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  1. Article ; Online: Peripherally inserted central venous catheter for pediatric acute leukemia: A retrospective 11-year single-center experience.

    Ligia, Silvio / Morano, Salvatore Giacomo / Kaiser, Francesca / Micozzi, Alessandra / Chistolini, Antonio / Barberi, Walter / Arena, Valentina / Piciocchi, Alfonso / Forgione, Maurizio / Gasperini, Giulia / Berneschi, Paola / Testi, Anna Maria

    The journal of vascular access

    2023  , Page(s) 11297298231185222

    Abstract: Background: Peripherally inserted central catheters (PICCs) are successfully increasingly used in children in onco-hematologic setting. PICC insertion, especially in oncologic patients, can be associated with adverse events (thrombosis, mechanical ... ...

    Abstract Background: Peripherally inserted central catheters (PICCs) are successfully increasingly used in children in onco-hematologic setting. PICC insertion, especially in oncologic patients, can be associated with adverse events (thrombosis, mechanical complications, and infections). Data regarding the use of PICC, as long-term access in pediatric patients with severe hematologic diseases, are still limited.
    Methods: We retrospectively evaluated the safety and efficacy of 196 PICC, inserted in 129 pediatric patients with acute leukemia diagnosed and treated at Pediatric Hematology Unit, Sapienza University of Rome.
    Results: The 196 PICC analyzed were in situ for a median dwell time of 190 days (range 12-898). In 42 children, PICC was inserted twice and in 10, three times or more due to hematopoietic stem cell transplant, disease recurrence, or PICC-related complications. The overall complication rate was 34%: catheter-related bloodstream infections (CRBSI) occurred in 22% of cases after a median time of 97 days; a catheter-related thrombosis (CRT) in 3.5% and mechanical complications in 9% of cases. Premature removal for complications occurred in 30% of PICC. One death from CRBSI was observed.
    Conclusions: To our knowledge, this study represents the largest cohort of pediatric patients who have inserted the PICC for acute leukemia. In our experience, PICC was a cheap, safe, and reliable device for long-term intravenous access in children with acute leukemia. This has been possible with the help of dedicated PICC team.
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2252820-9
    ISSN 1724-6032 ; 1129-7298
    ISSN (online) 1724-6032
    ISSN 1129-7298
    DOI 10.1177/11297298231185222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6414: Show issues Location:
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  2. Article ; Online: Peripherally inserted central catheters in allogeneic hematopoietic stem cell transplant recipients.

    Mariggiò, Elena / Iori, Anna Paola / Micozzi, Alessandra / Chistolini, Antonio / Latagliata, Roberto / Berneschi, Paola / Giampaoletti, Massimo / La Rocca, Ursula / Bruzzese, Antonella / Barberi, Walter / Foà, Robin / Morano, Salvatore Giacomo

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2020  Volume 28, Issue 9, Page(s) 4193–4199

    Abstract: Background: Central venous catheters (CVC) are essential for the management of patients with hematologic malignancies, facilitating chemotherapy infusion, antibiotics, parenteral nutrition, blood products, and blood samples collection. In this ... ...

    Abstract Background: Central venous catheters (CVC) are essential for the management of patients with hematologic malignancies, facilitating chemotherapy infusion, antibiotics, parenteral nutrition, blood products, and blood samples collection. In this population, peripherally inserted central catheters (PICC) seem to be associated with lower complications, compared with conventional percutaneously inserted devices (CICC). Data on the PICC in allogeneic hematopoietic stem cell recipients (allo-HSCT) are limited.
    Methods: We have prospectively evaluated the safety and efficacy of 100 polyurethanes or silicone PICC, inserted into 100 adult allo-HSCT recipients, at the Hematology of Sapienza University of Rome (Italy), between October 2012 and August 2017.
    Results: The median duration of PICC placement was 117 days. Overall, 68% of patients maintained the device for the entire transplant procedure and PICC were removed after day 100 from allo-HSCT; of these, 44% did not experienced any PICC-related complications. Catheter-related bloodstream infections (CRBSI) occurred in 32% of patients (2.5/1000 PICC days), associated with thrombosis in 8 cases. CRBSI were observed in 42% of patients with polyurethane and 20% with silicone PICC (p = 0.02). Catheter-related thrombosis occurred in 9% of patients, never requiring anticipated PICC removal. Mechanical complications occurred in 15% of cases (1.2/1000 PICC days). On the whole, adverse events were manageable and did not affect transplant outcome. No deaths related to PICC-complications were observed.
    Conclusions: PICC are a safe and reliable long-term venous access in allo-HSCT recipients.
    MeSH term(s) Adult ; Catheter-Related Infections/etiology ; Catheterization, Central Venous/adverse effects ; Catheterization, Central Venous/instrumentation ; Catheterization, Central Venous/methods ; Catheterization, Peripheral/adverse effects ; Catheterization, Peripheral/instrumentation ; Catheterization, Peripheral/methods ; Central Venous Catheters/adverse effects ; Female ; Hematologic Neoplasms/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/instrumentation ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Male ; Middle Aged ; Parenteral Nutrition, Total/adverse effects ; Parenteral Nutrition, Total/instrumentation ; Parenteral Nutrition, Total/methods ; Polyurethanes ; Silicones ; Thrombosis/etiology ; Young Adult
    Chemical Substances Polyurethanes ; Silicones
    Language English
    Publishing date 2020-01-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-019-05269-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3697: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Early and late complications related to central venous catheters in hematological malignancies: a retrospective analysis of 1102 patients.

    Morano, Salvatore Giacomo / Coppola, Lorenzo / Latagliata, Roberto / Berneschi, Paola / Chistolini, Antonio / Micozzi, Alessandra / Girmenia, Corrado / Breccia, Massimo / Brunetti, Gregorio / Massaro, Fulvio / Rosa, Giovanni / Guerrisi, Pietro / Mandelli, Franco / Foà, Roberto / Alimena, Giuliana

    Mediterranean journal of hematology and infectious diseases

    2014  Volume 6, Issue 1, Page(s) e2014011

    Abstract: Several severe complications may be associated with the use of central venous catheters (CVC). We retrospectively evaluated on a large cohort of patients the incidence of CVC-related early and late complications. From 7/99 to 12/2005, 1102 CVC have been ... ...

    Abstract Several severe complications may be associated with the use of central venous catheters (CVC). We retrospectively evaluated on a large cohort of patients the incidence of CVC-related early and late complications. From 7/99 to 12/2005, 1102 CVC have been implanted at our Institution in 881 patients with hematological malignancies (142,202 total day number of implanted CVC). Early mechanic complications were 79 (7.2% - 0.55/1,000 days/CVC). Thirty-nine episodes of early infective complications (<1 week from CVC implant) occurred (3.5% - 0.3/1000 days/CVC): furthermore, 187 episodes of CVC-related sepsis (17% - 1.3/1000 days/CVC) were recorded. There were 29 episodes (2.6%) of symptomatic CVC-related thrombotic complications, with a median interval from CVC implant of 60 days (range 7 - 395). The rate of CVC withdrawal due to CVC-related complications was 26%. The incidence of CVC-related complications in our series is in the range reported in the literature notwithstanding cytopenia often coexisting in hematological patients.
    Language English
    Publishing date 2014-02-14
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2014.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Catheter-associated bloodstream infections and thrombotic risk in hematologic patients with peripherally inserted central catheters (PICC).

    Morano, Salvatore Giacomo / Latagliata, Roberto / Girmenia, Corrado / Massaro, Fulvio / Berneschi, Paola / Guerriero, Alfonso / Giampaoletti, Massimo / Sammarco, Arianna / Annechini, Giorgia / Fama, Angelo / Di Rocco, Alice / Chistolini, Antonio / Micozzi, Alessandra / Molica, Matteo / Barberi, Walter / Minotti, Clara / Brunetti, Gregorio Antonio / Breccia, Massimo / Cartoni, Claudio /
    Capria, Saveria / Rosa, Giovanni / Alimena, Giuliana / Foà, Robin

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2015  Volume 23, Issue 11, Page(s) 3289–3295

    Abstract: Purpose: The use of peripherally inserted central catheters (PICC) as an alternative to other central venous access devices (CVAD) is becoming very frequent in cancer patients. To evaluate the impact of complications associated to these devices in ... ...

    Abstract Purpose: The use of peripherally inserted central catheters (PICC) as an alternative to other central venous access devices (CVAD) is becoming very frequent in cancer patients. To evaluate the impact of complications associated to these devices in patients with hematologic malignancies, we revised the catheter-related bloodstream infections (CRBSI) and the catheter-related thrombotic complications (CRTC) observed at our institute between January 2009 and December 2012.
    Methods: A total of 612 PICCs were inserted into 483 patients at diagnosis or in subsequent phases of their hematologic disease. PICCs were successfully inserted in all cases. The median duration of in situ PICC placement was 101 days (interquartile range, 48-184 days).
    Results: A CRBSI occurred in 47 cases (7.7 %), with a rate of 0.59 per 1000 PICC days. A CRTC was recorded in 16 cases (2.6 %), with a rate of 0.20 per 1000 PICC days. No serious complication was associated to these events. Cox regression analyses of variables associated to CRBSIs and to CRTCs showed that only the type of disease (acute leukemia compared to other diseases) was significantly associated to a higher incidence of CRBSIs, while no feature was predictive for a higher risk of CRTCs.
    Conclusions: PICCs represent a useful and safe alternative to conventional CVAD for the management of patients with hematologic malignancies.
    MeSH term(s) Acute Disease ; Adult ; Aged ; Bacteremia/complications ; Bacteremia/microbiology ; Catheter-Related Infections/epidemiology ; Catheter-Related Infections/microbiology ; Catheterization, Central Venous/adverse effects ; Catheterization, Peripheral/adverse effects ; Female ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/therapy ; Humans ; Incidence ; Male ; Middle Aged ; Risk Factors ; Thrombosis/epidemiology ; Thrombosis/etiology
    Language English
    Publishing date 2015-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-015-2740-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3697: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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