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  1. Article: Response of Medical Cannabis to Magnesium (Mg) Supply at the Vegetative Growth Phase.

    Morad, Dalit / Bernstein, Nirit

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 14

    Abstract: Recent studies demonstrated a significant impact of some major macronutrients on function and production of medical cannabis plants, yet information on the effect of most nutrients, including Mg, is scarce. Magnesium is required for major physiological ... ...

    Abstract Recent studies demonstrated a significant impact of some major macronutrients on function and production of medical cannabis plants, yet information on the effect of most nutrients, including Mg, is scarce. Magnesium is required for major physiological functions and metabolic processes in plants, and in the present study we studied the effects of five Mg treatments (2, 20, 35, 70, and 140 mg L
    Language English
    Publishing date 2023-07-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12142676
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  2. Article: Nitrogen Source Matters: High NH

    Saloner, Avia / Bernstein, Nirit

    Frontiers in plant science

    2022  Volume 13, Page(s) 830224

    Abstract: The N form supplied to the plant, ammonium ( ... ...

    Abstract The N form supplied to the plant, ammonium (NH
    Language English
    Publishing date 2022-06-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.830224
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  3. Article: Too Dense or Not Too Dense: Higher Planting Density Reduces Cannabinoid Uniformity but Increases Yield/Area in Drug-Type Medical Cannabis.

    Danziger, Nadav / Bernstein, Nirit

    Frontiers in plant science

    2022  Volume 13, Page(s) 713481

    Abstract: A major challenge for utilizing cannabis for modern medicine is the spatial variability of cannabinoids in the plant, which entail differences in medical potency. Since secondary metabolism is affected by environmental conditions, a key trigger for the ... ...

    Abstract A major challenge for utilizing cannabis for modern medicine is the spatial variability of cannabinoids in the plant, which entail differences in medical potency. Since secondary metabolism is affected by environmental conditions, a key trigger for the variability in secondary metabolites throughout the plant is variation in local micro-climates. We have, therefore, hypothesized that plant density, which is well-known to alter micro-climate in the canopy, affects spatial standardization, and concentrations of cannabinoids in cannabis plants. Canopy density is affected by shoot architecture and by plant spacing, and we have therefore evaluated the interplay between plant architecture and plant density on the standardization of the cannabinoid profile in the plant. Four plant architecture modulation treatments were employed on a drug-type medicinal cannabis cultivar, under a density of 1 or 2 plants/m
    Language English
    Publishing date 2022-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.713481
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  4. Article ; Online: Nitrogen deficiency stimulates cannabinoid biosynthesis in medical cannabis plants by inducing a metabolic shift towards production of low-N metabolites

    Song, Chao / Saloner, Avia / Fait, Aaron / Bernstein, Nirit

    Industrial Crops & Products. 2023 Oct., v. 202 p.116969-

    2023  

    Abstract: The primary and secondary metabolism of plants is closely connected to the resources supplied and obtained by the plant, including their mineral nutrition. We recently reported that nitrogen (N) deficiency enhances the production of terpenoids and ... ...

    Abstract The primary and secondary metabolism of plants is closely connected to the resources supplied and obtained by the plant, including their mineral nutrition. We recently reported that nitrogen (N) deficiency enhances the production of terpenoids and cannabinoids, the unique biologically-active secondary metabolites in medical cannabis plants. Knowledge-gaps concerning effects of N supply on primary metabolism in cannabis hinder understanding of the interrelations between N inputs and biosynthesis of the therapeutic secondary metabolites. The present study therefore evaluated the hypothesis that a decrease in the plant’s C (carbon): N ratio by N-limitation, induces a shift in the plant metabolism towards lower production of N-containing metabolites and higher production of metabolites that do not contain N. Effects of N input levels (30, 80, 160, 240, and 320 mg L⁻¹) on total C and N concentrations and C: N ratio in leaves and inflorescences of medical cannabis plants were studied; and gas chromatography-mass spectrometry (GC-MS) analysis of primary metabolites added to the analyses of secondary metabolites. Elevation of N supply resulted in an increase in total N and N-containing compounds (chlorophylls and most amino acids), and decreased total C and compounds that do not contain N, such as sugars (fructose, glucose, and xylose), and phosphates (phosphate and glucose-6-phosphate) in both inflorescences and leaves. In the inflorescences, the elevation of N input also decreased total cannabinoids, phenols, and flavonoids, that do not contain N. Integrating the metabolic datasets revealed positive correlations between C sources (fructose and glucose) and most of the cannabinoids and terpenoids; the latter were negatively correlated with N-compounds (most amino acids). Taken together, these results suggest that elevated N supply induce a metabolic shift in the inflorescences towards increased production of N-compounds via deflecting the C sources from the biologically active compounds. In addition, the cannabis leaf was found to be more sensitive than the inflorescence to N supply, presenting greater changes in primary metabolism and more coordinated metabolic associations. These findings highlight the importance of adequate and precise N nutrition for standardization of the therapeutic-metabolite profile and for preventing undesirable metabolic repartitioning in medical cannabis plants.
    Keywords biosynthesis ; cannabinoids ; carbon ; data collection ; flavonoids ; fructose ; gas chromatography-mass spectrometry ; glucose ; glucose 6-phosphate ; leaves ; nitrogen ; nutrition ; phosphates ; secondary metabolites ; terpenoids ; therapeutics ; total nitrogen ; xylose ; Cannabis ; Secondary metabolism ; Metabolomics ; C/N
    Language English
    Dates of publication 2023-10
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 1132158-1
    ISSN 1872-633X ; 0926-6690
    ISSN (online) 1872-633X
    ISSN 0926-6690
    DOI 10.1016/j.indcrop.2023.116969
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    In stock of ZB MED Bonn / Germany

    Z 5577: Show issues

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  5. Article: Shape Matters: Plant Architecture Affects Chemical Uniformity in Large-Size Medical Cannabis Plants.

    Danziger, Nadav / Bernstein, Nirit

    Plants (Basel, Switzerland)

    2021  Volume 10, Issue 9

    Abstract: Since plant organs sense their environment locally, gradients of micro-climates in the plant shoot may induce spatial variability in the physiological state of the plant tissue and hence secondary metabolism. Therefore, plant architecture, which affects ... ...

    Abstract Since plant organs sense their environment locally, gradients of micro-climates in the plant shoot may induce spatial variability in the physiological state of the plant tissue and hence secondary metabolism. Therefore, plant architecture, which affects micro-climate in the shoot, may considerably affect the uniformity of cannabinoids in the
    Language English
    Publishing date 2021-09-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10091834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Highs and Lows of P Supply in Medical Cannabis: Effects on Cannabinoids, the Ionome, and Morpho-Physiology.

    Shiponi, Sivan / Bernstein, Nirit

    Frontiers in plant science

    2021  Volume 12, Page(s) 657323

    Abstract: Environmental conditions, including the availability of mineral nutrients, affect secondary metabolism in plants. Therefore, growing conditions have significant pharmaceutical and economic importance ... ...

    Abstract Environmental conditions, including the availability of mineral nutrients, affect secondary metabolism in plants. Therefore, growing conditions have significant pharmaceutical and economic importance for
    Language English
    Publishing date 2021-07-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2021.657323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Shape Matters: Plant Architecture Affects Chemical Uniformity in Large-Size Medical Cannabis Plants

    Danziger, Nadav / Bernstein, Nirit

    Plants. 2021 Sept. 03, v. 10, no. 9

    2021  

    Abstract: Since plant organs sense their environment locally, gradients of micro-climates in the plant shoot may induce spatial variability in the physiological state of the plant tissue and hence secondary metabolism. Therefore, plant architecture, which affects ... ...

    Abstract Since plant organs sense their environment locally, gradients of micro-climates in the plant shoot may induce spatial variability in the physiological state of the plant tissue and hence secondary metabolism. Therefore, plant architecture, which affects micro-climate in the shoot, may considerably affect the uniformity of cannabinoids in the Cannabis sativa plant, which has significant pharmaceutical and economic importance. Variability of micro-climates in plant shoots intensifies with the increase in plant size, largely due to an increase in inter-shoot shading. In this study, we therefore focused on the interplay between shoot architecture and the cannabinoid profile in large cannabis plants, ~2.5 m in height, with the goal to harness architecture modulation for the standardization of cannabinoid concentrations in large plants. We hypothesized that (i) a gradient of light intensity along the plants is accompanied by changes to the cannabinoid profile, and (ii) manipulations of plant architecture that increase light penetration to the plant increase cannabinoid uniformity and yield biomass. To test these hypotheses, we investigated effects of eight plant architecture manipulation treatments involving branch removals, defoliation, and pruning on plant morpho-physiology, inflorescence yield, cannabinoid profile, and uniformity. The results revealed that low cannabinoid concentrations in inflorescences at the bottom of the plants correlate with low light penetration, and that increasing light penetration by defoliation or removal of bottom branches and leaves increases cannabinoid concentrations locally and thereby through spatial uniformity, thus supporting the hypotheses. Taken together, the results reveal that shoot architectural modulation can be utilized to increase cannabinoid standardization in large cannabis plants, and that the cannabinoid profile in an inflorescence is an outcome of exogenous and endogenous factors.
    Keywords Cannabis sativa ; biomass ; cannabinoids ; defoliation ; light intensity ; metabolism ; microclimate ; physiological state ; plant architecture ; plant tissues
    Language English
    Dates of publication 2021-0903
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10091834
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Portable biosensors for rapid on-site determination of cannabinoids in cannabis, a review

    Harpaz, Dorin / Bernstein, Nirit / Namdar, Dvora / Eltzov, Evgeni

    Biotechnology advances. 2022 Dec., v. 61

    2022  

    Abstract: Recent studies highlight the therapeutic virtues of cannabidiol (CBD). Furthermore, due to their molecular enriched profiles, cannabis inflorescences are biologically superior to a single cannabinoid for the treatment of various health conditions. Thus, ... ...

    Abstract Recent studies highlight the therapeutic virtues of cannabidiol (CBD). Furthermore, due to their molecular enriched profiles, cannabis inflorescences are biologically superior to a single cannabinoid for the treatment of various health conditions. Thus, there is flourishing demand for Cannabis sativa varieties containing high levels of CBD. Additionally, legal regulations around the world restrict the cultivation and consumption of tetrahydrocannabinol (THC)-rich cannabis plants for their psychotropic effects. Therefore, the use of cannabis varieties that are high in CBD is permitted as long as their THC content does not exceed a low threshold of 0.3%–0.5%, depending on the jurisdiction. These chemovars are legally termed ‘hemp’. This controlled cannabinoid requirement highlights the need to detect low levels of THC, already in the field. In this review, cannabis profiling and the existing methods used for the detection of cannabinoids are firstly evaluated. Then, selected valuable biosensor technologies are discussed, which suggest portable, rapid, sensitive, reproducible, and reliable methods for on-site identification of cannabinoids levels, mainly THC. Recent cutting-edge techniques of promising potential usage for both cannabis and hemp analysis are identified, as part of the future cultivation and agricultural improvement of this crop.
    Keywords Cannabis sativa ; biosensors ; biotechnology ; cannabidiol ; chemotypes ; hemp ; tetrahydrocannabinol ; therapeutics
    Language English
    Dates of publication 2022-12
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 47165-3
    ISSN 0734-9750
    ISSN 0734-9750
    DOI 10.1016/j.biotechadv.2022.108031
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3730: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Translational Platform for Increasing Water Use Efficiency in Agriculture: Comparative Analysis of Plantation Crops

    Shtull-Trauring, Eliav / Azenkot, Asher / Bernstein, Nirit

    Water resources management. 2022 Jan., v. 36, no. 2

    2022  

    Abstract: Shortage of water drives efforts to increase water use efficiency in agriculture. However, identification of hot-spots of water use inefficiency in agriculture is hindered by difficulty of monitoring the large number of factors that influence water use ... ...

    Abstract Shortage of water drives efforts to increase water use efficiency in agriculture. However, identification of hot-spots of water use inefficiency in agriculture is hindered by difficulty of monitoring the large number of factors that influence water use for irrigation. The goal of this study was to assess interrelations between crop type and topo-climate on water use, water use efficiency, and economic productivity, on a country and regional scales. We hypothesized that water use efficiency of plantation crops across topo-climatic regions do not match crop prevalence in each region. High-resolution datasets related to crop distribution, regional irrigation recommendation, and local multiyear reference evapotranspiration were integrated for the analysis of water demand (m³/ha), blue water footprint (m³/ton) and economic land (USD/ha) and water (USD/m³) productivity, across geographical regions throughout Israel. The results demonstrate a large variability in all indices across crops and regions, reflecting variability in water demand for individual crops, due to effects of topo-climatic conditions on reference evapotranspiration. Water footprint and water demand ranged ~ 90- 3,740 m³/ton and ~ 3,800- 23,500 m³/ha respectively, between crops. Large differences were identified between the highest and lowest water footprint amongst cultivation regions for some crops, such as avocado and almond, with a considerable portion of the cultivation area located in regions with the highest water footprint. This highlights the need to direct cultivation of crops to regions with relative low water footprint, to help reduce water use and increase water use efficiency. The results shown are a product of an interactive translational platform that facilitates access to an integrated high-resolution agricultural dataset via a user-friendly interactive Agri-Atlas, providing a comparative analysis of the agricultural and water footprints of different regions and crops in Israel. While the translational platform currently uses local data for Israel, it can be adapted for any country or region where agricultural data is collected, to support data-based studies and policies to help increase agricultural water use efficiency, in face of the growing demand for food and diminishing water supplies.
    Keywords administrative management ; agricultural statistics ; almonds ; avocados ; cultivation area ; data collection ; economic productivity ; evapotranspiration ; irrigation ; water ; water analysis ; water footprint ; water use efficiency ; Israel
    Language English
    Dates of publication 2022-01
    Size p. 571-587.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 59924-4
    ISSN 1573-1650 ; 0920-4741
    ISSN (online) 1573-1650
    ISSN 0920-4741
    DOI 10.1007/s11269-021-03040-w
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    In stock of ZB MED Bonn / Germany

    Z 6155: Show issues

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  10. Article ; Online: Portable biosensors for rapid on-site determination of cannabinoids in cannabis, a review.

    Harpaz, Dorin / Bernstein, Nirit / Namdar, Dvora / Eltzov, Evgeni

    Biotechnology advances

    2022  Volume 61, Page(s) 108031

    Abstract: Recent studies highlight the therapeutic virtues of cannabidiol (CBD). Furthermore, due to their molecular enriched profiles, cannabis inflorescences are biologically superior to a single cannabinoid for the treatment of various health conditions. Thus, ... ...

    Abstract Recent studies highlight the therapeutic virtues of cannabidiol (CBD). Furthermore, due to their molecular enriched profiles, cannabis inflorescences are biologically superior to a single cannabinoid for the treatment of various health conditions. Thus, there is flourishing demand for Cannabis sativa varieties containing high levels of CBD. Additionally, legal regulations around the world restrict the cultivation and consumption of tetrahydrocannabinol (THC)-rich cannabis plants for their psychotropic effects. Therefore, the use of cannabis varieties that are high in CBD is permitted as long as their THC content does not exceed a low threshold of 0.3%-0.5%, depending on the jurisdiction. These chemovars are legally termed 'hemp'. This controlled cannabinoid requirement highlights the need to detect low levels of THC, already in the field. In this review, cannabis profiling and the existing methods used for the detection of cannabinoids are firstly evaluated. Then, selected valuable biosensor technologies are discussed, which suggest portable, rapid, sensitive, reproducible, and reliable methods for on-site identification of cannabinoids levels, mainly THC. Recent cutting-edge techniques of promising potential usage for both cannabis and hemp analysis are identified, as part of the future cultivation and agricultural improvement of this crop.
    MeSH term(s) Cannabis ; Cannabinoids ; Dronabinol ; Cannabidiol ; Biosensing Techniques
    Chemical Substances Cannabinoids ; Dronabinol (7J8897W37S) ; Cannabidiol (19GBJ60SN5)
    Language English
    Publishing date 2022-09-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 47165-3
    ISSN 1873-1899 ; 0734-9750
    ISSN (online) 1873-1899
    ISSN 0734-9750
    DOI 10.1016/j.biotechadv.2022.108031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3730: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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