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Article: A Pragmatic Pilot Randomized Controlled Trial of the OA Go Away Among Individuals with Osteoarthritis of the Hip or Knee.

Paterson, Gail / Gaboury, Isabelle / Bernick, Jordan / Wells, George A / Tugwell, Peter / Toupin-April, Karine

Physiotherapy Canada. Physiotherapie Canada

2022 Volume 74, Issue 4, Page(s) 396–403

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2022-08-24
Publishing country	Canada
Document type	Journal Article
ZDB-ID	639189-8
ISSN	1708-8313 ; 0300-0508
ISSN (online)	1708-8313
ISSN	0300-0508
DOI	10.3138/ptc-2020-0110
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Zs.B 3116: Show issues

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Article ; Online: Low-Density Lipoprotein Cholesterol Level Trends and the Development of Cardiac Allograft Vasculopathy After Heart Transplantation.

Aleksova, Natasha / Umar, Fraz / Bernick, Jordan / Mielniczuk, Lisa M / Ross, Heather J / Chih, Sharon

CJC open

2021 Volume 3, Issue 12, Page(s) 1453–1462

Abstract: Background: Unlike the relationship with atherosclerotic coronary artery disease, that between low-density lipoprotein cholesterol (LDL-C) and cardiac allograft vasculopathy (CAV) is unclear. Our objectives were to characterize lipid profiles early ... ...

Abstract	Background: Unlike the relationship with atherosclerotic coronary artery disease, that between low-density lipoprotein cholesterol (LDL-C) and cardiac allograft vasculopathy (CAV) is unclear. Our objectives were to characterize lipid profiles early after heart transplantation (HT) and evaluate the relationship between early LDL-C and the development of CAV. Methods: We retrospectively reviewed consecutive adults who underwent HT at 2 centres during the time period 2010-2018. The primary outcome was the incidence of angiographic CAV. The relationship between LDL-C and CAV was assessed using Cox proportional hazards and logistic regression models adjusted a priori for clinically important covariates, including recipient and donor age, recipient sex, ischemic time, and pre-HT diabetes. Results: A total of 386 patients followed for a median (range) of 4.4 (2.8-6.8) years were included. LDL-C at baseline (2.11 ± 0.86 mmol/L) and 1 year after HT (2.20 ± 0.88 mmol/L) was similar ( Conclusions: No association was identified between early LDL-C and the development of CAV. Our findings do not support targeting a specific LDL-C for patients who do not otherwise meet criteria for guideline-recommended LDL-C target levels. Randomized studies are warranted to determine if lipid-lowering to a specific LDL-C target level modifies the risk of CAV.
Language	English
Publishing date	2021-07-16
Publishing country	United States
Document type	Journal Article
ISSN	2589-790X
ISSN (online)	2589-790X
DOI	10.1016/j.cjco.2021.07.011
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Article ; Online: Fibrotic Plaque and Microvascular Dysfunction Predict Early Cardiac Allograft Vasculopathy Progression After Heart Transplantation: The Early Post Transplant Cardiac Allograft Vasculopathy Study.

Chih, Sharon / Chong, Aun Yeong / Džavík, Vladimír / So, Derek Y / Aleksova, Natasha / Wells, George A / Bernick, Jordan / Overgaard, Christopher B / Stadnick, Ellamae / Mielniczuk, Lisa M / Beanlands, Rob S B / Ross, Heather J

Circulation. Heart failure

2023 Volume 16, Issue 6, Page(s) e010173

Abstract: Background: Early cardiac allograft vasculopathy (CAV) prognostication is needed to improve long-term outcomes after heart transplantation. We characterized first year posttransplant coronary anatomic-physiologic alterations to determine predictors of ... ...

Abstract	Background: Early cardiac allograft vasculopathy (CAV) prognostication is needed to improve long-term outcomes after heart transplantation. We characterized first year posttransplant coronary anatomic-physiologic alterations to determine predictors of early CAV progression. Methods: Heart transplant recipients at 2 institutions (enrolled January 2018 to March 2021) underwent prospective evaluation 3 and 12-month posttransplant with angiography and left anterior descending artery intravascular ultrasound, optical coherence tomography, fractional flow reserve, coronary flow reserve, and index of microcirculatory resistance measurements. CAV progression was assessed by intravascular ultrasound change in percentage intimal volume from baseline to 12-month follow-up. Results: Eighty-two patients (mean age, 51 years; 60% men) completed evaluation at mean 13.8 and 56.3 weeks posttransplant. Donor atherosclerosis (baseline intravascular ultrasound maximal intimal thickness, ≥0.5 mm) was evident in 50%. De novo (follow-up maximal intimal thickness, ≥0.5 mm) and rapidly progressive CAV (maximal intimal thickness, ≥0.5-mm increase from baseline) developed in 24% and 13%, respectively. On optical coherence tomography, baseline to follow-up median intimal volume increased 42% (0.58 mm Conclusions: Fibrotic plaque on optical coherence tomography and index of microcirculatory resistance early posttransplant predict CAV progression in the first year of transplantation. Registration: URL: https://www. Clinicaltrials: gov; Unique identifier: NCT03217786.
MeSH term(s)	Female ; Humans ; Male ; Middle Aged ; Allografts ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Fibrosis ; Fractional Flow Reserve, Myocardial ; Heart Failure ; Heart Transplantation/adverse effects ; Microcirculation ; Plaque, Atherosclerotic ; Ultrasonography, Interventional
Language	English
Publishing date	2023-05-11
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429459-7
ISSN	1941-3297 ; 1941-3289
ISSN (online)	1941-3297
ISSN	1941-3289
DOI	10.1161/CIRCHEARTFAILURE.122.010173
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Article ; Online: Off-Hours Presentation, Door-to-Balloon Time, and Clinical Outcomes in Patients Referred for Primary Percutaneous Coronary Intervention.

Rashid, Mohammed K / Wells, George / So, Derek Y / Chong, Aun-Yeong / Dick, Alexander / Froeschl, Michael / Glover, Christopher / Hibbert, Benjamin / Labinaz, Marino / Russo, Juan / Bernick, Jordan / Le May, Michel

The Journal of invasive cardiology

2023 Volume 35, Issue 4, Page(s) E185–E193

Abstract: Objectives: Presentation with ST-segment-elevation myocardial infarction (STEMI) during off-hours may impact timely reperfusion and clinical outcomes. We investigated the association between off-hours presentation, door-to-balloon time, and in-hospital ... ...

Abstract	Objectives: Presentation with ST-segment-elevation myocardial infarction (STEMI) during off-hours may impact timely reperfusion and clinical outcomes. We investigated the association between off-hours presentation, door-to-balloon time, and in-hospital mortality in patients with STEMI referred for primary percutaneous coronary intervention (PCI). Methods: We included consecutive patients referred for primary PCI at the University of Ottawa Heart Institute between July 2004 and December 2017. The off-hours group included patients presenting on weekends, statutory holidays, or between 18:00 to 07:59 hours on weekdays. The on-hours group included patients presenting between 08:00 and 17:59 hours on weekdays. The primary clinical outcome was the adjusted in-hospital mortality. The primary quality-of-care indicator was door-to-balloon time. Results: A total of 5132 patients were included, with 3152 (61.4%) in the off-hours group and 1980 (38.6%) in the on-hours group. The median door-to-balloon time was longer in the off-hours group compared with the on-hours group (102 minutes vs 77 minutes; P<.001), while the median onset-to-door time was similar (P=.40). There was no difference in the rates of in-hospital mortality (3.5% vs 3.0%; P=.32) or in the adjusted mortality (odds ratio, 1.2; 95% confidence interval, 0.8-1.8; P=.44) between off-hours and on-hours groups. However, door-to-balloon time was an independent predictor of in-hospital mortality (P<.01) and off-hours presentation was an independent predictor of longer door-to-balloon time (P<.001), with an excess of 22.1 minutes. Conclusion: Patients treated with primary PCI during off-hours had longer door-to-balloon times. Treatment during off-hours was an independent predictor of longer door-to-balloon time and longer door-to-balloon times were associated with higher mortality.
MeSH term(s)	Humans ; Percutaneous Coronary Intervention ; Angioplasty, Balloon, Coronary ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/surgery ; Treatment Outcome ; Myocardial Infarction/therapy ; Hospital Mortality
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1154372-3
ISSN	1557-2501 ; 1042-3931
ISSN (online)	1557-2501
ISSN	1042-3931
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Article ; Online: High-power short-duration versus low-power long-duration ablation for pulmonary vein isolation: A substudy of the AWARE randomized controlled trial.

Joza, Jacqueline / Nair, Girish M / Birnie, David H / Nery, Pablo B / Redpath, Calum J / Sarrazin, Jean-Francois / Champagne, Jean / Bernick, Jordan / Wells, George A / Essebag, Vidal

Journal of cardiovascular electrophysiology

2023 Volume 35, Issue 1, Page(s) 136–145

Abstract: Introduction: Pulmonary vein isolations (PVI) are being performed using a high-power, short-duration (HPSD) strategy. The purpose of this study was to compare the clinical efficacy and safety outcomes of an HPSD versus low-power, long-duration (LPLD) ... ...

Abstract	Introduction: Pulmonary vein isolations (PVI) are being performed using a high-power, short-duration (HPSD) strategy. The purpose of this study was to compare the clinical efficacy and safety outcomes of an HPSD versus low-power, long-duration (LPLD) approach to PVI in patients with paroxysmal atrial fibrillation (AF). Methods: Patients were grouped according to a HPSD (≥40 W) or LPLD (≤35 W) strategy. The primary endpoint was the 1-year recurrence of any atrial arrhythmia lasting ≥30 s, detected using three 14-day ambulatory continuous ECG monitoring. Procedural and safety endpoints were also evaluated. The primary analysis were regression models incorporating propensity scores yielding adjusted relative risk (RR Results: Of the 398 patients included in the AWARE Trial, 173 (43%) underwent HPSD and 225 (57%) LPLD ablation. The distribution of power was 50 W in 75%, 45 W in 20%, and 40 W in 5% in the HPSD group, and 35 W with 25 W on the posterior wall in the LPLD group. The primary outcome was not statistically significant at 30.1% versus 22.2% in HPSD and LPLD groups with RR Conclusions: An HPSD strategy was associated with significantly shorter procedural times with similar efficacy in terms of clinical arrhythmia recurrence. Importantly, there was no signal for increased harm with a HPSD strategy.
MeSH term(s)	Humans ; Pulmonary Veins/surgery ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Catheter Ablation/adverse effects ; Treatment Outcome ; Recurrence
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.16123
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Zs.A 2863: Show issues

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Article ; Online: Reply: Triple Antithrombotic Therapy Following Anterior ST-Segment Elevation Myocardial Infarction.

Le May, Michel / Bernick, Jordan / Wells, George A

JACC. Cardiovascular interventions

2015 Volume 8, Issue 8, Page(s) 1136–1137

MeSH term(s)	Anterior Wall Myocardial Infarction/therapy ; Anticoagulants/administration & dosage ; Female ; Humans ; Male ; Percutaneous Coronary Intervention ; Warfarin/administration & dosage
Chemical Substances	Anticoagulants ; Warfarin (5Q7ZVV76EI)
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2015.04.011
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Article ; Online: Single versus multi-item self-assessment of sedentary behaviour: A comparison with objectively measured sedentary time in nurses.

Prince, Stephanie A / Reid, Robert D / Bernick, Jordan / Clarke, Anna E / Reed, Jennifer L

Journal of science and medicine in sport

2018 Volume 21, Issue 9, Page(s) 925–929

Abstract: Objectives: To compare sedentary time (ST) measured by self-report using a single question from the short-form International Physical Activity Questionnaire (SF-IPAQ), 18-items from the Sedentary Behaviour Questionnaire (SBQ) and objectively using an ... ...

Abstract	Objectives: To compare sedentary time (ST) measured by self-report using a single question from the short-form International Physical Activity Questionnaire (SF-IPAQ), 18-items from the Sedentary Behaviour Questionnaire (SBQ) and objectively using an accelerometer among a large sample of nurses. Design: Cross-sectional. Methods: Participants wore an ActiGraph GT3X accelerometer (≥4 days, ≥10h/day) and self-reported usual day sitting using the IPAQ and sitting in different modes using the SBQ. Measures were compared using correlations, a Friedman test with Wilcoxon signed-ranks tests for pairwise comparisons, linear regression and Bland-Altman plots. Results: A total of 313 nurses (95% female; mean±SD: age=43±12 years) from 14 hospitals participated. Participants self-reported sitting for a median of 240min/day using the SF-IPAQ and 328min/day using the SBQ. Median ST measured by the ActiGraph was 434min/day. All measures were weakly correlated with each other (ρ=0.31-40, ps<0.001). Limits of agreement were wide between all measures. Significant proportional bias between the ActiGraph and the SF-IPAQ and SBQ existed, suggesting that with greater amounts of ST, there is greater disagreement between the self-report and objective measures. Conclusions: In a sample of nurses, self-reported ST using the SF-IPAQ and SBQ was significantly lower than that measured by accelerometer. A single-item tool performed more poorly than a multi-item questionnaire. Future studies should consider including both objective and self-report measures of ST, and where possible use a tool that quantifies ST across multiple domains, define a 'usual day' and are meaningful for those with daily schedule variations such as among shift-worker populations.
MeSH term(s)	Actigraphy ; Adult ; Cross-Sectional Studies ; Exercise ; Female ; Humans ; Male ; Middle Aged ; Nurses ; Sedentary Lifestyle ; Self Report ; Surveys and Questionnaires
Language	English
Publishing date	2018-02-08
Publishing country	Australia
Document type	Comparative Study ; Journal Article
ZDB-ID	1437829-2
ISSN	1878-1861 ; 1440-2440
ISSN (online)	1878-1861
ISSN	1440-2440
DOI	10.1016/j.jsams.2018.01.018
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Zs.A 4926: Show issues

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Article ; Online: The role of brain natriuretic peptide in atrial fibrillation: a substudy of the Substrate Modification with Aggressive Blood Pressure Control for Atrial Fibrillation (SMAC-AF) trial.

Weng, Willy / Choudhury, Rajin / Sapp, John / Tang, Anthony / Healey, Jeff S / Nault, Isabelle / Rivard, Lena / Greiss, Isabelle / Bernick, Jordan / Parkash, Ratika

BMC cardiovascular disorders

2021 Volume 21, Issue 1, Page(s) 445

Abstract: Background: Catheter ablation is an established therapy for atrial fibrillation but is limited by recurrence; efforts have been made to identify biomarkers that predict recurrence. We investigated the effect of baseline NT-proBNP on AF recurrence ... ...

Abstract	Background: Catheter ablation is an established therapy for atrial fibrillation but is limited by recurrence; efforts have been made to identify biomarkers that predict recurrence. We investigated the effect of baseline NT-proBNP on AF recurrence following catheter ablation in patients randomized to aggressive (< 120/80 mmHg) or standard blood pressure management (< 140/90 mmHg) in the Substrate Modification with Aggressive Blood Pressure Control trial (SMAC-AF). Methods: The SMAC-AF study included 173 patients resistant or intolerant to at least one class I or III antiarrhythmic drug. We studied the effect of baseline NT-proBNP on the primary outcome of AF recurrence > 3 months post-ablation. Results: Of the 173 patients, 88 were randomized to the aggressive cohort, and 85 into the standard group. The primary outcome occurred in 61.4% of those in the aggressive arm, versus 61.2% in the standard arm. In the aggressive group, logNT-proBNP predicted recurrence (HR 1.28, p = 0.04, adjusted HR 1.43, p = 0.03), while in the standard cohort, it did not (HR 0.94, p = 0.62, adjusted HR 0.83, p = 0.22). NT-proBNP ≥ 280 pg/mL also predicted occurrence in the aggressive (HR 1.98, p = 0.02) but not the standard cohort (HR 1.00, p = 1.00). Conclusion: We conclude that pre-ablation NT-proBNP may be useful in predicting recurrence in hypertensive patients and identifying patients who benefit from aggressive blood control and upstream therapies. Trial registration: NCT00438113, registered February 21, 2007.
MeSH term(s)	Action Potentials ; Aged ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use ; Atrial Fibrillation/blood ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Biomarkers/blood ; Blood Pressure/drug effects ; Canada ; Catheter Ablation/adverse effects ; Cryosurgery/adverse effects ; Female ; Heart Rate ; Humans ; Hypertension/blood ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/physiopathology ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Recurrence ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome
Chemical Substances	Antihypertensive Agents ; Biomarkers ; Peptide Fragments ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2021-09-16
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-021-02254-5
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Article ; Online: Utility of a smartphone application in assessing palmar circulation prior to radial artery harvesting for coronary artery bypass grafting: rationale and design of the randomised CAPITAL iRADIAL-CABG trial.

Goh, Cheng Yee / Parlow, Simon / Di Santo, Pietro / Simard, Trevor / Jung, Richard / Ahmed, Zeeshan / Verreault-Julien, Louis / Kuhar, Peter / Chan, Vincent / Al-Atassi, Talal / Toeg, Hadi / Bernick, Jordan / Wells, George A / Ruel, Marc / Hibbert, Benjamin

BMJ open

2022 Volume 12, Issue 4, Page(s) e055580

Abstract: Introduction: There is emerging evidence supporting the use of the radial artery (RA) as a preferred secondary conduit for coronary artery bypass grafting (CABG) as it is associated with higher rates of graft patency at 5 years when compared with ... ...

Abstract	Introduction: There is emerging evidence supporting the use of the radial artery (RA) as a preferred secondary conduit for coronary artery bypass grafting (CABG) as it is associated with higher rates of graft patency at 5 years when compared with saphenous vein grafts (SVG). The modified Allen's test (MAT) is traditionally regarded as the standard of care in the assessment of ulnar artery (UA) patency prior to RA harvesting. Unfortunately, due to high false-positive rates, a substantial number of pre-CABG patients are found to have an abnormal MAT despite normal UA patency, resulting in inappropriate exclusion from RA harvesting. The SVG is generally used in its place when this occurs, resulting in potentially lower rates of long-term graft patency. Methods and analysis: The CAPITAL iRADIAL-CABG trial is currently enrolling participants 18 years of age or older undergoing CABG for whom the treating physician is considering the use of an RA conduit. Eligible patients will be randomised in a 1:1 fashion to MAT or smartphone-based photoplethysmography application assessment to assess collateral palmar circulation prior to RA harvesting. The primary outcome of the trial is the use of the RA as a conduit during CABG. The primary safety outcome is postoperative palmar ischaemia as determined by clinical assessment or requirement of vascular intervention. Secondary outcomes include vascular complications, early graft failure, need for rescue percutaneous coronary intervention during the index hospitalisation and a composite cardiovascular outcome of myocardial infarction, stroke and cardiovascular death prior to discharge from hospital. A total of 236 participants are planned to be recruited. Ethics and dissemination: The study was approved by the Ottawa Heart Science Network Research Ethics Board (approval number 20180865-01H). The study results will be disseminated via conference presentations and peer-reviewed publications. Trial registration number: NCT03810729.
MeSH term(s)	Adolescent ; Adult ; Coronary Artery Bypass/methods ; Humans ; Radial Artery ; Randomized Controlled Trials as Topic ; Smartphone
Language	English
Publishing date	2022-04-08
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-055580
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Article ; Online: Contact force mapping and voltage thresholds during high-frequency stimulation of human cardiac ganglionated plexuses†.

Lemery, Robert / Cleland, Mark / Bernick, Jordan / Wells, George A

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

2015 Volume 17, Issue 4, Page(s) 552–558

Abstract: Aims: The intrinsic cardiac nervous system consists of ganglionated plexuses (GPs) localized epicardially to specific regions of the left atrium (LA). The relation between voltage thresholds and endocardial contact force associated with autonomic ... ...

Abstract	Aims: The intrinsic cardiac nervous system consists of ganglionated plexuses (GPs) localized epicardially to specific regions of the left atrium (LA). The relation between voltage thresholds and endocardial contact force associated with autonomic effects during stimulation of GPs has not previously been evaluated. Methods and results: Sixteen patients with symptomatic atrial fibrillation (AF) underwent mapping of GPs prior to radiofrequency ablation of AF. Pre-acquired computed tomographic images were merged with 3D non-fluoroscopic electroanatomic mapping of the LA. Using high-frequency stimulation (HFS), the voltage thresholds of GPs was obtained while patients received conscious sedation. At each location, the contact force measurement from the catheter was correlated with the voltage applied during HFS at 5, 10, or 15 V to obtain an autonomic effect, usually associated with asystole, or marked bradycardia. There were 192 applications of HFS, resulting in GP identification in all patients (mean 3.4 per patient, range 1-5). During HFS, an autonomic response was significantly more likely to occur at 10 V as compared with 5 V (P < 0.008). There was no significant relation between the measured contact force and the likelihood of obtaining an autonomic response. When performing HFS at 15 V, a sudden overshoot with maximal values of contact force of up to 100 g was also observed. High-frequency stimulation was well tolerated, without associated adverse events. Conclusion: An autonomic response during HFS was significantly more likely to occur at 10 V as compared with 5 V. Although the GPs are epicardial structures, significant contact force was not required for their localization.
MeSH term(s)	Aged ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Body Surface Potential Mapping/methods ; Electric Stimulation/methods ; Ganglia, Autonomic/physiopathology ; Humans ; Middle Aged ; Monitoring, Intraoperative/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Stress, Mechanical
Language	English
Publishing date	2015-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1449879-0
ISSN	1532-2092 ; 1099-5129
ISSN (online)	1532-2092
ISSN	1099-5129
DOI	10.1093/europace/euu336
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