6/metabolism ; Intervertebral Disc/pathology ; Intervertebral Disc Degeneration/pathology ; Keratin-19/metabolism ; Matrix Metalloproteinase 3/metabolism ; Matrix Metalloproteinase 9/metabolism ; Nitriles ; Nitrites/metabolism ; Nitrites/pharmacology ; Nucleus Pulposus/metabolism ; Prostaglandins/metabolism ; Prostaglandins/pharmacology ; Sodium/metabolism ; Sodium/pharmacology ; Tumor Necrosis Factor-alpha/metabolism
    Chemische Substanzen Butadienes ; Cytokines ; Interleukin-6 ; Keratin-19 ; Nitriles ; Nitrites ; Prostaglandins ; Tumor Necrosis Factor-alpha ; U 0126 ; Gelatin (9000-70-8) ; Sodium (9NEZ333N27) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Matrix Metalloproteinase 3 (EC 3.4.24.17) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
    Sprache Englisch
    Erscheinungsdatum 2022-02-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605542-4
    ISSN 1554-527X ; 0736-0266
    ISSN (online) 1554-527X
    ISSN 0736-0266
    DOI 10.1002/jor.25273
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Should Degenerated Intervertebral Discs of Patients with Modic Type 1 Changes Be Treated with Mesenchymal Stem Cells?

    Herger, Nick / Bermudez-Lekerika, Paola / Farshad, Mazda / Albers, Christoph E / Distler, Oliver / Gantenbein, Benjamin / Dudli, Stefan

    International journal of molecular sciences

    2022  Band 23, Heft 5

    Abstract: Low back pain (LBP) has been among the leading causes of disability for the past 30 years. This highlights the need for improvement in LBP management. Many clinical trials focus on developing treatments against degenerative disc disease (DDD). The ... ...

    Abstract Low back pain (LBP) has been among the leading causes of disability for the past 30 years. This highlights the need for improvement in LBP management. Many clinical trials focus on developing treatments against degenerative disc disease (DDD). The multifactorial etiology of DDD and associated risk factors lead to a heterogeneous patient population. It comes as no surprise that the outcomes of clinical trials on intradiscal mesenchymal stem cell (MSC) injections for patients with DDD are inconsistent. Intradiscal MSC injections have demonstrated substantial pain relief and significant disability-related improvements, yet they have failed to regenerate the intervertebral disc (IVD). Increasing evidence suggests that the positive outcomes in clinical trials might be attributed to the immunomodulatory potential of MSCs rather than to their regenerative properties. Therefore, patient stratification for inflammatory DDD phenotypes may (i) better serve the mechanisms of action of MSCs and (ii) increase the treatment effect. Modic type 1 changes-pathologic inflammatory, fibrotic changes in the vertebral bone marrow-are frequently observed adjacent to degenerated IVDs in chronic LBP patients and represent a clinically distinct subpopulation of patients with DDD. This review discusses whether degenerated IVDs of patients with Modic type 1 changes should be treated with an intradiscal MSC injection.
    Mesh-Begriff(e) Bone Marrow/metabolism ; Humans ; Intervertebral Disc/metabolism ; Intervertebral Disc Degeneration/metabolism ; Low Back Pain/etiology ; Low Back Pain/therapy ; Mesenchymal Stem Cells/metabolism
    Sprache Englisch
    Erscheinungsdatum 2022-02-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23052721
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Establishment of a Novel Method for Spinal Discectomy Surgery in Elderly Rats in an In Vivo Spinal Fusion Model.

    Oswald, Katharina A C / Bigdon, Sebastian F / Croft, Andreas S / Bermudez-Lekerika, Paola / Bergadano, Alessandra / Gantenbein, Benjamin / Albers, Christoph E

    Methods and protocols

    2021  Band 4, Heft 4

    Abstract: The rat model is a common model for intervertebral disc (IVD) and spinal research. However, complications remain challenging. Standard Operating Procedures (SOPs) are validated methods to minimize complications and improve safety and quality of studies. ... ...

    Abstract The rat model is a common model for intervertebral disc (IVD) and spinal research. However, complications remain challenging. Standard Operating Procedures (SOPs) are validated methods to minimize complications and improve safety and quality of studies. However, a SOP for rat spinal fusion surgery has been missing until now. Therefore, the aim of the study was to develop a SOP for spinal tail disc surgery in elderly Wistar rats (419.04 ± 54.84 g). An initial preoperative, intraoperative, and postoperative surgical setup, including specific anaesthesia and pain management protocols, was developed. Anaesthesia was induced by subcutaneous injection of a pre-mixture of fentanyl, midazolam, and medetomidin with the addition of 0.5% isoflurane in oxygen and caudal epidural analgesia. The surgery itself consisted of the fixation of a customized external ring fixator with ⌀ 0.8 mm Kirschner wires at the proximal rat tail and a discectomy and replacement with bone morphogenetic protein coated beta-tricalcium-phosphate carrier. The postoperative setup included heating, analgesia with buprenorphine, and meloxicam, as well as special supplementary food. Anaesthesia, surgery, and pain management were sufficient. In the presented optimized SOP, no animals developed any complications. A SOP for spinal surgery in elderly rats in an in vivo spinal fusion model was developed successfully. This novel protocol can improve transparency, reproducibility, and external validity in experimental rat spinal surgery experiments.
    Sprache Englisch
    Erscheinungsdatum 2021-11-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ISSN 2409-9279
    ISSN (online) 2409-9279
    DOI 10.3390/mps4040079
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: In Situ Cell Signalling of the Hippo-YAP/TAZ Pathway in Reaction to Complex Dynamic Loading in an Intervertebral Disc Organ Culture.

    Croft, Andreas S / Roth, Ysaline / Oswald, Katharina A C / Ćorluka, Slavko / Bermudez-Lekerika, Paola / Gantenbein, Benjamin

    International journal of molecular sciences

    2021  Band 22, Heft 24

    Abstract: Recently, a dysregulation of the Hippo-YAP/TAZ pathway has been correlated with intervertebral disc (IVD) degeneration (IDD), as it plays a key role in cell survival, tissue regeneration, and mechanical stress. We aimed to investigate the influence of ... ...

    Abstract Recently, a dysregulation of the Hippo-YAP/TAZ pathway has been correlated with intervertebral disc (IVD) degeneration (IDD), as it plays a key role in cell survival, tissue regeneration, and mechanical stress. We aimed to investigate the influence of different mechanical loading regimes, i.e., under compression and torsion, on the induction and progression of IDD and its association with the Hippo-YAP/TAZ pathway. Therefore, bovine IVDs were assigned to one of four different static or complex dynamic loading regimes: (i) static, (ii) "low-stress", (iii) "intermediate-stress", and (iv) "high-stress" regime using a bioreactor. After one week of loading, a significant loss of relative IVD height was observed in the intermediate- and high-stress regimes. Furthermore, the high-stress regime showed a significantly lower cell viability and a significant decrease in glycosaminoglycan content in the tissue. Finally, the mechanosensitive gene
    Mesh-Begriff(e) Animals ; Cattle ; Glycosaminoglycans/metabolism ; Hippo Signaling Pathway ; Intervertebral Disc/metabolism ; Intervertebral Disc/physiology ; Intervertebral Disc Degeneration ; Organ Culture Techniques ; Signal Transduction ; Stress, Mechanical
    Chemische Substanzen Glycosaminoglycans
    Sprache Englisch
    Erscheinungsdatum 2021-12-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222413641
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  7. Konferenzbeitrag: Verbesserung der spinalen Fusion mittels BMP2 und L51P in einem spinalen Fusionsmodell der Ratte in vivo

    Oswald, Katharina A. C. / Gantenbein, Benjamin / Bigdon, Sebastian F. / Croft, Andreas S. / Bermudez-Lekerika, Paola / Albers, Christoph E.

    2022  , Seite(n) AB70–499

    Veranstaltung/Kongress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2022); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2022
    Schlagwörter Medizin, Gesundheit ; Grundlagenforschung ; in vivo ; spinale Fusion ; BMP2 ; L51P
    Erscheinungsdatum 2022-10-25
    Verlag German Medical Science GMS Publishing House; Düsseldorf
    Dokumenttyp Konferenzbeitrag
    DOI 10.3205/22dkou555
    Datenquelle German Medical Science

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  8. Artikel ; Online: Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research.

    Crump, Katherine B / Alminnawi, Ahmad / Bermudez-Lekerika, Paola / Compte, Roger / Gualdi, Francesco / McSweeney, Terence / Muñoz-Moya, Estefano / Nüesch, Andrea / Geris, Liesbet / Dudli, Stefan / Karppinen, Jaro / Noailly, Jérôme / Le Maitre, Christine / Gantenbein, Benjamin

    JOR spine

    2023  Band 6, Heft 4, Seite(n) e1294

    Abstract: The cartilaginous endplates (CEP) are key components of the intervertebral disc (IVD) necessary for sustaining the nutrition of the disc while distributing mechanical loads and preventing the disc from bulging into the adjacent vertebral body. The size, ... ...

    Abstract The cartilaginous endplates (CEP) are key components of the intervertebral disc (IVD) necessary for sustaining the nutrition of the disc while distributing mechanical loads and preventing the disc from bulging into the adjacent vertebral body. The size, shape, and composition of the CEP are essential in maintaining its function, and degeneration of the CEP is considered a contributor to early IVD degeneration. In addition, the CEP is implicated in Modic changes, which are often associated with low back pain. This review aims to tackle the current knowledge of the CEP regarding its structure, composition, permeability, and mechanical role in a healthy disc, how they change with degeneration, and how they connect to IVD degeneration and low back pain. Additionally, the authors suggest a standardized naming convention regarding the CEP and bony endplate and suggest avoiding the term vertebral endplate. Currently, there is limited data on the CEP itself as reported data is often a combination of CEP and bony endplate, or the CEP is considered as articular cartilage. However, it is clear the CEP is a unique tissue type that differs from articular cartilage, bony endplate, and other IVD tissues. Thus, future research should investigate the CEP separately to fully understand its role in healthy and degenerated IVDs. Further, most IVD regeneration therapies in development failed to address, or even considered the CEP, despite its key role in nutrition and mechanical stability within the IVD. Thus, the CEP should be considered and potentially targeted for future sustainable treatments.
    Sprache Englisch
    Erscheinungsdatum 2023-10-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 2572-1143
    ISSN (online) 2572-1143
    DOI 10.1002/jsp2.1294
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  9. Artikel: The Allelic Variant A391T of Metal Ion Transporter ZIP8 (SLC39A8) Leads to Hypotension and Enhanced Insulin Resistance.

    Verouti, Sophia N / Pujol-Giménez, Jonai / Bermudez-Lekerika, Paola / Scherler, Laeticia / Bhardwaj, Rajesh / Thomas, Aurélien / Lenglet, Sébastien / Siegrist, Mark / Hofstetter, Willy / Fuster, Daniel G / Hediger, Matthias A / Escher, Geneviève / Vogt, Bruno

    Frontiers in physiology

    2022  Band 13, Seite(n) 912277

    Abstract: The metal ion transporter ZIP8 (SLC39A8) mediates cellular uptake of vital divalent metal ions. Genome-wide association studies (GWAS) showed that the single-nucleotide polymorphism (SNP) variant A391T (rs13107325) is associated with numerous human ... ...

    Abstract The metal ion transporter ZIP8 (SLC39A8) mediates cellular uptake of vital divalent metal ions. Genome-wide association studies (GWAS) showed that the single-nucleotide polymorphism (SNP) variant A391T (rs13107325) is associated with numerous human traits, including reduced arterial blood pressure, increased body mass index and hyperlipidemia. We analyzed
    Sprache Englisch
    Erscheinungsdatum 2022-06-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.912277
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  10. Artikel ; Online: Sulfated Hydrogels in Intervertebral Disc and Cartilage Research.

    Lazarus, Emily / Bermudez-Lekerika, Paola / Farchione, Daniel / Schofield, Taylor / Howard, Sloan / Mambetkadyrov, Iskender / Lamoca, Mikkael / Rivero, Iris V / Gantenbein, Benjamin / Lewis, Christopher L / Wuertz-Kozak, Karin

    Cells

    2021  Band 10, Heft 12

    Abstract: Hydrogels are commonly used for the 3D culture of musculoskeletal cells. Sulfated hydrogels, which have seen a growing interest over the past years, provide a microenvironment that help maintain the phenotype of chondrocytes and chondrocyte-like cells ... ...

    Abstract Hydrogels are commonly used for the 3D culture of musculoskeletal cells. Sulfated hydrogels, which have seen a growing interest over the past years, provide a microenvironment that help maintain the phenotype of chondrocytes and chondrocyte-like cells and can be used for sustained delivery of growth factors and other drugs. Sulfated hydrogels are hence valuable tools to improve cartilage and intervertebral disc tissue engineering. To further advance the utilization of these hydrogels, we identify and summarize the current knowledge about different sulfated hydrogels, highlight their beneficial effects in cartilage and disc research, and review the biofabrication processes most suitable to secure best quality assurance through deposition fidelity, repeatability, and attainment of biocompatible morphologies.
    Mesh-Begriff(e) Animals ; Cartilage/drug effects ; Humans ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Intervertebral Disc/drug effects ; Research ; Sulfates/chemistry ; Sulfates/pharmacology ; Tissue Engineering
    Chemische Substanzen Hydrogels ; Sulfates
    Sprache Englisch
    Erscheinungsdatum 2021-12-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10123568
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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