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  1. Article: Diabetes in Urban African Americans: Assessment of Diabetes-Specific Locus of Control in Patients With Type 2 Diabetes

    Hayes, Risa P / Bernard, Annette M / EI-Kebbi, Imad / Gallina, Daniel / Phillips, Lawrence S / Slocum, Wrenn / Ziemer, David

    Diabetes educator. 2000 Jan., v. 26, no. 1

    2000  

    Abstract: PURPOSE This study was conducted to examine the applicability and relationship to glycemic control of the Diabetes Locus of Control (DLC) Scales in a low-literacy, economically deprived, African American population with type 2 diabetes. METHODS The DLC ... ...

    Abstract PURPOSE This study was conducted to examine the applicability and relationship to glycemic control of the Diabetes Locus of Control (DLC) Scales in a low-literacy, economically deprived, African American population with type 2 diabetes. METHODS The DLC Scales were administered orally to African American patients with type 2 diabetes who had been referred to the diabetes unit of a large urban public hospital. Reliability, interscale correlations, and associations with patient characteristics were compared with those originally obtained for a better educated, predominately Caucasian population. RESULTS The structure and correlates of the DLC Scales in the African American population were more similar than different from those originally obtained from a primarily well-educated, Caucasian population. However, comprehension of some items was difficult for up to 10% of the low-literacy population. A significant relationship was found between belief in chance and both glycemic control at the 6-month follow-up and the change in glycemic control over time. CONCLUSIONS Although the DLC Scales operate similarly in an urban African American population with limited education, further modification is needed to enhance the prediction of glycemic control and provide direction for developing targeted interventions.
    MeSH term(s) African Americans/psychology ; Diabetes Mellitus, Type 2/blood/ethnology/prevention & control ; Educational Status ; European Continental Ancestry Group/psychology ; Female ; Hemoglobin A, Glycosylated/metabolism ; Humans ; Internal-External Control ; Male ; Middle Aged ; Nursing Assessment/methods ; Poverty/psychology ; Predictive Value of Tests ; Questionnaires/standards ; Reproducibility of Results ; Urban Health
    Keywords adults ; Blacks ; blood glucose ; diabetes mellitus ; glycemic control ; patient education ; Georgia
    Language English
    Dates of publication 2000-01
    Size p. 121-128.
    Publishing place Sage Publications
    Document type Article
    ZDB-ID 603168-7
    ISSN 0145-7217
    ISSN 0145-7217
    DOI 10.1177/014572170002600113
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

    Pereyra, Florencia / Jia, Xiaoming / McLaren, Paul J / Telenti, Amalio / de Bakker, Paul I W / Walker, Bruce D / Ripke, Stephan / Brumme, Chanson J / Pulit, Sara L / Carrington, Mary / Kadie, Carl M / Carlson, Jonathan M / Heckerman, David / Graham, Robert R / Plenge, Robert M / Deeks, Steven G / Gianniny, Lauren / Crawford, Gabriel / Sullivan, Jordan /
    Gonzalez, Elena / Davies, Leela / Camargo, Amy / Moore, Jamie M / Beattie, Nicole / Gupta, Supriya / Crenshaw, Andrew / Burtt, Noël P / Guiducci, Candace / Gupta, Namrata / Gao, Xiaojiang / Qi, Ying / Yuki, Yuko / Piechocka-Trocha, Alicja / Cutrell, Emily / Rosenberg, Rachel / Moss, Kristin L / Lemay, Paul / O'Leary, Jessica / Schaefer, Todd / Verma, Pranshu / Toth, Ildiko / Block, Brian / Baker, Brett / Rothchild, Alissa / Lian, Jeffrey / Proudfoot, Jacqueline / Alvino, Donna Marie L / Vine, Seanna / Addo, Marylyn M / Allen, Todd M / Altfeld, Marcus / Henn, Matthew R / Le Gall, Sylvie / Streeck, Hendrik / Haas, David W / Kuritzkes, Daniel R / Robbins, Gregory K / Shafer, Robert W / Gulick, Roy M / Shikuma, Cecilia M / Haubrich, Richard / Riddler, Sharon / Sax, Paul E / Daar, Eric S / Ribaudo, Heather J / Agan, Brian / Agarwal, Shanu / Ahern, Richard L / Allen, Brady L / Altidor, Sherly / Altschuler, Eric L / Ambardar, Sujata / Anastos, Kathryn / Anderson, Ben / Anderson, Val / Andrady, Ushan / Antoniskis, Diana / Bangsberg, David / Barbaro, Daniel / Barrie, William / Bartczak, J / Barton, Simon / Basden, Patricia / Basgoz, Nesli / Bazner, Suzane / Bellos, Nicholaos C / Benson, Anne M / Berger, Judith / Bernard, Nicole F / Bernard, Annette M / Birch, Christopher / Bodner, Stanley J / Bolan, Robert K / Boudreaux, Emilie T / Bradley, Meg / Braun, James F / Brndjar, Jon E / Brown, Stephen J / Brown, Katherine / Brown, Sheldon T / Burack, Jedidiah / Bush, Larry M / Cafaro, Virginia / Campbell, Omobolaji / Campbell, John / Carlson, Robert H / Carmichael, J Kevin / Casey, Kathleen K / Cavacuiti, Chris / Celestin, Gregory / Chambers, Steven T / Chez, Nancy / Chirch, Lisa M / Cimoch, Paul J / Cohen, Daniel / Cohn, Lillian E / Conway, Brian / Cooper, David A / Cornelson, Brian / Cox, David T / Cristofano, Michael V / Cuchural, George / Czartoski, Julie L / Dahman, Joseph M / Daly, Jennifer S / Davis, Benjamin T / Davis, Kristine / Davod, Sheila M / DeJesus, Edwin / Dietz, Craig A / Dunham, Eleanor / Dunn, Michael E / Ellerin, Todd B / Eron, Joseph J / Fangman, John J W / Farel, Claire E / Ferlazzo, Helen / Fidler, Sarah / Fleenor-Ford, Anita / Frankel, Renee / Freedberg, Kenneth A / French, Neel K / Fuchs, Jonathan D / Fuller, Jon D / Gaberman, Jonna / Gallant, Joel E / Gandhi, Rajesh T / Garcia, Efrain / Garmon, Donald / Gathe, Joseph C / Gaultier, Cyril R / Gebre, Wondwoosen / Gilman, Frank D / Gilson, Ian / Goepfert, Paul A / Gottlieb, Michael S / Goulston, Claudia / Groger, Richard K / Gurley, T Douglas / Haber, Stuart / Hardwicke, Robin / Hardy, W David / Harrigan, P Richard / Hawkins, Trevor N / Heath, Sonya / Hecht, Frederick M / Henry, W Keith / Hladek, Melissa / Hoffman, Robert P / Horton, James M / Hsu, Ricky K / Huhn, Gregory D / Hunt, Peter / Hupert, Mark J / Illeman, Mark L / Jaeger, Hans / Jellinger, Robert M / John, Mina / Johnson, Jennifer A / Johnson, Kristin L / Johnson, Heather / Johnson, Kay / Joly, Jennifer / Jordan, Wilbert C / Kauffman, Carol A / Khanlou, Homayoon / Killian, Robert K / Kim, Arthur Y / Kim, David D / Kinder, Clifford A / Kirchner, Jeffrey T / Kogelman, Laura / Kojic, Erna Milunka / Korthuis, P Todd / Kurisu, Wayne / Kwon, Douglas S / LaMar, Melissa / Lampiris, Harry / Lanzafame, Massimiliano / Lederman, Michael M / Lee, David M / Lee, Jean M L / Lee, Marah J / Lee, Edward T Y / Lemoine, Janice / Levy, Jay A / Llibre, Josep M / Liguori, Michael A / Little, Susan J / Liu, Anne Y / Lopez, Alvaro J / Loutfy, Mono R / Loy, Dawn / Mohammed, Debbie Y / Man, Alan / Mansour, Michael K / Marconi, Vincent C / Markowitz, Martin / Marques, Rui / Martin, Jeffrey N / Martin, Harold L / Mayer, Kenneth Hugh / McElrath, M Juliana / McGhee, Theresa A / McGovern, Barbara H / McGowan, Katherine / McIntyre, Dawn / Mcleod, Gavin X / Menezes, Prema / Mesa, Greg / Metroka, Craig E / Meyer-Olson, Dirk / Miller, Andy O / Montgomery, Kate / Mounzer, Karam C / Nagami, Ellen H / Nagin, Iris / Nahass, Ronald G / Nelson, Margret O / Nielsen, Craig / Norene, David L / O'Connor, David H / Ojikutu, Bisola O / Okulicz, Jason / Oladehin, Olakunle O / Oldfield, Edward C / Olender, Susan A / Ostrowski, Mario / Owen, William F / Pae, Eunice / Parsonnet, Jeffrey / Pavlatos, Andrew M / Perlmutter, Aaron M / Pierce, Michael N / Pincus, Jonathan M / Pisani, Leandro / Price, Lawrence Jay / Proia, Laurie / Prokesch, Richard C / Pujet, Heather Calderon / Ramgopal, Moti / Rathod, Almas / Rausch, Michael / Ravishankar, J / Rhame, Frank S / Richards, Constance Shamuyarira / Richman, Douglas D / Rodes, Berta / Rodriguez, Milagros / Rose, Richard C / Rosenberg, Eric S / Rosenthal, Daniel / Ross, Polly E / Rubin, David S / Rumbaugh, Elease / Saenz, Luis / Salvaggio, Michelle R / Sanchez, William C / Sanjana, Veeraf M / Santiago, Steven / Schmidt, Wolfgang / Schuitemaker, Hanneke / Sestak, Philip M / Shalit, Peter / Shay, William / Shirvani, Vivian N / Silebi, Vanessa I / Sizemore, James M / Skolnik, Paul R / Sokol-Anderson, Marcia / Sosman, James M / Stabile, Paul / Stapleton, Jack T / Starrett, Sheree / Stein, Francine / Stellbrink, Hans-Jurgen / Sterman, F Lisa / Stone, Valerie E / Stone, David R / Tambussi, Giuseppe / Taplitz, Randy A / Tedaldi, Ellen M / Theisen, William / Torres, Richard / Tosiello, Lorraine / Tremblay, Cecile / Tribble, Marc A / Trinh, Phuong D / Tsao, Alice / Ueda, Peggy / Vaccaro, Anthony / Valadas, Emilia / Vanig, Thanes J / Vecino, Isabel / Vega, Vilma M / Veikley, Wenoah / Wade, Barbara H / Walworth, Charles / Wanidworanun, Chingchai / Ward, Douglas J / Warner, Daniel A / Weber, Robert D / Webster, Duncan / Weis, Steve / Wheeler, David A / White, David J / Wilkins, Ed / Winston, Alan / Wlodaver, Clifford G / van't Wout, Angelique / Wright, David P / Yang, Otto O / Yurdin, David L / Zabukovic, Brandon W / Zachary, Kimon C / Zeeman, Beth / Zhao, Meng

    Science (New York, N.Y.)

    2010  Volume 330, Issue 6010, Page(s) 1551–1557

    Abstract: Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a ... ...

    Abstract Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection.
    MeSH term(s) Black or African American/genetics ; Alleles ; Amino Acids/physiology ; Antigen Presentation ; CD8-Positive T-Lymphocytes/immunology ; Cohort Studies ; Disease Progression ; Genes, MHC Class I ; Genome-Wide Association Study ; HIV Antigens/immunology ; HIV Infections/ethnology ; HIV Infections/genetics ; HIV Infections/immunology ; HIV Infections/virology ; HIV Long-Term Survivors ; HIV-1/immunology ; HLA-A Antigens/chemistry ; HLA-A Antigens/genetics ; HLA-A Antigens/immunology ; HLA-A Antigens/metabolism ; HLA-B Antigens/chemistry ; HLA-B Antigens/genetics ; HLA-B Antigens/immunology ; HLA-B Antigens/metabolism ; HLA-C Antigens/chemistry ; HLA-C Antigens/genetics ; HLA-C Antigens/immunology ; HLA-C Antigens/metabolism ; Haplotypes ; Hispanic or Latino/genetics ; Humans ; Immunity, Innate ; Logistic Models ; Models, Molecular ; Polymorphism, Single Nucleotide ; Protein Conformation ; Viral Load ; White People/genetics
    Chemical Substances Amino Acids ; HIV Antigens ; HLA-A Antigens ; HLA-B Antigens ; HLA-C Antigens
    Language English
    Publishing date 2010-11-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1195271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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