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  1. Article ; Online: Oral Supplementation Effect of Iron and its Complex Form With Quercetin on Oxidant Status and on Redistribution of Essential Metals in Organs of Streptozotocin Diabetic Rats

    Berroukeche Farid / Mokhtari-Soulimane Nassima / Imessaoudene Asmahan / Cherrak Ahmed Sabri / Ronot Pascale / Boos Anne / Belhandouz Amina / Merzouk Hafida / Elhabiri Mourad

    Romanian Journal of Diabetes Nutrition and Metabolic Diseases, Vol 26, Iss 1, Pp 39-

    2019  Volume 53

    Abstract: Background and aims: Quercetin, is a polyphenolic antioxidant compound. It is able to form complex with metal ions such as iron and exerts a broad range of biological activities like improving metabolic disorders. This research aims at investigating the ... ...

    Abstract Background and aims: Quercetin, is a polyphenolic antioxidant compound. It is able to form complex with metal ions such as iron and exerts a broad range of biological activities like improving metabolic disorders. This research aims at investigating the effect of oral supplementation of iron (2.5mg Fe/Kg/day) and its complex form (molar ratio 1:5; 2.5mg/25mg/Kg/day) with quercetin (25mg/Kg/day) on lipid metabolism, oxidant status and trace elements contents in organs of Wistar diabetic rats (45 mg/kg/rat.ip of streptozotocin) during eight weeks of experimentation.
    Keywords iron-quercetin complex ; diabetes ; oxidative stress ; lipoproteins ; trace elements ; Specialties of internal medicine ; RC581-951
    Language English
    Publishing date 2019-03-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: In Vitro Antioxidant versus Metal Ion Chelating Properties of Flavonoids: A Structure-Activity Investigation.

    Cherrak, Sabri Ahmed / Mokhtari-Soulimane, Nassima / Berroukeche, Farid / Bensenane, Bachir / Cherbonnel, Angéline / Merzouk, Hafida / Elhabiri, Mourad

    PloS one

    2016  Volume 11, Issue 10, Page(s) e0165575

    Abstract: Natural flavonoids such as quercetin, (+)catechin and rutin as well as four methoxylated derivatives of quercetin used as models were investigated to elucidate their impact on the oxidant and antioxidant status of human red blood cells (RBCs). The impact ...

    Abstract Natural flavonoids such as quercetin, (+)catechin and rutin as well as four methoxylated derivatives of quercetin used as models were investigated to elucidate their impact on the oxidant and antioxidant status of human red blood cells (RBCs). The impact of these compounds against metal toxicity was studied as well as their antiradical activities with DPPH assay. Antihemolytic experiments were conducted on quercetin, (+)catechin and rutin with excess of Fe, Cu and Zn (400 μM), and the oxidant (malondialdehyde, carbonyl proteins) and antioxidant (reduced glutathione, catalase activity) markers were evaluated. The results showed that Fe and Zn have the highest prooxidant effect (37 and 33% of hemolysis, respectively). Quercetin, rutin and (+)catechin exhibited strong antioxidant properties toward Fe, but this effect was decreased with respect to Zn ions. However, the Cu showed a weak antioxidant effect at the highest flavonoid concentration (200 μM), while a prooxidant effect was observed at the lowest flavonoid concentration (100 μM). These results are in agreement with the physico-chemical and antiradical data which demonstrated that binding of the metal ions (for FeNTA: (+)Catechin, KLFeNTA = 1.6(1) × 106 M-1 > Rutin, KLFeNTA = 2.0(9) × 105 M-1 > Quercetin, KLFeNTA = 1.0(7) × 105 M-1 > Q35OH, KLFeNTA = 6.3(8.7) × 104 M-1 > Quercetin3'4'OH and Quercetin 3OH, KLFeNTA ~ 2 × 104 M-1) reflects the (anti)oxidant status of the RBCs. This study reveals that flavonoids have both prooxidant and antioxidant activity depending on the nature and concentration of the flavonoids and metal ions.
    MeSH term(s) Chelating Agents/chemistry ; Chelating Agents/pharmacology ; Erythrocytes/drug effects ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Hemolysis/drug effects ; Humans ; In Vitro Techniques ; Metals/chemistry ; Structure-Activity Relationship
    Chemical Substances Chelating Agents ; Flavonoids ; Metals
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0165575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Beneficial effects of quercetin-iron complexes on serum and tissue lipids and redox status in obese rats.

    Imessaoudene, Asmahan / Merzouk, Hafida / Berroukeche, Farid / Mokhtari, Nassima / Bensenane, Bachir / Cherrak, Sabri / Merzouk, Sid Ahmed / Elhabiri, Mourad

    The Journal of nutritional biochemistry

    2016  Volume 29, Page(s) 107–115

    Abstract: Obesity is characterized by iron deficiency, carbohydrate and fat alterations as well as oxidative stress. Iron status monitoring is recommended because of the conventional oral iron preparations that frequently exacerbate the already present oxidative ... ...

    Abstract Obesity is characterized by iron deficiency, carbohydrate and fat alterations as well as oxidative stress. Iron status monitoring is recommended because of the conventional oral iron preparations that frequently exacerbate the already present oxidative stress. Iron complexation by natural antioxidants can be exploited. We herein investigated the metabolic effects of quercetin (25 mg/kg/day), iron (2.5 mg Fe/kg/day) or quercetin-iron complexes (molar ratio 5:1; 25 mg/2.5 mg/kg/day) in animal models of obesity. Our results emphasized that obese rats displayed metabolic alterations that were worsened by iron supplementation. In contrast, quercetin used alone or as iron complex clearly prevented adipose fat accumulation and alleviated the hyperglycemia, hyperlipidemia, liver steatosis and oxidative stress. In addition, it induced a modulation of lipase activities in obese rats. Interestingly, quercetin-iron complexes showed enhanced beneficial effects such as a corrected iron deficiency in obese rats when compared to quercetin alone. In conclusion, antianemic, hypoglycemic, hypolipidemic and antioxidative effects of the quercetin-iron complexes shed a light on their beneficial use against obesity-related metabolic alterations.
    MeSH term(s) Animals ; Body Weight/drug effects ; Iron/chemistry ; Iron/pharmacology ; Lipids/analysis ; Lipids/blood ; Male ; Obesity/blood ; Obesity/metabolism ; Organ Size/drug effects ; Oxidation-Reduction ; Quercetin/chemistry ; Quercetin/pharmacology ; Rats ; Rats, Wistar
    Chemical Substances Lipids ; Quercetin (9IKM0I5T1E) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1014929-6
    ISSN 1873-4847 ; 0955-2863
    ISSN (online) 1873-4847
    ISSN 0955-2863
    DOI 10.1016/j.jnutbio.2015.11.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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