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Article ; Online: Primary Prevention of Dementia: An Epidemiological Point of View.

Berr, C

The journal of prevention of Alzheimer's disease

2016 Volume 3, Issue 3, Page(s) 160–163

Abstract: From an epidemiological perspective, in order to increase the level of evidence, it is necessary to refer to data from longitudinal studies to validate the temporal relationship between exposure (e.g. the behavior or modifying factor) and the disease. ... ...

Abstract	From an epidemiological perspective, in order to increase the level of evidence, it is necessary to refer to data from longitudinal studies to validate the temporal relationship between exposure (e.g. the behavior or modifying factor) and the disease. Findings from such studies are useful for defining risk factors and laying the groundwork for proposing interventions for prevention. This step is crucial in order to define the periods (life-course approach) and groups at risk, which will then become the targets of interventions designed to modify behaviors or lifestyle. Specifying the underlying mechanisms of these risk factors is one of the objectives of etiological epidemiology which focuses on the origin of diseases but is not essential for a more pragmatic interventional approach. These questions are essential for dementia prevention and are discussed in this paper. Furthermore, timing interventions is a major problem even if we identify primary prevention pathways in dementia. Another important concern for epidemiologists is the need to make projections to estimate the number of dementia cases in the next decades considering different intervention scenarios. These models require adequate descriptive indicators of dementia, demography and mortality and precise estimations of the impact of potential interventions in terms of delaying disease onset for instance.
Language	English
Publishing date	2016
Publishing country	Switzerland
Document type	Journal Article
ISSN	2426-0266
ISSN (online)	2426-0266
DOI	10.14283/jpad.2016.103
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Article ; Online: « Avoir deux poids et deux mesures » mais surtout comprendre la temporalité : démence et indice de masse corporelle.

Berr, Claudine

Medecine sciences : M/S

2018 Volume 34, Issue 6-7, Page(s) 504–506

Title translation	"Having double standards" but especially understanding the temporality: dementia and body mass index.
MeSH term(s)	Body Mass Index ; Dementia/etiology ; Female ; Humans ; Male ; Obesity/complications ; Risk Factors
Language	French
Publishing date	2018-07-31
Publishing country	France
Document type	Journal Article
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/20183406003
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Article ; Online: Mapping Cognitive Trajectories and Detecting Early Dementia Using the Mini-Mental State Examination Cognitive Charts: Application to the French Three-City Cohort.

Norton, Joanna / Gutierrez, Laure-Anne / Gourdeau, Christian / Amieva, Hélène / Bernier, Patrick / Berr, Claudine

Journal of Alzheimer's disease : JAD

2024 Volume 98, Issue 2, Page(s) 403–409

Abstract: The Cognitive Quotient (QuoCo) classification algorithm monitoring decline on age- and education-adjusted Mini-Mental State Examination (MMSE)-derived cognitive charts has proved superior to the conventionally-used cut-off for identifying incident ... ...

Abstract	The Cognitive Quotient (QuoCo) classification algorithm monitoring decline on age- and education-adjusted Mini-Mental State Examination (MMSE)-derived cognitive charts has proved superior to the conventionally-used cut-off for identifying incident dementia; however, it remains to be tested in different settings. Data were drawn from the Three-City Cohort to 1) assess the screening accuracy of the QuoCo, and 2) compare its performance to that of serial MMSE tests applying different cut-offs. For the QuoCo, sensitivity was 74.2 (95% CI: 71.4-76.8) and specificity 84.1 (83.6-84.7) and for the MMSE < 24, 64.1 (61.1-67.0) and 94.8 (94.4-95.1), respectively; whereas overall accuracy and sensitivity was highest for MMSE cut-offs <25 and <26. User-friendly charts for mapping cognitive trajectories over visits with an alert for potentially 'abnormal' decline can be of practical use and encourage regular monitoring in primary care where the <24 cut-off is still widely used despite its poor sensitivity.
MeSH term(s)	Humans ; Dementia/diagnosis ; Dementia/psychology ; Neuropsychological Tests ; Mental Status and Dementia Tests ; Educational Status ; Cognition ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/psychology ; Sensitivity and Specificity
Language	English
Publishing date	2024-02-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-231176
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Article ; Conference proceedings: Interpretierbares maschinelles Lernen zur Rezidivvorhersage bei Schilddrüsenkarzinomen: Nutzung von XGBoost und SHAP-Analyse

Schindele, A. / Heiß, U. / Nimptsch, K. / Bundschuh, R. A. / Dierks, A. / Kircher, M. / Berr, C. / Pfob, C. / Lapa, C.

Nuklearmedizin - NuclearMedicine

2024 Volume 63, Issue 02

Event/congress	62. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin, Leipzig, 2024-04-10
Language	German
Publishing date	2024-03-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2030804-8
ISSN	2567-6407 ; 0029-5566
ISSN (online)	2567-6407
ISSN	0029-5566
DOI	10.1055/s-0044-1782383
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Article ; Online: Habitual coffee consumption and risk of dementia in older persons: modulation by CYP1A2 polymorphism.

Lefèvre-Arbogast, Sophie / Helmer, Catherine / Berr, Claudine / Debette, Stéphanie / Samieri, Cécilia

European journal of epidemiology

2023 Volume 39, Issue 1, Page(s) 81–86

Abstract: Higher coffee consumption has been associated with reduced dementia risk, yet with inconsistencies across studies. CYP1A2 polymorphisms, which affects caffeine metabolism, may modulate the association between coffee and the risk of dementia and Alzheimer' ...

Abstract	Higher coffee consumption has been associated with reduced dementia risk, yet with inconsistencies across studies. CYP1A2 polymorphisms, which affects caffeine metabolism, may modulate the association between coffee and the risk of dementia and Alzheimer's disease (AD). We included 5964 participants of the Three-City Study (mean age 74 years-old), free of dementia at baseline when they reported their daily coffee consumption, with available genome-wide genotyping and followed for dementia over a median of 9.0 (range 0.8-18.7) years. In Cox proportional-hazards models, the relationship between coffee consumption and dementia risk was modified by CYP1A2 polymorphism at rs762551 (p for interaction = 0.034). In multivariable-adjusted models, coffee intake was linearly associated with a decreased risk of dementia among carriers of the C allele only ("slower caffeine metabolizers"; HR for 1-cup increased [95% CI] 0.90 [0.83-0.97]), while in non-carriers ("faster caffeine metabolizers"), there was no significant association but a J-shaped trend toward a decrease in dementia risk up to 3 cups/day and increased risk beyond. Thus, compared to null intake, drinking ≥ 4 cups of coffee daily was associated with a reduced dementia risk in slower but not faster metabolizers (HR [95% CI] for ≥ 4 vs. 0 cup/day = 0.45 [0.25-0.80] and 1.32 [0.89-1.96], respectively). Results were similar when studying AD and another CYP1A2 candidate polymorphism (rs2472304), but no interaction was found with CYP1A2 rs2472297 or rs2470893. In this cohort, a linear association of coffee intake to lower dementia risk was apparent only among carriers of CYP1A2 polymorphisms predisposing to slower caffeine metabolism.
MeSH term(s)	Aged ; Humans ; Caffeine/pharmacology ; Caffeine/therapeutic use ; Coffee ; Cytochrome P-450 CYP1A2/genetics ; Cytochrome P-450 CYP1A2/metabolism ; Dementia/epidemiology ; Dementia/genetics ; Risk Factors
Chemical Substances	Caffeine (3G6A5W338E) ; Coffee ; CYP1A2 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP1A2 (EC 1.14.14.1)
Language	English
Publishing date	2023-10-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632614-6
ISSN	1573-7284 ; 0393-2990
ISSN (online)	1573-7284
ISSN	0393-2990
DOI	10.1007/s10654-023-01060-x
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Zs.A 2090: Show issues

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Article ; Conference proceedings: Einflussfaktoren auf den psychoonkologischen Beratungsbedarf anhand des Hornheider Screening Instruments bei Schilddrüsenkarzinompatienten

Schindele, A. / Scheurer, E. / Koch, J. / Schröder, E. / Bundschuh, R. A. / Dierks, A. / Kircher, M. / Enke, J. / Berr, C. / Pusl, T. / Lapa, C. / Pfob, C.

Nuklearmedizin - NuclearMedicine

2024 Volume 63, Issue 02

Event/congress	62. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin, Leipzig, 2024-04-10
Language	German
Publishing date	2024-03-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2030804-8
ISSN	2567-6407 ; 0029-5566
ISSN (online)	2567-6407
ISSN	0029-5566
DOI	10.1055/s-0044-1782427
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Article ; Online: Five-Year Dynamic Prediction of Dementia Using Repeated Measures of Cognitive Tests and a Dependency Scale.

Ben-Hassen, Céline / Helmer, Catherine / Berr, Claudine / Jacqmin-Gadda, Hélène

American journal of epidemiology

2021 Volume 191, Issue 3, Page(s) 453–464

Abstract: The progression of dementia prevalence over the years and the lack of efficient treatments to stop or reverse the cognitive decline make dementia a major public health challenge in the developed world. Identifying people at high risk of developing ... ...

Abstract	The progression of dementia prevalence over the years and the lack of efficient treatments to stop or reverse the cognitive decline make dementia a major public health challenge in the developed world. Identifying people at high risk of developing dementia could improve the treatment of these patients and help select the target population for preventive clinical trials. We used joint modeling to build a dynamic prediction tool of dementia based on the change over time of 2 neurocognitive tests (the Mini-Mental State Examination and the Isaacs Set Tests) as well as an autonomy scale (the Instrumental Activities of Daily Living). The model was estimated with data from the French cohort Personnes Agées QUID (1988-2015) and validated both by cross-validation and externally with data from the French Three City cohort (1999-2018). We evaluated its predictive abilities through area under the receiver operating characteristics curve and Brier score, accounting for right censoring and competing risk of death, and obtained an average area under the curve value of 0.95 for the risk of dementia in the next 5 or 10 years. This tool is able to discriminate a high-risk group of people from the rest of the population. This could be of help in clinical practice and research.
MeSH term(s)	Activities of Daily Living ; Cognitive Dysfunction/diagnosis ; Dementia/diagnosis ; Dementia/epidemiology ; Humans ; Neuropsychological Tests ; ROC Curve
Language	English
Publishing date	2021-11-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2937-3
ISSN	1476-6256 ; 0002-9262
ISSN (online)	1476-6256
ISSN	0002-9262
DOI	10.1093/aje/kwab269
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Article ; Online: Complaints of daytime sleepiness, insomnia, hypnotic use, and risk of dementia: a prospective cohort study in the elderly.

Cavaillès, Clémence / Berr, Claudine / Helmer, Catherine / Gabelle, Audrey / Jaussent, Isabelle / Dauvilliers, Yves

Alzheimer's research & therapy

2022 Volume 14, Issue 1, Page(s) 12

Abstract: Background: Sleep disturbances are common in elderly and occur frequently in dementia. The impact of excessive daytime sleepiness (EDS), insomnia complaints, sleep quality, and hypnotics on the risk of all-cause dementia, Alzheimer disease (AD), and ... ...

Abstract	Background: Sleep disturbances are common in elderly and occur frequently in dementia. The impact of excessive daytime sleepiness (EDS), insomnia complaints, sleep quality, and hypnotics on the risk of all-cause dementia, Alzheimer disease (AD), and dementia with vascular component (DVC) remains unclear, as does the association between sleep profile and plasma β-amyloid levels. Methods: Analyses were carried out on 6851 participants aged 65 years and over randomly recruited from three French cities and free of dementia at baseline. A structured interview and self-questionnaire assessed sleep complaints (EDS, insomnia complaints, sleep quality) and medications at baseline. Incident cases of dementia were diagnosed systematically over a 12-year period. Multivariate Cox models were used to estimate the risk of dementia associated with the sleep complaints considered individually and globally. Plasma β-amyloid levels were measured by an xMAP-based assay technology in 984 subjects. Results: After adjustment for socio-demographic characteristics, lifestyle, APOE-ε4, cardiovascular factors, and depressive status, EDS had a higher risk of all-cause dementia (HR = 1.21; 95%CI = [1.01-1.46]) and DVC (HR = 1.58; 95%CI = [1.07-2.32]) but not AD. Persistent use of hypnotics increased the risk for all-cause dementia, specifically AD (HR = 1.28; 95%CI = [1.04-1.58]), but not DVC. No association was found for insomnia complaints and sleep quality taken as individual factors or combined with EDS on the risk of dementia. No association was found between β-amyloid, sleep complaints, and incident dementia. Conclusions: The results suggest a deleterious role of EDS and hypnotics on dementia. Further studies are required to elucidate the mechanisms involved in these associations and whether its management can prevent the risk of dementia.
MeSH term(s)	Aged ; Dementia/epidemiology ; Disorders of Excessive Somnolence/diagnosis ; Disorders of Excessive Somnolence/epidemiology ; Humans ; Hypnotics and Sedatives/therapeutic use ; Prospective Studies ; Risk Factors ; Sleep Initiation and Maintenance Disorders/epidemiology
Chemical Substances	Hypnotics and Sedatives
Language	English
Publishing date	2022-01-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2506521-X
ISSN	1758-9193 ; 1758-9193
ISSN (online)	1758-9193
ISSN	1758-9193
DOI	10.1186/s13195-021-00952-y
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Article ; Online: Norms for standard neuropsychological tests from the French CONSTANCES cohort.

Ouvrard, C / Berr, C / Meillon, C / Ribet, C / Goldberg, M / Zins, M / Amieva, H

European journal of neurology

2019 Volume 26, Issue 5, Page(s) 786–793

Abstract: Background and purpose: Neuropsychological testing plays a key role in various clinical contexts. Even though a substantial number of adults suffer neurological disorders such as early-onset dementia, stroke, traumatic brain injury or multiple sclerosis, ...

Abstract	Background and purpose: Neuropsychological testing plays a key role in various clinical contexts. Even though a substantial number of adults suffer neurological disorders such as early-onset dementia, stroke, traumatic brain injury or multiple sclerosis, most normative data do not include persons below 65. The aim of this study was to produce updated norms for the Mini-Mental State Examination, the Free and Cued Selective Reminding Test, the Trail Making Test, verbal fluency tasks and the Digit Symbol Substitution Test for middle-aged and older adults. Methods: The sample consisted of 51 879 participants aged 45-70 years from the CONSTANCES study. Norms are presented in percentiles stratified on age, education and gender. Results: The results illustrated the effect of age in all tests considered. For tests involving speed processing, the impact of age was observed including in tight age range categories (5 years). The results also showed the well-known effect of education and an effect of gender in tests involving verbal memory and speed processing. Conclusions: The norms provided allow the variability of the cognitive performances of middle-aged to older populations to be understood, with a high precision in age categories. The tests considered are broadly used in neuropsychological practice and should be helpful in a variety of clinical contexts.
MeSH term(s)	Age Factors ; Aged ; Cohort Studies ; Cues ; Educational Status ; Female ; France ; Humans ; Male ; Memory ; Mental Status and Dementia Tests ; Middle Aged ; Neuropsychological Tests/standards ; Psychomotor Performance ; Reaction Time ; Reference Values ; Sex Factors ; Trail Making Test ; Verbal Behavior
Language	English
Publishing date	2019-01-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.13890
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Zs.A 4738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Oxidative stress and cognitive impairment in the elderly.

Berr, C

The journal of nutrition, health & aging

2002 Volume 6, Issue 4, Page(s) 261–266

Abstract: Cognitive impairment is a major component of age-related dementing diseases and it has been suggested that it could share the same pathological pathways with neurodegenerative processes and cerebrovascular lesions. The free radical theory of aging could ... ...

Abstract	Cognitive impairment is a major component of age-related dementing diseases and it has been suggested that it could share the same pathological pathways with neurodegenerative processes and cerebrovascular lesions. The free radical theory of aging could be one of these pathways. Observational studies of relationships between cognitive impairment and antioxidant status are based on the evaluation of dietary intake or on the levels of carotenoids, selenium and vitamins A, C and E in plasma. More convincing results were obtained on vitamin C and carotenoids. Despite some limitations, the comparison between results obtained in various populations is becoming increasingly informative and these studies argue for a protective effect of antioxidants on cognitive performance.
MeSH term(s)	Aged ; Aging/metabolism ; Antioxidants/metabolism ; Antioxidants/therapeutic use ; Brain/metabolism ; Cognition/drug effects ; Cognition/physiology ; Cognition Disorders/drug therapy ; Cognition Disorders/epidemiology ; Cognition Disorders/metabolism ; Dementia/drug therapy ; Dementia/epidemiology ; Dementia/metabolism ; Free Radicals ; Humans ; Oxidative Stress
Chemical Substances	Antioxidants ; Free Radicals
Language	English
Publishing date	2002
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
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