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  1. Article ; Online: Synergizing health: combined gynecological and bariatric robotic surgery for endometrial cancer in obese women.

    Perrone, Anna Myriam / Mezzapesa, Francesco / Bernante, Paolo / Balsamo, Francesca / Garelli, Silvia / De Iaco, Pierandrea

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2024  

    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-005121
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  2. Article ; Online: Surgery of the alimentary tract for benign and malignant disease with the novel robotic platform HUGO

    Gangemi, Antonio / Bernante, Paolo / Rottoli, Matteo / Pasquali, Federica / Poggioli, Gilberto

    The international journal of medical robotics + computer assisted surgery : MRCAS

    2023  Volume 19, Issue 4, Page(s) e2544

    Abstract: Introduction: As robotic surgery increases its reach, novel platforms are being released. We present the first 17 consecutive cases of alimentary tract surgery performed with the Hugo: Methods: patients were selected to undergo surgery from February ... ...

    Abstract Introduction: As robotic surgery increases its reach, novel platforms are being released. We present the first 17 consecutive cases of alimentary tract surgery performed with the Hugo
    Methods: patients were selected to undergo surgery from February through April 2023. Exclusion criteria were age <16 years, BMI>60, ASA IV.
    Results: 17 patients underwent ileocaecal resection for Chrons disease (2 M and 1 F) and pseudo-obstruction of the terminal ileum (1 M), cholecystectomy (3 M and 5 F), subtotal gastrectomy with D2 lymphadenectomy (1 F), sleeve gastrectomy (1 F), hiatal hernia repair with Nissen fundoplication (1 M), right hemicolectomy (1 M) and sigmoidectomy (1 M). No conversion to an open approach or any arm collisions requiring corrective actions were reported.
    Conclusions: Our preliminary experience with the Hugo
    MeSH term(s) Humans ; Adolescent ; Robotic Surgical Procedures/methods ; Feasibility Studies ; Robotics ; Fundoplication/methods ; Gastrectomy ; Laparoscopy/methods ; Retrospective Studies ; Treatment Outcome ; Hernia, Hiatal/surgery
    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2151860-9
    ISSN 1478-596X ; 1478-5951
    ISSN (online) 1478-596X
    ISSN 1478-5951
    DOI 10.1002/rcs.2544
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  3. Article ; Online: Comment on: Bariatric surgery outcomes in patients with systemic lupus erythematosus.

    Bernante, Paolo

    Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

    2015  Volume 11, Issue 3, Page(s) 688–689

    MeSH term(s) Bariatric Surgery/methods ; Female ; Humans ; Laparoscopy/methods ; Lupus Erythematosus, Systemic/complications ; Male ; Obesity, Morbid/surgery ; Postoperative Complications/epidemiology
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 2274243-8
    ISSN 1878-7533 ; 1550-7289
    ISSN (online) 1878-7533
    ISSN 1550-7289
    DOI 10.1016/j.soard.2014.11.002
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  4. Article ; Online: Robotic Surgery: Rediscovering Human Anatomy.

    Gangemi, Antonio / Chang, Betty / Bernante, Paolo / Poggioli, Gilberto

    International journal of environmental research and public health

    2021  Volume 18, Issue 23

    Abstract: Since its advent, robotic surgery has redefined the operating room experience. It directly addressed and resolved many of the shortcomings of laparoscopic methods while maintaining a minimally invasive approach that brought benefits in cosmesis and ... ...

    Abstract Since its advent, robotic surgery has redefined the operating room experience. It directly addressed and resolved many of the shortcomings of laparoscopic methods while maintaining a minimally invasive approach that brought benefits in cosmesis and healing for patients but also benefits in ergonomics and precision for surgeons. This new platform has brought with it changes in surgical training and education, principally through the utilization of virtual reality. Accurate depictions of human anatomy seen through augmented reality allow the surgeon-in-training to learn, practice and perfect their skills before they operate on their first patient. However, the anatomical knowledge required for minimally invasive surgery (MIS) is distinct from current methods of dissection and prosection that inherently cater towards open surgery with large cuts and unobstructed field. It is integral that robotic surgeons are also equipped with accurate anatomical information, heralding a new era in which anatomists can work alongside those developing virtual reality technology to create anatomical training curricula for MIS. As the field of surgery and medicine in general moves to include more and more technology, it is only fitting that the building blocks of medical education follow suit and rediscover human anatomy in a modern context.
    MeSH term(s) Clinical Competence ; Humans ; Laparoscopy ; Robotic Surgical Procedures ; Robotics ; Surgeons ; Virtual Reality
    Language English
    Publishing date 2021-12-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph182312744
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  5. Article ; Online: The impact of psychological distress on weight regain in post-bariatric patients during the COVID-19 pandemic: A latent profile analysis.

    Salituro, N / Landi, G / Garelli, S / Balsamo, F / Rottoli, M / Cattivelli, R / Tossani, E / Grandi, S / Pagotto, U / Bernante, P / Agostini, A

    Journal of psychosomatic research

    2022  Volume 165, Page(s) 111144

    Abstract: Objective: The COVID-19 pandemic has caused a global health crisis disrupting healthcare delivery for people with severe obesity who have undergone bariatric surgery. This study examined the role of psychological distress during the first Italian COVID- ... ...

    Abstract Objective: The COVID-19 pandemic has caused a global health crisis disrupting healthcare delivery for people with severe obesity who have undergone bariatric surgery. This study examined the role of psychological distress during the first Italian COVID-19 lockdown in predicting post-operative outcomes in post-bariatric patients reaching the end of the 12-18 months follow-up during the lockdown. By using a person-centered approach, groups of patients with different psychological distress profiles were identified. We hypothesized that compared to post-bariatric patients with low psychological distress, post-bariatric patients with high psychological distress will be more at risk of weight regain.
    Methods: A total of 67 patients (71.6% female, M
    Results: Significant differences were highlighted in the high and low psychological distressed group in weight changes, F(1,58) = 5.2, p < 0.001, η
    Conclusion: Results highlight the need to target post-bariatric patients with high psychological distress who are at risk for weight regain during the COVID-19 pandemic. Interventions mitigating psychological distress and obesogenic behaviors during future pandemics or in post-COVID times are needed in vulnerable post-bariatric patients reporting high psychological distress.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; COVID-19/psychology ; Pandemics ; Retrospective Studies ; Communicable Disease Control ; Bariatric Surgery/psychology ; Psychological Distress ; Weight Gain
    Language English
    Publishing date 2022-12-31
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 80166-5
    ISSN 1879-1360 ; 0022-3999
    ISSN (online) 1879-1360
    ISSN 0022-3999
    DOI 10.1016/j.jpsychores.2022.111144
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  6. Article ; Online: miRNA levels are associated with body mass index in endometrial cancer and may have implications for therapy.

    Ravegnini, Gloria / Gorini, Francesca / Coada, Camelia Alexandra / De Leo, Antonio / de Biase, Dario / Di Costanzo, Stella / De Crescenzo, Eugenia / Coschina, Emma / Monesmith, Sarah / Bernante, Paolo / Garelli, Silvia / Balsamo, Francesca / Hrelia, Patrizia / De Iaco, Pierandrea / Angelini, Sabrina / Perrone, Anna Myriam

    Cancer science

    2024  Volume 115, Issue 3, Page(s) 883–893

    Abstract: Endometrial cancer (EC) is the most prevalent gynecological cancer in high-income countries. Its incidence is skyrocketing due to the increase in risk factors such as obesity, which represents a true pandemic. This study aimed to evaluate microRNA (miRNA) ...

    Abstract Endometrial cancer (EC) is the most prevalent gynecological cancer in high-income countries. Its incidence is skyrocketing due to the increase in risk factors such as obesity, which represents a true pandemic. This study aimed to evaluate microRNA (miRNA) expression in obesity-related EC to identify potential associations between this specific cancer type and obesity. miRNA levels were analyzed in 84 EC patients stratified based on body mass index (BMI; ≥30 or <30) and nine noncancer women with obesity. The data were further tested in The Cancer Genome Atlas (TCGA) cohort, including 384 EC patients, 235 with BMI ≥30 and 149 with BMI <30. Prediction of miRNA targets and analysis of their expression were also performed to identify the potential epigenetic networks involved in obesity modulation. In the EC cohort, BMI ≥30 was significantly associated with 11 deregulated miRNAs. The topmost deregulated miRNAs were first analyzed in 84 EC samples by single miRNA assay and then tested in the TCGA dataset. This independent validation provided further confirmation about the significant difference of three miRNAs (miR-199a-5p, miR-449a, miR-449b-5p) in normal-weight EC patients versus EC patients with obesity, resulting significantly higher expressed in the latter. Moreover, the three miRNAs were significantly correlated with grade, histological type, and overall survival. Analysis of their target genes revealed that these miRNAs may regulate obesity-related pathways. In conclusion, we identified specific miRNAs associated with BMI that are potentially involved in modulating obesity-related pathways and that may provide novel implications for the clinical management of obese EC patients.
    MeSH term(s) Humans ; Female ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Body Mass Index ; Gene Expression Profiling/methods ; Endometrial Neoplasms/genetics ; Obesity/complications ; Obesity/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1349-7006
    ISSN (online) 1349-7006
    ISSN 1349-7006
    DOI 10.1111/cas.15977
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  7. Article ; Online: Trends and safety of bariatric revisional surgery in Italy: multicenter, prospective, observational study.

    Boru, Cristian E / Marinari, Giuseppe M / Olmi, Stefano / Gentileschi, Paolo / Morino, Mario / Anselmino, Marco / Foletto, Mirto / Bernante, Paolo / Piazza, Luigi / Perrotta, Nicola / Morganti, Riccardo / Silecchia, Gianfranco

    Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

    2023  Volume 19, Issue 11, Page(s) 1270–1280

    Abstract: Background: Revisional bariatric surgery (RBS) represents a further solution for patients who experience inadequate weight loss (IWL) following primary bariatric surgery (BS) or significant weight regain (WR) following initial satisfactory response. RBS ...

    Abstract Background: Revisional bariatric surgery (RBS) represents a further solution for patients who experience inadequate weight loss (IWL) following primary bariatric surgery (BS) or significant weight regain (WR) following initial satisfactory response. RBS guidelines are lacking; however, an increased trend in further BS offerings has been reported recently.
    Objective: Analyze trend, mortality, complication, readmission, and reoperation rates for any reason at 30 days after RBS in Italy.
    Setting: Ten Italian high-volume BS centers (university hospitals and private centers).
    Methods: Prospective, observational, multicenter study enrolling patients undergoing RBS between October 1, 2021, and March 31, 2022, registering reasons for RBS, technique, mortality, intraoperative and perioperative complications, readmissions, and reinterventions for any reason. Patients undergoing RBS during the same calendar interval in 2016-2020 were considered control patients.
    Results: A total of 220 patients were enrolled and compared with 560 control-group patients. Mortality was .45% versus .35% (n.s), with an overall mortality of .25%, while open surgery or conversion to open surgery was registered in 1%. No difference was found for mortality, morbidity, complications, readmission (1.3%), and reoperation rates (2.2%). IWL/WR was the most frequent cause, followed by gastroesophageal reflux disease; Roux-en-Y gastric bypass was the most used revisional procedure (56%). Sleeve gastrectomy was the most revised procedure in the study group, while gastric banding was the most revised in the control group. RBS represents up to 9% of the total BS in the Italian participating centers.
    Conclusions: Laparoscopy represents the standard approach for RBS, which appears safe. Current Italian trends show a shift toward sleeve gastrectomy being the most revised procedure and Roux-en-Y gastric bypass being the most frequent revisional procedure.
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274243-8
    ISSN 1878-7533 ; 1550-7289
    ISSN (online) 1878-7533
    ISSN 1550-7289
    DOI 10.1016/j.soard.2023.05.009
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  8. Article ; Online: Bariatric Surgery and COVID-19: a Change of Perspective in a New Phase of the Pandemic.

    Marchesi, Federico / Dalmonte, Giorgio / Riccò, Matteo / Martines, Gennaro / Dibra, Rigers / Bernante, Paolo / Balsamo, Francesca / Anzolin, Francesca / Gagliardi, Stefano / Conti, Luigi / Rampulla, Alessandro / Prioriello, Concetta / Ballabeni, Lucia / Tartamella, Francesco / Del Rio, Paolo / Valente, Marina

    Obesity surgery

    2023  Volume 33, Issue 12, Page(s) 4049–4057

    Abstract: Purpose: The protective role of bariatric surgery (BS) against COVID-19 has been reported by several studies, showing, in the first pandemic waves, better outcome of the infection in patients that had undergone BS. With the virus progressive endemicity, ...

    Abstract Purpose: The protective role of bariatric surgery (BS) against COVID-19 has been reported by several studies, showing, in the first pandemic waves, better outcome of the infection in patients that had undergone BS. With the virus progressive endemicity, BS benefits on COVID-19 clinical course could appear less evident, while COVID-19 effects on BS outcomes must be investigated. In this national multicentric cross-sectional study, we compared COVID-19 incidence and clinical course between a cohort of patients that had undergone BS (OP) and a cohort of candidates to BS (WS); moreover, we analyzed BS outcomes based on SARS-CoV-2 positivity/negativity.
    Methods: From June to December 2021, 522 patients from five Italian referral centers were administered an 87-item telephonic questionnaire completing the analysis of electronic medical records. Demographics, COVID-19 "tested" incidence, suggestive symptoms and clinical outcome parameters of OP and WS were compared. BS outcomes parameters were compared between OP that developed the disease or not.
    Results: COVID-19 incidence was the same in OP and WS, while symptoms and clinical course seemed milder in OP, with no data individually reaching statistical significance. OP who developed SARS-CoV-2 infection had higher excess weight loss than negative OP (66.8% ± 22.1 vs. 57.7% ± 22.8, p = 0.029). Positive OP had had gastric-bypass (RYGB/OAGB) more frequently than negative ones (38.4% vs. 18.2%, p = 0.025).
    Conclusion: With the disease becoming endemic, BS protective role against COVID-19 seems clinically less relevant. BS outcomes can be affected by COVID-19, thus imposing careful follow-up for positive patients, especially if undergoing gastric-bypass.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/etiology ; Pandemics ; Cross-Sectional Studies ; Obesity, Morbid/surgery ; SARS-CoV-2 ; Bariatric Surgery/adverse effects ; Disease Progression ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2023-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-023-06923-6
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  9. Article ; Online: Cascade Stomach as a Risk Factor for Incomplete Resection of the Gastric Fundus in Laparoscopic Sleeve Gastrectomy: a Point of Technique.

    Bernante, Paolo / Balsamo, Francesca / Rottoli, Matteo / Sciannamea, Andrea / Di Simone, Massimo P / Iannelli, Antonio / Poggioli, Gilberto

    Obesity surgery

    2020  Volume 30, Issue 12, Page(s) 5139–5141

    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Letter
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-020-04718-7
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  10. Article ; Online: Endoscopic Ultrasound-Guided Stented Gastro-Gastrostomy for Strictured Vertical Banded Gastroplasty.

    Balsamo, Francesca / Pagano, Nico / Rottoli, Matteo / Di Simone, Massimo P / Sciannamea, Andrea / Poggioli, Gilberto / Bernante, Paolo

    Obesity surgery

    2020  Volume 30, Issue 9, Page(s) 3645–3646

    Abstract: Herein, we make a video presentation of an endoscopic reversal of a strictured vertical banded gastroplasty (VBG), carried out through an endoscopic ultrasonography (EUS)-guided transluminal therapy system, in order to accurately identify the common ... ...

    Abstract Herein, we make a video presentation of an endoscopic reversal of a strictured vertical banded gastroplasty (VBG), carried out through an endoscopic ultrasonography (EUS)-guided transluminal therapy system, in order to accurately identify the common gastric wall and to allow the application of an endoscopic stent. The operative time was 60 min, and no intraoperative complication was recorded. On postoperative day 1, an upper GI swallow showed the oral contrast easily flowing into the body of the stomach throughout the stent. A semi-solid diet was started on day 1. The postoperative course was uneventful, and the patient was discharged on day 2. At the 3-month follow-up visit, the patient denied further symptoms. The follow-up upper GI swallow and endoscopy showed a patent gastro-gastrostomy and no residual gastric pouch dilation or stagnation of the oral contrast, and the stent was therefore removed. Gastro-gastrostomy by endoscopic stenting appears to be an effective option to relief symptoms in strictured VBG, and EUS guidance has made access to the target structure easier and safer.
    MeSH term(s) Gastroplasty ; Gastrostomy ; Humans ; Obesity, Morbid/surgery ; Postoperative Complications/surgery ; Stents ; Stomach/diagnostic imaging ; Stomach/surgery ; Ultrasonography, Interventional
    Language English
    Publishing date 2020-06-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-020-04773-0
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