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  1. Article ; Online: Natural killer (NK) cell receptor-HLA ligand genotype combinations associated with protection from HIV infection: investigation of how protective genotypes influence anti HIV NK cell functions.

    Bernard, Nicole F

    AIDS research and therapy

    2017  Volume 14, Issue 1, Page(s) 38

    Abstract: The anti-HIV activity of natural killer (NK) cells could be induced fast enough to potentially prevent the establishment of HIV infection. Epidemiological studies identified two genotypes encoding NK receptors that contribute to NK cell function, that ... ...

    Abstract The anti-HIV activity of natural killer (NK) cells could be induced fast enough to potentially prevent the establishment of HIV infection. Epidemiological studies identified two genotypes encoding NK receptors that contribute to NK cell function, that were more frequent in people who remained uninfected despite multiple HIV exposures than in HIV-susceptible subjects. NK cells from carriers of the *h/*y+B*57 genotype have higher NK cell functional potential and inhibit HIV replication in autologous HIV-infected CD4+ T cells (iCD4) more potently than those from carriers of non-protective genotypes. HIV suppression depends on the secretion of CC-chemokines that block HIV entry into CD4+ cells. NK cell education and the effect of HIV infection on iCD4 cell surface expression of MHC-I antigens both influenced NK cell responses to autologous iCD4. The second KIR3DS1 homozygous protective genotype encodes an activating receptor that upon interacting with its HLA-F ligand on iCD4 induces anti-viral activity.
    Language English
    Publishing date 2017-09-12
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1742-6405
    ISSN (online) 1742-6405
    DOI 10.1186/s12981-017-0172-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: NK Cells in Protection from HIV Infection.

    Bernard, Nicole F / Alsulami, Khlood / Pavey, Erik / Dupuy, Franck P

    Viruses

    2022  Volume 14, Issue 6

    Abstract: Some people, known as HIV-exposed seronegative (HESN) individuals, remain uninfected despite high levels of exposure to HIV. Understanding the mechanisms underlying their apparent resistance to HIV infection may inform strategies designed to protect ... ...

    Abstract Some people, known as HIV-exposed seronegative (HESN) individuals, remain uninfected despite high levels of exposure to HIV. Understanding the mechanisms underlying their apparent resistance to HIV infection may inform strategies designed to protect against HIV infection. Natural Killer (NK) cells are innate immune cells whose activation state depends on the integration of activating and inhibitory signals arising from cell surface receptors interacting with their ligands on neighboring cells. Inhibitory NK cell receptors use a subset of major histocompatibility (MHC) class I antigens as ligands. This interaction educates NK cells, priming them to respond to cells with reduced MHC class I antigen expression levels as occurs on HIV-infected cells. NK cells can interact with both autologous HIV-infected cells and allogeneic cells bearing MHC antigens seen as non self by educated NK cells. NK cells are rapidly activated upon interacting with HIV-infected or allogenic cells to elicit anti-viral activity that blocks HIV spread to new target cells, suppresses HIV replication, and kills HIV-infected cells before HIV reservoirs can be seeded and infection can be established. In this manuscript, we will review the epidemiological and functional evidence for a role for NK cells in protection from HIV infection.
    MeSH term(s) CD4-Positive T-Lymphocytes ; HIV Infections ; HIV-1/physiology ; Histocompatibility Antigens Class I ; Humans ; Killer Cells, Natural ; Ligands
    Chemical Substances Histocompatibility Antigens Class I ; Ligands
    Language English
    Publishing date 2022-05-25
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14061143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: NK Cells in Protection from HIV Infection

    Bernard, Nicole F. / Alsulami, Khlood / Pavey, Erik / Dupuy, Franck P.

    Viruses. 2022 May 25, v. 14, no. 6

    2022  

    Abstract: Some people, known as HIV-exposed seronegative (HESN) individuals, remain uninfected despite high levels of exposure to HIV. Understanding the mechanisms underlying their apparent resistance to HIV infection may inform strategies designed to protect ... ...

    Abstract Some people, known as HIV-exposed seronegative (HESN) individuals, remain uninfected despite high levels of exposure to HIV. Understanding the mechanisms underlying their apparent resistance to HIV infection may inform strategies designed to protect against HIV infection. Natural Killer (NK) cells are innate immune cells whose activation state depends on the integration of activating and inhibitory signals arising from cell surface receptors interacting with their ligands on neighboring cells. Inhibitory NK cell receptors use a subset of major histocompatibility (MHC) class I antigens as ligands. This interaction educates NK cells, priming them to respond to cells with reduced MHC class I antigen expression levels as occurs on HIV-infected cells. NK cells can interact with both autologous HIV-infected cells and allogeneic cells bearing MHC antigens seen as non self by educated NK cells. NK cells are rapidly activated upon interacting with HIV-infected or allogenic cells to elicit anti-viral activity that blocks HIV spread to new target cells, suppresses HIV replication, and kills HIV-infected cells before HIV reservoirs can be seeded and infection can be established. In this manuscript, we will review the epidemiological and functional evidence for a role for NK cells in protection from HIV infection.
    Keywords HIV infections ; antigens ; antiviral properties ; ligands
    Language English
    Dates of publication 2022-0525
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14061143
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Natural Killer Cells in Antibody Independent and Antibody Dependent HIV Control.

    Bernard, Nicole F / Kant, Sanket / Kiani, Zahra / Tremblay, Cécile / Dupuy, Franck P

    Frontiers in immunology

    2022  Volume 13, Page(s) 879124

    Abstract: Infection with the human immunodeficiency virus (HIV), when left untreated, typically leads to disease progression towards acquired immunodeficiency syndrome. Some people living with HIV (PLWH) control their virus to levels below the limit of detection ... ...

    Abstract Infection with the human immunodeficiency virus (HIV), when left untreated, typically leads to disease progression towards acquired immunodeficiency syndrome. Some people living with HIV (PLWH) control their virus to levels below the limit of detection of standard viral load assays, without treatment. As such, they represent examples of a functional HIV cure. These individuals, called Elite Controllers (ECs), are rare, making up <1% of PLWH. Genome wide association studies mapped genes in the major histocompatibility complex (MHC) class I region as important in HIV control. ECs have potent virus specific CD8
    MeSH term(s) Genome-Wide Association Study ; HIV Infections ; HIV-1 ; HLA Antigens ; Histocompatibility Antigens Class I/genetics ; Humans ; Immunoglobulin G/genetics ; Killer Cells, Natural ; Ligands ; Receptors, Natural Killer Cell/genetics
    Chemical Substances HLA Antigens ; Histocompatibility Antigens Class I ; Immunoglobulin G ; Ligands ; Receptors, Natural Killer Cell
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.879124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [No title information]

    Kant, Sanket / Dupuy, Franck P / Kiani, Zahra / Tremblay, Cécile L / Bernard, Nicole F

    Virologie (Montrouge, France)

    2022  Volume 26, Issue 1, Page(s) 73–89

    Abstract: Résumé En l'absence de traitement antirétroviral, l'infection par le VIH progresse normalement vers le syndrome d'immunodéficience acquise. Une minorité de sujets infectés par le VIH sont toutefois capables de contrôler la réplication virale en l'absence ...

    Title translation Contribution des cellules tueuses naturelles chez les sujets contrôleurs d’élite du VIH.
    Abstract Résumé En l'absence de traitement antirétroviral, l'infection par le VIH progresse normalement vers le syndrome d'immunodéficience acquise. Une minorité de sujets infectés par le VIH sont toutefois capables de contrôler la réplication virale en l'absence de traitement. Ces patients appelés sujets contrôleurs d'élite (EC pour elite controllers) représentent un exemple de guérison fonctionnelle de l'infection par le VIH. Certains EC sont infectés par des virus défectifs, alors que d'autres ont des provirus intégrés dans des zones non transcrites de la chromatine. Cependant, la plupart des EC se distinguent des sujets non-contrôleurs parce qu'ils développent de fortes réponses T CD4 et CD8 spécifiques au VIH. Les cellules tueuses naturelles (NK pour Natural Killer) sont des cellules du système immunitaire inné qui fonctionnent à l'interface entre l'immunité innée et l'immunité acquise. Les cellules NK sont capables de reconnaître et de répondre à des cellules infectées dès les stades précoces de l'infection. Les cellules NK peuvent être activées de fac¸on indépendante et dépendante des anticorps afin d'exercer des fonctions antivirales et éliminer les cellules infectées. Ce manuscrit discutera du rôle des cellules NK dans le contrôle de l'infection par le VIH.
    MeSH term(s) Elite Controllers ; HIV Infections ; Humans ; Killer Cells, Natural
    Language French
    Publishing date 2022-07-13
    Publishing country France
    Document type Journal Article
    ZDB-ID 2118387-9
    ISSN 1950-6961 ; 1267-8694
    ISSN (online) 1950-6961
    ISSN 1267-8694
    DOI 10.1684/vir.2022.0932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Contribution of Natural Killer cells to HIV control in Elite Controllers.

    Kant, Sanket / Dupuy, Franck P / Kiani, Zahra / Tremblay, Cécile L / Bernard, Nicole F

    Virologie (Montrouge, France)

    2022  Volume 26, Issue 1, Page(s) 34–49

    Abstract: Untreated HIV infection usually leads to disease progression and development of the acquired immunodeficiency syndrome. A rare subset of people living with HIV control HIV without anti-retroviral therapy. These individuals, known as Elite Controllers ( ... ...

    Title translation Contribution of Natural Killer cells to HIV control in Elite Controllers.
    Abstract Untreated HIV infection usually leads to disease progression and development of the acquired immunodeficiency syndrome. A rare subset of people living with HIV control HIV without anti-retroviral therapy. These individuals, known as Elite Controllers (ECs), represent examples of a functional HIV cure. ECs differ from non-controllers is many aspects. Some are infected with defective virus, most have potent CD4 and CD8 virus-specific T cell responses and proviruses in these individuals tend to be inserted into regions with characteristics of deep latency. Natural Killer (NK) cells are innate immune cells that function at the intersection of innate and adaptive immunity. They have the capacity to recognize and respond to HIV-infected cells from the earliest stages in infection. NK cells can be activated through antibody independent and antibody dependent mechanisms to elicit functions that control HIV and kill infected cells. This manuscript will review the role of NK cells in HIV control.
    MeSH term(s) Acquired Immunodeficiency Syndrome ; Adaptive Immunity ; Elite Controllers ; HIV Infections/drug therapy ; Humans ; Killer Cells, Natural
    Language English
    Publishing date 2022-07-13
    Publishing country France
    Document type Journal Article
    ZDB-ID 2118387-9
    ISSN 1950-6961 ; 1267-8694
    ISSN (online) 1950-6961
    ISSN 1267-8694
    DOI 10.1684/vir.2022.0933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: HLA-F on Autologous HIV-Infected Cells Activates Primary NK Cells Expressing the Activating Killer Immunoglobulin-Like Receptor KIR3DS1.

    Kiani, Zahra / Bruneau, Julie / Geraghty, Daniel E / Bernard, Nicole F

    Journal of virology

    2019  Volume 93, Issue 18

    Abstract: HIV-exposed ... ...

    Abstract HIV-exposed seronegative
    MeSH term(s) Adult ; CD4-Positive T-Lymphocytes/immunology ; Chemokine CCL4/metabolism ; Female ; Genotype ; HIV Infections/immunology ; HIV-1/immunology ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class I/metabolism ; Humans ; Killer Cells, Natural/immunology ; Lymphocyte Activation ; Male ; Receptors, CCR5/metabolism ; Receptors, KIR ; Receptors, KIR3DS1/genetics ; Receptors, KIR3DS1/immunology
    Chemical Substances CCL4 protein, human ; CCR5 protein, human ; Chemokine CCL4 ; HLA-F antigens ; Histocompatibility Antigens Class I ; KIR3DS1 protein, human ; Receptors, CCR5 ; Receptors, KIR ; Receptors, KIR3DS1
    Language English
    Publishing date 2019-08-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00933-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article ; Online: The Frequency and Function of NKG2C

    Alsulami, Khlood / Dupuy, Franck P / Gilbert, Louise / Messier-Peet, Marc / Durand, Madeleine / Tremblay, Cécile / Routy, Jean-Pierre / Bruneau, Julie / Baril, Jean-Guy / Trottier, Benoit / Bernard, Nicole F

    Viruses

    2023  Volume 15, Issue 2

    Abstract: Human cytomegalovirus (CMV) infection drives the expansion and differentiation of natural killer (NK) cells with adaptive-like features. We investigated whether age and time on antiretroviral therapy (ART) influenced adaptive NK cell frequency and ... ...

    Abstract Human cytomegalovirus (CMV) infection drives the expansion and differentiation of natural killer (NK) cells with adaptive-like features. We investigated whether age and time on antiretroviral therapy (ART) influenced adaptive NK cell frequency and functionality. Flow cytometry was used to evaluate the frequency of adaptive and conventional NK cells in 229 CMV
    MeSH term(s) Aged ; Aged, 80 and over ; Humans ; Coinfection ; Cytomegalovirus Infections/complications ; HIV Infections/complications ; HIV Infections/drug therapy ; Killer Cells, Natural ; Tumor Necrosis Factor-alpha ; CD57 Antigens/immunology
    Chemical Substances Tumor Necrosis Factor-alpha ; KLRC2 protein, human ; CD57 Antigens
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Expression of ligands for activating natural killer cell receptors on cell lines commonly used to assess natural killer cell function.

    Tremblay-McLean, Alexandra / Coenraads, Sita / Kiani, Zahra / Dupuy, Franck P / Bernard, Nicole F

    BMC immunology

    2019  Volume 20, Issue 1, Page(s) 8

    Abstract: Background: Natural killer cell responses to virally-infected or transformed cells depend on the integration of signals received through inhibitory and activating natural killer cell receptors. Human Leukocyte Antigen null cells are used in vitro to ... ...

    Abstract Background: Natural killer cell responses to virally-infected or transformed cells depend on the integration of signals received through inhibitory and activating natural killer cell receptors. Human Leukocyte Antigen null cells are used in vitro to stimulate natural killer cell activation through missing-self mechanisms. On the other hand, CEM.NKr.CCR5 cells are used to stimulate natural killer cells in an antibody dependent manner since they are resistant to direct killing by natural killer cells. Both K562 and 721.221 cell lines lack surface major histocompatibility compatibility complex class Ia ligands for inhibitory natural killer cell receptors. Previous work comparing natural killer cell stimulation by K562 and 721.221 found that they stimulated different frequencies of natural killer cell functional subsets. We hypothesized that natural killer cell function following K562, 721.221 or CEM.NKr.CCR5 stimulation reflected differences in the expression of ligands for activating natural killer cell receptors.
    Results: K562 expressed a higher intensity of ligands for Natural Killer G2D and the Natural Cytotoxicity Receptors, which are implicated in triggering natural killer cell cytotoxicity. 721.221 cells expressed a greater number of ligands for activating natural killer cell receptors. 721.221 expressed cluster of differentiation 48, 80 and 86 with a higher mean fluorescence intensity than did K562. The only ligands for activating receptor that were detected on CEM.NKr.CCR5 cells at a high intensity were cluster of differentiation 48, and intercellular adhesion molecule-2.
    Conclusions: The ligands expressed by K562 engage natural killer cell receptors that induce cytolysis. This is consistent with the elevated contribution that the cluster of differentiation 107a function makes to total K562 induced natural killer cell functionality compared to 721.221 cells. The ligands expressed on 721.221 cells can engage a larger number of activating natural killer cell receptors, which may explain their ability to activate a larger frequency of these cells to become functional and secrete cytokines. The few ligands for activating natural killer cell receptors expressed by CEM.NKr.CCR5 may reduce their ability to activate natural killer cells in an antibody independent manner explaining their relative resistance to direct natural killer cell cytotoxicity.
    MeSH term(s) Biomarkers ; Cell Line, Tumor ; Gene Expression ; HLA Antigens/immunology ; Humans ; Immunophenotyping ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Ligands ; Lymphocyte Activation/genetics ; Lymphocyte Activation/immunology ; Receptors, Natural Killer Cell/genetics ; Receptors, Natural Killer Cell/metabolism
    Chemical Substances Biomarkers ; HLA Antigens ; Ligands ; Receptors, Natural Killer Cell
    Language English
    Publishing date 2019-01-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-2172
    ISSN (online) 1471-2172
    DOI 10.1186/s12865-018-0272-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: MiRNA-103 downmodulates CCR5 expression reducing human immunodeficiency virus type-1 entry and impacting latency establishment in CD4

    Bellini, Nicolas / Lodge, Robert / Pham, Tram N Q / Jain, Jaspreet / Murooka, Thomas T / Herschhorn, Alon / Bernard, Nicole F / Routy, Jean-Pierre / Tremblay, Cécile L / Cohen, Éric A

    iScience

    2022  Volume 25, Issue 10, Page(s) 105234

    Abstract: Activated-to-memory transitioning ... ...

    Abstract Activated-to-memory transitioning CD4
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.105234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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