Article ; Online: Vitamin D as a Potential Preventive Agent For Young Women's Breast Cancer.
Cancer prevention research (Philadelphia, Pa.)
2021 Volume 14, Issue 9, Page(s) 825–838
Abstract: Clinical studies backed by research in animal models suggest that vitamin D may protect against the development of breast cancer, implicating vitamin D as a promising candidate for breast cancer prevention. However, despite clear preclinical evidence ... ...
Abstract | Clinical studies backed by research in animal models suggest that vitamin D may protect against the development of breast cancer, implicating vitamin D as a promising candidate for breast cancer prevention. However, despite clear preclinical evidence showing protective roles for vitamin D, broadly targeted clinical trials of vitamin D supplementation have yielded conflicting findings, highlighting the complexity of translating preclinical data to efficacy in humans. While vitamin D supplementation targeted to high-risk populations is a strategy anticipated to increase prevention efficacy, a complimentary approach is to target transient, developmental windows of elevated breast cancer risk. Postpartum mammary gland involution represents a developmental window of increased breast cancer promotion that may be poised for vitamin D supplementation. Targeting the window of involution with short-term vitamin D intervention may offer a simple, cost-effective approach for the prevention of breast cancers that develop postpartum. In this review, we highlight epidemiologic and preclinical studies linking vitamin D deficiency with breast cancer development. We discuss the underlying mechanisms through which vitamin D deficiency contributes to cancer development, with an emphasis on the anti-inflammatory activity of vitamin D. We also discuss current evidence for vitamin D as an immunotherapeutic agent and the potential for vitamin D as a preventative strategy for young woman's breast cancer. |
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MeSH term(s) | Age of Onset ; Animals ; Breast/drug effects ; Breast/physiology ; Breast Neoplasms/epidemiology ; Breast Neoplasms/prevention & control ; Dietary Supplements ; Female ; Humans ; Protective Agents/administration & dosage ; Vitamin D/administration & dosage |
Chemical Substances | Protective Agents ; Vitamin D (1406-16-2) |
Language | English |
Publishing date | 2021-07-09 |
Publishing country | United States |
Document type | Journal Article ; Research Support, N.I.H., Extramural ; Review |
ZDB-ID | 2434717-6 |
ISSN | 1940-6215 ; 1940-6207 |
ISSN (online) | 1940-6215 |
ISSN | 1940-6207 |
DOI | 10.1158/1940-6207.CAPR-21-0114 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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