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Article ; Online: Impaired fertility in adenomyosis: a murine model reveals endometrial receptivity and progesterone resistance imbalances.

Squatrito, Marlyne / Vervier, Julie / Bindels, Jules / Bernet, Laëtitia / Blacher, Silvia / Nisolle, Michelle / Munaut, Carine

Reproduction (Cambridge, England)

2024 Volume 167, Issue 5

Abstract: In brief: The impact of adenomyosis on reproductive health needs to be fully understood. By using a murine model, this study provides novel insights into the nuanced mechanisms associated with fertility challenges and offers a foundation for targeted ... ...

Abstract	In brief: The impact of adenomyosis on reproductive health needs to be fully understood. By using a murine model, this study provides novel insights into the nuanced mechanisms associated with fertility challenges and offers a foundation for targeted interventions. Abstract: This study investigates the intricate relationship between adenomyosis and reproductive health using a murine model, offering novel insights into this prevalent gynecological disorder. Adenomyosis, characterized by the invasive growth of endometrial tissue into the myometrium, is believed to negatively impact fertility. However, the challenge lies in disentangling this influence, as adenomyosis often coexists with other gynecological diseases. A tamoxifen-induced mice model presents a significant advantage by enabling the specific study of adenomyosis, devoid of confounding influences of concurrent gynecological diseases such as endometriosis. Focusing exclusively on adenomyosis, our study aims to elucidate pathogenic mechanisms underlying fertility issues, focusing on estrous cyclicity, ovarian follicle development, and overall fertility. Our findings uncover disruptions in estrous cyclicity, characterized by an increased duration of time spent in the estrus phase in adenomyosis-induced mice. These disturbances are potentially linked to observed compromised folliculogenesis and the remarkable reduction in litter number and size in mice affected by adenomyosis. Moreover, this study unveils potential drivers of subfertility such as progesterone resistance and altered endometrial receptivity. Within the uteri of mice with adenomyosis, reduced expression of the progesterone receptor and a decreased expression of two implantation-related markers (HoxA10 and integrin β3) were observed. This comprehensive examination sheds light on the nuanced complexities of adenomyosis-associated reproductive challenges, providing a foundation for targeted interventions in addressing fertility issues related to this disease.
MeSH term(s)	Female ; Humans ; Animals ; Mice ; Adenomyosis ; Disease Models, Animal ; Uterine Diseases/metabolism ; Endometrium/metabolism ; Endometrium/abnormalities ; Endometriosis/pathology ; Fertility
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2034501-X
ISSN	1741-7899 ; 1470-1626 ; 1476-3990
ISSN (online)	1741-7899
ISSN	1470-1626 ; 1476-3990
DOI	10.1530/REP-24-0019
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Article ; Online: The mTOR Inhibitor Rapamycin Counteracts Follicle Activation Induced by Ovarian Cryopreservation in Murine Transplantation Models.

Bindels, Jules / Squatrito, Marlyne / Bernet, Laëtitia / Nisolle, Michelle / Henry, Laurie / Munaut, Carine

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 8

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Mice ; Animals ; Female ; Mice, Inbred C57BL ; Ovary ; Sirolimus/pharmacology ; Sirolimus/therapeutic use ; Phosphatidylinositol 3-Kinases ; Cryopreservation ; TOR Serine-Threonine Kinases
Chemical Substances	Sirolimus (W36ZG6FT64) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2023-08-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59081474
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Article ; Online: HER2 immunohistochemistry inter-observer reproducibility in 205 cases of invasive breast carcinoma additionally tested by ISH.

Casterá, Carlos / Bernet, Laia

Annals of diagnostic pathology

2019 Volume 45, Page(s) 151451

Abstract: Assessment of HER2 biomarker in invasive breast carcinoma patients allows a specific therapeutic approach. Clinical guidelines indicate immunohistochemistry (IHC) and in situ hybridization (ISH) to test HER2, however both have drawbacks which results in ... ...

Abstract	Assessment of HER2 biomarker in invasive breast carcinoma patients allows a specific therapeutic approach. Clinical guidelines indicate immunohistochemistry (IHC) and in situ hybridization (ISH) to test HER2, however both have drawbacks which results in low reproducibility of results especially in equivocal cases. Our main objective is to quantify inter-observer IHC reproducibility and cross it with the ISH result. Our series includes 205 invasive breast carcinoma cases sent for ISH retest from 14 hospitals, 5 observers to assess the IHC and 2 observers for the ISH of each case. We found that the observers only achieve an absolute agreement for IHC in 1 out of 3 cases. The inter-observer concordance for IHC is low (0.2 ≤ k ≤ 0.4) or moderate (0.41 ≤ k ≤ 0.6). In ISH positive cases the concordance for IHC is higher than in the ISH negative cases. In conclusion, the study shows low and moderate IHC inter-observer concordance, finding the more worrying values among the ISH negative cases which are the most part of this particular sample. Subjective interpretation of the techniques, among other factors, has negative impact in HER2 evaluation. To offset this limitation we have checked that reaching a consensus from different observers for HER2 IHC assessment improves the results.
MeSH term(s)	Biomarkers, Tumor/metabolism ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/metabolism ; Female ; Humans ; Immunohistochemistry/methods ; In Situ Hybridization/methods ; Observer Variation ; Receptor, ErbB-2/metabolism ; Reproducibility of Results
Chemical Substances	Biomarkers, Tumor ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2019-12-17
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1440011-x
ISSN	1532-8198 ; 1092-9134
ISSN (online)	1532-8198
ISSN	1092-9134
DOI	10.1016/j.anndiagpath.2019.151451
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Article ; Online: OSNA Total Tumor Load for the Prediction of Axillary Involvement in Breast Cancer Patients: Should We use Different Thresholds According to the Intrinsic Molecular Subtype? MOTTO Study.

Bernet, L / Hardisson, D / Rodrigo, M / Córdoba, A / Sancho, M / Peg, V / Ruiz, I / Godey, F / Sánchez-Méndez, J I / Prat, A

Clinical pathology (Thousand Oaks, Ventura County, Calif.)

2023 Volume 16, Page(s) 2632010X231183693

Abstract: Aims: To assess the impact of the molecular subtype (MS) on the total number of CK19 mRNA copies in all positive SLN (TTL) threshold, to predict non-SLN affectation, and to compare 5 years progression-free survival (PFS) according to the risk of ... ...

Abstract	Aims: To assess the impact of the molecular subtype (MS) on the total number of CK19 mRNA copies in all positive SLN (TTL) threshold, to predict non-SLN affectation, and to compare 5 years progression-free survival (PFS) according to the risk of recurrence (ROR) group by PAM50. Methods: Cohort with infiltrating breast cancer with intra-operative metastatic SLN detected by one-step nucleic acid amplification (OSNA) assay who underwent subsequent ALND. Logistic regression was used to assess a possible interaction between TTL and MS(Triple Negative, Her-2-Enriched, Luminal A, or Luminal B), or hormone receptors (HR: positive or negative) by immunohistochemistry (IMH). Cox regression was used to compare PFS and OS in the 3 ROR groups (high, medium, or low). Results: TTL was predictive of non-SLN affectation in both univariate (OR [95% CI]: 1.72 [1.43, 2.05], Conclusions: our results do not provide evidence to support the utilization of subtype-specific thresholds for TTL values to make therapeutic decisions on the axilla. The ROR group was predictive of 5 years-PFS.
Language	English
Publishing date	2023-07-31
Publishing country	United States
Document type	Journal Article
ISSN	2632-010X
ISSN (online)	2632-010X
DOI	10.1177/2632010X231183693
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Article ; Online: Human Papillomavirus in the region of La Ribera-Valencia: Present and future.

Burgos-Teruel, A / Bernet, L / Gil-Tomás, J J / Jover-García, J / López, A / Osca, A

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

2020 Volume 33, Issue 2, Page(s) 103–109

Abstract: Objective: Human Papillomavirus (HPV) is the main cause of cervical cancer. The etiology and effects derived from this infection are set by molecular techniques and cytological diagnosis, respectively. In the present study, data obtained by an ... ...

Abstract	Objective: Human Papillomavirus (HPV) is the main cause of cervical cancer. The etiology and effects derived from this infection are set by molecular techniques and cytological diagnosis, respectively. In the present study, data obtained by an opportunist screening of cervical cancer in La Ribera region are revised and related statistically. Methods: Data considering different variables such as age, degree of lesion, HPV type detected and number of virus in coinfection were collected from 1,372 HPV positive cytology samples. HPV detection was carried out by means of three molecular techniques and the degree of lesion was analyzed by cytological diagnosis (Bethesda). In order to determine the relationship between different selected variables, several statistical analyses were performed. Results: Only degree of lesion variable showed a direct relationship with the rest of variables, increasing with aging process, viral oncogenicity, presence of at least one high-risk virus and with the fact of being mono-infected. The probability of presenting a higher-level degree of lesion multiplied by 28.4 when high-risk HPV was detected in mono-infection. Conclusions: HPV molecular detection is the most suitable technique to perform a cervix cancer primary screening for the management of women with negative cytological diagnose. The number of detected types is statistically related to the degree of lesion. The establishment of a properly regulated screening to identify HPV infection, and therefore, of cervical cancer risk, is essential.
MeSH term(s)	Adult ; Aged ; Aging ; Alphapapillomavirus/classification ; Alphapapillomavirus/genetics ; Alphapapillomavirus/isolation & purification ; Early Detection of Cancer ; Female ; Genotype ; Humans ; Middle Aged ; Papanicolaou Test ; Papillomavirus Infections/pathology ; Papillomavirus Infections/virology ; Spain ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/virology ; Vaginal Smears
Language	English
Publishing date	2020-02-21
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1018135-0
ISSN	1988-9518 ; 0214-3429
ISSN (online)	1988-9518
ISSN	0214-3429
DOI	10.37201/req/090.2019
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Article: Validation and Trend Analysis of Stratospheric Ozone Data from Ground-Based Observations at Lauder, New Zealand

Bernet, Leonie / Boyd, Ian / Nedoluha, Gerald / Querel, Richard / Swart, Daan / Hocke, Klemens

Remote Sensing. 2020 Dec. 31, v. 13, no. 1

2020

Abstract: Changes in stratospheric ozone have to be assessed continuously to evaluate the effectiveness of the Montreal Protocol. In the southern hemisphere, few ground-based observational datasets exist, making measurements at the Network for the Detection of ... ...

Abstract	Changes in stratospheric ozone have to be assessed continuously to evaluate the effectiveness of the Montreal Protocol. In the southern hemisphere, few ground-based observational datasets exist, making measurements at the Network for the Detection of Atmospheric Composition Change (NDACC) station at Lauder, New Zealand invaluable. Investigating these datasets in detail is essential to derive realistic ozone trends. We compared lidar data and microwave radiometer data with collocated Aura Microwave Limb sounder (MLS) satellite data and ERA5 reanalysis data. The detailed comparison makes it possible to assess inhomogeneities in the data. We find good agreement between the datasets but also some possible biases, especially in the ERA5 data. The data uncertainties and the inhomogeneities were then considered when deriving trends. Using two regression models from the Long-term Ozone Trends and Uncertainties in the Stratosphere (LOTUS) project and from the Karlsruhe Institute of Technology (KIT), we estimated resulting ozone trends. Further, we assessed how trends are affected by data uncertainties and inhomogeneities. We find positive ozone trends throughout the stratosphere between 0% and 5% per decade and show that considering data uncertainties and inhomogeneities in the regression affects the resulting trends.
Keywords	Lotus ; atmospheric chemistry ; bias ; data collection ; detection ; lidar ; microwave radiometers ; ozone ; protocols ; regression analysis ; remote sensing ; stratosphere ; uncertainty ; New Zealand
Language	English
Dates of publication	2020-1231
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs13010109
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Generalized morphea in the setting of pembrolizumab.

Cheng, Michelle W / Hisaw, Lisa D / Bernet, Laura

International journal of dermatology

2018 Volume 58, Issue 6, Page(s) 736–738

MeSH term(s)	Antibodies, Monoclonal, Humanized/adverse effects ; Antineoplastic Agents, Immunological/adverse effects ; Biopsy ; Choroid Neoplasms/drug therapy ; Choroid Neoplasms/pathology ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/secondary ; Male ; Melanoma/drug therapy ; Melanoma/secondary ; Middle Aged ; Prednisone/therapeutic use ; Scleroderma, Systemic/chemically induced ; Scleroderma, Systemic/diagnosis ; Scleroderma, Systemic/drug therapy ; Skin/drug effects ; Skin/immunology ; Skin/pathology ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal, Humanized ; Antineoplastic Agents, Immunological ; pembrolizumab (DPT0O3T46P) ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2018-06-22
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.14097
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Book ; Online: Total ozone trends at three northern high-latitude stations

Bernet, Leonie / Svendby, Tove / Hansen, Georg / Orsolini, Yvan / Dahlback, Arne / Goutail, Florence / Pazmiño, Andrea / Petkov, Boyan / Kylling, Arve

eISSN: 1680-7324

2023

Abstract: After the decrease of ozone-depleting substances (ODSs) as a consequence of the Montreal Protocol, it is still challenging to detect a recovery in the total column amount of ozone (total ozone) at northern high latitudes. To assess regional total ozone ... ...

Abstract	After the decrease of ozone-depleting substances (ODSs) as a consequence of the Montreal Protocol, it is still challenging to detect a recovery in the total column amount of ozone (total ozone) at northern high latitudes. To assess regional total ozone changes in the “ozone-recovery” period (2000–2020) at northern high latitudes, this study investigates trends from ground-based total ozone measurements at three stations in Norway (Oslo, Andøya, and Ny-Ålesund). For this purpose, we combine measurements from Brewer spectrophotometers, ground-based UV filter radiometers (GUVs), and a SAOZ (Système d'Analyse par Observation Zénithale) instrument. The Brewer measurements have been extended to work under cloudy conditions using the global irradiance (GI) technique, which is also presented in this study. We derive trends from the combined ground-based time series with the multiple linear regression model from the Long-term Ozone Trends and Uncertainties in the Stratosphere (LOTUS) project. We evaluate various predictors in the regression model and found that tropopause pressure and lower-stratospheric temperature contribute most to ozone variability at the three stations. We report significantly positive annual trends at Andøya ( 0.9±0.7 % per decade) and Ny-Ålesund ( 1.5±0.1 % per decade) and no significant annual trend at Oslo ( 0.1±0.5 % per decade) but significantly positive trends in autumn at all stations. Finally we found positive but insignificant trends of around 3 % per decade in March at all three stations, which may be an indication of Arctic springtime ozone recovery. Our results contribute to a better understanding of regional total ozone trends at northern high latitudes, which is essential to assess how Arctic ozone responds to changes in ODSs and to climate change.
Subject code	910
Language	English
Publishing date	2023-04-06
Publishing country	de
Document type	Book ; Online
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Article: Metastatic sentinel node and axillary lymphadenectomy revisited.

Bernet, Laia / Cano, Rafael

Gland surgery

2014 Volume 1, Issue 1, Page(s) 7–8

Language	English
Publishing date	2014-06-19
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	3016969-0
ISSN	2227-8575 ; 2227-684X
ISSN (online)	2227-8575
ISSN	2227-684X
DOI	10.3978/j.issn.2227-684X.2012.04.05
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Article: Molecular analysis of sentinel lymph nodes and search for molecular signatures of the metastatic potential of breast cancer.

Hoon, D S / Bernet, L / Cano, R / Viale, G

The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...

2014 Volume 58, Issue 2, Page(s) 180–192

Abstract: Molecular assays are a new and invaluable tool in the assessment of axillary lymph node status and metastatic potential of breast cancer. Many protocols for assessing the sentinel lymph node (SLN) status have been developed based on cytology and/or ... ...

Abstract	Molecular assays are a new and invaluable tool in the assessment of axillary lymph node status and metastatic potential of breast cancer. Many protocols for assessing the sentinel lymph node (SLN) status have been developed based on cytology and/or histology, showing that the rate of detection of metastasis increases with the number of histologic sections examined and with use of immunohistochemical staining in addition to conventional Hematoxylin & Eosin staining. However, full standardization of protocols for this procedure has not been achieved. Further attempts to increase sensitivity and specificity of sentinel node analysis include molecular biology-based techniques such as the real-time polymerase chain reaction (RT-PCR) and, more recently, one step nucleic acid amplification (OSNA). The latter technique, that has sensitivity close to 100% and extremely high specificity along with good reproducibility, allows analysis of the SLN in full with an intraoperative procedure in approximately 30 minutes. This highly standardized method permits to compare results between groups and predicts the probability of involvement of the remaining axillary lymph nodes based on the total tumor load of the SLN(s). Results of multicenter clinical trials suggest that OSNA allows a better personalization of patients' care based on the results of SLN analysis, because it offers criteria to select patient with metastatic SLN who will not receive additional benefit from axillary clearance. Due to the current controversy on the best treatment of the axilla after a positive SLN, the SLN copy number of CK19 mRNA can have a high impact on therapeutic decisions in this group of patients. Breast cancer is a highly heterogeneous group of diseases, characterized by remarkable differences in the histopathological features, response to treatment and clinical outcome. Most of the clinical and translational research efforts during the last decades aimed at identifying markers that would allow to predict the metastatic potential of early breast cancer, and hence to assess accurately its prognosis and to inform the choice of adjuvant systemic treatments. It is now clear that neoplastic transformation, tumor progression and response to treatment are driven and accompanied by the deregulated expression of hundred or thousand genes, whose status cannot be assessed by the currently established histopathological and immunohistochemical approach. The new molecular assays have elicited a great deal of expectations, and for the most part they have been enthusiastically welcomed as potentially offering new chances for a better and more personalized care of the patients. Many, however, are still reluctant to consider these assays ready for use in the clinical practice, and keep waiting for a confirmatory evidence of their utility when the results of ongoing clinical trials will be mature.
MeSH term(s)	Biomarkers, Tumor/metabolism ; Breast Neoplasms/diagnosis ; Breast Neoplasms/metabolism ; Evidence-Based Medicine ; Humans ; Lymph Nodes/metabolism ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Pathology, Molecular/methods ; Reproducibility of Results ; Risk Assessment ; Sensitivity and Specificity ; Sentinel Lymph Node Biopsy/methods
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2014-06
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	1281687-5
ISSN	1827-1936 ; 1824-4785 ; 0392-0208 ; 1125-0135 ; 1824-4661
ISSN (online)	1827-1936
ISSN	1824-4785 ; 0392-0208 ; 1125-0135 ; 1824-4661
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