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  1. Article ; Online: Metallation-Induced Heterogeneous Dynamics of DNA Revealed by Single-Molecule FRET.

    Berrocal-Martin, Raul / Sanchez-Cano, Carlos / Chiu, Cookson K C / Needham, Russell J / Sadler, Peter J / Magennis, Steven W

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2020  Volume 26, Issue 22, Page(s) 4980–4987

    Abstract: The metallation of nucleic acids is key to wide-ranging applications, from anticancer medicine to nanomaterials, yet there is a lack of understanding of the molecular-level effects of metallation. Here, we apply single-molecule fluorescence methods to ... ...

    Abstract The metallation of nucleic acids is key to wide-ranging applications, from anticancer medicine to nanomaterials, yet there is a lack of understanding of the molecular-level effects of metallation. Here, we apply single-molecule fluorescence methods to study the reaction of an organo-osmium anticancer complex and DNA. Individual metallated DNA hairpins are characterised using Förster resonance energy transfer (FRET). Although ensemble measurements suggest a simple two-state system, single-molecule experiments reveal an underlying heterogeneity in the oligonucleotide dynamics, attributable to different degrees of metallation of the GC-rich hairpin stem. Metallated hairpins display fast two-state transitions with a two-fold increase in the opening rate to ≈2 s
    MeSH term(s) Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; DNA/chemistry ; DNA/metabolism ; Fluorescence ; Fluorescence Resonance Energy Transfer ; Nanotechnology ; Nucleic Acid Conformation
    Chemical Substances Antineoplastic Agents ; DNA (9007-49-2)
    Language English
    Publishing date 2020-03-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202000458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes.

    Venkatesh, V / Berrocal-Martin, Raul / Wedge, Christopher J / Romero-Canelón, Isolda / Sanchez-Cano, Carlos / Song, Ji-Inn / Coverdale, James P C / Zhang, Pingyu / Clarkson, Guy J / Habtemariam, Abraha / Magennis, Steven W / Deeth, Robert J / Sadler, Peter J

    Chemical science

    2017  Volume 8, Issue 12, Page(s) 8271–8278

    Abstract: Mitochondria generate energy but malfunction in many cancer cells, hence targeting mitochondrial metabolism is a promising approach for cancer therapy. Here we have designed cyclometallated iridium(iii) complexes, containing one TEMPO (2,2,6,6- ... ...

    Abstract Mitochondria generate energy but malfunction in many cancer cells, hence targeting mitochondrial metabolism is a promising approach for cancer therapy. Here we have designed cyclometallated iridium(iii) complexes, containing one TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl) spin label [C
    Language English
    Publishing date 2017-10-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/c7sc03216a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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